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Rice Bran-derived Peptide KF-8 Attenuates Dexamethasone-induced Myopathy in Caenorhabditis elegans by Regulating Locomotion-related Genes

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Food Science and Human Wellness 2024年

作者： Yixin Wu Jianqiang Wang Fang Huang Yajuan Chen Qinlu lin Zhongxu Chen Zhigang liu Yao Jiang Wenqing Xie Hengzhen li yusheng li Ying liang National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Molecular Nutrition Branch National Engineering Research Center of Rice and By-product Deep Processing College of Food Science and Engineering Central South University of Forestry and Technology Laboratory of Functional Chemistry and Nutrition of Food College of Food Science and Engineering Northwest A&F University The Key Lab of Non-wood Forest Cultivation and Protection of Education Ministry The Key Lab of Non-wood Forest Products of Forestry Ministry Forestry Institute Central South University of Forestry & Technology Department of Orthopedics Xiangya Hospital Central South University

Background and aims: Dexamethasone is a common glucocorticoid medication with adverse effects that can cause muscle atrophy， but no drug intervention has been approved or recommended for this condition. KF-8 is a rice bran-derived anti-oxidant peptide that extends the life span of Caenorhabditis elegans. Methods: We established a C. elegans model of dexamethasone-induced myopathy to evaluate the potential therapeutic effects of KF-8 in this model. C. elegans muscle function was assessed in terms of locomotory behaviors including crawling， swimming， burrowing， pharyngeal pumping， and head swing. Muscle actin filament integrity was evaluated using fluorescence imaging. The molecular mechanisms of KF-8 were investigated using transcriptome sequencing， qRT-PCR， RNA interference， and western blot analysis. Results: Dexamethasone disrupted actin filaments in the striated muscles of the body wall and inhibited C. elegans crawling， swimming， burrowing， pharyngeal pumping， and head swing. KF-8 reversed the actin filament disruption and locomotor dysfunction induced by dexamethasone. Transcriptome sequencing， pathway enrichment， and qRT-PCR analyses revealed that KF-8 regulated the locomotion-related genes W04G5.10， vha-12， and ddr-1， as well as age-1 (the catalytic subunit ortholog of PI3K)， and akt1. RNA interference， conducted using a genetically engineered E. coli HT115 strain as a food source， confirmed age-1 as a key regulator of locomotor function of C. elegans. Further mechanistic studies with C2C12 myotubes showed that KF-8 regulated the IRS-PI3K-Akt pathway， the master regulator of protein synthesis and degradation. Conclusion: Together， these findings suggest that KF-8 protects against dexamethasone-induced myopathy in C. elegans by regulating locomotion-related genes and the IRS-PI3K-Akt pathway.

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Progress in osteoarthritis research by the National Natural Science Foundation of China

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Bone Research 2022年第3期10卷 409-420页

作者： yusheng li Wenqing Xie Wenfeng Xiao Dou Dou Deparment of Orthopedics Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Department of Health Sciences National Natural Science Foundation of ChinaBeijing 100085China

Osteoarthritis(OA) in China is gradually becoming an important scientific research area that has had a significant impact on research and development(R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in China in recent years. The National Natural Science Foundation of China(NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars’ R&D activities. We collected and analyzed information on NSFC funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the NSFC in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in China.

关键词： NSFC supporting becoming

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Gradient structure induced simultaneous enhancement of strength and ductility in AZ31 Mg alloy with twin-twin interactions

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Journal of Magnesium and Alloys 2023年第8期11卷 2872-2882页

作者： Qinghui Zhang Jianguo li Kun Jiang Pu li yusheng li Yong Zhang Tao Suo School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Shaanxi Key Laboratory of Impact Dynamics and Its Engineering Application Xi'an 710072China Joint International Research Laboratory of Impact Dynamics and Its Engineering Application Xi'an 710072China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Materials Science and Engineering Herbert Gleiter Institute of NanoscienceNanjing University of Science and TechnologyNanjing 210094China

Gradient nanostructure was introduced to enhance the strength and ductility via deformation incompatibility accommodated by geometrical necessary dislocations for most metallic materials recently.However,few intensive researches were carried out to investigate the effect of gradient structure on the deformation twin evolution and resulting performance improvements.In the present paper,we produced gradient-structured AZ31 Mg alloy with fine-grain layers,parallel twin laminates and a coarse-grain core from two upmost surfaces to the center of plate.Surprisingly,this architected Mg alloy exhibited simultaneous enhancement of strength and ductility.Subsequent microstructural observations demonstrated that abundant twin-twin interactions resulting from higher strength and multi-axial stress state could make great contributions to the increase of work-hardening capability.This was further proved by the measurement of full-field strain evolution during the plastic deformation.Such a design strategy may provide a new path for producing advanced structure materials in which the deformation twinning works as one of the dominant plasticity mechanisms.

关键词： Mg alloy Gradient structure Strength-ductility synergy Multi-orientational twins Twin-twin interactions

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Role of adipokines in sarcopenia

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Chinese Medical Journal 2023年第15期136卷 1794-1804页

作者： Wenhao Lu Wenjie Feng Jieyu Lai Dongliang Yuan Wenfeng Xiao yusheng li Department of Orthopaedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Burns and Plastic Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Xiangya School of Medicine Central South UniversityChangshaHunan 410083China.

Sarcopenia is an age-related disease that mainly involves decreases in muscle mass,muscle strength and muscle function.At the same time,the body fat content increases with aging,especially the visceral fat content.Adipose tissue is an endocrine organ that secretes biologically active factors called adipokines,which act on local and distant tissues.Studies have revealed that some adipokines exert regulatory effects on muscle,such as higher serum leptin levels causing a decrease in muscle function and adiponectin inhibits the transcriptional activity of Forkhead box O3(FoxO3)by activating peroxisome proliferators-activated receptor-γcoactivator-1α(PGC-1α)and sensitizing cells to insulin,thereby repressing atrophy-related genes(atrogin-1 and muscle RING finger 1[MuRF1])to prevent the loss of muscle mass.Here,we describe the effects on muscle of adipokines produced by adipose tissue,such as leptin,adiponectin,resistin,mucin and lipocalin-2,and discuss the importance of these adipokines for understanding the development of sarcopenia.

关键词： Sarcopenia Adipokines Leptin Adiponectin lipocalin-2 Visfatin Resistin

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Bone Research 2023年第1期11卷 1-20页

作者： Qin Ru yusheng li Wenqing Xie Yilan Ding lin Chen Guodong Xu Yuxiang Wu Fudi Wang Department of Health and Physical Education Jianghan UniversityWuhan430056China Department of Orthopedics Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China The Second Affiliated Hospital School of Public HealthState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhouChina The First Affiliated Hospital Basic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyangChina

Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid metabolism, and the biosynthesis of compounds with antioxidant activities, including glutathione. In the past 10 years, increasing evidence has indicated a potentially strong relationship between ferroptosis and the onset and progression of age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Therefore, in-depth knowledge of the regulatory mechanisms of ferroptosis in age-related orthopedic diseases may help improve disease treatment and prevention. This review provides an overview of recent research on ferroptosis and its influences on bone and cartilage homeostasis. It begins with a brief overview of systemic iron metabolism and ferroptosis,particularly the potential mechanisms of ferroptosis. It presents a discussion on the role of ferroptosis in age-related orthopedic diseases, including promotion of bone loss and cartilage degradation and the inhibition of osteogenesis. Finally, it focuses on the future of targeting ferroptosis to treat age-related orthopedic diseases with the intention of inspiring further clinical research and the development of therapeutic strategies.

关键词： metabolism diseases peroxidation

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Alternating Direction Method for Separable Variables Under Pair-Wise Constraints

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Communications in Mathematics and Statistics 2017年第1期5卷 59-82页

作者： Jiaojiao Yang yusheng li Xinchang Xie Zhouwang Yang University of Science and Technology of China HefeiChina Luoyang Electronic Equipment Test Center LuoyangChina Duke University DurhamNCUSA

While the convergence of alternating direction method(ADM)for two sep-arable variables has been established for years,the validity of its direct generalizationto more than two blocks has been studying now.In this paper,we propose an additionalrequirement on the constraints,i.e.,the pair-wise linear constraints and establish theconvergence of ADM for more than two blocks.Then we apply our approach to twokinds of optimization problems.We also show several numerical experiments to verifythe rationality of proposed algorithm.

关键词： Alternating direction method Convergence analysis Pair-wise constraints l1-Analysis problem

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Enhanced efficiency and stability in Sn-based perovskite solar cells by trimethylsilyl halide surface passivation

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Journal of Energy Chemistry 2022年第8期31卷 604-611,I0016页

作者： Zheng Zhang liang Wang Ajay Kumar Baranwal Shahrir Razey Sahamir Gaurav Kapil Yoshitaka Sanehira Muhammad Akmal Kamarudin Kohei Nishimura Chao Ding Dong liu yusheng li Hua li Mengmeng Chen Qing Shen Teresa SRipolles Juan Bisquert Shuzi Hayase Graduate School of Informatics and Engineering University of Electro-Communication1-5-1 ChofugaokaChofuTokyo 182-8585Japan Escuela Técnica Superior de Ingeniería de Telecomunicación Universidad Rey Juan CarlosMadrid 28933Spain Institute of Advanced Materials(INAM) Universitat Jaume ICastelló12006Spain

Lead free tin perovskite solar cells(PKSCs)are the most suitable alternative candidate for conventional lead perovskite solar cells.However,the efficiency and the stability are insufficient,mainly because of the poor film quality and numerous defects.Here we introduce an efficient strategy based on a simple trimethylsilyl halide surface passivation to increase the film quality and reduce the defect density.At the same time,a hydrophobic protective layer on the perovskite surface is formed,which enhanced the PKSCs’stability.The efficiency of the solar cell after the passivation was enhanced from 10.05%to 12.22%with the improved open-circuit voltage from 0.57 V to 0.70 V.In addition,after 92 days of storage in N_(2) filled glovebox,the modified T-PKSCs demonstrated high stability maintaining 80%of its initial efficiency.This work provides a simple and widely used strategy to optimize the surface/interface optoelectronic properties of perovskites for giving more efficient and stable solar cells and other optoelectronic devices.

关键词： Tin halide perovskite Trimethylsilyl halide Surface passivation Stability

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Alternating Direction Method of Multipliers for Solving Dictionary Learning Models

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Communications in Mathematics and Statistics 2015年第1期3卷 37-55页

作者： yusheng li Xinchang Xie Zhouwang Yang University of Science and Technology of China HefeiChina Duke University DurhamUSA

In recent years,there has been a growing usage of sparse representations in signal processing.This paper revisits theK-SVD,an algorithm for designing overcomplete dictionaries for sparse and redundant representations.We present a newapproach to solve dictionary learning models by combining the alternating direction method of multipliers and the orthogonal matching pursuit.The experimental results show that our approach can reliably obtain better learned dictionary elements and outperform other algorithms.

关键词： Dictionary learning K-SVD Alternating direction method of multipliers Orthogonal matching pursuit

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Neutralization of excessive levels of active TGF-β1 reduces MSC recruitment and differentiation to mitigate peritendinous adhesion

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Bone Research 2023年第2期11卷 368-383页

作者： Yu Sheng li Xiao Wang Bo Hu Qi Sun Mei Wan Andrew Carr Shen liu Xu Cao Department of Orthopedic Surgery The Johns Hopkins University School of MedicineBaltimoreMD21205USA Nuffield Department of Orthopedics Rheumatology and Musculoskeletal SciencesBotnar Research CentreUniversity of OxfordWindmill RoadOxford OX 37 LDUK

PPeritendinous adhesion formation(PAF)can substantially limit the range of motion of digits.However,the origin of myofibroblasts in PAF tissues is still unclear.In this study,we found that the concentration of active TGF-β1 and the numbers of macrophages,mesenchymal stromal cells(MSCs),and myofibroblasts in human and mouse adhesion tissues were increased.Furthermore,knockout of TGF-β1 in macrophages or TGF-β1R2 in MSCs inhibited PAF by reducing MSC and myofibroblast infiltration and collagenⅠandⅢdeposition,respectively.Moreover,we found that MSCs differentiated into myofibroblasts to form adhesion tissues.Systemic injection of the TGF-β–neutralizing antibody 1D11 during the granulation formation stage of PAF significantly reduced the infiltration of MSCs and myofibroblasts and,subsequently,PAF.These results suggest that macrophage-derived TGF-β1 recruits MSCs to form myofibroblasts in peritendinous adhesions.An improved understanding of PAF mechanisms could help identify a potential therapeutic strategy.

关键词： inhibited injection MSC

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Hardening after annealing in nanostructured 316L stainless steel

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Nano Materials Science 2020年第1期2卷 80-82页

作者： Zhongchen Zhou Shuaizhuo Wang Jiansheng li yusheng li Xiaolei Wu Yuntian Zhu Nano and Heterogeneous Materials Center School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing210094China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing100190China Department of Materials Science and Engineering North Carolina State UniversityRaleighNC27695USA

In this work,coarse-grained 316 L stainless steels were cold rolled with a thickness reduction of^83%(CR 83%).After annealing,the behaviors of the nanostructured stainless steel samples were systematically investigated in the temperatures range of 200C–650C.It was found that with increasing annealing temperature the volume fraction of theα0-martensite first increased to reach a maximum value at 400C,then the volume fraction decreased with further increases of the annealing temperature.The yield strength was increased from 1400 MPa to 1720 MPa after annealing;this strong hardening effect in cold rolled 316 L stainless steel was mainly attributed to the increase of the volume fraction ofα0-martensite.

关键词： Metals and alloys Nanostructure Heterostructure 316L stainless steel Annealing hardening Martensitic transformation

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