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Hepatobiliary system and intestinal injury in new coronavirus infection(COvID-19):A retrospective study

World Journal of Clinical Cases 2023年第10期11卷 2226-2236页

作者： Konstantin v Kozlov Konstantin v Zhdanov Anna K Ratnikova vyacheslav A Ratnikov Artem v Tishkov vladimir Grinevich yuriy A Kravchuk Panteley I Miklush Polina O Nikiforova vera v Gordienko Alexander F Popov Boris G Andryukov Department of Infectious Disease Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia Department of Admission Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Roentgenology Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Physics Mathematics and InformaticsFSBEI HE IP.Pavlov SPbSMU MOH RussiaSaint-Petersburg 197022Russia 2nd Department of Therapy(Advanced Medical Education) Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia School of Medicine Far Eastern Federal UniversityVladivostok 690922Russia

BACKGROUND An important area of effective control of the coronavirus disease 19(COvID-19)pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection,including those based on assessing the state of the intestinal microbiota and *** To study the clinical features of the new COvID-19 in patients with mild and moderate severity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with *** The study was performed in 80 patients with COvID-19,with an average age of 45 years,19 of whom had mild disease,and 61 had moderate disease *** scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal *** The clinical course of COvID-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate severity were *** permeability characteristics against the background of COvID-19 were evaluated by measuring levels of proinflammatory cytokines,insulin,faecal calprotectin,and *** This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COvID-19 severity.

关键词： Novel coronavirus infection COvID-19 SARS-Cov-2 Zonulin Faecal calprotectin Microbiota

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改良剂对土壤镉吸附能力和小白菜生长的影响

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黑龙江农业科学 2024年第9期 25-34页

作者：孙思淼王晓军谷学佳 АНТОНИНОВАЯ.Наталья УСМАНОВИ.Альберт СОБЕНИНВ.Артем 高洪生黑龙江省肥料工程技术研究中心/黑龙江省黑土保护利用研究院/农业农村部东北平原农业环境重点实验室黑龙江哈尔滨150086 俄罗斯科学院乌拉尔分院/采矿研究所采矿生态学实验室俄罗斯叶卡捷琳堡620075

为探究泥炭硅藻改良剂、牡蛎钙、生物炭和钢渣的吸附特征以及对镉(Cd)污染下小白菜生长性状的影响,通过吸附试验研究时间、浓度及投入量对改良剂吸附溶液中Cd的影响,并通过室内试验,研究在Cd污染下不同改良剂对小白菜生长、Cd浓度、根... 详细信息

为探究泥炭硅藻改良剂、牡蛎钙、生物炭和钢渣的吸附特征以及对镉(Cd)污染下小白菜生长性状的影响,通过吸附试验研究时间、浓度及投入量对改良剂吸附溶液中Cd的影响,并通过室内试验,研究在Cd污染下不同改良剂对小白菜生长、Cd浓度、根际土壤全量和有效态Cd浓度的影响。结果表明,(1)准二级动力学模型、Langmuir模型和颗粒内扩散模型更符合改良剂对Cd的吸附过程,钢渣和生物炭具有较好的吸附性能,当投入量>1.0 g时,二者对Cd的去除率均为99.0%以上;(2)施用改良剂均显著促进小白菜生长,与CK对比,4个处理干重分别增加了63.82%、42.38%、98.45%和30.23%,其中生物炭的促生效果最显著;改良剂促进Cd在根部富集并向地上部转运,钢渣的转运作用最显著,转运系数(TF)达到1.84;(3)泥炭硅藻改良剂显著降低根际土壤全Cd浓度,与对照相比降低了16.72%,并降低了潜在生态风险。钢渣能显著降低根际土壤有效态Cd浓度,与对照相比降低了56.91%,显著提高根际土壤pH,达到7.96。研究表明,钢渣具有良好的吸附Cd的性能,泥炭硅藻改良剂的综合改良效果最好。

关键词：泥炭硅藻改良剂生物炭钢渣吸附镉土壤修复

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Myorelaxation in the training process of skilled athletes

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Open Journal of Molecular and Integrative Physiology 2013年第2期3卷 83-86页

作者： yuriy P. Denisenko yuriy v. vysochin Leonid G. Yatsenko Department of Physical Education St. Petersburg State Technological University of Vegetative Polymers St. Petersburg Russia Department of Theory and Methods of Sports Games Branch of Povolzhskaya State Academy of Physical Culture Sports and Tourism Naberezhnye Chelny Russia

At the present time, a number of various ways of sportspersons’ special physical capability (SPC) based mainly on training and competitive loadings ramp up. They are effective enough to reach the main goal, but none of them provides sportspersons’ health safety. Moreover, with the increase in volume and intensity of the loadings, which in sport have almost reached their limits, the sport traumatism and morbidity rate grow progressively. Proceeding from this, there was an evident necessity for the search of conceptually new ways for a simultaneous solution of these two the most complex and, in the opinion of many research workers, almost incompatible problems—the problem of achieving the highest levels of special physical working capacity, and the problem of sportspersons’ health maintenance and improving-associated by us into one general problem of human motor activity efficiency enhancement. Therefore it is necessary to physiologically substantiated the basic methods and principles of special relaxation training, directed on increase of efficiency of process of training of sportsmen at all stages of the development of athletic skills. Under the efficiency of the motor activity, we understand achieve the highest levels of the special physical performance while maintaining sports longevity and health of athletes.

关键词： Extreme Conditions Protection Functional System Muscle Relaxation Rate Physical Efficiency Central Nervous System Relaxation

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Identification of genes involved in the formation of soluble dietary fiber in winter rye grain and their expression in cultivars with different viscosities of wholemeal water extract

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The Crop Journal 2022年第2期10卷 532-549页

作者： Liudmila v.Kozlova Alsu R.Nazipova Oleg v.Gorshkov Liliya F.Gilmullina Olga v.Sautkina natalia v.Petrova Oksana I.Trofimova Sergey N.Ponomarev Mira L Ponomareva Tatyana A.Gorshkova Kazan Institute of Biochemistry and Biophysics Federal Research CenterKazan Scientific Center of the Russian Academy of Sciences420111 KazanRussia Tatar Scientific Research Institute of Agriculture Federal Research CenterKazan Scientific Center of the Russian Academy of Sciences420059 KazanRussia

The grain of rye(Secale cereale L.) used for baking contains a large amount of non-starch polysaccharides,making it an excellent component of functional foods. But rye grain intended for alcohol production and forage use should have a reduced content of these polysaccharides. A comprehensive parameter that can predict the best field of application for winter rye grain is the viscosity of its wholemeal water ***, our understanding of the genetic background underlying this key trait and associated features of rye grain is poor. By analyzing six Russian winter rye cultivars, we identified the most contrasting forms and characterized the peculiarities of their water-soluble carbohydrates capable of influencing the viscosity of water extracts. Then, using phylogenetic and transcriptomic analyses, we identified in the rye genome many genes encoding putative glycosyltransferases and glycosylhydrolases responsible for the synthesis and degradation of arabinoxylans, mixed-linkage glucans, cellulose, and some other polysaccharides. We determined the dynamics of m RNA abundance for these genes at three stages of kernel development. Comparisons of gene expression levels in two contrasting cultivars revealed specific members of multigene families that may serve as promising targets for manipulating non-starch polysaccharide content in rye grain. High-viscosity cultivars were characterized by up-regulation of many glycosyltransferases involved in the biosynthesis of arabinoxylans and other cell-wall polysaccharides,whereas low-viscosity cultivars showed up-regulation of several genes encoding polysaccharidedegrading enzymes.

关键词： Rye(Secale cereale) Kernel development Arabinoxylan Mixed-linkage glucan viscosity

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The effect of high fat food on erythrocyte phospholipids, fatty acids composition and glutathione redox-system of rats with alimentary dyslipidemia

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Health 2010年第1期2卷 45-50页

作者： natalia v. Zhukova Yulia K. Karaman natalia v. Zhukova 不详

To evaluate the effects of high fat food consisted of tallow (19% of total diets) and cholesterol (2%) on modification of erythrocyte phospholipids, fatty acids composition and glutathione redox- system of male Wistar rats with alimentary dysli- pidemia. The results demonstrated that after 30 and 180 days of high-fat feed erythrocyte phos- phatidylinositol and phosphatidylcholine levels were reduced, phosphatidylserine were in-creased. Only on the 90 days of the experiment phosphatidylinositol level increased. In all grow- ups the erythrocyte 18:0 saturated fatty acids and 20:4n6, 22:4n6 polyunsaturated fatty acids (PUFA) were increased. Deficit of n3 PUFA- 20:5n3 and 22:6n3 after 90 and 180 days high fat feed promoted compensatory synthesis from 18:1n9 on 20:3n9. Erythrocyte maleic dialde-hyde increased, glutathione level decreased in all groups of rats after fed with high-fat feed. Glutathione reductase and glutathione peroxi-dase activity decreased in erythrocytes after 30 and 180 days of high-fat feed. In conclusion: high-fat diet during 30-90 days started adaptive answer in lipids of membrane and glutathione redox-system. Important mechanism of adapta-tion of a cellular membrane to high-fat diet is increase major, structuring a membrane phos-phatidylethanolamine and minor, most meta-bolic significant fractions phospholipids (phos- phatidylinositol), keeps homeostasis of 18:2n6 and 22:6n3, 20:3n9 compensatory synthesis, decrease in activity of processes lipid peroxi-dation, activation of enzymes of redox-system glutathione. But prolonging the high-fat feeding (180 days and more) formed failure compensa-tory processes (dysadaptation). It is a risk factor of developmening atherosclerosis, diabetes, steatogepatitis and other diseases.

关键词： Fatty Acids Phospholipids Adaptation Dyslipidemia GSH Glutathione Reductase Glutathione Peroxidase

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HLA class Ⅰ loss in colorectal cancer:implications for immune escape and immunotherapy

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Cellular & Molecular Immunology 2021年第3期18卷 556-565页

作者： Per Anderson natalia Aptsiauri Francisco Ruiz-Cabello Federico Garrido Instituto de Investigaci6n Biosanitaria(ibs.GRANADA) GranadaSpain Servicio de Analisis Clinicos e Inmunologia Hospital Universitario Virgen de las Nieves18014 GranadaSpain Departamento de Bioqufmica Bioiogta Molecular 3 e InmunologiaUniversidad de GranadaGranadaSpain

T cell-mediated immune therapies have emerged as a promising treatment modality in different malignancies including colorectal cancer(CRC).However,only a fraction of patients currently respond to *** the lack of responses and finding biomarkers with predictive value is of great *** is evidence that CRC is a heterogeneous disease and several classification systems have been proposed that are based on genomic instability,immune cell infiltration,stromal content and molecular subtypes of gene *** leukocyte antigen class Ⅰ(HLA-Ⅰ)plays a pivotal role in presenting processed antigens to T lymphocytes,including tumour *** molecules are frequently lost in different types of cancers,including CRC resulting in tumour immune escape from cytotoxic T lymphocytes during the natural history of cancer *** aim of this review is to(i)summarize the prevalence and molecular mechanisms behind HLA-Ⅰ loss in CRC,(ii)discuss HLA-Ⅰ expression/loss in the context of the newly identified CRC molecular subtypes,(iii)analyze the HLA-Ⅰ phenotypes of CRC metastases disseminated via blood or the lymphatic system,(iv)discuss strategies to recover/circumvent HLA-I expression/loss and finally(v)review the role of HLA class Ⅱ(HLA-Ⅱ)in CRC prognosis.

关键词： Colorectal cancer Immune escape HLA ClassⅠ

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Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 51-63页

作者： vladimir Y.Zaitsev Alexandr L.Matveyev Lev A.Matveev Ekaterina v.Gubarkova Alexandr A.Sovetsky Marina A.Sirotkina Grigory v.Gelikonov Elena v.Zagaynova natalia D.Gladkova Alex vitkin Institute of Applied Physics Russian Academy of Sciences Ulyanova Street 46 Nizhny Novgorod 603950 Russia Nizhny Novgorod State Medical Academy 10/1 Minina Square Nizhny Novgorod 603005 Russia University of Toronto and University Health Network 610 University Avenue Toronto ON M5G 2M9Canada

In this paper,we point out some practical obstacles arising in realization of compressional optical coherence elastography(OCE)that have not attracted sufficient attention ***-cally,we discuss(i)complications in quantification of the Young modulus of tissues related to partial adhesion between the OCE probe and soft intervening reference layer sensor,(i)distorting influence of tisue suface curvature/corrugation on the subsurface strain distri-bution mapping,(ii)ways of signal-to-noise mtio(SNR)enhancement in OCE strain mapping when periodic averaging is not realized,and(iv)potentially significant infuence of tissue elastic nonlinearity on quantification of its *** pnactical approaches to mitigate the effects of these complications are also described.

关键词： Optical coherence elastography optical coherence tomography phase-resolved methods strain mapping stiffness characterization

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Labeling of influenza viruses with synthetic fluorescent and biotin-labeled lipids

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virologica Sinica 2014年第4期29卷 199-210页

作者： natalia A Ilyushina Evgeny S Chernyy Elena Y Korchagina Aleksra S Gambaryan Stephen M Henry Nicolai v Bovin Food and Drug Administration 29 Lincoln DriveBethesda 20892 MD USA Shemyakin Institute of Bioorganic Chemistry Russian Academy of Sciences Miklukho Maklaya 16/10Moscow 117997 Russia Chumakov Institute of Poliomyelitis and viral Encephalitides Russian Academy of Medical SciencesMoscow Region 142782 Russia Biotechnology Research Institute AUT University Private Bag 92006Auckland 1142 New Zealand

Direct labeling of virus particles is a powerful tool for the visualization of virus–cell interaction events. However, this technique involves the chemical modification of viral proteins that affects viral biological properties. Here we describe an alternative approach of influenza virus labeling that utilizes Function-Spacer-Lipid(FSL) constructs that can be gently inserted into the virus membrane. We assessed whether labeling with fluorescent(fluo-Ad-DOPE) or biotin-labeled(biot-CMG2-DOPE) probes has any deleterious effect on influenza virus hemagglutinin(HA) receptor specificity, neuraminidase(NA) activity, or replicative ability in vitro. Our data clearly show that neither construct significantly affected influenza virus infectivity or viral affinity to sialyl receptors. Neither construct influenced the NA activities of the influenza viruses tested, except the A/Puerto Rico/8/34(H1N1) strain. Our data indicate that lipid labeling provides a powerful tool to analyze influenza virus infection in vitro.

关键词： bioimaging Function-Spacer-Lipid (FSL) constructs labeling of influenza viruses synthetic lipids

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Characterization of cerebral blood flow dynamics with multiscale entropy

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 85-93页

作者： Alexey N.Pavlov Arkady S.Abdurashitov Olga N.Pavlova Maria v.Ulanova Anastasia A.Bodrova natalia A.Shushunova Alexander P.Khorovodov Oxana v.Semyachkina-Glushkovskaya Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Street Saratov 410054Russia Saratov National Research State University 83 Astrakhanskaya Street Saratov 410012Russia

Based on the laser speckle contrast imaging(LSCI)and the multiscale entropy(MSE),we study in this work the blood flow dynamics at the levels of cerebral veins and the surrounding network of microcerebral *** discuss how the phenylephrine-related acute peripheral bypertension is refected in the cerebral circulation and show that the observed changes are scale dependent,and they are signifcantly more pronounced in microcerebral vessels,while the macrocerebral dynamics does not demonstrate authentic inter-group *** also consider the permeability of blood-brain barrier(BBB)and study its opening caused by sound *** show that alterations associated with the BBB opening can be revealed by the analysis of blood flow at the level of macrocerebral vessels.

关键词： Cerebral blood flow laser speckle contrast imaging arterial pressure complexity

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Collagen scaffolds functionalized with triple-helical peptides support 3D HUvEC culture

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Regenerative Biomaterials 2020年第5期7卷 471-482页

作者： Jean-Daniel Malcor Emma J.Hunter natalia Davidenko Daniel v.Bax Ruth Cameron Serena Best Sanjay Sinha Richard W.Farndale Department of Biochemistry University of CambridgeCambridge CB21QWUK Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK Division of Medicine and Wellcome Trust Medical Research Council Cambridge Stem Cell InstituteUniversity of CambridgeCambridge CB20AWUK Present address:CambCol Laboratories Ltd Oak Lane Business ParkLittleportElyCambridgeshireCB79RPUK

Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue *** biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered ***-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze–drying of collagen suspensions,followed by chemical cross-linking which maintains their ***,cross-linking scaffolds renders their biological activity suboptimal for many cell types,including human umbilical vein endothelial cells(HUvECs),by inhibiting cell–collagen ***,we have improved crucial HUvEC interactions with such cross-linked collagen biomaterials by covalently coupling combinations of triple-helical peptides(THPs).These are ligands for collagen-binding cell-surface receptors(integrins or discoidin domain receptors)or secreted proteins(SPARC and von Willebrand factor).THPs enhanced HUvEC adhesion,spreading and proliferation on 2D collagen *** grafted to 3D-cross-linked collagen scaffolds promoted cell survival over seven *** study demonstrates that THP-functionalized collagen scaffolds are promising candidates for hosting endothelial cells with potential for the production of vascularized engineered tissues in regenerative medicine applications.

关键词： collagen biomaterial endothelial cells 3D cell scaffold collagen-mimetic peptides

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