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Nitrogen and Carbon Isotope Data of Olenekian to Anisian Deposits from Kamenushka/South Primorye, Far-Eastern Russia and Their Palaeoenvironmental Significance

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Journal of Earth Science 2018年第4期29卷 837-853页

作者： yuri D Zakharov Micha Horacek Alexander M Popov Liana G Bondarenko Far Eastern Geological Institute of Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia BLT Wieselburg Research Center HBLFA Francisco-Josephinum Wieselburg 3250 Austria Institute of Lithospheric Research Vienna University Vienna 1090 Austria

The Kamenushka Formation, exposed in the northern part of South Primorye （Kamennshka-1 and Kamenushka-2 sections）, is one of the few localities in the world with richly fossiliferous Lower-Upper Olenekian sedimentary successions. Lower to Middle Triassic ammonoid-, brachiopod- and conodont-bearing silty-clayey deposits of the Kamenushka-1 and Kamenushka-2 sections have been isotope-geochemically investigated in detail. As a result, these sections, together with the previously investigated Abrek Section, exposed in the southern part of South Primorye, provide almost complete ^15Non- and ^13Corg- records for the Lower Triassic of this region. Nine N- isotope intervals and the five negative C-isotope excursions, reflecting, apparently, unstable climatic and hydrological conditions, have been distinguished in the Lower Triassic of South Primorye. On the basis of the new C-isotope data the Mesohedenstroemia bosphorensis Zone （upper part）, Shimanskyites shimanskyi and Neocolumbites insignis zones of South Primorye are correlated now with the Lower Smithian part of the Yinkeng Formation, the Upper Smithian part of the Helongshan Formation and the Middle Spathian part of the Nanlinghu Formation in South China, respectively, as has been observed in the Abrek, Kamenushka-2, West Pingdingshan and Majiashan sections.

关键词： Triassic N- and C-isotopes palaeoclimatology bio- and chemostratigraphy Pri- morye Russia.

Polariton polarization rectifier

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Light(Science & Applications) 2019年第1期8卷 505-514页

作者： Evgeny S.Sedov yuri G.Rubo Alexey V.Kavokin Westlake University 18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina Institute of Natural Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024 Zhejiang ProvinceChina Vladimir State University Gorky str.87Vladimir 600000Russia Instituto de Energias Renovables Universidad Nacional Autonoma de Mexico62580 TemixcoMORMexico Spin Optics Laboratory Saint Petersburg State University1 UlianovskayaSt.Petersburg 198504Russia

We propose a novel photonic device,the polariton polarization rectifier,intended to transform polariton pulses with arbitrary polarization into linearly polarized pulses with controllable orientation of the polarization *** is based on the interplay between the orbital motion of the polariton wave packet and the dynamics of the polariton pseudospin governed by the spatially dependent effective magnetic *** latter is controlled by the TE-TM splitting in a harmonic *** show that the unpolarized polariton pulse acquires linear polarization in the course of propagation in a harmonic *** gives the considered structure an extra function as a linear polarizer of polariton pulses.

关键词： field polarized harmonic

Multiscale wood micromechanics and size effects study via nanoindentation

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生物质资源与工程(英文) 2023年第3期8卷 246-264页

作者： yuri I.Golovin Alexander A.Gusev Dmitry Yu.Golovin Sergey M.Matveev Alexander I.Tyrin Alexander A.Samodurov Viktor V.Korenkov Inna A.Vasyukova Maria A.Yunack Institute“Nanotechnology and Nanomaterials” G.R.Derzhavin Tambov State University392000 TambovRussia Department of Chemical Enzymology School of ChemistryLomonosov Moscow State University119991 MoscowRussia Research and Educational Center«Sustainable Development of the Forest Complex» Voronezh State Forestry University Named after G.F.Morozov394087 VoronezhRussia Department of Functional Nanosystems and High-Temperature Materials National University of Science and Technology“MISIS”119991 MoscowRussia

Wood as a material is a natural composite with a complex hierarchically arranged *** scale levels of wood structure contribute to its macroscopic mechanical *** nature of such characteristics and deformation modes differs radically at different scale *** macroscopic properties are well studied,and the relevant information can be easily found in the ***,the knowledge of the deformation mechanisms at the mesoscopic level corresponding to the cellular structure of early and late wood layers of annual growth rings is *** hinders building the comprehensive multiscale model of how wood mechanical properties are *** paper described the results of scanning of mechanical properties of softwood and hardwood samples,such as common pine,small-leaf lime,and pedunculate oak,by means of nanoindentation(NI).The NI technique allows varying the size of deformed region within a wide range by altering maximal load(P max)applied to the indenter so that one can re-peatedly and non-destructively test wood structural components at different scale levels on the same sample without changing the technique or *** was discovered that the effective microhardness(H eff)and Young’s modulus(E eff)decreased manifold with P max growing from 0.2 to 2000 *** drop in H effwas observed when the locally deformed region grew,and re-sulting from P max increase generally follows the rule similar to the Hall-Petch relation for yield stress,strength,and hardness initially established for metals and alloys,though obviously in those cases the underlying internal mechanisms are quite *** nature and micromechanisms of such size effect(SE)in wood revealed using NI were discussed in this *** P max<0.2 mN,the deformed area under the pyramidal Berckovich indenter was much smaller than the cell wall ***,in this case,NI measured the internal mechanical properties of the cell wall material as long as free boundaries impact

关键词： Nano/microhardness Scanning nanoindentation Annual growth ring Early and late wood Dendrochronology

CT as a first-line modality in elderly patients with stable blunt chest trauma

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Chinese Journal of Traumatology 2021年第5期24卷 255-260页

作者： Alexander Becker Tamar Dola yuri Berlin Dan Hershko Department of Surgery A Emek Medical CenterAfula18101Israel Faculty of Medicine.Technion-lsrael Institute of Technology Haifa31096Israel

Blunt thoracic injuries are common among elderly patients and may be a common cause of morbidity and death from blunt trauma *** aimed to examine the impact of chest CT on the diagnosis and change of management plan in elderly patients with stable blunt chest *** hypothesized that chest CT may play an important role in providing optimal management to this subgroup of trauma patients.;A retrospective analysis was performed on all the admitted adult blunt trauma patients between January 2014 and December *** blunt chest trauma patients with abbreviated injury severity(AIS)<3 for extra-thoracic injuries confirmed with chest X-ray(CXR)and chest CT on admission or during hospitalization were included in the *** AIS is an international scale for grading the severity of anatomic injury following blunt *** outcome variables were occult injuries,change in management,need for surgical procedures,missed injuries,readmission rate,intensive care unit(ICU)and length of hospital stay.;There are 473 patients with blunt chest trauma included in the *** study patients were divided into two groups according to the age range:group 1:289 patients were included and aged 18-64 years;group 2:184 patients were included and aged 65-99 *** patients in group 2 more often required ICU admission(11.4%vs.5.2%),had a longer length of ICU stay(days)(median 11 vs.6,p=0.01),and the length of hospital stay(days)(median 14 vs.6,p=0.04).Injuries identified on chest CT has led to a change of management in 4.4%of young patients in group 1 and in 10.9%of elderly patients in group 2 with initially normal *** CT resulted in a change of management in 12.8%of young patients in group 1 and in 25.7%of elderly patients in group 2 with initially abnormal CXR.;Chest CT led to a change of management in a substantial proportion of elderly ***,we recommend chest CT as a first-line imaging modality in patients aged over 65 years with isolated b

关键词： Blunt chest trauma Elderly Chest computed tomography

Differential risk of 23 site-specific incident cancers and cancer-related mortality among patients withmetabolic dysfunction-associated fatty liver disease:a population-based cohort study with 9.7 million Korean subjects

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Cancer Communications 2023年第8期43卷 863-876页

作者： Goh Eun Chung Su Jong Yu Jeong-Ju Yoo yuri Cho Kyu-na Lee Dong Wook Shin Yoon Jun Kim Jung-Hwan Yoon Kyungdo Han Eun Ju Cho Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoulRepublic of Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Gastroenterology and Hepatology Soonchunhyang University Bucheon HospitalBucheonGyeonggi-doRepublic of Korea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangGyeonggi-doRepublic of Korea Department of Biomedicine&Health Science Catholic University of KoreaSeoulRepublic of Korea Department of Family Medicine/Supportive care center Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Clinical Research Design and Evaluation/Department of Digital Health Samsung Advanced Institute for Health ScienceSeoulRepublic of Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoulRepublic of Korea

Introduction:Although an association between metabolic dysfunctionassociated fatty liver disease(MAFLD)and cardiovascular disease or overall mortality has been reported,it is unclearwhether there is an association between MAFLD and cancer incidence or *** aimed to investigate the differential risk of all-and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver ***:Using the Korean National Health Insurance Service database,we stratified the participants into three groups:(1)single-etiology MAFLD(SMAFLD)or MAFLD of pure metabolic origin;(2)mixed-etiology MAFLD(M-MAFLD)or MAFLD with additional etiological factor(s)(i.e.,concomitant liver diseases and/or heavy alcohol consumption);and(3)*** steatosis and fibrosiswere defined using the fatty liver index and the BARDscore,*** proportional hazards regression was performed to estimate the risk of cancer ***:Among the 9,718,182 participants,the prevalence of S-MAFLD and M-MAFLD was 29.2%and 6.7%,*** the median 8.3 years of follow-up,510,330(5.3%)individuals were newly diagnosed with cancer,and 122,774(1.3%)cancer-related deaths occurred among the entire *** with the non-MAFLD group,the risk of all-cancer incidence and mortality was slightly higher among patients in the S-MAFLD group(incidence,adjusted hazard ratio[aHR]=1.03;95%confidence interval[CI]:1.02−1.04;mortality,aHR=1.06;95%CI:1.04−1.08)and highest among patients with M-MAFLD group(incidence,aHR=1.31;95%CI:1.29−1.32;mortality,aHR=1.45;95%CI:1.42−1.48,respectively).The M-MAFLD with fibrosis group(BARD score≥2)showed the highest relative risk of all-cancer incidence(aHR=1.38,95%CI=1.36–1.39),followed by the M-MAFLD without fibrosis group(aHR=1.09,95%CI=1.06–1.11).Similar trends were observed for cancer-related ***:MAFLD classification,by applying additional etiologies other than pure metabolic origi

关键词： cancer etiology metabolic mortality steatosis

Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release

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Bioactive Materials 2023年第3期21卷 284-298页

作者： Jing-Jing Ye Long-Fei Li Rui-Nan Hao Min Gong Tong Wang Jian Song Qing-Han Meng Na-Na Zhao Fu-Jian Xu yuri Lvov Li-Qun Zhang Jia-Jia Xue Beijing Laboratory of Biomedical Materials State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing100029PR China College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijing100029PR China Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing100029PR China Institute for Micromanufacturing and Biomedical Engineering Program Louisiana Tech UniversityRustonLA71272USA

It is of great importance to treat a bacterial-infected wound by a smart dressing capable of delivering antibiotics in a smart manner without causing drug *** construction of smart release nanocontainers responsive to near-infrared(NIR)laser irradiation in an on-demand and stepwise way is a promising strategy for avoiding the emergence of multidrug-resistant ***,we develop a hydrogel composite made of alginate and nanotubes with an efficient NIR-triggered release of rifampicin and outstanding antibacterial *** composite hydrogel is prepared through co-encapsulating antibacterial drug(rifampicin),NIR-absorbing dye(indocyanine green),and phase-change materials(a eutectic mixture of fatty acids)into halloysite nanotubes,followed by incorporation into alginate hydrogels,allowing the in-situ gelation at room temperature and maintaining the integrity of drug-loaded *** them,the eutectic mixture with a melting point of 39℃ serves as the biocompatible phase-change material to facilitate the NIR-triggered drug *** resultant phase-change material gated-nanotubes exhibit a prominent photothermal efficiency with multistep drug release under laser *** an in vitro assay,composite hydrogel provides good antibacterial potency against Staphylococcus aureus,one of the most prevalent microorganisms of dangerous gas gangrene.A bacterial-infected rat full-thickness wound model demonstrates that the NIR-responsive composite hydrogel inhibits the bacteria colonization and suppresses the inflammatory response caused by bacteria,promoting angiogenesis and collagen deposition to accelerate wound *** NIR-responsive composite hydrogel has a great po-tential as an antibacterial wound dressing functionalized with controlled multistep treatment of the infected sites.

关键词： Anti-bacteria Clay nanotubes Alginate hydrogel Phase-change material NIR-Triggered drug release Infected wound healing

Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity

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Asian Journal of Pharmaceutical Sciences 2022年第4期17卷 544-556页

作者： yuri Svirkin Jaeweon Lee Richard Marx Seongkyu Yoon Nelson Landrau Md Abul Kaisar Bin Qin Jin H.Park Khondoker Alam Darby Kozak Yan Wang Xiaoming Xu Jiwen Zheng Benjamin Rivnay Landrau Scientific Innovations LeominsterMAUnited States of America University of Massachusetts Lowell LowellMAUnited States of America Office of Research and Standards Office of Generic DrugsCenter for Drug Evaluation and ResearchU.S.Food and Drug AdministrationSilver SpringMDUnited States of America Office of Testing and Research Office of Pharmaceutical QualityCenter for Drug Evaluation and ResearchU.S.Food and Drug AdministrationSilver SpringMDUnited States of America Office of Science and Engineering Laboratories Center for Devices and Radiological HealthU.S.Food and Drug AdministrationSilver SpringMDUnited States of America

Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal *** studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)*** toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell *** study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro ***–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter *** vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug *** kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral *** in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of *** study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the lip

关键词： Amphotericin B UV–Vis Spectrum Drug Release In Vitro Toxicity Aggregation Status Liposomes

Applications of two electric arc plasma torches for the beneficiation of natural quartz

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International Journal of Minerals,Metallurgy and Materials 2019年第3期26卷 267-273页

作者： yuri-Mikhailovich Grishin Long Miao Lev-Alekseevich Borisov Nikolay-Mikhailovich Serykh Alexey-yurievich Kulagin Department of Thermal physics Bauman Moscow State Technical University Federal State Unitary Enterprise Tsentrkvarts

Experimental beneficiation processes of quartz concentrate in arc plasma torches of two different types and electric powers were studied. An emission scanning electron microscope and a universal laser analyzer were used to investigate the structures as well as the size distributions of grains and microparticles. Inductively coupled plasma–mass spectrometry was used to determine the chemical compositions of nonstructural solid-phase mineral impurities in quartz concentrate. Results related to the modified grains' structure and size distribution, the compositions of impurities, and the gas–liquid inclusions in the quartz concentrate were investigated. The total impurities concentrations in the processed grains were found to satisfy the IOTA-STD standard(industry standard for grading high quality fused quartz products). The optimal condition(i.e., the optimal specific plasma enthalpy) for the production of high-purity quartz in arc plasma torches was found to depend on the geological-genetic type and the structural and textural features(i.e., chemical composition and gas–liquid inclusions) of the quartz concentrate.

关键词： low-temperature plasma beneficiation high purity quartz arc plasma torch IOTA-STD standard

Intragingival injection of Porphyromonas gingivalis-derived lipopolysaccharide induces a transient increase in gingival tumour necrosis factor-a, but not interleukin-6,in anaesthetised rats

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International Journal of Oral Science 2015年第3期7卷 155-160页

作者： Hiroko Taguchi yuri Aono Takayuki Kawato Masatake Asano Noriyoshi Shimizu Tadashi Saigusa Department of Orthodontics Nihon University School of Dentistry Department of Pharmacology Nihon University School of Dentistry at Matsudo Department of Pharmacology Nihon University School of Dentistry Department of Oral Health Sciences Nihon University School of Dentistry Department of Pathology Nihon University School of Dentistry

This study used in vivo microdialysis to examine the effects of intragingival application of lipopolysaccharide（LPS） derived from Porphyromonas gingivalis（Pg-LPS） on gingival tumour necrosis factor（TNF）-a and interleukin（IL）-6 levels in rats. A microdialysis probe with an injection needle attached to the surface of the dialysis membrane was implanted into the gingiva of the upper incisor. For comparison, the effects of LPS derived from Escherichia coli（Ec-LPS） on IL-6 and TNF-a levels were also analysed. Pg-LPS（1 mg/1 m L） or Ec-LPS（1 or 6 mg/1 m L） was applied by microsyringe, with gingival dialysates collected every hour. Enzyme-linked immunosorbent assay（ELISA） revealed that gingival dialysates contained approximately 389 pg？m L21 of IL-6 basally; basal TNF-a levels were lower than the detection limit of the ELISA. Pg-LPS failed to alter IL-6 levels but markedly increased TNF-a levels, which remained elevated for 2 h after treatment. Neither IL-6 nor TNF-a were affected by Ec-LPS. Reverse transcriptase-polymerase chain reaction（RT-PCR） analysis revealed that the gingiva expresses Toll-like receptor（TLR） 2 and TLR4 m RNA. Immunohistochemical examination showed that TLR2 and TLR4 are expressed by gingival epithelial cells. The present study provides in vivo evidence that locally applied Pg-LPS, but not Ec-LPS, into the gingiva transiently increases gingival TNF-a without affecting IL-6. The present results suggest that TLR2 but not TLR4 expressed on gingival epithelial cells may mediate the Pg-LPS-induced increase in gingival TNF-a in rats.

关键词： Porphyromonas gingivalis lipopolysaccharide gingiva tumour necrosis factor-a microdialysis