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Intimal pericytes as the second line of immune defence in atherosclerosis

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World Journal of Cardiology 2015年第10期7卷 583-593页

作者： Ekaterina A Ivanova yuri V Bobryshev Alexander n Orekhov Department of Development and Regeneration Biomedical Sciences Group KU LeuveLeuvenBelgium Faculty of Medicine School of Medical Sciences University of New South Wales School of Medicine University of Western Sydney Laboratory of Angiopathology Institute of General Pathology and Pathophysiology Russian Academy of Sciences Institute for Atherosclerosis Research Skolkovo Innovative Center Department of Biophysics Faculty of Biology Lomonosov Moscow State University

Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions.

关键词： Atherosclerosis Arteries Intima Immune-inflammator

The Impact of Agricultural Import Tariff on Economic Growth： Evidence From Mercosur Countries

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Chinese Business Review 2014年第3期13卷 137-153页

作者： yuri n. Moseykin Irina V. Levchenko Peoples' Friendship University of Russia Moscow Russian Federation

This research paper attempts to determine the relationship between agricultural import tariff and economic growth of Mercosur countries over the period 1996-2007 using regression analysis as well as evaluates the gains and losses from the group＇s trade policy over the same period. The introductory part of this paper focuses on the dynamics of changes in economic growth, trade, and import tariff of these countries over the last two decades. The results of the performed regression analysis of panel data suggest that trade liberalization has a quantitatively significant positive effect on growth. By using the coefficient estimates on tariff, the authors perform a quantitative evaluation of gains and losses from trade policy, for which tariff measures to trade （imports） are used as a proxy.

关键词： Mercosur economic growth trade import tariff panel data regression

Risk factors associated with Barrett's epithelial dysplasia

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World Journal of Gastroenterology 2014年第15期20卷 4353-4361页

作者： Mikiko Fujita yuri nakamura Saeko Kasashima Maiko Furukawa Ryoichi Misaka Hikaru nagahara Department of Gastroenterology Aoyama HospitalTokyo Women’s Medical University

AIM: To elucidate risk factors associated with dysplasia of short-segment Barrett’s esophagus (BE).

关键词： Barrett’ s esophagus, Dysplasia, Helicobacter pylori, p53, Risk factors

natural variation of physical-habitat conditions among least-disturbed streams of a neotropical river basin in Brazil

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Water Biology and Security 2023年第1期2卷 49-58页

作者： yuri Malta Caldeira Ruanny Casarim Paulo Santos Pompeu Laboratorio de Ecologia de Peixes Departamento de Ecologia e Conservaç~aoUniversidade Federal de LavrasBrazil Cemig Geraç~ao e Transmiss~ao Ger^encia de Estudos e Manejo da Ictiofauna e Programas EspeciaisPrograma Peixe VivoAv.Barbacena 1200Belo HorizonteMG30190-131Brazil

The determination of natural variation in physical habitat conditions and the establishment of least-disturbed reference standards is important for ecosystem *** regions hold most of the global freshwater diversity,nevertheless little is known about the natural conditions of their physical *** calculated 255 physical habitat metrics for 31 stream sites in five protected areas of the Brazilian S~ao Francisco River basin to identify the most variable characteristics among tropical streams in least-disturbed *** performed principal components analyses(PCA)to find the most relevant metrics for ordination of streams in the following categories:water quality(2);substrate(7);fish shelter(6);riparian vegetation(9);and channel morphology(7).We used distance-based linear models(DISTLM)to test how much of the variation of these metrics could be explained by geographic position,average elevation,and average discharge of stream *** best statistically significant models explained 42%of substrate(33%geographic position;9%average elevation),26%of channel morphology(22%geographic position;4%average discharge),23%of water quality(14%geographic position;9%average discharge),17%of fish shelter(9%geographic position;8%average elevation),and 14%of riparian vegetation(7%geographic position;7%average elevation)***,regional features(*** and climate)related to the geographic position are of greatest importance,followed by average elevation and discharge for determining physical habitat ***,we suggest that reference sites should be set for tropical streams in the same regional landscape and with similar average elevation and discharge.

关键词： Reference condition Habitat characteristics Habitat spatial structure Tropical streams Lotic ecosystems

Second-Order Formulas in Action

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Applied Mathematics 2024年第9期15卷 651-685页

作者： yuri Movsisyan Department of Mathematics and Mechanics Yerevan State University Yerevan Armenia

This survey article illustrates many important current trends and perspectives for the field and their applications, of interest to researchers in modern algebra, mathematical logic and discrete mathematics. It covers a number of directions, including completeness theorem and compactness theorem for hyperidentities;the characterizations of the Boolean algebra of n-ary Boolean functions and the bounded distributive lattice of n-ary monotone Boolean functions;the functional representations of finitely-generated free algebras of various varieties of lattices via generalized Boolean functions, etc.

关键词： Boolean Algebra Boolean Function Distributive Lattice Monotone Boolean Function De Morgan Algebra De Morgan Function Boole-De Morgan Algebra Quasi-De Morgan Function Hyperidentity Coidentity

A SURVEY OF THE HOLARCTIC LInYPHIIDAE (ARAnEAE),A REVIEW OF THE ERIGOnInE GEnUS ZORnELLA JACKSOn, 1932

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动物分类学报 2007年第1期32卷 21-34页

作者： yuri M. Marusik Donald J. Buckle Seppo Koponen Institute for Biological Problems of the north Portovaya Str. 18 Magadan 685000 Russia 620 Albert Avenue Saskatoon Saskatchewan S7N 1G7 Canada Zoological Museum University of Turku FI-20014 Turku Finland

The Holarctic erigonid genus Zornella has been surveyed. Four species are recognized in this genus, two Palaearctic: ***(***,11879) & *** ***., and two nearctic: ***(Banks, 1906) & *** Chamberlin,*** is demonstrated that neither nearctic species is conspecific with *** as was thought by Holm and other authors. *** ***. is described from northeastern Siberia. All of the species are illustrated and their distributions mapped.

关键词： Spiders Araneae Erigoninae Holarctic Zornella new species redescription

Exercise training as an intervention for frailty in cirrhotic patients on the liver transplant waiting list:A systematic review

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World Journal of Hepatology 2023年第10期15卷 1153-1163页

作者： Thais Mellato Loschi Melline D T A Baccan Bianca Della Guardia Paulo n Martins Amanda P C S Boteon yuri L Boteon Transplant Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States

BACKGROUnD The existing literature suggests that exercise for cirrhotic patients is safe and favours significant improvement to their physical ***,exercise training for this population and how to deliver activities,especially in severe stages of the disease and while waiting for a liver transplant(LT),remain *** To review the existing exercise prescriptions for cirrhotic patients on the waiting list for LT,their results for frailty evolution and their effect on clinical *** A systematic review was performed following the Preferred Reporting Review and Meta-Analysis guidelines and searching the PubMed,MEDLInE,and Scopus *** keyword“liver transplant”was used in combination with the free terms“frailty”and“exercise”for the literature *** studies that evaluated the effect of a regular training program,independent of supervision or the duration or intensity of physical exercise,in cirrhotic patients on the waiting list for LT were *** data on safe physical activity prescriptions following Frequency,Intensity,Time,and Type recommendations were extracted and *** nine articles met the inclusion criteria for this *** instruments for frailty assessment were used,frequently in *** studies prescribed physical activity for patients,one in-person and four to be performed remotely and *** remaining four studies only used a self-report instrument to assess the level of physical *** reported adverse events related to exercise *** exercise frequency mainly varied from daily to a minimum of twice per *** intensity depended on frailty and included increasing levels of *** type of exercise was predominantly a combination of aerobic and resistance *** duration of exercise varied from 4 to 12 *** articles evaluated the effect of the exercise program on clinical outcomes,reporting a reduction in 90-d readmission rates post-tran

关键词： End-stage liver disease Liver transplant Frailty Exercise Rehabilitation Sarcopenia

Mitochondrial dysfunction and mitochondrial DnA mutations in atherosclerotic complications in diabetes

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World Journal of Cardiology 2012年第5期4卷 148-156页

作者： Dimitry A Chistiakov Igor A Sobenin yuri V Bobryshev Alexander n Orekhov Department of Medical nanobiotechnology Pirogov Russian State Medical University117997 MoscowRussia Institute for Atherosclerosis Research Skolkovo Innovative Centre121609 MoscowRussia Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences125315 MoscowRussia Russian Cardiology Research and Production Complex 121552 MoscowRussia Faculty of Medicine School of Medical SciencesUniversity of New South WalesNSW 2052SydneyAustralia

Mitochondrial DnA(mtDnA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair *** explains an increased mutation rate of mtDnA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDnA molecules within the same *** diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis.

关键词： Mitochondrial DnA Mutation Heteroplasmy Atherosclerosis Diabetes Oxidative stress Ultrastructure

Influence of vacuoles with gas–liquid inclusions on the thermobaric destruction conditions of natural quartz under dynamic heating in an RF-TICP torch system

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Plasma Science and Technology 2023年第4期25卷 138-147页

作者：苗龙聂明卿 yuri Mihailovich GRISHIn 王晓宇朱政羲宋家辉梁福文何梓豪田丰王宁飞 School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Department of Thermophysics Moscow State Technical University N E BaumanMoscow 105005Russia

In the present work,the turbulent mixing process of a polydisperse quartz particle flow with a plasma stream generated by a radio-frequency(RF)inductively coupled plasma torch was numerically *** thermobaric stress in the quartz particles under dynamic heating in a heterogeneous plasma flow was determined by a two-stage approximation *** effect of the presence of vacuoles in natural quartz on the particle thermobaric destruction conditions was *** was found that the equivalent thermal and baric stresses in quartz particles may significantly increase in the presence of vacuoles within a small gas volume *** influence of the regime and energetic working conditions of an RF inductively coupled plasma torch system on the particle thermobaric destruction conditions was examined,and a recommendation was given to promote the degree of thermobaric destruction of quartz particles,which is of substantial importance for improving the overall enrichment efficiency of quartz concentrates.

关键词： high purity quartz dynamic heating vacuole with gas–liquid inclusions thermobaric destruction radio-frequency inductively coupled plasma torch