Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes

作     者：Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov 

作者机构：Department of Medical NanobiotechnologyPirogov Russian State Medical University117997 MoscowRussia Institute for Atherosclerosis ResearchSkolkovo Innovative Centre121609 MoscowRussia Institute of General Pathology and PathophysiologyRussian Academy of Medical Sciences125315 MoscowRussia Russian Cardiology Research and Production Complex121552 MoscowRussia Faculty of MedicineSchool of Medical SciencesUniversity of New South WalesNSW 2052SydneyAustralia 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第5期

页      面：148-156页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The Russian Ministry of Science and Education 

主　　题：Mitochondrial DNA Mutation Heteroplasmy Atherosclerosis Diabetes Oxidative stress Ultrastructure 

摘      要：Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair *** explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same *** diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis.