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Clinical Study on the Effect of Continuity of Care in CICU on Improving Cognitive Function and Psychological State in Patients with Heart Failure

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Journal of Clinical and Nursing Research 2024年第10期8卷 133-139页

作者： Jin Sang yuqing xie Xintong Zhu Xuzhou Traditional Chinese Medicine Hospital Xuzhou 221000Jiangsu ProvinceChina

Objective:To analyze the effect of continuity of care in the cardiac intensive care unit(CICU)on improving cognitive function and psychological state in patients with heart failure(HF).Methods:A total of 112 chronic HF patients admitted to the CICU of Xuzhou Traditional Chinese Medicine Hospital from July 2022 to August 2024 were selected and randomly divided into two groups using the red and blue ball method:a control group(n=56)and a study group(n=56).The control group received routine CICU nursing management,while the study group received routine CICU nursing combined with continuity of care *** function(using the Montreal Cognitive Assessment,MoCA),psychological state(using the Self-Rating Depression Scale,SDS,and Self-Rating Anxiety Scale,SAS),and quality of life(using the Minnesota Living with Heart Failure Questionnaire,MLHFQ)were compared between the two ***:After the intervention,the cognitive function scores of the study group were significantly higher than those of the control group(P<0.05).The SDS and SAS scores of the study group were significantly lower than those of the control group after the intervention(P<0.05).The quality of life in the study group was also significantly better than in the control group(P<0.05).Conclusion:CICU continuity of care can effectively improve cognitive function and psychological state in patients with HF,while also enhancing their quality of life.

关键词： CICU continuity of care Heart failure patients Cognitive function Psychological state

基于本征正交分解的换流变压器极性反转电场降阶模型

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中国电机工程学报 2016年第23期36卷 6544-6551,6622页

作者：谢裕清李琳新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

为了解决在求解换流变压器极性反转瞬态电场过程中计算时间过长,占用存储空间过大的问题,该文基于本征正交分解(proper orthogonal decomposition,POD)方法构建了求解换流变压器极性反转瞬态电场的低阶有限元模型。首先,应用传统伽辽金... 详细信息

为了解决在求解换流变压器极性反转瞬态电场过程中计算时间过长,占用存储空间过大的问题,该文基于本征正交分解(proper orthogonal decomposition,POD)方法构建了求解换流变压器极性反转瞬态电场的低阶有限元模型。首先,应用传统伽辽金有限元法计算部分时刻的场域电位组成样本数据,并对样本数据组成的矩阵进行特征值分解得到一组POD正交基,最后通过生成的POD正交基构建准静态电场方程的降阶模型。应用所提出的POD降阶模型,分析了一台?500k V换流变压器在极性反转情况下绕组端部电场随时间的变化情况。计算结果表明:POD降阶模型的计算结果与全阶模型(传统伽辽金有限元模型)的计算结果较吻合,验证了POD降阶模型的准确性。同时,应用降阶模型计算换流变压器瞬态电场的计算时间远小于全阶模型的计算时间,说明了降阶模型的高效性。

关键词：换流变压器本征正交分解降阶模型极性反转瞬态电场

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3861-3876页

作者： Jinlian Wei Xin Chen Yongyun Li Ruoxi Li Keting Bao Liang Liao yuqing xie Tiannuo Yang Jin Zhu Fei Mao Shuaishuai Ni Renbing Jia Xiaofang Xu Jian Li State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismFrontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Key Laboratory of New Drug DesignSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from West Yunnan College of PharmacyDali UniversityDali 671000China Clinical Medicine Scientific and Technical Innovation Center Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200092China Key Laboratory of Tropical Biological Resources of Ministry of Education College of PharmacyHainan UniversityHaikou 570228China

Conjunctival melanoma(CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B(CuB). We found that CuB remarkably inhibited the proliferation of CM cells including CM-AS16,CRMM1, CRMM2 and CM2005.1, without toxicity to normal cells. CuB can also induce CM cells G2/M cell cycle arrest. RNA-seq screening identified KIF20A, a key downstream effector of FOXM1 pathway, was abolished by CuB treatment. Further target identification by activity-based protein profiling chemoproteomic approach revealed that GRP78 is a potential target of CuB. Several lines of evidence demonstrated that CuB interacted with GRP78 and bound with a Kdvalue of0.11 μmol/L. Furthermore, ATPase activity evaluation showed that CuB suppressed GRP78 both in human recombinant GRP78 protein and cellular lysates. Knockdown of the GRP78 gene significantly induced the downregulation of FOXM1 and related pathway proteins including KIF20A, underlying an interesting therapeutic perspective. Finally, CuB significantly inhibited tumor progression in NCG mice without causing obvious side effects in vivo. Taken together, our current work proved that GRP78-FOXM1-KIF20A as a promising pathway for CM therapy, and the traditional medicine CuB as a candidate drug to hinder this pathway.

关键词： Conjunctival melanoma Cucurbitacin B Activity-based protein profiling G2/M cell cycle GRP78 FOXM1 KIF20A Rare tumor

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汪元量岳渎祭祀诗与元初的文化认同

民族文学研究 2024年第4期42卷 168-176页

作者：谢雨情北京师范大学文学院

宋元易代之际,宋室降臣汪元量为元朝代祀岳渎,在岳渎祭祀诗中展现出对身份与观念的重塑。随着汪元量南归,其诗作的流播使南宋遗民真切感受到元朝的大一统建构及对中原礼仪的接续,进而深刻认识多族共通的深层礼制结构、南北共同的历史文... 详细信息

宋元易代之际,宋室降臣汪元量为元朝代祀岳渎,在岳渎祭祀诗中展现出对身份与观念的重塑。随着汪元量南归,其诗作的流播使南宋遗民真切感受到元朝的大一统建构及对中原礼仪的接续,进而深刻认识多族共通的深层礼制结构、南北共同的历史文化源流。选取汪元量岳渎祭祀诗为个案进行考察,有助于细致了解南宋遗民对元初大一统文化认同的建立过程,深入抉发元朝大一统礼制实践对于多民族交往、交流、交融的学术价值和历史意义。

关键词：汪元量岳渎祭祀诗大一统文化认同南宋遗民

Revealing the formation mechanism of umami peptides in fermented broad bean paste based on peptidomics and macrogenomics

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Food Science and Human Wellness 2024年

作者： yuqing xie Jianhua Zhao Binbin Zhou Ping Liu Jie Zhao Min Xu Jiaxin Chen Hongbin Lin Jie Tang School of Food and Bio-engineering， Xihua University Chongqing Key Laboratory of Specialty Food Co-Built by Sichuan and Chongqing Chengdu Food Microbiology Key Laboratory of Sichuan Province

Umami peptides play important roles in the flavor of fermented broad bean paste (FBBP)， and proteases produced by microorganisms contributed to the production of umami peptides. In order to reveal the formation of umami peptides and their relationships with protease-producing microorganisms during the natural fermentation of FBBP， peptidomics and virtual screening were used to identify and screen umami peptides. Meanwhile， macrogenomics was used to analyze the abundance of microbial-derived protease genes during FBBP fermentation. Then， based on the Pearson correlation coefficient， the correlation network diagram of each protease-producing microorganism with umami peptides was constructed. The results showed that a total of two exopeptidases and four endopeptidases were annotated from FBBP. Staphylococcus， Lactobacillus， Aspergillus， and Weissella can produce most proteases. The species Lactobacillus＿curvatus， Dyella＿jiangningensis， Erythrobacter＿sp， and unclassified＿g＿Pantoea had strong correlation with umami peptides， and they may contribute to the process of protein hydrolysis to produce umami peptides. This study is expected to reveal the formation mechanism of umami peptides in FBBP， and the results of this study provided a better understanding of the relationship between proteases， microbiota， and core umami peptides in FBBP， which could help to improve the umami taste of Pixian Douban paste (PDBP) during fermentation.

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承压含水层应力场与井水位变化的数值模拟

北京大学学报（自然科学版） 2017年第4期53卷 683-691页

作者：谢雨晴赵永红北京大学地球与空间科学学院北京100871

将含水层看成孔隙弹性介质,建立二维承压含水层理想模型,计算周围应力场变化引起的井水位变化的分布和量级,讨论井水位突变的消散规律。根据消散过程,用反褶积的方法,从井水位数据计算周围应力应变场的变化,并用数值方法和会理川06井的... 详细信息

将含水层看成孔隙弹性介质,建立二维承压含水层理想模型,计算周围应力场变化引起的井水位变化的分布和量级,讨论井水位突变的消散规律。根据消散过程,用反褶积的方法,从井水位数据计算周围应力应变场的变化,并用数值方法和会理川06井的固体潮数据验证这种方法的可行性。应用数值模拟结果探讨同震井水位阶变的机制,认为简单的孔隙弹性模型不能解释同震井水位变化特征。

关键词：井水位渗流应力场变化

TGF-β and IL-2 signaling are both required for generating stable thymus regulatory T cells

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TGF-β and IL-2 signaling are both required for generating s...

IFN-γ and CD8+ T cells Contribute to Hematopoietic System Dysregulation in p40(-/-)interleukin-2Rα(-/-) mice

第十届全国免疫学学术大会

作者： Liang Li Yuan Yao yuqing xie Zhexiong Lian Institute of Immunology and School of Life Sciences University of Science and Technology of China

Objective:To investigate the synergic role of TGF-βand IL-2 in regulating the balance between the regulatory T cells and conventional T cells,thus the homeostasis of the immune ***:We crossed dn TGF-βRII mice with C... 详细信息

关键词： TGF-β IL-2 thymus regulatory T cells DNA methylation

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IFN-γ and CD8+ T cells Contribute to Hematopoietic System D...

Perovskite-quantum-dots activated silica fiber X-ray dosimeter

第十届全国免疫学学术大会

作者： Yuan Yao Liang Li Xueying Yin yuqing xie 中国科学技术大学生命科学学院肝脏免疫学实验室

Objective:We had found hematopoietic system dysregulation in p40-/-IL-2Rα-/-mice and wanted to explore the ***:leukocyte isolation,flow cytometry,bone marrow ***:Lineage-c-Kit+Sca-1+cells(LSK cells)were usually considered to contain hemopoietic stem and progenitor cells.p40-/-IL-2Rα-/-mice had increased number and percentage of bone marrow LSK cells compared with wild type ***,bone marrow LSK cells in p40-/-IL-2Rα-/-mice had high expression of MHCII molecules,indicating that these cells may act as antigen-presenting *** number and percent of erythrocytes,B cells,NK cells were reduced in the bone marrow of p40-/-IL-2Rα-/-mice,suggesting the hematopoiesis disorder of HSCs,while T cell infiltration were *** reconstitution ability of bone marrow cells from p40-/-IL-2Rα-/-mice was lower than control *** we generated IFN-γ-/-p40-/-IL-2Rα-/-mice and found these mice still contained liver inflammation but did not have a huge *** found T cell infiltration was decreased in the bone marrow of IFN-γ-/-p40-/-IL-2Rα-/-mice,and the percent and number of B cells and erythrocytes were ***,the percent,number and phenotype of bone marrow LSK cells in IFN-γ-/-p40-/-IL-2Rα-/-mice were completely recovered and close to wild type *** reconstitution ability of total bone marrow cells from IFN-γ-/-p40-/-IL-2Rα-/-mice was *** last,we generated CD8a-/-p40-/-IL-2Rα-/-mice which lacked CD8+T *** found CD8a-/-p40-/-IL-2Rα-/-mice did not develop liver inflammation with a normal percentage of B cells,NK cells and NKT *** in these mice,CD4+T cells had a less activated phenotype and reduced IFN-γ***,CD8a-/-p40-/-IL-2Rα-/-mice displayed a complete normal bone marrow hematopoietic ***:p40-/-IL-2Rα-/-mice had hemotopoietic system dysregulation mediated by IFN-γ.And in p40-/-IL-2Rα-/-mice,CD8+T cells were critical for liver inflammation and CD8+T cells derived IFN-γc

关键词： HSC MHCII IFN-γ CD8+ T

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Chinese Optics Letters 2022年第6期20卷 61-65页

作者： yuqing xie Yue Jing Luyue Niu Ci Wang Lei Zhao Jing Ren Jianzhong Zhang Key Laboratory of In-fiber Integrated Optics Ministry of EducationHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China

A new type of X-ray fiber dosimeters is proposed that is based on the X-ray response of CsPbBr_(3) perovskite-quantum-dots[PQDs]activated silica *** a fiber sensor is constructed by covering a multimode silica fiber with PQDs embedded glass powders using a transparent high-temperature *** X-ray irradiation,the fiber sensor emits bright green light at 525 nm,which can be readily recorded by a CCD *** integrated radioluminescence intensity has an excellent linear response to the X-ray *** is given to the fiber sensor concerning its thermal stability in a temperature range of room temperature up to 300℃,resistance to water erosion,and prolonged X-ray *** results verify that the proposed fiber sensor has the advantages of good thermal stability,chemical durability,and radiation *** studied X-ray fiber sensor holds promise to be used in a real-time,in-situ,and remote radiation dose monitoring.

关键词： perovskite quantum dots glass ceramics X-ray radiation fiber dosimeter