检索结果-南通市图书馆

Hallmark guided identification and characterization of a novel immune-relevant signature for prognostication of recurrence in stageⅠ-Ⅲlung adenocarcinoma

引用

Genes & Diseases 2023年第4期10卷 1657-1674页

作者： Yongqiang Zhang Zhao Yang yuqin tang Chengbin Guo Danni Lin d Linling Cheng Xun Hu Kang Zhang Gen Li West China School of Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhouGuangdong 510620China State Key Laboratory of Southwestern Chinese Medicine Resources School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengduSichuan 611137China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China Clinical Research Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310003China Biorepository State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China

The high risk of postoperative mortality in lung adenocarcinoma(LUAD)patients is principally driven by cancer recurrence and low response rates to adjuvant treatment.Here,A combined cohort containing 1,026 stageⅠ-Ⅲpatients was divided into the learning(n Z 678)and validation datasets(n Z 348).The former was used to establish a 16-mRNA risk signature for recurrence prediction with multiple statistical algorithms,which was verified in the valida-tion set.Univariate and multivariate analyses confirmed it as an independent indicator for both recurrence-free survival(RFS)and overall survival(OS).Distinct molecular characteristics between the two groups including genomic alterations,and hallmark pathways were compre-hensively analyzed.Remarkably,the classifier was tightly linked to immune infiltrations,high-lighting the critical role of immune surveillance in prolonging survival for LUAD.Moreover,the classifier was a valuable predictor for therapeutic responses in patients,and the low-risk group was more likely to yield clinical benefits from immunotherapy.A transcription factor regulato-ry proteineprotein interaction network(TF-PPI-network)was constructed via weighted gene co-expression network analysis(WGCNA)concerning the hub genes of the signature.The con-structed multidimensional nomogram dramatically increased the predictive accuracy.There-fore,our signature provides a forceful basis for individualized LUAD management with promising potential implications.

关键词： Immune infiltration Lung adenocarcinoma Nomogram Recurrence Risk signature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

思维导图在高中生物学教学中的应用与拓展

引用

生物学通报 2024年第4期59卷 13-17页

作者：唐玉琴李莉龚西旭贵州师范大学生命科学学院贵州贵阳550025 贵州师范大学附属中学贵州贵阳550025

思维导图因图文结合的可视化优势在教学中应用广泛,尤其适用于内容覆盖面广和层次多样的生物学课程教学。思维导图作为教学常用的工具之一,具有激发思维、整理知识、改善记忆等优势。通过文献分析工具SATI3.2,从思维导图在不同学段、学... 详细信息

思维导图因图文结合的可视化优势在教学中应用广泛,尤其适用于内容覆盖面广和层次多样的生物学课程教学。思维导图作为教学常用的工具之一,具有激发思维、整理知识、改善记忆等优势。通过文献分析工具SATI3.2,从思维导图在不同学段、学科中的应用及对高中生物学学科核心素养的支撑等方面,综述了在高中生物学教学中的适用性和普遍性,并结合高中生物学学科核心素养的基本要求,综合分析思维导图在高中生物学教学中的重要功能和拓展需求。

关键词：思维导图生物学教学高中生物学核心素养科学思维

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding the rapid spread of antimicrobial resistance genes mediated by Is26

引用

mLife 2024年第1期3卷 101-109页

作者： Na tang Dawei Wei Yuan Zeng Gang Zhang Chao Wang Jie Feng yuqin Song State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBejingChina College of Life Science University of Chinese Academy of SciencesBeijingChina

Insertion sequences(ISs)promote the transmission of antimicrobial resistance genes(ARGs)across bacterial populations.However,their contributions and dynamics during the transmission of resistance remain unclear.In this study,we selected is26 as a representative transposable element to decipher the relationship between ISs and ARGs and to investigate their transfer features and transmission trends.We retrieved 2656 translocatable IS26-bounded units with ARGs(tiS26-bUs-ARGs)in complete bacterial genomes from the NCBI RefSeq database.In total,124 ARGs spanning 12 classes of antibiotics were detected,and the average contribution rate of IS26 to these genes was 41.2%.We found that IS26-bounded units(IS26-bUs)mediated extensive ARG dissemination within the bacteria of the Gammaproteobacteria class,showing strong transfer po-tential between strains,species,and even phyla.The Is26-bUs expanded in bacterial populations over time,and their temporal expansion trend was significantly correlated with antibiotic usage.This wide dissemination could be due to the nonspecific target site preference of is26.Finally,we experimentally confirmed that the introduction of a single copy of is26 could lead to the formation of a composite transposon mediating the transmission of“passenger”genes.These observations extend our knowledge of the Is26 and provide new insights into the mediating role of ISs in the dissemination of antibiotic resistance.

关键词： antibiotic consumption antibiotic resistance genes horizontal gene transfer insertion sequence Is26

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanced 2D molybdenum disulfide for green hydrogen production: Recent progress and future perspectives

引用

Frontiers in Energy 2024年第3期18卷 308-329页

作者： Meng FANG yuqin PENG Puwei WU Huan WANG Lixin XING Ning WANG Chunmei tang Ling MENG Yuekuan ZHOU Lei DU Siyu YE Huangpu Hydrogen Energy Innovation Centre School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyHong KongChina SinoHykey Technology Company Ltd. Guangzhou 510760China

The development of renewable and affordable energy is crucial for building a sustainable society. In this context, establishing a sustainable infrastructure for renewable energy requires the integration of energy storage, specifically use of renewable hydrogen. The hydrogen evolution reaction (HER) of electrochemical water splitting is a promising method for producing green hydrogen. Recently, two-dimensional nanomaterials have shown great promise in promoting the HER in terms of both fundamental research and practical applications due to their high specific surface areas and tunable electronic properties. Among them, molybdenum disulfide (MoS2), a non-noble metal catalyst, has emerged as a promising alternative to replace expensive platinum-based catalysts for the HER because MoS_(2)has a high inherent activity, low cost, and abundant reserves. At present, greatly improved activity and stability are urgently needed for MoS_(2)to enable wide deployment of water electrolysis devices. In this regard, efficient strategies for precisely modifying MoS_(2)are of interest. Herein, the progress made with MoS_(2)as an HER catalyst is reviewed, with a focus on modification strategies, including phase engineering, morphology design, defect engineering, heteroatom doping, and heterostructure construction. It is believed that these strategies will be helpful in designing and developing high-performance and low-cost MoS2-based catalysts by lowering the charge transfer barrier, increasing the active site density, and optimizing the surface hydrophilicity. In addition, the challenges of MoS_(2)electrocatalysts and perspectives for future research and development of these catalysts are discussed.

关键词： molybdenum disulfide(MoS_(2)) hydrogen evolution reaction(HER) active site electrocatalyst modification strategie

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

播种期对早熟油菜万油410品质性状的影响

引用

中国种业 2024年第7期 96-100页

作者：贺成龙曾川尹璐徐洪志唐玉琴黄涌向思柔陈吉光何利华重庆市万州区农业技术与机械推广中心万州404001 重庆三峡学院重庆三峡农业科学院万州404155

为了探讨播种期对油菜品质性状的影响,为早熟高品质菜籽油原料的生产提供参考,以早熟油菜品种万油410为试验材料开展了不同播种期处理试验。结果表明:播种期对万油410的品质有极显著影响,平均芥酸含量随着播种期的推迟而逐渐升高,在0.01... 详细信息

为了探讨播种期对油菜品质性状的影响,为早熟高品质菜籽油原料的生产提供参考,以早熟油菜品种万油410为试验材料开展了不同播种期处理试验。结果表明:播种期对万油410的品质有极显著影响,平均芥酸含量随着播种期的推迟而逐渐升高,在0.01%~0.62%之间,平均硫苷含量随着播种期推迟先升高后降低,在14.21~34.46μmol/g之间,芥酸含量变化范围在双低油菜籽标准内;平均含油量、油酸含量、亚麻酸含量均随着播种期的推迟先升高后降低,分别在42.17%~46.59%、49.21%~58.20%、8.34%~13.27%之间;平均蛋白质含量和亚油酸含量随着播种期的推迟先降低后升高,分别在21.04%~25.22%、16.31%~19.47%之间;万油410在10月20左右播种可以获得较为理想的品质性状,此时芥酸含量为0.40%,硫苷含量为18.72μmol/g,含油量为46.59%,油酸含量为58.20%,亚麻酸含量为13.27%,蛋白质含量为21.04%,亚油酸含量为16.31%。适宜的播种期可为万油410在重庆万州及类似地区的大面积推广奠定基础。

关键词：早熟油菜万油410 播种期品质性状

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease:Prospective cohort study and genetic analyses

引用

Chinese Medical Journal 2024年第5期137卷 577-587页

作者： Wenqiang Zhang Li Zhang Chenghan Xiao Xueyao Wu Huijie Cui Chao Yang Peijing Yan Mingshuang tang Yutong Wang Lin Chen Yunjie Liu Yanqiu Zou Ling Zhang Chunxia Yang yuqin Yao Jiayuan Li Zhenmi Liu Xia Jiang Ben Zhang Department of Epidemiology and Biostatistics Institute of Systems EpidemiologyWest China-Peking Union Medical College C.C.Chen Institute of HealthWest China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Maternal Child and Adolescent HealthWest China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Iatrical Polymer Material and Artificial Apparatus School of Polymer Science and EngineeringSichuan UniversityChengduSichuan 610041China Department of Occupational and Environmental Health West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Nutrition and Food Hygiene West China School of Public Health and West China Fourth HospitalSichuan UniversityChengduSichuan 610041China Department of Clinical Neuroscience Karolinska InstitutetStockholm 17177Sweden

Background:While type 2 diabetes mellitus(T2DM)is considered a putative causal risk factor for coronary artery disease(CAD),the intrinsic link underlying T2DM and CAD is not fully understood.We aimed to highlight the importance of integrated care targeting both diseases by investigating the phenotypic and genetic relationships between T2DM and CAD.Methods:We evaluated phenotypic associations using data from the United Kingdom Biobank(N=472,050).We investigated genetic relationships by leveraging genomic data conducted in European ancestry for T2DM,with and without adjustment for body mass index(BMI)(T2DM:N_(case)/N_(control)=74,124/824,006;T2DM adjusted for BMI[T2DM_(adj)BMI]:N_(case)/N_(control)=50,409/523,897)and for CAD(N_(case)/N_(control)=181,522/984,168).We performed additional analyses using genomic data conducted in multiancestry individuals for T2DM(N_(case)/N_(control)=180,834/1,159,055).Results:Observational analysis suggested a bidirectional relationship between T2DM and CAD(T2DM→CAD:hazard ratio[HR]=2.12,95%confidence interval[CI]:2.01–2.24;CAD→T2DM:HR=1.72,95%CI:1.63–1.81).A positive overall genetic correlation between T2DM and CAD was observed(r_(g)=0.39,P=1.43×10^(-75)),which was largely independent of BMI(T2DM_(adj)BMI–CAD:r_(g)=0.31,P=1.20×10^(–36)).This was corroborated by six local signals,among which 9p21.3 showed the strongest genetic correlation.Cross-trait meta-analysis replicated 101 previously reported loci and discovered six novel pleiotropic loci.Mendelian randomization analysis supported a bidirectional causal relationship(T2DM→CAD:odds ratio[OR]=1.13,95%CI:1.11-1.16;CAD→T2DM:OR=1.12,95%CI:1.07-1.18),which was confirmed in multiancestry individuals(T2DM→CAD:OR=1.13,95%CI:1.10-1.16;CAD→T2DM:OR=1.08,95%CI:1.04-1.13).This bidirectional relationship was significantly mediated by systolic blood pressure and intake of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors,with mediation proportions of 54.1%(95%CI:24.9-83.4%)and 90.4%(95%CI:29.3-151.5%),respectively.Conclusion:Our observ

关键词： Type 2 diabetes mellitus Coronary artery disease Phenotypic association Genetic correlation Mendelian randomization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Flexible and Robust Functionalized Boron Nitride/Poly(p‑Phenylene Benzobisoxazole)Nanocomposite Paper with High Thermal Conductivity and Outstanding Electrical Insulation

引用

Nano-Micro Letters 2024年第2期16卷 423-437页

作者： Lin tang Kunpeng Ruan Xi Liu Yusheng tang Yali Zhang Junwei Gu Chongqing Key Laboratory of Green Synthesis and Applications College of ChemistryChongqing Normal UniversityChongqing 401331People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China

With the rapid development of 5G information technology,thermal conductivity/dissipation problems of highly integrated electronic devices and electrical equipment are becoming prominent.In this work,“high-temperature solid-phase&diazonium salt decomposition”method is carried out to prepare benzidine-functionalized boron nitride(m-BN).Subsequently,m-BN/poly(pphenylene benzobisoxazole)nanofiber(PNF)nanocomposite paper with nacremimetic layered structures is prepared via sol–gel film transformation approach.The obtained m-BN/PNF nanocomposite paper with 50 wt%m-BN presents excellent thermal conductivity,incredible electrical insulation,outstanding mechanical properties and thermal stability,due to the construction of extensive hydrogen bonds andπ–πinteractions between m-BN and PNF,and stable nacre-mimetic layered structures.Itsλ∥andλ_(⊥)are 9.68 and 0.84 W m^(-1)K^(-1),and the volume resistivity and breakdown strength are as high as 2.3×10^(15)Ωcm and 324.2 kV mm^(-1),respectively.Besides,it also presents extremely high tensile strength of 193.6 MPa and thermal decomposition temperature of 640°C,showing a broad application prospect in high-end thermal management fields such as electronic devices and electrical equipment.

关键词： Poly(p-phenylene-2,6-benzobisoxazole)nanofiber Boron nitride Thermal conductivity Electrical insulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

引用

Research 2024年第1期2023卷 199-208页

作者： Yuchen tang Xingxing Zheng Tingjuan Gao China Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical diagnostics.Although super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction conditions.This challenge results in either inaccurate or insufficient decoding outputs.Here,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide library.The accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding strategy.The orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening process.We anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage:an intrinsic review of a hematoma resolving pathway

引用

Neural Regeneration Research 2024年第2期19卷 350-354页

作者： Jerry Flores Jiping tang Department of Physiology&Pharmacology Loma Linda University School of MedicineLoma LindaCAUSA

Germinal matrix hemorrhage is one of the leading causes of morbidity,mortality,and acquired infantile hydrocephalus in preterm infants in the United States,with little progress made in its clinical management.Blood clots have been shown to elicit secondary brain injury after germinal matrix hemorrhage,by disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage causing post-hemorrhagic hydrocephalus development.Current evidence suggests that rapid hematoma resolution is necessary to improve neurological outcomes after hemorrhagic stroke.Various articles have demonstrated the beneficial effects of stimulating the polarization of microglia cells into the M2 phenotype,as it has been suggested that they play an essential role in the rapid phagocytosis of the blood clot after hemorrhagic models of stroke.N-formyl peptide receptor 2(FPR2),a G-protein-coupled receptor,has been shown to be neuroprotective after stroke.FPR2 activation has been associated with the upregulation of phagocytic macrophage clearance,yet its mechanism has not been fully explored.Recent literature suggests that FPR2 may play a role in the stimulation of scavenger receptor CD36.Scavenger receptor CD36 plays a vital role in microglia phagocytic blood clot clearance after germinal matrix hemorrhage.FPR2 has been shown to phosphorylate extracellular-signal-regulated kinase 1/2(ERK1/2),which then promotes the transcription of the dual-specificity protein phosphatase 1(DUSP1)gene.In this review,we present an intrinsic outline of the main components involved in FPR2 stimulation and hematoma resolution after germinal matrix hemorrhage.

关键词： AnxA1 FPR2 GMH hematoma resolution hemorrhagic stroke M1 M2 microglia polarization microglia phagocytosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Commentary:Mammokine directs beige adipocytes to reserve energy for milk production in breast

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1472-1476页

作者： Lina tang Jianping Ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Beige/brown adipocytes play a crucial role in regulating the body’s overall energy balance.The thermogenic function is under the influence of various tissues,including the brain,muscles,and liver.However,the breast t... 详细信息

关键词： Beige Breast Epitheliail cells scRNA-seq Thermogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：