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Tunable metallic-like transport in polypyrrole

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Materials Futures 2022年第1期1卷 3-8页

作者： Xiaoling Zang yuqian Jiang Yuqiao Chai Fengwang Li Junhui Ji Mianqi xue Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijingPeople’s Republic of China Laboratory for Nanosystem and Hierarchy Fabrication National Center for Nanoscience and TechnologyBeijingPeople’s Republic of China School of Chemical and Biomolecular Engineering and The University of Sydney Nano Institute The University of SydneySydneyNew South WalesAustralia College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijingPeople’s Republic of China Beijing National Laboratory for Molecular Sciences BeijingPeople’s Republic of China

Conjugated polymers(CPs),organic macromolecules with a linear backbone of alternating C–C and C=C bonds,possess unique semiconductive properties,providing new opportunities for organic electronics,photonics,information,and energy *** the metallic or metallic-like,even superconducting properties beyond semiconductivity in CPs is always one of the ultimate goals in polymer science and condensed *** two metallic and semi-metallic transport cases—aniline-derived polyaniline and thiophene-derived poly(3,4-ethylenedioxythiophene)—have been reported since the development of CPs for four *** synthesis is a key challenge in discovering more *** we report the metallic-like transport behavior of another CP,polypyrrole(PPy).We observe that the transport behavior of PPy changes from semiconductor to insulator-metal transition,and gradually realizes metallic-like performance when the crystalline degree *** a generalized Einstein relation model,we rationalized the mechanism behind the *** metallic-like transport in PPy demonstrates electron strong correlation and phonon–electron interaction in soft condensation matter,and may find practical applications of CPs in electrics and spintronics.

关键词： conjugated polymers metallic-like polypyrrole transport behavior

Sustained release of magnesium and zinc ions synergistically accelerates wound healing

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Bioactive Materials 2023年第8期26卷 88-101页

作者： Fan Yang Yijia xue Feilong Wang Danni Guo Yunjiao He Xiao Zhao Fanyu Yan yuqian Xu Dandan Xia Yunsong Liu Department of Prosthodontics Peking University Hospital of StomatologyBeijing100081China National Center for Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100081China Department of Dental Materials Peking University Hospital of StomatologyBeijing100081China

Skin wounds are a major medical challenge that threaten human *** hydrogel dressings demonstrate great potential to promote wound *** this study,magnesium(Mg)and zinc(Zn)are introduced into methacrylate gelatin(GelMA)hydrogel via low-temperature magnetic stirring and photocuring,and their effects on skin wounds and the underlying mechanisms are *** testing confirmed that the GelMA/Mg/Zn hydrogel released magnesium ions(Mg^(2+))and zinc ions(Zn^(2+))in a sustained *** Mg^(2+) and Zn^(2+)not only enhanced the migration of human skin fibroblasts(HSFs)and human immortalized keratinocytes(HaCats),but also promoted the transformation of HSFs into myofibroblasts and accelerated the production and remodeling of extracellular ***,the GelMA/Mg/Zn hydrogel enhanced the healing of full-thickness skin defects in rats via accelerated collagen deposition,angiogenesis and skin wound *** also identified the mechanisms through which GelMA/Mg/Zn hydrogel promoted wound healing:the Mg^(2+) promoted Zn^(2+)entry into HSFs and increased the concentration of Zn^(2+)in HSFs,which effectively induced HSFs to differentiate into myofibroblasts by activating the STAT3 signaling *** synergistic effect of Mg^(2+) and Zn^(2+)promoted wound *** conclusion,our study provides a promising strategy for skin wounds regeneration.

关键词： Biodegradable magnesium Biodegradable zinc GelMA hydrogel Skin wound healing STAT3 signaling pathway

Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling

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Protein & Cell 2023年第8期14卷 603-617页

作者： Min Wei Yanping Sun Shouzhen Li Yunuo Chen Longfei Li Minghao Fang Ronghua Shi Dali Tong Jutao Chen yuqian Ma Kun Qu Mei Zhang Tian xue Division of Life Sciences and Medicine Department of OphthalmologyThe First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale Neurodegenerative Disorder Research CenterCAS Key Laboratory of Brain Function and DiseaseUniversity of Science and Technology of ChinaHefei 230026China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100864China

Light adaptation enables the vertebrate visual system to operate over a wide range of ambient *** of phototransduction in photoreceptors is considered a major mechanism underlying light ***,various types of neurons and glial cells exist in the retina,and whether and how all retinal cells interact to adapt to light/dark conditions at the cellular and molecular levels requires systematic ***,we utilized single-cell RNA sequencing to dissect retinal cell-type-specific transcriptomes during light/dark adaptation in *** results demonstrated that,in addition to photoreceptors,other retinal cell types also showed dynamic molecular changes and specifically enriched signaling pathways under light/dark ***,Müller glial cells(MGs)were identified as hub cells for intercellular interactions,displaying complex cell‒cell communication with other retinal ***,light increased the transcription of the deiodinase Dio2 in MGs,which converted thyroxine(T4)to active triiodothyronine(T3).Subsequently,light increased T3 levels and regulated mitochondrial respiration in retinal cells in response to light *** cones specifically express the thyroid hormone receptor Thrb,they responded to the increase in T3 by adjusting light *** of the expression of Dio2 specifically in MGs decreased the light responsive ability of *** results suggest that retinal cells display global transcriptional changes under light/dark adaptation and that MGs coordinate intercellular communication during light/dark adaptation via thyroid hormone signaling.

关键词： single cell Müller glial cells intercellular communication light/dark adaptation thyroid hormone signaling

Size dependence of photovoltaic properties and surface states modulation in ZnO nanowire/poly（3-hexylthiophene） hybrid nanostructures

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Science Bulletin 2016年第3期61卷 245-251页

作者： yuqian Huang Ke Cheng Jingjing Liu Ming xue Zhongcheng Kuang Zuliang Du Key Laboratory for Special Functional Materials of Ministry ofEducation Collaborative Innovation Center of Nano FunctionalMaterials and Applications Henan University Kaifeng 475004China

An appropriate diameter and wire-to-wire dis- tance is critical for optimizing the performance of hybrid inorganic/organic photovoltaic devices. For a deep under- standing of their influences on such hybrid structures, the well-ordered ZnO nanowires with different diameters are fabricated by the versatile hydrothermal growth. The dependence of the photovoltaic performance on the surface states, wire diameter and wire-to-wire distance is investi- gated. We demonstrate that the pristine thick ZnO nanowires film possess a higher surface photovoltage （SPV） response than the thin one. This is mainly due to the influence of surface states on the thin ZnO nanowires, which can capture the photo-generated carriers. When the two kinds of ZnO nanowires are fabricated into a hybrid inorganic/organic structure, the thin ZnO nanowires/poly（3-hexylthiophene） hybrid film has a higher SPV response than the thick one, which is contrary to the pristine ZnO nanowires. This is benefited from the smaller diameter and wire-to-wire dis- tance of the thin ZnO nanowires owned. The crystallinity, wire diameter and wire-to-wire distance have the crucial influence on the final photovoltaic performance. The results shown here give us insights toward designing efficient hybrid photovoltaic devices.

关键词： ZnO nanowires - Crystallinity - Wirediameter Surface states Hybrid heterojunction solarceils

China's Intelligent Space Robot Enters World Advanced Level

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Aerospace China 2015年第4期16卷 29-34页

作者： HU yuqian xue Yingmin YUE Yi SHI Xiaodan CAST

SPACE OPERATION,THE NECESSARY PATH FOR SPACE DEVELOPMENT Space operations refer to operations using platforms with special functions and payloads which include flexible robotic arms and space nets to accomplish specific missions through the operation and control of space *** conduct various operations in space may greatly enhance the ability to control

关键词：机器人手臂智能化中国进水世界空间操作目标控制经营空间

A single-cell transcriptome atlas of the aging human and macaque retina

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National Science Review 2021年第4期8卷 48-65页

作者： Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian xue Eye Center at The First Affiliated Hospital of USTC Hefei National Laboratory for Physical Sciences at the MicroscaleSchool of Life Sciences Division of Life Sciences and Medicine University of Science and Technology of China State Key Laboratory of Brain and Cognitive Science Institute of Brain-Intelligence TechnologyBioland Laboratory Institute of Biophysics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University IDG/McGovern Institute for Brain Research Beijing Normal University Neurodegenerative Disorder Research Center CAS Key Laboratory of Brain Function and DiseaseUniversity of Science and Technology of China Department of Ophthalmology Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third Hospital Chinese Academy of Medical Sciences & Peking Union Medical College State Key Laboratory of Brain and Cognitive Science Institute of Brain-Intelligence Technology (Shanghai)Bioland Laboratory (Guangzhou) Institute of Biophysics Chinese Academy of Sciences Institute for Stem Cell and Regeneration Chinese Academy of Sciences Advanced Innovation Center for Human Brain Protection Beijing Institute for Brain DisordersCapital Medical University Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences National Resource Center for Non-Human Primates(Kunming) Primate Research Center at IBP(Beijing) Chinese Academy of Sciences

The human retina is a complex neural tissue that detects light and sends visual information to the ***, the molecular and cellular processes that underlie aging primate retina remain unclear. Here, we provide a comprehensive transcriptomic atlas based on 119 520 single cells of the foveal and peripheral retina of humans and macaques covering different ages. The molecular features of retinal cells differed between the two species, suggesting distinct regional and species specializations of the human and macaque retinae. In addition, human retinal aging occurred in a region-and cell-type-specific manner. Aging of human retina exhibited a foveal to peripheral gradient. MYO9A~-rods and a horizontal cell subtype were greatly reduced in aging retina, indicating their vulnerability to aging. Moreover, we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease, which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases. Such datasets are valuable to understanding of the molecular characteristics of primate retina, as well as molecular regulation of aging progression and related diseases.

关键词： single-cell RNA sequencing primate retina aging cell heterogeneity age-related disease cell-cell communication

Inconel 713LC铸造高温合金微束等离子弧焊接裂纹形成机理及抑制

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焊接学报 2024年第6期45卷 39-45页

作者：贾鹏薛纪远刘昱乾王志平中国民航大学天津市民用航空器适航与维修重点实验室天津300300

针对Inconel 713LC铸造高温合金焊接增材时热影响区易产生裂纹这一问题,采用微束等离子弧焊接技术,运用扫描电镜和能谱仪对裂纹的微观形貌、合金元素分布进行分析,探究合金热影响区焊接裂纹的形成机理,研究裂纹抑制技术.结果表明,热影... 详细信息

针对Inconel 713LC铸造高温合金焊接增材时热影响区易产生裂纹这一问题,采用微束等离子弧焊接技术,运用扫描电镜和能谱仪对裂纹的微观形貌、合金元素分布进行分析,探究合金热影响区焊接裂纹的形成机理,研究裂纹抑制技术.结果表明,热影响区焊接裂纹的出现主要是受焊接热输入作用晶间碳化物发生部分溶解和液化形成液相,同时晶粒受热长大推动原始晶界发生移动后与液相交汇形成更大面积的液相,晶粒及晶界中的Nb元素、Mo元素和Ti元素等合金元素向液相偏聚,液相冷却凝固后形成尺寸超过10μm的碳化物,在焊接热应力作用下裂纹萌生于碳化物周围并沿晶界扩展,焊接裂纹数量和尺寸均随着热输入的增大而增大.通过脉冲焊接降低焊接热输入,热影响区的高温停留时间变短,降低焊接过程中热影响区合金元素的偏聚,减少合金中有害碳化物的长大,抑制裂纹生成;对铸态母材进行固溶处理后,合金元素偏聚得到均匀化处理,母材硬度下降,塑性得以改善,减弱了合金元素的富集倾向,降低了焊接时的裂纹敏感性.

关键词：焊接裂纹微束等离子弧元素偏聚脉冲焊接固溶处理

白细胞介素27参与了腰椎间盘突出症的病理过程

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中国组织工程研究 2022年第23期26卷 3750-3755页

作者：薛华伟朱敏李玉前南通市第三人民医院骨科江苏南通226000 南通大学医学院江苏南通226000

背景:炎症是腰椎间盘突出症发生的重要机制,Th17细胞在免疫激活中起着关键作用。白细胞介素27可以通过下调白细胞介素6和转化生长因子β的表达抑制Th17细胞分化,在多种自身免疫性疾病中发挥重要作用,然而人们对白细胞介素27和腰椎间盘... 详细信息

背景:炎症是腰椎间盘突出症发生的重要机制,Th17细胞在免疫激活中起着关键作用。白细胞介素27可以通过下调白细胞介素6和转化生长因子β的表达抑制Th17细胞分化,在多种自身免疫性疾病中发挥重要作用,然而人们对白细胞介素27和腰椎间盘突出症之间的关系知之甚少。目的:检测腰椎间盘突出症患者血液及髓核中白细胞介素27表达情况,探讨它与腰椎间盘突出症的关系。方法:选择腰椎间盘突出症患者36例,健康志愿者18例,急诊手术的腰椎爆裂性骨折患者8例。腰椎间盘突出症患者行开窗髓核摘除、腰椎后路椎间融合器融合或经椎间孔椎间融合器融合手术,术前使用目测类比评分法评估患者的疼痛强度。取腰椎间盘突出症患者与健康志愿者血液样本,ELISA法检测术前外周血血清白细胞介素27、白细胞介素17表达情况;取腰椎间盘突出症患者髓核样本与腰椎爆裂性骨折患者的髓核样本(视为正常髓核样本),qRT-PCR与Western blot测定髓核组织中白细胞介素27、白细胞介素17 mRNA及蛋白的表达情况。结果与结论:①腰椎间盘突出症患者血清的白细胞介素27表达水平显著高于健康对照组(P<0.001);白细胞介素17在腰椎间盘突出症患者血清中的表达水平也明显升高;②在蛋白水平,腰椎间盘突出症患者髓核中的白细胞介素27及白细胞介素17表达水平明显高于正常髓核(P<0.001);③在mRNA水平,腰椎间盘突出症患者髓核中白细胞介素27及白细胞介素17表达水平明显高于正常髓核(P<0.001);④轻度疼痛患者白细胞介素27表达水平高于重度疼痛患者(P<0.01);⑤提示炎症是腰椎间盘突出症患者疼痛的原因,白细胞介素27参与了腰椎间盘突出症的病理过程。

关键词：白细胞介素27 白细胞介素17 腰椎间盘突出症血液髓核椎间盘

麻疯树JcGASA6基因克隆及其原核表达分析

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植物生理学报 2021年第12期57卷 2346-2356页

作者：令狐前前徐刚李雪陈雨倩贵州大学贵州省森林资源与环境研究中心/贵州省高原山地林木培育重点实验室/林学院贵阳550025 贵州大学生命科学学院贵阳550025

GASA基因位于DELLA下游,其表达受赤霉素诱导。通过RACE-PCR技术从麻疯树花蕾中获得JcGASA6基因cDNA全长,并对其原核表达产物进行质谱鉴定,分析其亚细胞定位情况以及在麻疯树花发育不同时期的表达模式。结果表明:该基因cDNA全长859 bp,... 详细信息

GASA基因位于DELLA下游,其表达受赤霉素诱导。通过RACE-PCR技术从麻疯树花蕾中获得JcGASA6基因cDNA全长,并对其原核表达产物进行质谱鉴定,分析其亚细胞定位情况以及在麻疯树花发育不同时期的表达模式。结果表明:该基因cDNA全长859 bp,开放阅读框长324 bp,编码的JcGASA6蛋白包括108个氨基酸;该蛋白定位于液泡膜上,是膜整合蛋白。JcGASA6基因参与麻疯树雄花发育的各个时期(尤其是花粉成熟期)以及雌花的大孢子母细胞发生和减数分裂两个时期,且在雄花中的表达量远高于雌花。本研究为进一步探究JcGASA6基因在麻疯树雌雄花发育中的功能奠定基础。

关键词：麻疯树 JcGASA6 原核表达亚细胞定位