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Resveratrol and Sir2 Reverse Sleep and Memory Defects Induced by Amyloid Precursor Protein

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Neuroscience Bulletin 2023年第7期39卷 1117-1130页

作者： Yuping Hao Lingzhan Shao Jianan Hou Yan Zhang yuqian ma Jinhao Liu Chuan Xu Fujun Chen Li-Hui Cao Yong Ping Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China School of Basic Medical Sciences Capital Medical UniversityBeijing 100069China

Resveratrol(RES),a natural polyphenolic phytochemical,has been suggested as a putative anti-aging molecule for the prevention and treatment of Alzheimer’s disease(AD)by the activation of sirtuin 1(Sirt1/Sir2).In this study,we tested the effects of RES and Sirt1/Sir2 on sleep and courtship memory in a Drosophila model by overexpression of amyloid precursor protein(APP),whose duplications and mutations cause familial AD.We found a mild but significant transcriptional increase of Drosophila Sir2(dSir2)by RES supplementation for up to 17 days in APP flies,but not for 7 days.RES and dSir2 almost completely reversed the sleep and memory deficits in APP flies.We further demonstrated that dSir2 acts as a sleep promotor in Drosophila neurons.Interestingly,RES increased sleep in the absence of dSir2 in dSir2-null mutants,and RES further enhanced sleep when dSir2 was either overexpressed or knocked down in APP flies.Finally,we showed that Aβaggregates in APP flies were reduced by RES and dSir2,probably via inhibiting Drosophilaβ-secretase(dBACE).Our data suggest that RES rescues the APP-induced behavioral deficits and Aβburden largely,but not exclusively,via dSir2.

关键词： Resveratrol Sir2 Sleep Amyloid precursor protein β-Secretase Drosophila

Single-cell profiling reveals Müller glia coordinate retinal intercellular communication during light/dark adaptation via thyroid hormone signaling

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蛋白质与细胞:英文版 2023年第8期14卷 603-617页

作者： Min Wei Yanping Sun Shouzhen Li Yunuo Chen Longfei Li Minghao Fang Ronghua Shi Dali Tong Jutao Chen yuqian ma Kun Qu Mei Zhang Tian Xue Division of Life Sciences and Medicine Department of OphthalmologyThe First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefei 230026China Hefei National Research Center for Physical Sciences at the Microscale Neurodegenerative Disorder Research CenterCAS Key Laboratory of Brain Function and DiseaseUniversity of Science and Technology of ChinaHefei 230026China Division of Life Sciences and Medicine School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100864China

Light adaptation enables the vertebrate visual system to operate over a wide range of ambient illumination.Regulation of phototransduction in photoreceptors is considered a major mechanism underlying light adaptation.However,various types of neurons and glial cells exist in the retina,and whether and how all retinal cells interact to adapt to light/dark conditions at the cellular and molecular levels requires systematic investigation.Therefore,we utilized single-cell RNA sequencing to dissect retinal cell-type-specific transcriptomes during light/dark adaptation in mice.The results demonstrated that,in addition to photoreceptors,other retinal cell types also showed dynamic molecular changes and specifically enriched signaling pathways under light/dark adaptation.Importantly,Müller glial cells(MGs)were identified as hub cells for intercellular interactions,displaying complex cell‒cell communication with other retinal cells.Furthermore,light increased the transcription of the deiodinase Dio2 in MGs,which converted thyroxine(T4)to active triiodothyronine(T3).Subsequently,light increased T3 levels and regulated mitochondrial respiration in retinal cells in response to light conditions.As cones specifically express the thyroid hormone receptor Thrb,they responded to the increase in T3 by adjusting light responsiveness.Loss of the expression of Dio2 specifically in MGs decreased the light responsive ability of cones.These results suggest that retinal cells display global transcriptional changes under light/dark adaptation and that MGs coordinate intercellular communication during light/dark adaptation via thyroid hormone signaling.

关键词： single cell Müller glial cells intercellular communication light/dark adaptation thyroid hormone signaling

Multilayer core-shell nanostructures for enhanced 808 nm responsive upconversion

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Chinese Chemical Letters 2022年第2期33卷 1087-1090页

作者： Yao Wang Jingxiang Low Yafei Bi Yu Bai Yawen Jiang Huihui Wang Weiyong Liu yuqian ma Yunuo Chen Ran Long Yujie Xiong Hefei National Laboratory for Physical Sciences at the Microscale Frontiers Science Center for Planetary Exploration and Emerging TechnologiesSchool of Chemistry and Materials ScienceNational Synchrotron Radiation LaboratoryNeurodegenerative Disorder Research CenterCAS Key Laboratory of Brain Function and Diseaseand School of Life SciencesUniversity of Science and Technology of ChinaHefei 230026China Department of Ultrasound The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036China

The construction of core-shell structure is an effective strategy for promoting the emission efficiency of upconversion nanocrystals(UCNCs). In this work, the UCNCs based on Nd-doping with a multilayer coreshell nanostructure are fabricated toward achieving efficient upconversion for 808 nm excitation, which have great potential for optical applications, especially photobiological applications.

关键词： 808 nm excitation Upconversion nanocrystals Core-shell structure Structure construction Emission enhancement

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部分旋流对加力燃烧室流动和燃烧性能的影响

推进技术 2024年第2期45卷 114-123页

作者：毕亚宁范育新肖锋马宗伯陈玉乾南京航空航天大学能源与动力学院江苏南京210016

为改善先进加力/冲压燃烧室燃烧组织困难等问题,采用设置进口部分旋流,在燃烧室中产生局部离心力来增强油气掺混和加速火焰传播。通过数值模拟和试验的方法,研究了不同旋流进口位置及角度下部分旋流加力/冲压燃烧室的流动特性、燃烧效... 详细信息

为改善先进加力/冲压燃烧室燃烧组织困难等问题,采用设置进口部分旋流,在燃烧室中产生局部离心力来增强油气掺混和加速火焰传播。通过数值模拟和试验的方法,研究了不同旋流进口位置及角度下部分旋流加力/冲压燃烧室的流动特性、燃烧效率及值班点火火焰发展过程。研究发现:多区域旋流进口与不同旋流角度的组合会使流动损失增大,但可以在燃烧室建立一个局部超重力场,增强油气掺混和加速点火过程火焰传播。相比于无旋流,旋流进口可以提高值班火焰传播速度;旋流进口最高可提升2.35%的燃烧效率。

关键词：加力燃烧室超重力燃烧旋流离心力流动特性

基于主次屏障的化工装置事故根因分析及“双预”机制应用

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中国安全科学学报 2024年第2期34卷 131-137页

作者：王海清张玉倩郑威马佳雯中国石油大学(华东)机电工程学院山东青岛266580 杭州汉德质量认证服务有限公司浙江杭州310019

双重预防机制(“双预”)是当前国内危化品领域正在广泛推行的一种风险管控系统,但目前缺乏底层和运行层面的理论架构,更缺乏以根因分析(RCA)结果来指导实施“双预”的方法工具,为此,提出“主-次”屏障理论与事件与原因因素分析(ECF)相... 详细信息

双重预防机制(“双预”)是当前国内危化品领域正在广泛推行的一种风险管控系统,但目前缺乏底层和运行层面的理论架构,更缺乏以根因分析(RCA)结果来指导实施“双预”的方法工具,为此,提出“主-次”屏障理论与事件与原因因素分析(ECF)相结合的可视化主-次屏障(VPSB)模型。ECF作为一种典型的RCA技术,由特定主/次屏障失效模式组成灾害事件的致因路径,为VPSB建模提供可视化框图。应用该模型对英国石油BP公司的Texas爆炸中的典型事故场景进行隐患识别和RCA,获得“双预”相关管理措施的具体失效模式,通过与美国化学品安全委员会(CSB)和英国石油(BP)公司对该事件的调查结果对比,发现CSB和BP公司将人的不安全动作作为直接原因开展深层次的原因分析,将关注点放在了人的管理上,并将根本原因宏观地总结为安全主管失职和操作工违规作业,而VPSB模型则关注的是对重大事故隐患本身和工艺过程的管理,用描述具体的次屏障失效模式来突出管理系统存在的根本性问题,其中,在机械完整性管理上的问题最多,且主要是由于管理措施未被合规执行。这为企业优化“双预”的相关工作内容提供了重点整改方向和可操作性建议。

关键词：可视化主-次屏障(VPSB)模型化工装置根因分析(RCA) 双重预防机制事件与原因因素分析(ECF) 事故场景

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储层流体可动性在油田开发中的应用及展望

西南石油大学学报（自然科学版） 2024年第1期46卷 1-20页

作者：谭锋奇马春苗黎宪坤静禹钱中国科学院大学地球与行星科学学院北京海淀100049 中国科学院计算地球动力学重点实验室北京海淀100049

储层微观孔喉内流体可动性研究对于储层的精确评价和油藏的高效开发具有重要意义,是油气藏提高采收率的必要条件。依据研究对象的差异性,将孔喉流体可动性的研究方法分为矿物成分、孔隙结构及流体动用3个维度。核磁共振技术能够快速准... 详细信息

储层微观孔喉内流体可动性研究对于储层的精确评价和油藏的高效开发具有重要意义,是油气藏提高采收率的必要条件。依据研究对象的差异性,将孔喉流体可动性的研究方法分为矿物成分、孔隙结构及流体动用3个维度。核磁共振技术能够快速准确地确定可动流体饱和度、可动流体孔隙度和束缚水饱和度等常用的可动流体参数,进而有效地对各类油气储层进行流体评价和产能预测。目前,国内外各大油田均采用核磁共振与其他实验手段相结合的方法来确定储层内流体的动用规律,并在致密砂砾岩、碳酸盐岩、煤层和油页岩等不同类型储层中取得了良好的应用效果。另外,为了达到对不同类型油气资源的有效勘探和高效开发,必须明确储层内流体可动性的控制因素。在已有研究成果的基础上,流体可动性控制因素可以分为宏观和微观两方面,其中,宏观因素主要包括沉积环境、成岩作用和岩相类型;微观因素主要包括孔喉结构、储层物性、矿物成分及水膜厚度等。目前,虽然流体可动性研究方法的种类已较为丰富,并且在不同类型油气资源的评价中取得了良好的应用效果,但是,在其应用的广度和精度上还需要进一步深入研究与探索,在后续的发展中可综合应用孔隙网络模型、油藏数值模拟、多参数评价指标以及联立地球化学参数等新思路和新方法,深入揭示微观孔喉流体可动性的渗流机理,不断提高可动流体综合评价的精度,为油藏开发方案的合理制定提供地质依据,推动石油行业的高效发展。

关键词：流体可动性研究方法影响因素致密储层核磁共振技术

Human Activity Recognition Based on Frequency-Modulated Continuous Wave and DenseNet

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Journal of Computer and Communications 2023年第7期11卷 15-28页

作者： Wenshuo Jiang yuqian ma Wencheng Zhuang Zhongqiang Wu Yiming Hua Meng Li Zhengjie Wang College of Electronic and Information Engineering Shandong University of Science and Technology Qingdao China

With the development of wireless technology, Frequency-Modulated Continuous Wave (FMCW) radar has increased sensing capability and can be used to recognize human activity. These applications have gained wide-spread attention and become a hot research area. FMCW signals reflected by target activity can be collected, and human activity can be recognized based on the measurements. This paper focused on human activity recognition based on FMCW and DenseNet. We collected point clouds from FMCW and analyzed them to recognize human activity because different activities could lead to unique point cloud features. We built and trained the neural network to implement human activities using a FMCW signal. Firstly, this paper presented recent reviews about human activity recognition using wireless signals. Then, it introduced the basic concepts of FMCW radar and described the fundamental principles of the system using FMCW radar. We also provided the system framework, experiment scenario, and DenseNet neural network structure. Finally, we presented the experimental results and analyzed the accuracy of different neural network models. The system achieved recognition accuracy of 100 percent for five activities using the DenseNet. We concluded the paper by discussing the current issues and future research directions.

关键词： Human Behavior Recognition Millimeter-Wave Radar Convolutional Neural Networks Wireless Signal

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矿田构造岩相学填图理论及应用

地质力学学报 2024年第1期30卷 88-106页

作者：方维萱郭玉乾李天成贾润幸马振飞有色金属矿产地质调查中心北京100012 矿山生态环境资源创新实验室北京100012 云南锡业集团(控股)有限责任公司云南个旧661000

开展成矿蚀变−构造岩相解析建相和建模预测研究已成为矿田构造与找矿预测的创新方向之一。文章对国内外8类重要的成矿蚀变−构造岩相模型和形成机制进行论述总结,南美洲智利科皮亚波地区IOCG型矿田受到主岛弧带−弧相关盆地及岩浆叠加−盆... 详细信息

开展成矿蚀变−构造岩相解析建相和建模预测研究已成为矿田构造与找矿预测的创新方向之一。文章对国内外8类重要的成矿蚀变−构造岩相模型和形成机制进行论述总结,南美洲智利科皮亚波地区IOCG型矿田受到主岛弧带−弧相关盆地及岩浆叠加−盆地变形样式的复合控制,而中国云南东川沉积岩型铜矿床(SSC型)+IOCG型铁铜矿田受陆缘裂谷盆地、盆地变形构造样式和岩浆叠加侵入构造系统的复合控制。中国内蒙古甲−查浅成低温热液型银铅锌矿田受火山洼地、火山穹隆构造、火山岩岩相类型和火山热液隐爆角砾岩的复合控制,而深成岩浆弧控制了蒙古国南戈壁斑岩型金铜钼−浅成低温热液金银矿田;中国秦岭热水沉积型(SEDEX)银铜铅锌−菱铁矿−重晶石矿田受到陆缘拉分盆地内三级热水沉积盆地、同生断裂带和热水沉积岩相的控制。大陆造山带内不同层次的脆韧性剪切带,控制了金矿田和金钼多金属矿田定位。在新疆塔西盆−山−原镶嵌区盆地系统内,侏罗系煤系烃矿源岩是金属矿田和天然气气田的成矿成藏物质供给源区;乌拉根砂砾岩型天青石−铅锌矿田受到山前挤压—伸展转换盆地、气成热流柱构造和山前冲断褶皱带的复合控制;萨热克铜多金属矿田赋存于旱地扇杂砾岩,受到对冲式厚皮型逆冲推覆断裂带和幔源热流柱带的复合控制。其中在矿集区−矿田尺度上,电气石热流柱构造、岩浆气囊构造、复合岩溶构造岩相等是成矿蚀变−构造岩相的3种新类型;在归纳前期对矿田构造岩相、矿田构造古地理单元和典型矿田构造岩相形成机制研究基础上,文章提出了矿田成矿蚀变−构造岩相类型的新划分方法和划分原则方案,并划分确定了12种变形构造岩相类型。研究成果为矿田构造研究和找矿预测提供了新理论和新方法支撑。

关键词：矿田构造矿田岩相学成矿蚀变−构造岩相成矿系统构造岩相模型形成机制

Discovery of a Novel Aminopeptidase N Inhibitor Dino-Leucine Borate

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Journal of Biosciences and Medicines 2022年第5期10卷 150-168页

作者： yuqian ma Minzhi Fang Yutian Li Dongqi Zhu Yanmei Du Binbin Ge Jiliang Song Xinyue Xu Chuhan ma Xiaojun Jia Xiurong Zhang Jian Zhang Dexiu Wang Xuejian Wang School of Pharmacy Weifang Medical University Weifang China School of Basic Medicine Weifang Medical University Weifang China School of Clinical Medicine Weifang Medical University Weifang China

Aminopeptidase N(APN/CD13), a Zn2+-dependent ectopeptidase localized on the cell surface, is widely considered to influence the invasion of tumor cells. We found that boroleucine and dino-leucine borate exhibited a strong inhibitory effect on the enzyme activity of aminopeptidase N. The tested assay indicated that both compounds had an anti-proliferative effect on triple-negative breast cancer cells. Wound healing assay, migration test and matrigel-coated transwell assay showed that both boroleucine and dino-leucine borate inhibited the migration and invasion of breast cancer cells. Immunoblot analysis showed that both compounds down-regulated the expression of matrix metalloproteinase-2/9. In the capillary tube formation assay of human umbilical vein endothelial cells (HUVECs), dino-leucine borate showed better antiangiogenic activity than ubenimex even at a low concentration (10 μM). Moreover, compared with ubenimex, the anti-metastatic activity of dino-leucine borate in vivo was similar to or even better than that of ubenimex in the H22 pulmonary metastasis mouse model. In this paper, we found the novel APN inhibitors to markedly suppress the enzyme activity of APN and inhibit the migration and invasion of tumor cells in vitro and in vivo.

关键词： Aminopeptidase Inhibitor Anti-Tumor Boroleucine Dino-Leucine Borate