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Scientific connotation of “treating different diseases with the same method” from the perspective of metabolic-immune dysregulation in inflammation-mediated carcinogenesis of digestive organs

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 3-9页

作者： Xia Ding yunze liu Ruilin Wang Hong Shen Qi Wang Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Centre of Research for Traditional Chinese Medicine Digestive Beijing University of Chinese MedicineBeijing 100029China Department of Hepatology of Traditional Chinese Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China Digestive Department Jiangsu Province Hospital of Chinese MedicineNanjing 210029China National Institute of TCM Constitution and Preventive Medicine Beijing University of Chinese MedicineBeijing 100029China

Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive *** the chronic inflammation microenvironment,the metabolic activity of tissue cells undergoes extensive changes,which interfere with the normal function of immune *** of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs,such as the stomach,liver,and *** metabolic-immune imbalance also corresponds to traditional Chinese medicine(TCM)theories of“yin-yang disharmony”and“disharmony between Ying-nutrients and Wei-defense.”The metabolic-immune imbalance has also been regarded as the key factor supporting“treatment of different diseases with the same method”,in which the same approach is adopted in the treatment of different *** the TCM treatment process,it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function,thereby blocking the progression from inflammation to *** study findings deepen the TCM understanding of metabolic-immune dysregulation and the relationship between metabolic-immune dysregulation,pattern identification,and treatment *** also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of“treating different diseases with the same method”.

关键词： Inflammation-mediated carcinogenesis Treating different diseases with the same method Metaboliceimmune regulation Metabolism Immunity Digestive system

达原饮调控TLR/MAPK/NF-κB通路防治H1N1感染诱发急性肺损伤的作用机制

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中国实验方剂学杂志 2024年第18期30卷 52-60页

作者：李承泽褚福浩李园刘运泽郑浩呈王思慈顾益枭朱万鸿张若诗宋行健盖聪丁霞北京中医药大学中医学院北京100102 北京中医药大学中药学院北京100102 北京中医药大学国家中医体质与治未病研究院北京100102 北京中医药大学东直门医院北京101121

目的:探究达原饮对H1N1感染诱发的急性肺损伤的药效及其潜在机制。方法:使用超高效液相色谱-四级杆静电场轨道阱质谱仪对达原饮水煎液进行药物成分分析。将48只雌性BALB/c小鼠随机分为正常组、模型组、奥司他韦组(19.5 mg·kg^(-1))、... 详细信息

目的:探究达原饮对H1N1感染诱发的急性肺损伤的药效及其潜在机制。方法:使用超高效液相色谱-四级杆静电场轨道阱质谱仪对达原饮水煎液进行药物成分分析。将48只雌性BALB/c小鼠随机分为正常组、模型组、奥司他韦组(19.5 mg·kg^(-1))、达原饮低、中、高剂量组(2.73、5.46、10.92 g·kg^(-1))。正常组和模型组给予去离子水灌胃,其他各组给予对应药物灌胃。给药第3天,正常组给予生理盐水滴鼻,其他各组在鼻内接种A/RP/8/34(H1N1)构建流感病毒感染的动物模型。连续给药7 d,每日称体质量。末次给药12 h后进行取材,肺组织称重,计算肺指数;苏木素-伊红(HE)染色观察肺组织及支气管病理形态学变化;微球免疫分析系统(CBA)检测血清中的γ干扰素(IFN-γ)、趋化因子(C-X-C基序)配体1(CXCL1)、肿瘤坏死因子-α(TNF-α)、趋化因子配体2(CCL2)、白细胞介素-12p70(IL-12p70)、趋化因子配体5(CCL5)、白细胞介素-1β(IL-1β)、趋化因子(C-X-C基序)配体10(CXCL10)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素-10(IL-10)、干扰素-β(IFN-β)、干扰素-α(IFN-α)、白细胞介素-6(IL-6)。基于质谱结果联合网络药理学,分析达原饮防治甲流病毒引起的急性肺损伤的作用机制。通过蛋白免疫印迹法(Western bolt)检测肺组织中的细胞外信号调节激酶1/2(ERK1/2)、p38丝裂原活化蛋白激酶(p38 MAPK)、核转录因子-κB(NF-κB),及其磷酸化蛋白的表达;实时荧光定量聚合酶链式反应(Real-time PCR)检测肺组织中的髓样分化因子88(MyD88)、Toll样受体3(TLR3)、Toll样受体7(TLR7)、Toll样受体8(TLR8)的mRNA表达。结果:质谱分析确定达原饮水煎液中含有芍药苷、黄芩素等57种化合物。与正常组比较,模型组小鼠体质量下降(P<0.01),肺部水肿和出血,肺指数升高(P<0.01),IFN-γ、IL-12p70、CCL5、IL-1β、CXCL10、GM-CSF、IFN-β、IL-6显著升高(P<0.01)。与模型组比较,达原饮治疗组小鼠肺泡壁增厚、毛细血管充血和免疫细胞浸润的病理变化明显减轻,体质量和肺指数改变减轻(P<0.01),IFN-γ、IL-12p70、CCL5、IL-1β、CXCL10、GM-CSF、IFN-β、IL-6蛋白表达量显著下降(P<0.01);网络药理学分析共获得57个关键基因,其中MAPK信号通路为主要的靶向信号通路。与正常组比较,模型组小鼠肺组织的p-ERK1/2、p-p38MAPK、p-NF-κB表达上升(P<0.01),TLR7、TLR8、MyD88、TLR3的mRNA表达上升(P<0.05,P<0.01)。与模型组比较,达原饮治疗组表现出剂量依赖性地抑制ERK1/2、p38 MAPK和NF-κB p65的磷酸化水平(P<0.01),同时能够下调TLR3、TLR7、TLR8、MyD88的mRNA表达(P<0.01)。结论:达原饮能够通过抑制TLR/MAPK/NF-κB信号通路,有效防治H1N1感染诱发的急性肺损伤。

关键词：达原饮流感病毒急性肺损伤炎症 Toll样受体(TLR)/丝裂原活化蛋白激酶(MAPK)/核转录因子-κB(NF-κB)信号通路

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优化碱酸法提纯石墨的研究

中国粉体技术 2024年第3期30卷 76-87页

作者：刘云泽孟繁荣崔学民王林杰何振全李仁涛盖国胜广西大学化学化工学院广西南宁530004 清华大学无锡应用技术研究院江苏无锡214100 山东省粉体材料中试示范基地山东东营257061 山东石油化工学院化学工程学院山东东营257061 淄博清大粉体材料工程有限公司山东淄博255086

【目的】优化天然石墨提纯效果,降低酸在提纯过程中的过多使用对环境造成的影响,满足各行各业对高品质石墨的需求,实现更环保、高效的石墨提纯。【方法】以鳞片石墨为原料,采取NaOH-HCl-HF联合处理的工艺对石墨进行提纯研究,提高石墨的... 详细信息

【目的】优化天然石墨提纯效果,降低酸在提纯过程中的过多使用对环境造成的影响,满足各行各业对高品质石墨的需求,实现更环保、高效的石墨提纯。【方法】以鳞片石墨为原料,采取NaOH-HCl-HF联合处理的工艺对石墨进行提纯研究,提高石墨的固定碳含量(质量分数,下同),降低石墨中的主要杂质元素如Si、Fe、Al、Cu等的含量,详细考察NaOH的用量以及焙烧温度2个关键因素对该工艺提纯效果的影响;通过扫描电子显微镜(SEM)观察石墨形貌特征,X射线荧光光谱仪(XRF)和电感耦合等离子体原子发射光谱仪(ICP)测定提纯处理前后石墨的杂质含量,X射线衍射仪(XRD)确定石墨及其灰分的晶体结构。【结果】当焙烧温度为500℃、焙烧时间为2.5h,HCl的体积与石墨的质量比为2∶1,氢氟酸的体积与石墨的质量比为2∶1时,石墨的平均固定碳含量从原来的95.3%提高到99.93%;当NaOH与石墨的质量比分别为0.5∶1和0.6∶1时,石墨的平均固定碳含量为99.91%和99.93%;考虑到成本效益等因素,确定当NaOH与石墨的质量比设定为0.5∶1时为理想工艺条件;经过提纯处理后的石墨层结构并不会出现明显的变化,基本性能不变,提纯处理后的石墨相比于提纯处理前的石墨,杂质含量明显地降低。【结论】该碱酸工艺不仅能有效地去除石墨中的杂质,盐酸和氢氟酸的组合还可以显著地提升提纯效果,可有望应用在石墨提纯处理和新能源材料领域。

关键词：石墨碱酸法加碱焙烧固定碳纯化

Selective photosynthesis of Z-olefins through crystalline metal-organic cage-initiated expeditious cascade reactions

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Carbon Energy 2024年第3期6卷 118-131页

作者： Jia-Ni Lu yunze Huang Yuan-Sheng Xia Long-Zhang Dong Lei Zhang Jing-Jing liu Lan-Gui Xie Jiang liu Ya-Qian Lan Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsNanjing Normal UniversityNanjingChina School of Chemistry South China Normal UniversityGuangzhouChina

The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical ***,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial ***,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton *** the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen *** them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple ***“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions.

关键词： alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis Z-olefins

自洽法和Mori Tanaka法预测水泥浆体徐变的比较

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北京工业大学学报 2023年第11期49卷 1159-1166页

作者：李悦刘运泽北京工业大学城市与工程安全减灾教育部重点实验室北京100124 工程抗震与结构诊治北京市重点实验室北京100124

为了预测水泥浆体的徐变性能,并对比不同预测模型的精度。使用微米压痕测试确定了水泥浆体的徐变模量,使用纳米压痕点阵测试获得微观物相的接触徐变模量。随后基于一系列微观测试获得物相的体积分数。将水泥浆体划分为2个尺度,分别基于... 详细信息

为了预测水泥浆体的徐变性能,并对比不同预测模型的精度。使用微米压痕测试确定了水泥浆体的徐变模量,使用纳米压痕点阵测试获得微观物相的接触徐变模量。随后基于一系列微观测试获得物相的体积分数。将水泥浆体划分为2个尺度,分别基于自洽(self-consistent,SC)法和Mori Tanaka法,采用4种组合方式进行徐变均匀化预测。结果表明,在凝胶尺度采用Mori Tanaka法,在浆体尺度采用SC法时,水泥浆体的长期徐变性能的预测精度较高。该研究为进行水泥基材料徐变均匀化时选择合适的计算方法提供了依据。

关键词：水泥浆体徐变压痕测试均匀化自洽法 Mori Tanaka法

Force model in electrostatic atomization minimum quantity lubrication milling GH4169 and performance evaluation

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Frontiers of Mechanical Engineering 2024年第4期19卷 55-72页

作者： Min YANG Hao MA Zhonghao LI Jiachao HAO Mingzheng liu Xin CUI Yanbin ZHANG Zongming ZHOU yunze LONG Changhe LI School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China College of Physics QingdaoUniversityQingdao 266071China Hanergy Lubrication Technology Co. Ltd.Qingdao 266200China

The nickel-based high-temperature alloy GH4169 is the material of choice for manufacturing critical components in aeroengines,and electrostatic atomization minimum quantity lubrication(EMQL)milling represents a fundamental machining process for ***,the effects of electric field parameters,jet parameters,nozzle position,and milling parameters on milling performance remain unclear,which constrains the broad application of EMQL in aerospace *** study evaluated the milling performance of EMQL on nickel-based alloys using soybean oil as the lubrication *** revealed that compared with conventional pneumatic atomization MQL milling,EMQL reduced the milling force by 15.2%-15.9%,lowered the surface roughness by 30.9%-54.2%,decreased the average roughness spacing by 47.4%-58.3%,and decreased the coefficient of friction and the specific energy of cutting by 55%and 19.6%,*** optimization experiments using orthogonal arrays demonstrated that air pressure most significantly affected the milling force and specific energy of cutting,with a contribution rate of 22%,whereas voltage had the greatest effect on workpiece surface roughness,contributing 36.71%.Considering the workpiece surface morphology and the potential impact of droplet drift on environmental and health safety,the optimal parameter combination identified were a flow rate of 80 mL/h,an air pressure of 0.1 MPa,a voltage of 30 kV,a nozzle incidence angle of 35°,an elevation angle of 30°,and a target distance of 40 *** research aimed to provide technical insights for improving the surface integrity of aerospace materials that are difficult to machine during cutting operations.

关键词： electrostatic atomization MQL nickel-based alloys milling force surface roughness force model

Wavelength-dependent nonlinear wavefront shaping in 3D nonlinear photonic crystal

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Chinese Optics Letters 2024年第7期22卷 66-70页

作者： yunze Wang Yan Sheng Shan liu Ruwei Zhao Tianxiang Xu Tiefeng Xu Feng Chen Wieslaw Krolikowski Laboratory of Infrared Materials and Devices Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Engineering Research Center for Advanced Infrared Photoelectric Materials and Devices of Zhejiang Province Ningbo UniversityNingbo 315211China Quantum Science and Technology Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia Ningbo Institute of Oceanography Ningbo 315832China State Key Laboratory of Crystal Materials and Key Laboratory of Particle Physics and Particle Irradiation of the Ministry of Education School of PhysicsShandong UniversityJinan 250100China

A 3D nonlinear photonic crystal containing four parallel segments of periodicχ^((2))grating structure is fabricated employing the femtosecond laser poling of ferroelectric Ca_(0.28)Ba_(0.72)Nb_(2)O_(6) *** second harmonic generation from this foursegment structure is studied with a fundamental Gaussian *** tuning the wavelength of the fundamental wave,the second harmonic varies from the Laguerre-Gaussian beam(topological charge l_(c)=1)to the higher-order Hermite-Gaussian beam and Laguerre-Gaussian again(l_(c)=−1).This effect is caused by the wavelength-dependent phase delays introduced by the four-grating *** study contributes to a deeper understanding of nonlinear wave interactions in 3D nonlinear photonic *** also offers new possibilities for special beam generation at new frequencies and their control.

关键词： quasi-phase matching nonlinear photonic crystal second harmonic generation nonlinear beam shaping

隧道洞口古滑坡堆积体边坡综合加固治理技术研究

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西安建筑科技大学学报（自然科学版） 2020年第3期52卷 351-358页

作者：刘运泽洪勇李柏霄中铁十二局集团第一工程有限公司陕西西安710038 西安建筑科技大学土木工程学院陕西西安710055

为保证隧道安全进洞施工,须对隧道洞口人工取土扰动的古滑坡堆积体边坡进行综合加固治理.通过理论计算对抗滑桩、锚杆-锚索框架梁、坡脚回填反压等加固治理方案进行设计,利用Flac3D软件分析了堆积体治理前后的稳定性,对支护结构相关参... 详细信息

为保证隧道安全进洞施工,须对隧道洞口人工取土扰动的古滑坡堆积体边坡进行综合加固治理.通过理论计算对抗滑桩、锚杆-锚索框架梁、坡脚回填反压等加固治理方案进行设计,利用Flac3D软件分析了堆积体治理前后的稳定性,对支护结构相关参数进行了优化,并对综合治理效果进行了评价,形成了一套较完整的隧道洞口堆积体综合治理技术.研究结果表明:优化的综合支护措施相比单一支护措施显著提高了边坡稳定性,且满足规范及边坡进洞安全要求,抗滑桩尺寸和距坡顶距离、锚索施加预应力值对边坡稳定性影响较大,此外,结合工程实际采用减一跨桥台增设路基的方案,实现边坡反压,提高洞口边坡稳定性.现场监测数据表明,经过综合加固治理后的古滑坡堆积体边坡满足规范要求,保证了隧道安全进洞施工.

关键词：古堆积体洞口边坡边坡加固数值分析

Research on the Penetration Characteristic of Supersonic Molecule Beam on the HL-1M Tokamak

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中国核科技报告 2002年 881-885页

作者： DONG Jiafu LUO Junling TANG Nianyi LI Wei ZHONG yunze liu Yi FU Binzhong YAO Lianghua FENG Baibing QIN Yunwen

In the HL-1M plasma experiments, two refueling ways, the pellet injection and the gas puffing, are usually used. In recent years, a new refueling method, the supersonic molecule beam (SMB) injection, has been develope... 详细信息

关键词： SMB Penetration