检索结果-南通市图书馆

Petrogenesis and tectonic significance of the early Paleozoic Delenuoer ophiolite in the Central Qilian Shan, northeastern Tibetan Plateau

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2020年第6期11卷 2017-2029页

作者： Zhen Ma Jinrong Wang Liangliang Zhang Yixin Liu yunyun gao Xiang Zhang Sheng Yu Cheng Zhang Key Laboratory of Mineral Resources in Western China School of Earth SciencesLanzhou UniversityLanzhou730000China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of Geosciences(Beijing)Beijing100083China Changqing Branch Research Institute of Bureau of Geophysical ProspectingChina National Petroleum CorporationXi’an710021China Geological Survey of Gansu Province Lanzhou730000China No.2 Geology and Mineral Exploration Team Gansu Provincial Bureau of Geology and Mineral Exploration and DevelopmentLanzhou730000China

The newly discovered early Paleozoic Delenuoer ophiolite,in the western margin of the Central Qilian Shan,is composed of serpentinized peridotite,cumulate gabbro,diabase,massive basalt,and pillow *** study presents geochronological and geochemical data for the cumulate gabbro and ***-ICP-MS U-Pb dating of zircons from the cumulate gabbro yielded a magmatic crystallization age of 472±4 *** basalts have normal mid-ocean ridge basalt(N-MORB)compositions and a narrow range ofεNd(t)values(+4.5 to+5.3),which indicates they were derived from a depleted mantle *** the basis of regional geological constraints,it is proposed that the Delenuoer ophiolite is a westward extension of the South Ophiolite Belt(Yushigou-Youhulugou-Donggou-Dongcaohe Ophiolite Belt)in the North Qilian *** Delenuoer ophiolite,along with the Gulangxia-Delenuoer fault,defines the westernmost part of the tectonic boundary between the North and Central Qilian *** ophiolite may have formed during southward subduction of the Qilian Ocean slab during the early Paleozoic.

关键词： Ophiolite Delenuoer Central Qilian Shan Early Paleozoic Tectonic boundary

A systematic in vitro investigation on poly-arginine modified nanostructured lipid carrier: Pharmaceutical characteristics, cellular uptake, mechanisms and cytotoxicity

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 51-58页

作者： Mingshuang Sun yunyun gao Zhihong Zhu Huixin Wang Cuiyan Han Xinggang Yang Weisan Pan Shenyang Pharmaceutical University No.103Wenhua RoadShenyang 110016China Qiqihar Medical University No.333Bukuibei RoadQiqihar 161000China

The aim of the present study was to develop a poly-arginine modified nanostructured lipid carrier(R-NLC) by fusion-emulsification method and to test its pharmaceutical characteristics. The influence of R-NLC on A549 cells like cellular uptake and cytotoxicity was also appraised using unmodified NLC as the controlled group. As the results revealed, R-NLC had an average diameter of about 40 nm and a positive zeta potential of about +17 mv, the entrapment efficiency decreased apparently, and no significant difference on the in vitro drug release was found after R8-modification. The cellular uptake and cytotoxicity increased obviously compared with unmodified NLC. The cellular uptake mechanisms of R-NLC involved energy, macropinocytosis, clathrin-mediated endocytosis, and caveolin-mediated endocytosis. The outcomes of the present study strongly support the theory that cell penetrating peptides have the ability of enhancing the cellular uptake of nanocarriers.

关键词： Poly-arginine NLC Cellular uptake Mechanisms Cytotoxicity

Nanopore sequencing: flourishing in its teenage years

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第12期51卷 1361-1374页

作者： Tianyuan Zhang Hanzhou Li Mian Jiang Huiyu Hou yunyun gao Yali Li Fuhao Wang Jun Wang Kai Peng Yong-Xin Liu Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Wuhan Benagen Technology Co. Ltd Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou University

Over the past decade, nanopore sequencing has experienced significant advancements and changes,transitioning from an initially emerging technology to a significant instrument in the field of genomic sequencing. However, as advancements in next-generation sequencing technology persist, nanopore sequencing also improves. This paper reviews the developments, applications, and outlook on nanopore sequencing technology. Currently, nanopore sequencing supports both DNA and RNA sequencing, making it widely applicable in areas such as telomere-to-telomere(T2T) genome assembly, direct RNA sequencing(DRS), and metagenomics. The openness and versatility of nanopore sequencing have established it as a preferred option for an increasing number of research teams, signaling a transformative influence on life science research. As the nanopore sequencing technology advances, it provides a faster, more costeffective approach with extended read lengths, demonstrating the significant potential for complex genome assembly, pathogen detection, environmental monitoring, and human disease research, offering a fresh perspective in sequencing technologies.

关键词： Nanopore sequencing Long-Read Sequencing Application Accuracy Outlook Direct RNA sequencing Metagenomics

A time-released osmotic pump fabricated by compression-coated method: Formulation screen, mechanism research and pharmacokinetic study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2014年第4期9卷 208-217页

作者： Tiegang Xin Yang Zhao Hengpan Jing Wenji Zhang yunyun gao Xinggang Yang Xukai Qu Weisan Pan Department of Pharmaceutics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyang 110016China College of Pharmaceutical Science Zhejiang University of Technology18 Chaowang RoadHangzhou 310014China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical ResearchTianjin 300193China

In this investigation,time-released monolithic osmotic pump(TMOP)tablets containing diltiazem hydrochloride(DIL)were prepared on the basis of osmotic pumping *** developed dosage forms were coated by Kollidon®SR-Polyethylene Glycol(PEG)mixtures via compression-coated technology instead of spray-coating method to form the outer *** more efficient formulation screening,a three-factor five-level central composite design(CCD)was introduced to explore the optimal TMOP formulation during the *** in vitro tests showed that the optimized formulation of DIL-loaded TMOP had a lag time of 4 h and a following 20-h drug release at an approximate zero-order ***,the releasemechanismwas proven based on osmotic pressure and its profile could be well simulated by a dynamic *** oral administration by beagle dogs,the comparison of parameters with the TMOP tablets and reference preparations show no significant differences for C_(max)(111.56±20.42,128.38±29.46 ng/ml)and AUC_(0-48 h)(1654.97±283.77,1625.10±313.58 ng h/ml)but show significant differences for T_(max)(13.00±1.16,4.00±0.82 h).These pharmacokinetic parameters were consistent with the dissolution tests that the TMOP tablets had turned out to prolong the lag time of DIL release.

关键词： Time-released Osmotic pump Compression-coated Central composite design Pharmacokinetic

Effects of electroacupuncture on angiogenesis and cortical VEGF and BDNF expression in rats with focal cerebral ischemia

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Acupuncture and Tuina Science 2022年第2期20卷 91-103页

作者： LI Mengxing WANG Yu gao yunyun YAO Xiaowen LAN Wei TANG Wei College of Acupuncture and Moxibustion Anhui University of Chinese MedicineHefei230012China Graduate School Anhui University of Chinese MedicineHefei230012China

Objective To observe the effect of electroacupuncture(EA)of“concurrent treatment of the brain and heart”on angiogenesis and cortical vascular endothelial growth factor(VEGF)and brain-derived neurotrophic factor(BDNF)in rats with focal cerebral ischemia,and to explore the mechanism of EA in cerebral ischemia *** A total of 108 Sprague-Dawley rats,27 rats were randomly selected as the sham-operation group,and the rest rats received the right middle cerebral artery occlusion operation for model preparation firstly,and then were divided into a model group,a traditional acupoint group,and a concurrent treatment of the brain and heart group,with 27 rats in each *** the sham-operation group,only the carotid artery was *** at Shuigou(CV26),Quchi(LI11),Hegu(LI4),and Zusanli(ST36)in the traditional acupoint group,and EA at Fengfu(GV16),Baihui(GV20),Xinshu(BL15),and Neiguan(PC6)in the concurrent treatment of the brain and heart group were performed 4 h after the operation,once a day,for 14 consecutive *** in the sham-operation group and the model group were identically fixed without any *** and after treatment,the modified neurological severity score(mNSS),regional cerebral blood flow(rCBF),and CD34 positive expression by immunohistochemistry were *** positive protein expression levels of VEGF and BDNF were detected by immunofluorescence,and the mRNA expression levels of VEGF and BDNF were detected by quantitative reverse transcription-polymerase chain reaction(qRT-PCR).Results Compared with the sham-operation group,the mNSS,rCBF,and ischemic side cortical micro-vessel density(MVD)decreased,and the protein and mRNA expression levels of VEGF and BDNF increased in the model group(P<0.01).Compared with the model group,the mNSS of the two EA groups decreased,and the mNSS of the concurrent treatment of the brain and heart group was lower than that of the traditional acupoint group on the 14th day(P<0.05).Compared with the model

关键词： Acupuncture Therapy Electroacupuncture Brain Ischemia Ischemic Stroke Cerebrovascular Circulation Vascular Endothelial Growth Factors Brain-derived Neurotrophic Factor Rats

THz扩展互作用振荡器的多段式折叠波导高频结构注波互作用分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

真空科学与技术学报 2015年第9期35卷 1069-1074页

作者：高云云刘文鑫王勇朱觉远中国科学院电子学研究所高功率微波源与技术重点实验室北京100190 中国科学院大学北京100049

为了提高大赫兹扩展互作用振荡器(EIO)的输出功率,改进了两段式折叠波导慢波结构,并提出了三段式折叠波导新型慢波结构。分析了折叠波导的色散特性,通过进行三维粒子模拟,研究了单段式、两段式和三段式折叠波导的输出特性。单段式折叠波... 详细信息

为了提高大赫兹扩展互作用振荡器(EIO)的输出功率,改进了两段式折叠波导慢波结构,并提出了三段式折叠波导新型慢波结构。分析了折叠波导的色散特性,通过进行三维粒子模拟,研究了单段式、两段式和三段式折叠波导的输出特性。单段式折叠波导EIO最大输出功率为46 W,改进后两段式EIO输出功率提升了84.8%到86 W,并比改进前提高了10.3%,三段式EIO输出功率比单段式提高了143.5%,达到112 W。采用多段式折叠波导作为EIO的慢波结构比单段式具有显著的优越性。

关键词：太赫兹扩展互作用振荡器两段式三段式折叠波导

在线全文

学校读者我要写书评

暂无评论

浅析幼儿良好学习品质的培养策略

家长 2021年第28期 157-158页

作者：高芸芸甘肃省天水市秦安县第一幼儿园

想要培养幼儿良好学习品质,就要必须重视扣好学习生涯中第一颗扣子。良好学习品质不仅仅可以为幼儿学习提供坚实基础,还对幼儿今后生活、工作、人际关系等多方面都有正面作用。因此,幼儿教师对幼儿良好学习品质的培养在幼儿的一生中都... 详细信息

想要培养幼儿良好学习品质,就要必须重视扣好学习生涯中第一颗扣子。良好学习品质不仅仅可以为幼儿学习提供坚实基础,还对幼儿今后生活、工作、人际关系等多方面都有正面作用。因此,幼儿教师对幼儿良好学习品质的培养在幼儿的一生中都发挥着举足轻重的作用,本文就教师应如何培养幼儿良好学习品质提出一些个人思考和建议。

关键词：幼儿良好学习品质培养策略

烧结助剂CuO掺杂对0.97(K0.5Na0.5)NbO3–0.03Bi(Zn2/3Nb1/3)O3陶瓷相结构、微观形貌及电性能的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

硅酸盐学报 2018年第3期46卷 361-368页

作者：程花蕾肖健高鹏严云云高拴平赵立芳陕西省植物重点实验室宝鸡文理学院化学与化工学院陕西宝鸡721013 凝固技术国家重点实验室西北工业大学西安710072

采用传统固相法制备了0.97（K0.5Na0.5）NbO3–0.03Bi（Zn2/3Nb1/3）O3＋x CuO（KNN–3BZN–x Cu）陶瓷,探讨烧结助剂CuO对陶瓷烧结,相结构,微观形貌及电性能的影响规律。结果表明：添加CuO降低了KNN–3BZN–x Cu陶瓷的烧结温度。由于... 详细信息

采用传统固相法制备了0.97（K0.5Na0.5）NbO3–0.03Bi（Zn2/3Nb1/3）O3＋x CuO（KNN–3BZN–x Cu）陶瓷,探讨烧结助剂CuO对陶瓷烧结,相结构,微观形貌及电性能的影响规律。结果表明：添加CuO降低了KNN–3BZN–x Cu陶瓷的烧结温度。由于固液传质作用,陶瓷晶粒明显长大,形状发生了改变。添加CuO同时优化了陶瓷的介电性能,提高了弛豫性。KNN–3BZN–0.02Cu陶瓷在150～300℃温度范围内具有优异的电性能：介电常数εr=1 886,容温变化率–15%≤ΔC/C150℃≤15%,介电损耗tgδ〈0.029。同时由于体积密度大,KNN–3BZN–0.02Cu陶瓷具有较高的压电性能：d33=164 p C/N和kp=0.37。

关键词：相结构微观结构电性能铌酸钾钠氧化铜

基于双向长短时记忆和卷积Transformer的声学词嵌入模型

在线全文

学校读者我要写书评

暂无评论

计算机应用 2024年第1期44卷 123-128页

作者：高芸芸赵腊生张强先进设计与智能计算省部共建教育部重点实验室(大连大学) 辽宁大连116622

示例查询语音关键词检测中,卷积神经网络(CNN)或者循环神经网络(RNN)提取到的声学词嵌入语音信息有限,为更好地表示语音内容以及改善模型的性能,提出一种基于双向长短时记忆(Bi-LSTM)和卷积Transformer的声学词嵌入模型。首先,使用Bi-L... 详细信息

示例查询语音关键词检测中,卷积神经网络(CNN)或者循环神经网络(RNN)提取到的声学词嵌入语音信息有限,为更好地表示语音内容以及改善模型的性能,提出一种基于双向长短时记忆(Bi-LSTM)和卷积Transformer的声学词嵌入模型。首先,使用Bi-LSTM提取特征、对语音序列进行建模,并通过叠加方式来提高模型的学习能力;其次,为了能在捕获全局信息的同时学习到局部信息,将CNN和Transformer编码器并联连接组成卷积Transformer,充分利用它在特征提取上的优势,聚合更多有效的信息,提高嵌入的区分性。在对比损失约束下,所提模型平均精度达到了94.36%,与基于注意力的Bi-LSTM模型相比,平均精度提高了1.76%。实验结果表明,所提模型可以有效改善模型性能,更好地实现示例查询语音关键词检测。

关键词：卷积神经网络声学词嵌入语音信息示例查询语音关键词检测循环神经网络