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Network analysis of suicide ideation and depression-anxiety symptoms among Chinese adolescents

General Psychiatry 2024年第2期37卷 216-223页

作者： Shuyin Xu Yumeng Ju Xiyu Wei Wenwen Ou Mohan Ma Guanyi Lv Xiaotian Zhao Yaqi Qin yunjing Li Liang Li Mei Huang Siqi Yang Yimei Lu Yafei Chen Junwu Liu Jin Liu Bangshan Liu Yan zhang Department of Psychiatry National Clinical Research Center for Mental Disordersand National Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangshaHunanChina Mental Health Institute of Central South University China National Technology Institute on Mental DisordersHunan Technology Institute of PsychiatryHunan Key Laboratory of Psychiatry and Mental HealthHunan Medical Center for Mental HealthChangshaHunanChina

Background The co-occurrence of depression and anxiety among adolescents is typically associated with suicide ideation.Aims The study aimed to investigate the symptom-level relationship between suicide ideation and the comorbidity of depression and anxiety.Methods 1501 adolescents aged 12-19 years were assessed using the Patient Health Questionnaire(PHQ-9)and the Generalized Anxiety Disorder Scale,and 716 adolescents who scored≥5 on both scales were selected as participants.Network analysis was used to identify the network structure of depressive symptoms and anxiety symptoms.Participants were categorised into either the suicide ideation or non-suicide ideation groups based on their scoring on the suicide-related item in PHQ-9.A comparison was made between the depression-anxiety symptom networks of the two groups.Results‘Restlessness’,‘sad mood’and‘trouble relaxing’were the most prominent central symptoms in the depression-anxiety symptom network,and‘restlessness’,‘nervousness’and‘reduced movement’were the bridge symptoms in this network.‘Sad mood’was found to be directly related to‘suicide ideation’with the highest variance.The network structure was significantly different in properties between the suicide ideation group and the non-suicide ideation group,with‘restlessness’and‘sad mood’exhibiting significantly higher influence in the network of the suicide ideation group than that in the non-suicide ideation group.Conclusion Restlessness and sad mood could be targeted for the intervention of depression-anxiety symptoms among adolescents with suicide ideation.

关键词： symptoms adolescent assessed

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Targeting iron metabolism using gallium nanoparticles to suppress ferroptosis and effectively mitigate acute kidney injury

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Nano Research 2022年第7期15卷 6315-6327页

作者： Xishao Xie yunjing zhang Xinwan Su Junni Wang Xi Yao Dou Lv Qin Zhou Jianhua Mao Jianghua Chen Fei Han Yangyang Li Weiqiang Lin Kidney Disease Center the First Affiliated HospitalZhejiang University College of MedicineHangzhou 310003China International Institutes of Medicine the Fourth Affiliated HospitalZhejiang University School of MedicineJinhua 322000China Institute of Translational Medicine Zhejiang University School of MedicineHangzhou 310029China Department of Clinical Pharmacy the First Affiliated HospitalZhejiang University College of MedicineZhejiang Provincial Key Laboratory for Drug Evaluation and Clinical ResearchHangzhou 310003China Department of Nephrology National Clinical Research Center For Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Women’s Reproductive Health Research of Zhejiang Province Women’s HospitalZhejiang University School of MedicineHangzhou 310006China Cancer Center Zhejiang UniversityHangzhou 310058China

Ferroptosis plays a critical pathophysiological role in several types of acute kidney injury(AKI).The development of nanomaterials targeting iron metabolism and ferroptosis is a promising approach for AKI treatment.Herein,we synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles(GGP NPs)as a potential iron-scavenging agent because of their nearly ionic radius and chemical similarity with iron.The results indicated that GGP NPs accumulated in tubular epithelial cells and showed good biocompatibility.GGP NPs significantly inhibited cisplatin(CP)-induced ferroptosis in HK-2 cells by reducing the accumulation of intracellular free iron and mitochondrial dysfunction,and suppressing the perturbations of ferroptosis processes,including lipid peroxidation,nicotinamide adenine dinucleotide phosphate(NADPH)and glutathione(GSH)levels,glutathione peroxidase 4(GPX4)activity,and ferritinophagy.An in vivo study demonstrated that treatment with GGP NPs significantly ameliorated the renal tubular injury and mitochondrial damage induced by CP treatment or ischemia-reperfusion injury.Our study suggests that GGP NPs may be an effective and promising candidate for AKI treatment and enable potential clinical translation.

关键词： gallium nanoparticles acute kidney injury ischemia-reperfusion injury iron metabolism ferroptosis

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Preliminary assessment of the data appropriateness of electronic health records for real-world studies: A survey of hospitals in a developing region in China

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中华医学杂志(英文版) 2024年第9期137卷 2024 Mar 21页

作者： Yu Yuelin Zhuo Lin Meng Ruogu Guo Wanqian Chen Yuanyuan zhang yunjing Chen Ying Shi Hongjing Lin Zhi Zhan Siyan Wang Shengfeng Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China Research Center of Clinical Epidemiology Peking University Third Hospital Beijing China National Institute of Health Data Science Peking University Beijing China Health Science Center Peking University Beijing China

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Isolation and oral immunogenicity assessment of porcine epidemic diarrhea virus NH-TA2020 strain:One of the predominant strains circulating in China from 2017 to 2021

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Virologica Sinica 2022年第5期37卷 646-655页

作者： Xiaowen Li Yang Li Jiapei Huang Yali Yao Wenying Zhao yunjing zhang Jie Qing Jing Ren Zhong Yan Zewei Wang Xiaofang Hu Duli Kang Hongqiang Liu Zhichun Yan New Hope Liuhe Co. Ltd.Chengdu610041China National Research Center for Veterinary Medicine Luoyang471000China Shandong New Hope Liuhe Agriculture and Animal Husbandry Technology Co. Ltd.(NHLH Academy of Swine Research)Dezhou253034China Swine Health Data and Intelligent Monitoring Project Laboratory Dezhou UniversityDezhou253011China Pulike Biological Engineering Inc. Luoyang471000China

Porcine epidemic diarrhea(PED)caused by porcine epidemic diarrhea virus(PEDV)is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets.Maternal vaccines can effectively enhance the gut-mammary gland-secretory IgA axis to boost lactogenic immunity and passive protection of nursing piglets against PEDV challenge.From 2017 to 2021,we collected 882 diarrhea samples from 303 farms in China to investigate the epidemiology of PEDV.The result showed that about 52.15%(158/303)of the farms were positive for PEDV with an overall detection rate of 63.95%(564/882)of the samples.The S1 fragments of S gene from 104 strains were sequenced for the phylogenetic analysis.A total of 71 PEDV strains(68.27%)sequenced in this study were clustered into the predominant G2c subgroup,while the newly-defined G2d strains(9.62%)were identified in three provinces of China.The NH-TA2020 strain of G2c subgroup was isolated and cultured,and its infection to piglets caused watery diarrhea within 24 h,indicating its strong pathogenicity.Oral administration of NH-TA2020 strain to pregnant gilts stimulated high levels of IgA antibody in colostrum.The piglets fed by the gilts above were challenged with NH-TA2020 strain or CH-HeB-RY-2020 strain from G2d subgroup,and the clinical symptoms and virus shedding were significantly reduced compared to the mock group.Our findings suggest that G2c subgroup is the predominant branch circulating in China from 2017 to 2021.Oral administration of NH-TA2020 enhances maternal IgA and lactogenic immune responses,which confer protection against the homologous and emerging G2d PEDV strains challenges in neonates.

关键词： Porcine epidemic diarrhea virus(PEDV) Molecular epidemiological investigation Virus isolation Lactogenic immune IgA

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Renal tubule-targeted dexrazoxane suppresses ferroptosis in acute kidney injury by inhibiting ACMSD

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Nano Research 2023年第7期16卷 9701-9714页

作者： yunjing zhang Jicheng Wu Quanlin An Huanhuan Zhu Xinwan Su Ying Wang Xishao Xie Jian zhang Xi Yao Chunhua Weng Shi Feng Jianhua Mao Xianghui Fu Fei Han Xin Cao Ben Wang Weiqiang Lin International Institute of Medicine The Fourth Affiliated HospitalZhejiang University School of MedicineJinhua 322000China Institute of Translational Medicine Zhejiang UniversityHangzhou 310029China Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhongshan Hospital Institute of Clinical Science Fudan UniversityShanghai 200032China Kidney Disease Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Kidney Disease Prevention and Control Technology Zhejiang ProvinceHangzhou 310003China Department of Nephrology The Children's HospitalZhejiang University School of Medicine and National Clinical Research Center for Child HealthHangzhou 310000China Division of Endocrinology and Metabolism National Clinical Research Center for GeriatricsState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Acute kidney injury(AKI)is a heterogeneous clinical complication with no existing definite or particular therapies.Therefore,molecular mechanisms and approaches for treating acute kidney injury are in urgent need.Herein,we demonstrated that dexrazoxane(DXZ),a U.S.Food and Drug Administration(FDA)-approved cardioprotective drug,can both functionally and histologically attenuate cisplatin or ischemia-reperfusion injury-induced AKI in vitro and in vivo via inhibiting ferroptosis specifically.This effect is characterized by decreasing lipid peroxidation,shown by the biomarker of oxidative stress 4-hydroxynonenal(HNE)and prostaglandinendoperoxide synthase 2(Ptgs2),while reversing the downregulation of glutathione peroxidase 4(GPX4)and ferritin 1(FTH-1).Mechanistically,the results revealed that DXZ targeted at the renal tubule significantly inhibits ferroptosis by suppressingα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase(ACMSD).Furthermore,the conjugation of dexrazoxane and polysialic acid(DXZ-PSA)is specifically designed and utilized to enhance the therapeutic effect of DXZ by long-term effect in the kidney,especially retention and targeting in the renal tubules.This study provides a novel therapeutic approach and mechanistic insight for AKI by inhibiting ferroptosis through a new type drug DXZPSA with the enhanced renal distribution.

关键词： dexrazoxane dexrazoxane-polysialic acid acute kidney injury ischemia-reperfusion injury ferroptosis α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase(ACMSD)

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Recent advances in engineered nanomaterials for acute kidney injury theranostics

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Nano Research 2021年第4期14卷 920-933页

作者： Lefeng Wang yunjing zhang Yangyang Li Jianghua Chen Weiqiang Lin Kidney Disease Center the First Affiliated Hospital Zhejiang University School of MedicineInstitute of NephrologyZhejiang UniversityHangzhou 310003China Key Laboratory of Kidney Disease Prevention and Control Technology Hangzhou 310003China The Fourth Affiliated Hospital Institute of Translational Medicine Zhejiang University School of MedicineJinhua 322000China Key Laboratory of Womens Reproductive Health Research of Zhejiang Province Womens Hospital Zhejiang University School of Mediciney Hangzhou 310006China

Acute kidney injury(AKI),has become the focus of increasing attention due to its high risk of death.The early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney dysfunction.However,the efficient early diagnosis and treatment approach for AKI remains a challenge.AKI screening via precise nanomaterial theranostics is a new alternative approach.This study summarizes the recent advances in functional nanomaterials in the early detection and treatment of AKI.The challenges and problems in the use of nanomaterials for AKI in clinical applications are also discussed.It is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI.

关键词： acute kidney injury nanomaterials early detection therapy translational applications

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基于文本匹配-组态优化的两阶段技术供需匹配方法研究

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情报学报 2024年第3期43卷 261-273页

作者：余辉夏文蕾黄炜吴昀璟张羽帆湖北工业大学经济与管理学院武汉430068 武汉理工大学管理学院武汉430070 武汉大学经济与管理学院武汉430072 武汉大学信息资源研究中心武汉430072

技术供需匹配作为技术转移的关键环节,是提高技术转移效率、加快产业升级、实现科技强国的重要保障。针对技术供需匹配过程中匹配结果过多和影响因素复杂两大挑战,本文基于前期技术文本内容匹配方法和技术转移影响因素的研究成果,对技... 详细信息

技术供需匹配作为技术转移的关键环节,是提高技术转移效率、加快产业升级、实现科技强国的重要保障。针对技术供需匹配过程中匹配结果过多和影响因素复杂两大挑战,本文基于前期技术文本内容匹配方法和技术转移影响因素的研究成果,对技术供需匹配过程进行详细解析,提出了基于文本匹配-组态优化的两阶段技术供需匹配模型;采用近年发布的技术需求信息进行实验,在真实技术市场对模型进行验证。向技术需求方进行技术成果推荐后,收集这些技术需求方的反馈。反馈结果表明,本文提出的供需匹配模型具有一定的准确性和可行性,可以在实践中为科技服务平台的建设提供依据。

关键词：技术转移技术供需匹配文本匹配组态分析

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The CRL3^(BTBD9) E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1984-1992页

作者： Lihui Li Wenjuan zhang Yue Liu Xiaojun Liu Lili Cai Jihui Kang yunjing zhang Wenlian Chen Changsheng Dong Yanmei zhang Mingsong Wang Wenyi Wei Lijun Jia Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghaiChina Department of Laboratory Medicine Huadong HospitalAffiliated to Fudan UniversityShanghaiChina Xinhua Hospital Shanghai Jiaotong UniversityShanghaiChina Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Tumor necrosis factor alpha-induced protein 1(TNFAIP1)modulates a plethora of important biological processes,including tumorigenesis and cancer cell migration.However,the regulatory mechanism of TNFAIP1 degradation remains largely elusive.In the present study,with a label-free quantitative proteomic approach,TNFAIP1 was identified as a novel ubiquitin target of the Cullin-RING E3 ubiquitin ligase(CRL)complex.More importantly,Cul3-ROC1(CRL3),a subfamily of CRLs,was identified to specifically interact with TNFAIP1 and promote its polyubiquitination and degradation.Mechanistically,BTBD9,a specific adaptor component of CRL3 complex,was further defined to bind and promote the ubiquitination and degradation of TNFAIP1 in cells.As such,downregulation of BTBD9 promoted lung cancer cell migration by upregulating the expression of TNFAIP1,whereas TNFAIP1 deletion abrogated this effect.Finally,bioinformatics and clinical sample analyses revealed that BTBD9 was downregulated while TNFAIP1 was overexpressed in human lung cancer,which was associated with poor overall survival of patients.Taken together,these findings reveal a previously unrecognized mechanism by which the CRL3^(BTBD9) ubiquitin ligase controls TNFAIP1 degradation to regulate cancer cell migration.

关键词： TNFAIP1 CRL complex

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10例炎性线性疣状表皮痣临床及组织病理分析

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临床皮肤科杂志 2024年第6期53卷 339-342页

作者：张莉浦芸静李霁伟刘彤云张曌昆明医科大学附属儿童医院(昆明市儿童医院)皮肤科云南昆明650228 昆明医科大学附属儿童医院(昆明市儿童医院)病理科云南昆明650228 昆明医科大学第一附属医院皮肤科云南昆明650032

目的:总结10例炎性线性疣状表皮痣(ILVEN)临床特征及组织病理特点。方法:采用回顾性分析10例ILVEN患儿的临床和组织病理资料。结果:10例患儿中,男2例,女8例,男女比例为1∶4;9例均表现为不同程度瘙痒,1例无自觉症状;7例皮损为局限性,3例... 详细信息

目的:总结10例炎性线性疣状表皮痣(ILVEN)临床特征及组织病理特点。方法:采用回顾性分析10例ILVEN患儿的临床和组织病理资料。结果:10例患儿中,男2例,女8例,男女比例为1∶4;9例均表现为不同程度瘙痒,1例无自觉症状;7例皮损为局限性,3例为全身泛发,均表现为沿Blaschko线分布的疣状丘疹、斑块或鳞屑,局部皮损呈苔藓样改变。组织病理均表现为交替出现的角化过度及角化不全,角化过度区下方颗粒层增厚,角化不全区下方颗粒层减少或消失,3例出现典型Munro微脓肿,1例出现少量嗜酸性粒细胞。结论:该病临床少见,容易被误诊,结合临床及组织病理可早期诊断。

关键词：表皮痣疣状线性炎性临床表现组织病理

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重症患者下肢深静脉血栓物理治疗的研究进展

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中国医学创新 2024年第3期21卷 179-184页

作者：黄云镜张唐馨广西壮族自治区南溪山医院血管外科广西桂林541002

重症患者病情较为复杂,治疗期间常出现下肢深静脉血栓(DVT),不利于其病情的恢复,虽常规药物防治效果较好,但极易引起患者出血。物理治疗可弥补药物治疗的不足,基于此,本研究针对重症患者下肢DVT的物理治疗展开综述,旨在为重症患者早期... 详细信息

重症患者病情较为复杂,治疗期间常出现下肢深静脉血栓(DVT),不利于其病情的恢复,虽常规药物防治效果较好,但极易引起患者出血。物理治疗可弥补药物治疗的不足,基于此,本研究针对重症患者下肢DVT的物理治疗展开综述,旨在为重症患者早期进行物理治疗预防下肢DVT提供参考依据。

关键词：重症患者下肢深静脉血栓物理治疗

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