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Neuroscience Bulletin 2017年第6期33卷 722-730页

作者： Yun Li Hui Fang Wenming Zheng Lu Qian yunhua xiao Qiaorong Wu Chen Chang Chaoyong xiao Kangkang Chu xiaoyan Ke Nanjing Brain Hospital Affiliated to Nanjing Medical University Child Mental Health Research Center Key Laboratory of Child Development and Learning Science of the Ministry of Education Research Center for Learning Science Southeast University

The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional＇＇ ***, in this study we compared the facial emotional recognition（FER） feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD（HFA） and their typically developing（TD） counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group（P ／ 0.01）. In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.

关键词： Autism spectrum disorder Facial emotional recognition Social-emotional related white matter fiber tracts Diffusion tensor imaging Tractography

The Power of Inbreeding： NGS-Based GWAS of Rice Reveals Convergent Evolution during Rice Domestication

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Molecular Plant 2016年第7期9卷 975-985页

作者： Hongru Wang Xun Xu Filipe Garrett Vieira yunhua xiao Zhikang Li Jun Wang Rasmus Nielsen Chengcai Chu State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academyof Sciences Beijing 100101 China Cotlege of Life Sciences University of Chinese Academy of Sciences Beijing 100101 China BGI-Shenzhen Shenzhen 518083 China Centre for GeoGenetics University of Copenhagen 1350 Copenhagen Denmark Institute of Crop Sciences/National Key Facilities for Crop Gene Resources and Genetic Improvement Chinese Academy of Agricultural Sciences 12 SouthZhong-Guan-Cun Street Beijing 100081 China Department of Integrative Biology University of California Berkeley CA 94720 USA These authors contributed equally to this article.

Low-coverage whole-genome sequencing is an effective strategy for genome-wide association studies in hu- mans, due to the availability of large reference panels for genotype imputation. However, it is unclear whether this strategy can be utilized in other species without reference panels. Using simulations, we show that this approach is even more relevant in inbred species such as rice （Oryza sativa L.）, which are effectively haploid, allowing easy haplotype construction and imputation-based genotype calling, even without the availability of large reference panels. We sequenced 203 rice varieties with well-characterized phenotypes from the United States Department of Agriculture Rice Mini-Core Collection at an average depth of 1.5~ and used the data for mapping three traits. For the first two traits, amylose content and seed length, our approach leads to direct identification of the previously identified causal SN Ps in the major-effect loci. For the third trait, pericarp color, an important trait underwent selection during domestication, we identified a new major-effect locus. Although known loci can explain color variation in the varieties of two main subspecies of Asian domesticated rice,japonica and indica, the new locus identified is unique to another domesticated rice subgroup, aus, and together with existing loci, can fully explain the major variation in pericarp color in aus. Our discovery of a unique genetic basis of white pericarp in aus provides an example of convergent evolution during rice domestication and suggests that aus may have a domestication history independent of japonica and indica.

关键词： inbreeding GWAS rice pericarp color

水稻硝酸盐信号核心转录因子OsNLP3氮高效单倍型分析

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杂交水稻 2024年第3期39卷 20-31页

作者：程功叶于江辉李玲玲李文宇张迪肖云华段美娟刘次桃湖南农业大学农学院湖南长沙410128

水稻NIN-like转录因子OsNLP3是硝酸盐信号的核心转录因子,可提高水稻对硝酸盐的吸收、同化、转运并最终提升产量。为鉴定OsNLP3基因的优异单倍型,在136份水稻核心种质资源群体中对OsNLP3基因的核苷酸等位变异与该群体对氯酸盐(硝酸盐毒... 详细信息

水稻NIN-like转录因子OsNLP3是硝酸盐信号的核心转录因子,可提高水稻对硝酸盐的吸收、同化、转运并最终提升产量。为鉴定OsNLP3基因的优异单倍型,在136份水稻核心种质资源群体中对OsNLP3基因的核苷酸等位变异与该群体对氯酸盐(硝酸盐毒性类似物)敏感表型进行关联分析。在OsNLP3基因中共鉴定出35个等位基因变异,其中19个等位基因变异(启动子区14个、编码区5个)与氯酸盐敏感表型显著关联。单倍型分析结果表明,13个等位基因变异(启动子区10个、编码区3个)对氯酸盐敏感表型起决定作用,进一步对上述关键等位基因变异进行单倍型分析,单倍型Hap2和Hap3对氯酸盐的敏感性极显著高于Hap1。此外,Hap2和Hap3分别主要由硝酸盐利用效率较高的籼稻和秋稻组成;Hap1主要由硝酸盐利用效率较低的粳稻组成。综上,OsNLP3基因的单倍型Hap2和Hap3是氯酸盐敏感单倍型,也是硝酸盐吸收利用的优异单倍型,可为后续开发OsNLP3基因分子标记及应用分子标记辅助育种提供参考。

关键词：水稻 OsNLP3 等位变异单倍型氮高效

Big Grain3, encoding a purine permease, regulates grain size via modulating cytokinin transport in rice

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Journal of Integrative Plant Biology 2019年第5期61卷 581-597页

作者： yunhua xiao Dapu Liu Guoxia Zhang Shaopei Gao Linchuan Liu Fan Xu Ronghui Che Yiqin Wang Hongning Tong Chengcai Chu State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing) Institute of Genetics and Developmental Biologythe Chinese Academy of SciencesBeijing 100101China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop Sciencesthe Chinese Academy of Agricultural SciencesBeijing 100081China

Grain size is an important agronomic trait affecting grain yield,but the underlying molecular mechanisms remain to be ***,we isolated a dominant mutant,big grainy(bg3-D),which exhibits a remarkable increase of grain size caused by activation of the PURINE PERMEASE gene,***3/OSPUP4 is predominantly expressed in vascular tissues and is specifically suppressed by exogenous cytokinin *** profiling revealed that the distribution of different cytokinin forms,in roots and shoots of the bg3-D mutant,is *** reverse transcription-PCR(qRT-PCR)analysis indicated that expression of rice cytokinin type-A RESPONSE REGULATOR(OsRR)genes is enhanced in the roots of the bgj-D *** results suggest that OSPUP4 might contribute to the long-distance transport of cytokinin,by reinforcing cytokinin loading into vascular bundle ***,plants overexpressing OsPUP7,the closest homolog of OsPUP4,also exhibited a similar phenotype to the bg3-D ***,subcellular localization demonstrated that OSPUP4 was localized on the plasma membrane,whereas OSPUP7 was localized to the endoplasmic *** on these findings,we propose that OSPUP4 and OSPUP7 function in a linear pathway to direct cytokinin cell-to-cell transport,affecting both its long-distance movement and local allocation.

关键词： Grain size is an important underlying molecular local allocation

A cryptic inhibitor of cytokinin phosphorelay controls rice grain size

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Molecular Plant 2022年第2期15卷 293-307页

作者： Dapu Liu He Zhao yunhua xiao Guoxia Zhang Shouyun Cao Wenchao Yin Yangwen Qian Yanhai Yin Jinsong Zhang Shouyi Chen Chengcai Chu Hongning Tong National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biologythe Innovative Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Biogle Genome Editing Center ChangzhouJiangsu Province 213125China Department of Genetics Development and Cell BiologyIowa State UniversityAmesIA 50011USA

Plant hormone cytokinin signals through histidine-aspartic acid(H-D)phosphorelay to regulate plant growth and *** it is well known that the phosphorelay involves histidine kinases,histidine phosphotransfer proteins(HPs),and response regulators(RRs),how this process is regulated by external components remains *** we demonstrate that protein phosphatase with kelch-like domains(PPKL1),known as a signaling component of steroid hormone brassinosteroid,is actually a cryptic inhibitor of cytokinin phosphorelay in rice(Oryza sativa).Mutation at a specific amino acid D364 of PPKL1 activates cytokinin response and thus enlarges grain size in a semi-dominant mutant named *** of PPKL1 containing D364,either with the deletion of the phosphatase domain or not,rescues the s48 mutant ***1 interacts with OsAHP2,one of authentic HPs,and D364 resides in a region resembling the receiver domain of ***,PPKL1 can utilize D364 to suppress OsAHP2-to-RR phosphorelay,whereas mutation of D364 abolishes the *** function of PPKL1 is independent of the phosphatase domain that is required for brassinosteroid ***,editing of the D364-residential region produces a diversity of semi-dominant mutations associated with variously increased grain *** screening of the edited plants enables the identification of two genotypes that confer significantly improved grain ***,our study uncovers a noncanonical cytokinin signaling suppressor and provides a robust tool for seed rational design.

关键词： cytokinin brassinosteroid grain size signaling PPKL1 rice

125I Radioactive Particles Drive Protective Autophagy in Hepatocellular Carcinoma by Upregulating ATG9B

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 360-368页

作者： yunhua xiao Jing Yuan Chongshuang Yang Junru Xiong Liangyu Deng Qinghua Liang Chuang He Liangshan Li Fengtian He Xuequan Huang Department of Nuclear Medicine the First Affiliated Hospital of Army Medical UniversityArmy Medical UniversityChongqingChina Department of Radiology Army Medical CenterChongqingChina Department of Biochemistry and Molecular Biology College of Basic Medical SciencesArmy Medical UniversityChongqingChina

Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its wide clinical ***:We investigated the cellular responses to 125I radioactive particles treatment and autophagy-related 9B(ATG9B)silencing in HCC cell lines and Hep3B xenografted tumor model using Cell Counting Kit-8 reagent,western blotting,immunofluorescence,flow cytometry,transmission electron microscopy and ***:In this study,we demonstrated that 125I radioactive particles induced cell apoptosis and protective autophagy of HCC in vitro and in *** of autophagy enhanced the radiosensitivity of HCC to 125I radioactive ***,125I radioactive particles induced autophagy by upregulating ATG9B,with increased expression level of LC3B and decreased expression level of ***,ATG9B silencing downregulated LC3B expression and upregulated p62 expression and enhanced radiosensitivity of HCC to 125I radioactive particles in vitro and in ***:Inhibition of ATG9B enhanced the antitumor effects of 125I particle radiation against HCC in vitro and in *** findings suggest that 125I particle radiation plus chloroquine or/and the ATG9B inhibitor may be a novel therapeutic strategy for HCC.

关键词： 125I radioactive particles Hepatocellular carcinoma Autophagy ATG9B

A verifiable and efficient cross-chain calculation model for charging pile reputation

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High-Confidence Computing 2024年第2期4卷 105-115页

作者： Cui Zhang yunhua He Bin Wu Hui Yang Ke xiao Hong Li School of Information Science and Technology North China University of TechnologyBeijing 100144China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Institute of Information Engineering Chinese Academy of SciencesBeijing 100195China

To solve the current situation of low vehicle-to-pile ratio,charging pile(CP)operators incorporate private CPs into the shared charging ***,the introduction of private CP has brought about the problem of poor service *** is a common service evaluation scheme,in which the third-party reputation scheme has the issue of single point of failure;although the blockchain-based reputation scheme solves the single point of failure issue,it also brings the challenges of storage and query *** is a feasible solution to classify and store information on multiple chains,and at this time,reputation needs to be calculated in a cross-chain *** reputation calculation faces the problems of correctness verification,integrity verification and ***,this paper proposes a verifiable and efficient cross-chain calculation model for CP ***,in this model,we propose a verifiable cross-chain contract calculation scheme that adopts polynomial commitment to solve the problems of polynomial damage and tampering that may be encountered in the crosschain process of outsourced polynomials,so as to ensure the integrity and correctness of polynomial *** addition,the miner selection and incentive mechanism algorithm in this scheme ensures the correctness of extracted information when the outsourced polynomial is calculated on the *** security analysis and experimental results demonstrate that this scheme is feasible in practice.

关键词： Blockchain Shared charging Reputation Cross-chain Verifiable

Review of data security within energy blockchain:A comprehensive analysis of storage,management,and utilization

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High-Confidence Computing 2024年第3期4卷 82-102页

作者： yunhua He Zhihao Zhou Yan Pan Fahui Chong Bin Wu Ke xiao Hong Li School of Information Science and Technology North China University of TechnologyBeijing 100144China China Industrial Control Systems Cyber Emergency Response Team Beijing 100040China Key Laboratory in Blockchain and Data Security by Ministry of Industry and Information Technology Beijing 100040China Institute of Information Engineering Chinese Academy of Sciences Beijing 100195China

Energy systems are currently undergoing a transformation towards new paradigms characterized by decarbonization,decentralization,democratization,and *** this evolving context,energy blockchain,aiming to enhance efficiency,transparency,and security,emerges as an integrated technological solution designed to address the diverse challenges in this *** security is essential for the reliable and efficient functioning of energy *** pressing need to address challenges related to secure data storage,effective data management,and efficient data utilization is increasingly *** paper offers a comprehensive survey of academic discourse on energy blockchain data security over the past five years,adopting an all-encompassing perspective that spans data storage,management,and *** work systematically evaluates and contrasts the strengths and weaknesses of various research ***,this paper proposes an integrated hierarchical on-chain and off-chain security energy blockchain architecture,specifically designed to meet the complex security requirements of multi-blockchain business ***,this paper identifies key directions for future research,particularly in advancing the integration of storage,management,and utilization of energy blockchain data security.

关键词： Energy blockchain Data security Storage Management Utilization

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某铁矿西排土场边坡稳定性分析

山西冶金 2024年第4期47卷 105-108,111页

作者：肖云华毕建春高仲谋周杨官伟胡家仓刘金鑫北京洛斯达科技发展有限公司北京100089 富蕴蒙库铁矿有限责任公司新疆阿勒泰836199 湖北宜安联合实业有限责任公司湖北宜昌444299 武汉理工大学湖北武汉430070 新疆钢铁雅满苏矿业有限责任公司新疆哈密839001

某铁矿西排土场紧邻采场西端布置,主要服务前期露天采场和现阶段井下开采产生的废石,是目前在用的排土场,为保障矿山的安全生产,采用工程测量、工程地质测绘、室内试验与现场试验、理论研究与数值模拟相结合的研究方法,对该排土场在现... 详细信息

某铁矿西排土场紧邻采场西端布置,主要服务前期露天采场和现阶段井下开采产生的废石,是目前在用的排土场,为保障矿山的安全生产,采用工程测量、工程地质测绘、室内试验与现场试验、理论研究与数值模拟相结合的研究方法,对该排土场在现状条件及影响因素作用下的稳定性进行分析研究。结果表明,该矿排土场在自然工况、降雨工况和地震工况条件下的最小安全系数均大于规范要求的极限值,排土场整体处于稳定状态。

关键词：矿山排土场边坡稳定性安全系数数值模拟

人类纪视野下的菲利普·拉金诗歌——以《去海边》为例

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外国文学研究 2018年第4期40卷 69-82页

作者：肖云华南方医科大学外国语学院

艺术审美是应对人类纪诸多问题必不可少的手段;诗歌作为一种主要的艺术形式,必然对此有着深刻和超前的表达。拉金后期代表作《去海边》创作于温室效应日渐明显的背景之下,它表达了作者对变异的气候环境的感知,以及基于这种感知的对传统... 详细信息

艺术审美是应对人类纪诸多问题必不可少的手段;诗歌作为一种主要的艺术形式,必然对此有着深刻和超前的表达。拉金后期代表作《去海边》创作于温室效应日渐明显的背景之下,它表达了作者对变异的气候环境的感知,以及基于这种感知的对传统与存在的忧虑。以该作品为代表的拉金诗歌描绘了20世纪六十年代英格兰雾霭弥漫、气温异常和植物疯长的自然环境。环境的异常使拉金感觉到其陌生与敌意,引发了他对环境问题以及人类未来生活的忧虑,从而深刻影响了他的诗歌思想。气象资料证明,拉金在诗作中敏锐地观察到了人类纪的主要问题,是建立在客观实际之上的艺术审美。

关键词：拉金诗歌气候人类纪