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Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan he Jia Wang Gaofeng Chen Chengyu Zou Daichao Xu Hongbing Zhang Junying Yuan yunhong Zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS ***1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(Phe severity of bulbar symptoms(Pheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

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Sporadic Creutzfeldt-Jakob Disease Presenting with Visual Disturbance—A Case Report in China

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International Journal of Clinical Medicine 2013年第7期4卷 321-324页

作者： Guohong Tian Lin Sun yunhong he Xiaojun Zhang Department of Neurology Beijing Tongren Hospital Capital Medical University Beijing China. Department of Ophthalmology Eye and ENT Hospital Fudan University Shanghai China

Creutzfeldt-Jakob disease (CJD) is a rare but fatal neurodegenerative prion disease. Classic CJD comprises a clinical triad of rapidly progressive dementia, myoclonus, and EEG abnormality. At initial presentation, this classic triad is present only in a minority of cases. Visual impairment is one of the predominant manifestations in the course of CJD, especially in heidenhain variant phenotype. We reported a case presenting with progressive blurred vision, along with other neurological symptoms, who diagnosed as sporadic CJD with cortical blindness in China.

关键词： Creutzfeldt-Jakob Disease Visual Disturbance heidenhain Variant Diffusion Weighted Imaging

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《我们的家园》:用“四力”把控乡村振兴报道创作流程

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电视研究 2021年第10期 46-48页

作者：何云红中央广播电视总台社教节目中心

做好主题报道是主流媒体的重要任务。本文认为,以乡村振兴为主题的系列节目《我们的家园》,在创作上遵循"四力"要求,用"脑力"拓展对乡村振兴的深度广度思考,确定好节目的底层要素;用"脚力"和"眼力"抓取要点集中、具有内生动力的素材;在... 详细信息

做好主题报道是主流媒体的重要任务。本文认为,以乡村振兴为主题的系列节目《我们的家园》,在创作上遵循"四力"要求,用"脑力"拓展对乡村振兴的深度广度思考,确定好节目的底层要素;用"脚力"和"眼力"抓取要点集中、具有内生动力的素材;在"笔力"上下功夫,借助鲜活生动的视听语言,提高可视性和传播力。

关键词：乡村振兴《我们的家园》 “四力” 主题报道

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新型Cr-Mo-Ni-Mn-Si合金钢的等温淬火

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金属热处理 2016年第9期41卷 148-152页

作者：黄泽亭和云红宁夏天地奔牛实业集团有限公司宁夏银川750000

对美国研制的Cr-Mo-Ni-Mn-Si低合金耐磨钢进行了合理化成分改进,获得一种新型Cr-Mo-Ni-Mn-Si合金钢,对该合金钢进行了不同工艺的热处理,并测定了其力学性能。结果表明:新型Cr-Mo-Ni-Mn-Si合金钢等温淬火后可得到下贝氏体组织,在300℃盐... 详细信息

对美国研制的Cr-Mo-Ni-Mn-Si低合金耐磨钢进行了合理化成分改进,获得一种新型Cr-Mo-Ni-Mn-Si合金钢,对该合金钢进行了不同工艺的热处理,并测定了其力学性能。结果表明:新型Cr-Mo-Ni-Mn-Si合金钢等温淬火后可得到下贝氏体组织,在300℃盐浴等温淬火120 min后,下贝氏体组织均匀、细小,抗拉强度高达1230 MPa,冲击韧度可达30 J/cm^2以上,耐磨性最佳。

关键词：新型Cr-Mo-Ni-Mn-Si合金钢等温淬火下贝氏体力学性能

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Plasma nitrogen fixation system with dual-loop enhancement for improved energy efficiency and its efficacy for lettuce cultivation

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Plasma Science and Technology 2024年第1期26卷 82-92页

作者：韩泽阳张梦雪张頔何欣井天军葛知轩李玉鸽朱童任云鸿仲崇山季方 College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083People’s Republic of China College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083People’s Republic of China Electric Power Research Institute State Grid Gansu Electric Power Company GansuLanzhou 730030People’s Republic of China

Plasma nitrogen fixation(PNF)has been emerging as a promising technology for greenhouse gasfree and renewable energy-based ***,most PNF studies seldom address practical application-specific *** this work,we present the development of a compact and automatic PNF system for on-site agricultural *** system utilized a gliding-arc discharge as the plasma source and employed a dual-loop design to generate NO_(x)from air and water under atmospheric *** results showed that the system with a dualloop design performs well in terms of energy costs and production *** operational parameters for the system were determined through experimentation,resulting in an energy cost of 13.9 MJ mol^(-1)and an energy efficiency of 16 g kWh^(-1)for NO_(3)^(-)production,***,the concentration of exhausted NO_(x)was below the emission *** lettuce cultivation experiments demonstrated that NO_(x)^(-)produced by the PNF system could serve as liquid nitrate nitrogen ***,our work demonstrates the potential of the developed PNF system for on-site application in the production of green-leaf vegetables.

关键词： plasma nitrogen fixation gliding arc soilless cultivation lettuce

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Degradation of lipids in seasonal hypoxic seawater under different oxygen saturation

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Journal of Oceanology and Limnology 2018年第5期36卷 1570-1585页

作者：何云红孙承君李文娟杨桂朋丁海兵 Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of China Marine Ecology Center the First Institute of OceanographyState Oceanic Administration (SOA) Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and Technology College of Chemistry and Chemical Engineering Ocean University of China Qingdao Collaborative Innovation Center of Marine Science and Technology Ocean University of China

The hypoxic phenomena of seawater have been found in the Changjiang esturay and its adjacent area for several decades. To study organic matter degradation in seasonal hypoxic seawater, series of stimulated incubation experiments with S keletonema costatum in seawater under different oxygen saturations were conducted. By tracking variations of lipids originated from the alga, time-dependent concentrations of neutral lipids(hexadecanol, otctadecanol, cholesterol, brassicasterol and phytol) and fatty acids(12:0, 14:0, 16:0, 16:1, 18:0, 18:1(9), 20:5 and 22:6) were obtained during three month of incubation. The results indicate that residence time, oxygen saturation, bacterial community and the structure of lipids were key factors controlling preservation and degradation of lipids in seawater. The degradation rate constants calculated from multi-G model showed that under same oxygen saturation, algal fatty acid degraded faster than neutral lipids, and unsaturated fatty acids degraded faster than saturated fatty acids. Our new discovery showed that degradation rate constant had linear positive correlation with oxygen saturation of seawater, indicating the critical role of oxygen on degradation of algal lipids in hypoxic seawater. The results of this study will be helpful to understand organic carbon cycling in seawater and marine environment more deeply. Future field experiments and investigation should be conducted tracking control factors, especially the role of oxygen saturation on organic matter degradation in natural environment.

关键词：肋骨链球菌海水海洋学科普知识

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High Pressure Stability of the /m-3 formed KSbO3

High Pressure Stability of the /m-3 formed KSbO3

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2016年全国矿物科学与工程学术研讨会

作者： Dayong Tan Xueting Liu Wei Zhou Yu Tian Huifang Zhao yunhong he Bin Chen Wansheng Xiao Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of GeochemistryChinese Academy of Sciences Center for High Pressure Science and Technology Advanced Research

KSb03-type modeling frameworks have been widely applied for the design of functional materials,but very little is known about their structural stability with the change of the temperature and/or pressure,especially under the high *** work,a three-dimension cubic tunnel structured KSbO(/m-3)was synthesized under2.1 GPa and 800°C using a piston-cylinder *** the structural stability was

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解淀粉芽胞杆菌TR2复配育苗基质对西瓜幼苗生长的影响

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北方园艺 2023年第6期 12-18页

作者：李晨雨贾绍雷赫云泓高坦坦任争光赵晓燕北京农学院生物与资源环境学院农业农村部华北都市农业重点实验室北京102206

以解淀粉芽胞杆菌TR2和不同育苗基质以及西瓜幼苗为试材,采用稀释涂布平板法和盆栽试验法,研究了9种不同配方基质对解淀粉芽胞杆菌TR2的定殖量随时间变化的影响,以及盆栽条件下复配TR2对西瓜幼苗各项生长指标的影响,以期筛选出草炭使用... 详细信息

以解淀粉芽胞杆菌TR2和不同育苗基质以及西瓜幼苗为试材,采用稀释涂布平板法和盆栽试验法,研究了9种不同配方基质对解淀粉芽胞杆菌TR2的定殖量随时间变化的影响,以及盆栽条件下复配TR2对西瓜幼苗各项生长指标的影响,以期筛选出草炭使用量低、TR2稳定定殖以及西瓜幼苗健康生长的基质配方。结果表明:解淀粉芽胞杆菌TR2在供试基质中均能定殖,并且30 d内的平均定殖量在5×10^(6)CFU·cm^(-3)左右,其中B6基质中定殖量最高,为8.1×10^(6)CFU·cm^(-3)。西瓜幼苗在含有蚯蚓粪的基质(B2、B6、B7、B8)中在株高和鲜质量方面的生长均明显优于不含蚯蚓粪的基质,含有椰糠的基质B8在根长方面表现最好。基质复配解淀粉芽胞杆菌TR2后,西瓜幼苗的株高和鲜质量相较于不加生防菌有明显增加,其中基质B2复配菌株TR2对西瓜促进作用最明显,比未添加生防菌高出44.2%。基质中添加生防菌对西瓜幼苗的根长和根鲜质量的促进作用不明显。

关键词：生防芽胞杆菌基质西瓜生长

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履带板用钢25MnBM夹杂物控制实践

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山西冶金 2017年第2期40卷 51-54页

作者：贺云鸿山东钢铁股份有限公司莱芜分公司特钢事业部山东莱芜271105

通过对履带板用钢25MnBM连铸坯断面进行分析,发现夹杂物的成分主要是Al_2O_3。主要介绍在冶炼过程中通过提高电炉终点碳至0.12%以上,电炉出钢过程向钢包中加入2.0kg/t钢钢芯铝,精炼过程中减少铝的加入量,优化钙处理工艺,提高VD处理强度... 详细信息

通过对履带板用钢25MnBM连铸坯断面进行分析,发现夹杂物的成分主要是Al_2O_3。主要介绍在冶炼过程中通过提高电炉终点碳至0.12%以上,电炉出钢过程向钢包中加入2.0kg/t钢钢芯铝,精炼过程中减少铝的加入量,优化钙处理工艺,提高VD处理强度,延长软吹时间至20 min,在连铸生产中全程保护浇注,将B类夹杂物级别控制在0.5级以下,满足产品质量要求。

关键词： 25MnBM 夹杂物钙处理保护浇注

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非调质钢F45MnVS钢水流动性研究

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山西冶金 2017年第3期40卷 7-9页

作者：贺云鸿山东钢铁股份有限公司莱芜分公司特钢事业部山东莱芜271105

非调质钢F45MnVS钢水中S含量较高,钢水流动性较差,在连铸生产过程中易发生水口结瘤,甚至堵塞水口,中断生产。通过对堵塞水口的夹杂物进行分析,主要为CaS和Al_2O_3。针对夹杂物的种类,通过对在冶炼过程中钙线加入量和加入时机的研究,调... 详细信息

非调质钢F45MnVS钢水中S含量较高,钢水流动性较差,在连铸生产过程中易发生水口结瘤,甚至堵塞水口,中断生产。通过对堵塞水口的夹杂物进行分析,主要为CaS和Al_2O_3。针对夹杂物的种类,通过对在冶炼过程中钙线加入量和加入时机的研究,调整中包温度和连铸拉速,使钢水流动性明显提升,使连续生产炉数稳定到8炉。

关键词： F45MnVS 流动性钙处理拉速过热度

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