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The Relationship between Corporate Social Responsibility and Firm Performance： An Application of Quantile Regression

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Frontiers of Business Research in China 2012年第2期6卷 218-244页

作者： yungchih george wang Wen-Hsi Lydia Hsu Kuang-Wen Chang Department of International Business National Kaohsiung University of Applied Sciences Department of Business Administration National Ping-Tung University of Science and Technology Ping-Tung Taiwan China Department of Business Administration Soochow University Taiwan China

This study empirically examines the relationship between a firm＇s fulfilling of corporate social responsibility （CSR） and performance. We developed a CSR index （CSRI） to quantitatively evaluate CSR, which consists of four dimensions measuring a firm＇s contributions to the economy, society, environment, and corporate governance, respectively. With data from publicly-listed firms in Taiwan during the period of 2004--2009, results of quantile regression show that fulfilling CSR has a significantly positive impact on firm performance, and that the impact in a more profitable firm tends to be significantly greater than that in a less profitable firm. Specifically, when a firm is more profitable, its management would be more willing to implement CSR. The implication is that a firm could pursue better performance while serving as a good corporate citizen.

关键词： corporate social responsibility (CSR) corporate social responsibility index (CSRI) stakeholders firm performance socially responsible investment

Accelerated thermal ageing on performance of polypropylene-based semiconducting screen for high voltage direct current cable applications-Effect of antioxidants

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High Voltage 2024年第2期9卷 410-418页

作者： Haitian wang Yi Luo Mingyu Zhou Xintong Ren george Chen GEIRI BerlinGermany The Tony Davies High Voltage Laboratory University of SouthamptonSouthamptonUK

The potential of using eco-friendly thermoplastic polypropylene(PP)-based insulation for high voltage direct current(HVDC)cable has been widely investigated but much less work on the PP-based semiconducting screen(SC).Considering a long service life(>30 years)under high temperature and high electrical stress is required for typical HVDC cables,and investigations on the effect of antioxidant(AO)concentration and thermal oxidative sta-bility,mechanical,and electrical properties of PP-based SCs have been *** has been demonstrated that an appropriate combination and amounts of AOs are critical for achieving high thermal stability and maintaining the mechanical properties of SC after ageing in a harsh environment(150°C,with Cu,in air,7 days).Although higher amounts of space charges have been observed in SC/PP/SC samples with higher AO concentrations,the impact on space charge behaviours is less after ageing,suggesting that ageing(or operating at high temperature)leads to microstructure evolution in SC and can potentially mitigate space accumulation in PP-based insulating materials.

关键词： microstructure thermal high

On the use of deep learning for phase recovery

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Light(Science & Applications) 2024年第2期13卷 190-235页

作者： Kaiqiang wang Li Song Chutian wang Zhenbo Ren Guangyuan Zhao Jiazhen Dou Jianglei Di george Barbastathis Renjie Zhou Jianlin Zhao Edmund Y.Lam Department of Electrical and Electronic Engineering The University of Hong KongHong Kong SARChina School of Physical Science and Technology Northwestern Polytechnical UniversityXi’anChina Department of Biomedical Engineering The Chinese University of Hong KongHong Kong SARChina School of Information Engineering Guangdong University of TechnologyGuangzhouChina Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA

Phase recovery(PR)refers to calculating the phase of the light field from its intensity *** exemplified from quantitative phase imaging and coherent diffraction imaging to adaptive optics,PR is essential for reconstructing the refractive index distribution or topography of an object and correcting the aberration of an imaging *** recent years,deep learning(DL),often implemented through deep neural networks,has provided unprecedented support for computational imaging,leading to more efficient solutions for various PR *** this review,we first briefly introduce conventional methods for ***,we review how DL provides support for PR from the following three stages,namely,pre-processing,in-processing,and *** also review how DL is used in phase image ***,we summarize the work in DL for PR and provide an outlook on how to better use DL to improve the reliability and efficiency of ***,we present a live-updating resource(https://***/kqwang/phase-recovery)for readers to learn more about PR.

关键词： networks phase optics

Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine

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Signal Transduction and Targeted Therapy 2024年第1期9卷 47-50页

作者： Mengyu Guo Mingjing Cao Jiufeng Sun Ziwei Chen Xin wang Lianpan Dai george F.Gao Yuliang Zhao Yaling wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyBeijingChina

Dear editor,Vaccines are the most efficient and effective means to prevent infectious diseases,but improving the long-term protective efficacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversification of the pathogen and the number of booster doses.1 Strategies to overcome this warrant is using adjuvants that amplify the immune response,and drive the production of memory B and T cells or long-lived plasma cells that recognize the pathogen for durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen formulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of MnARK for subunit vaccine development,we further explored the durable immune regulation abilities of MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine ZF2001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surface and epitope can be well preserved(Supplementary Fig.1a).The size and zeta potential of MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary Fig.1b,c).

关键词： manganese immunity protective

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2726-2737页

作者： Bo Liu Honghui Liu Pu Han Xiaoyun wang Chunmei wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian george F.Gao Qihui wang College of Veterinary Medicine Shanxi Agricultural University030801 JinzhongChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)100101 BeijingChina School of Life Sciences Yunnan University650504 KunmingYunnan ProvinceChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)102206 BeijingChina Savaid Medical School University of Chinese Academy of Sciences101408 BeijingChina

Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging variants,such as Omicron and its *** suggests that highly conserved epitopes are crucial for the development of neutralizing ***,we present one nanobody,N235,displaying broad neutralization against the SARS-CoV-2 prototype and multiple variants,including the newly emerged Omicron and its ***-electron microscopy demonstrates N235 binds a novel,conserved,cryptic epitope in the N-terminal domain(NTD)of the S protein,which interferes with the RBD in the neighboring S *** neutralization mechanism interpreted via flow cytometry and Western blot shows that N235 appears to induce the S1 subunit shedding from the trimeric S ***,a nano-IgM construct(MN235),engineered by fusing N235 with the human IgM Fc region,displays prevention via inducing S1 shedding and cross-linking virus *** to N235,MN235 exhibits varied enhancement in neutralization against pseudotyped and authentic viruses in *** intranasal administration of MN235 in low doses can effectively prevent the infection of Omicron sub-variant BA.1 and XBB in vivo,suggesting that it can be developed as a promising prophylactic antibody to cope with the ongoing and future infection.

关键词： doses prevention conserved

Deformations at Earth’s dayside magnetopause during quasi-radial IMF conditions:Global kinetic simulations and Soft X-ray Imaging

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Earth and Planetary Physics 2024年第1期8卷 59-69页

作者： ZhongWei Yang RiKu Jarvinen XiaoCheng Guo TianRan Sun Dimitra Koutroumpa george K.Parks Can Huang BinBin Tang QuanMing Lu Chi wang State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Finnish Meteorological Institute FI-00101 HelsinkiFinland LATMOS/IPSL CNRSUVSQ UniversitéParis-SaclaySorbonne UniversitéGuyancourt78280France Space Sciences Laboratory University of CaliforniaBerkeleyCalifornia 94720USA CAS Engineering Laboratory for Deep Resources Equipment and Technology Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029 China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China

The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)is a joint mission of the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS).Primary goals are investigating the dynamic response of the Earth's magnetosphere to the solar wind(SW)impact via simultaneous in situ magnetosheath plasma and magnetic field measurements,X-Ray images of the magnetosheath and magnetic cusps,and UV images of global auroral *** deformations associated with magnetosheath high speed jets(HSJs)under a quasi-parallel interplanetary magnetic field condition are studied using a threedimensional(3-D)global hybrid *** X-ray intensity calculated based on both physical quantities of solar wind proton and oxygen ions is *** obtain key findings concerning deformations at the magnetopause:(1)Magnetopause deformations are highly coherent with the magnetosheath HSJs generated at the quasi-parallel region of the bow shock,(2)X-ray intensities estimated using solar wind h+and self-consistentO7+ions are consistent with each other,(3)Visual spacecraft are employed to check the discrimination ability for capturing magnetopause deformations on Lunar and polar orbits,*** SMILE spacecraft on the polar orbit could be expected to provide opportunities for capturing the global geometry of the magnetopause in the equatorial plane.A striking point is that SMILE has the potential to capture small-scale magnetopause deformations and magnetosheath transients,such as HSJs,at medium altitudes on its *** results also demonstrate that a lunar based imager(e.g.,Lunar Environment heliospheric X-ray Imager,LEXI)is expected to observe a localized brightening of the magnetosheath during HSJ events in the meridian *** preliminary results might contribute to the pre-studies for the SMILE and LEXI missions by providing qualitative and quantitative soft X-ray estimates of dayside kinetic processes.

关键词： collisionless shock SMILE mission foreshock

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2984-2998页

作者： Xin wang Jie Zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting Zhang Xi wang Ronghua Jin Jikun Zhou george F.Gao Jun Liu Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Laboratory of Biosafety Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Institute of Infectious Diseases Beijing 100015China National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015P.R.China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China School of Ophthalmology&Optometry Wenzhou Medical UniversityWenzhou 325027China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Shijiazhuang Fifth Hospital Shijiazhuang 050011China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing ***,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human coronaviruses is not well *** our research,we assessed T cell responses to both conserved and nonconserved peptides shared by SARS-CoV-2 and SARS-CoV,identifying cross-reactive CD8^(+)T cell epitopes using enzyme-linked immunospot and intracellular cytokine staining ***,in vitro refolding and circular dichroism were performed to evaluate the thermal stability of the HLA/peptide ***,single-cell T cell receptor reservoir was analyzed based on tetramer ***,we discovered that cross-reactive T cells targeting SARS-CoV were present in individuals who had recovered from COVID-19,and identified SARS-CoV-2 CD8^(+)T cell epitopes spanning the major structural antigens.T cell responses induced by the nonconserved peptides between SARS-CoV-2 and SARS-CoV were higher and played a dominant role in the cross-reactivity in COVID-19 ***-T cell reactivity was also observed within the identified series of CD8^(+)T cell *** representative immunodominant peptide pairs,although the HLA binding capacities for peptides from SARS-CoV-2 and SARS-CoV were similar,the TCR repertoires recognizing these peptides were *** results could provide beneficial information for the development of peptide-based universal vaccines against coronaviruses.

关键词： immunity conserved assessed

Construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： Chen Tan Lingwa wang Yifan Yang Shizhi He george G.Chen Jason YK.Chan Michael CF.Tong C.A.van Hasselt Wenbin Xu Ling Feng Ru wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of China) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHCs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(IC)as a larynxpreserving approach for LA-LHCs has been verified and refined.^(3)However,the short-term tumor response to IC varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

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Biosafety and Health 2024年第2期6卷 101-115页

作者： Yanan wang Mengqi Qu Yuhai Bi William J.Liu Sufang Ma Bo Wan Yongfei Hu Baoli Zhu Gaiping Zhang george F.Gao International Joint Research Center of National Animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu Laboratory Zhengzhou 450046China University of Chinese Academy of Sciences Beijing 100049China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene