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Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients

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World Journal of Gastroenterology 2021年第42期27卷 7311-7323页

作者： yung-yu hsieh Shui-Yi Tung Hung-yu Pan Te-Sheng Chang Kuo-Liang Wei Wei-Ming Chen Yi-Fang Deng Chung-Kuang Lu yu-Hsuan Lai Cheng-Shyong Wu Chin Li Department of Gastroenterology and Hepatology Chiayi Chang Gung Memorial HospitalChiayi 61301Taiwan College of Medicine Chang Gung UniversityTaoyuan 33302Taiwan Department of Applied Mathematics National Chiayi UniversityChiayi 60035Taiwan Department of Biomedical Sciences National Chung Cheng UniversityChiayi 62130Taiwan

BACKGROUND An increased amount of Fusobacterium nucleatum(***)is frequently detected in the gastric cancer-associated microbiota of the Taiwan Residents *** is known to exert cytotoxic effects and play a role in the progression of colorectal cancer,though the impact of *** colonization on gastric cancer cells and patient prognosis has not yet been *** To identify ***-dependent molecular pathways in gastric cancer cells and to determine the impact of *** on survival in gastric *** Coculture of *** with a gastric cancer cell line was performed,and changes in gene expression were *** with significant changes in expression were identified by RNA *** analysis was carried out to determine deregulated cellular functions.A cohort of gastric cancer patients undergoing gastrectomy was recruited,and nested polymerase chain reaction was performed to detect the presence of *** in resected cancer *** analysis was performed to determine whether *** colonization affects patient *** RNA sequencing and subsequent pathway analysis revealed a drastic interferon response induced by a high colonization *** response peaked within 24 h and subsided after 72 h of *** contrast,deregulation of actin and its regulators was observed during prolonged incubation under a low colonization load,likely altering the mobility of gastric cancer *** to the clinical specimen analysis,approximately one-third of the gastric cancer patients were positive for ***,and statistical analysis indicated that the risk for colonization increases in late-stage cancer *** analysis demonstrated that *** colonization was associated with poorer outcomes among patients also positive for Helicobacter pylori(***).CONCLUSION *** colonization leads to deregulation of actin dynamics and likely changes cance

关键词： Fusobacterium nucleatum Helicobacter pylori Gastric cancer Survival Interferon Mobility

Quantum speedup in adaptive boosting of binary classification

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Science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 51-60页

作者： XiMing Wang yueChi Ma Min-Hsiu hsieh Man-Hong yung School of Physics and Mathmatical Science Nanyang Technological UniversitySingaporeSingapore Department of Physics Southern University of Science and TechnologyShenzhen518055China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing100084China Center for Quantum Software and Information University of Technology SydneySydney2007Australia Guangdong Provincial Key Laboratory of Quantum Science and Engineering Southern University of Science and TechnologyShenzhen518055China

In classical machine learning,a set of weak classifiers can be adaptively combined for improving the overall performance,a technique called adaptive boosting(or AdaBoost).However,constructing a combined classifier for a large data set is typically resource *** we propose a quantum extension of AdaBoost,demonstrating a quantum algorithm that can output the optimal strong classifier with a quadratic speedup in the number of queries of the weak *** results also include a generalization of the standard AdaBoost to the cases where the output of each classifier may be *** prove that the query complexity of the non-deterministic classifiers is the same as those of deterministic classifiers,which may be of independent interest to the classical machine-learning ***,once the optimal classifier is determined by our quantum algorithm,no quantum resources are further *** fact may lead to applications on near term quantum devices.

关键词： AdaBoost quantum machine learning quantum algorithm

Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

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World Journal of Gastroenterology 2008年第11期14卷 1759-1767页

作者： Tsung-Chieh Shih Sen-yung hsieh Yi-yueh hsieh Tse-Chin Chen Chien-yu Yeh Chun-Jung Lin Deng-Yn Lin Cheng-Tang Chiu Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-GastroenterologyChang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Colorecto-Surgery Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-Gastroenterology Chang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan

AIM:To investigate the role of nuclear factor of activated T cell 2(NFAT2),the major NFAT protein in peripheral T cells,in sustained T cell activation and intractable inflammation in human ulcerative colitis(UC). METHODS:We used two-dimensional gel-electrophoresis, immunohistochemistry,double immunohistochemical staining,and confocal microscopy to inspect the expression of NFAT2 in 107,15,48 and 5 cases of UC, Crohn's disease(CD),non-specific colitis,and 5 healthy individuals,respectively. RESULTS:Up-regulation with profound nucleo- translocation/activation of NFAT2 of lamina propria mononuclear cells(LPMC)of colonic mucosa was found specifically in the affected colonic mucosa from patients with UC,as compared to CD or NC(P<0.001,Kruskal- Wallis test).Nucleo-translocation/activation of NFAT2 primarily occurred in CD8+T,but was less prominent in CD4+T cells or CD20+B *** was strongly associated with the disease activity,including endoscopic stage (τ=0.2145,P=0.0281)and histologic grade(τ=0.4167, P<0.001). CONCLUSION:We disclose for the first time the nucleo-translocation/activatin of NFAT2 in lamina propria mononuclear cells in ulcerative *** of NFAT2 was specific for ulcerative colitis and highly associated with disease *** activation of NFAT2is implicated in an auto-regulatory positive feedback loop of sustained T-cell activation and NFAT proteins play key roles in the calcium/calcineurin signaling pathways,our results not only provide new insights into the mechanism for sustained intractable inflammation,but also suggest the calcium-calcineurin/NFAT pathway as a new therapeutic target for ulcerative colitis.

关键词： Nuclear factor of activated T cells Ulcerative colitis Inflammatory bowel disease Nuclear factor of activated T cells cl Nuclear factor of activated T cells 2

Diverticulosis of the jejunum with intestinal obstruction: A case report

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World Journal of Gastroenterology 2005年第34期11卷 5416-5417页

作者： Chien-Hua Lin Huan-Fa hsieh Chih-yung yu Jyh-Chemg yu De-Chuan Chan Teng-Wei Chen Peng-Jen Chen Yao-Chi Liu Division of General Surgery Department ofSurgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Department of Radiology Tri-Service GeneralHospital National Defense Medical Center Taipei Taiwan China Division of Gastroenterology Department ofInternal Medicine Tri-Service General Hospital National Defense Medical Center Taipei Taiwan China Department of Surgery Yee-Zen General HospitalTauyan Taiwan China

A diagnosis of intestinal diverticulosis is difficult to make pre-operatively because the clinical symptoms are usually non-specific. We report the case of a 70-year-old man who had suffered from three episodes of intestinal obstruction in 1 year. He experienced dull pain and a sensation of fullness over the whole abdomen. The symptoms did not improve after conservative *** presumptive diagnosis was intestinal obstruction, and an exploratory laparotomy found diverticulosis of the proximal jejunum, with an adhesion band formed from the base of one diverticulum. Strangulation of a segment of the jejunum resulted from the internal herniation caused by the band. The band was removed and the proximal jejunum segmentally resected. His postoperative course was uneventful.

关键词： Diverticulosis of jejunum Intestinal obstruction

Polyelectrolyte multilayer electrostatic gating of graphene field-effect transistors

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Nano Research 2014年第11期7卷 1650-1658页

作者： yung yu Wang Peter J. Burke Department of Chemical Engineering and Materials Science University of California Irvine Irvine California 92697 USA Department of Electrical Engineering and Computer Science University of California Irvine Irvine California 92697 USA

We apply polyelectrolyte multilayer films by consecutive alternate adsorption of positively charged polyallylamine hydrochloride and negatively charged sodium polystyrene sulfonate to the surface of graphene field effect transistors. Oscillations in the Dirac voltage shift with alternating positive and negative layers clearly demonstrate the electrostatic gating effect in this simple model system. A simple electrostatic model accounts well for the sign and magnitude of the Dirac voltage shift. Using this system, we are able to create p-type or n-type graphene at will. This model serves as the basis for understanding the mechanism of charged polymer sensing using graphene devices, a potentially technologically important application of graphene in areas such as DNA sequencing, biomarker assays for cancer detection, and other protein sensing applications.

关键词： dirac point graphene transistor electrostatic gating polyallylaminehydrochloride (PAH) sodium polystyrenesulfonate (PSS)

Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families

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World Journal of Gastroenterology 2021年第37期27卷 6262-6276页

作者： Ai-Ru hsieh Cathy S J Fann Hung-Chun Lin Jennifer Tai Sen-yung hsieh Dar-In Tai Department of Statistics Tamkang UniversityNew Taipei City 25137Taiwan Institute of Biomedical Sciences Academia SinicaNankangTaipei 11529Taiwan Division of Hepatology Department of Gastroenterology and HepatologyChang Gung Memorial HospitalLinkou Medical CenterTaoyuan 33305Taiwan

BACKGROUND Genome-wide association studies from Asia indicate that HLA-DP and HLA-DQ loci are important in persistent hepatitis B virus(HBV)*** of the key elements for HBV-related carcinogenesis is persistent viral replication and *** To examine genetic and nongenetic factors with persistent HBV infection and viral load in families with hepatocellular carcinoma(HCC).METHODS The HCC families included 301 hepatitis B surface antigen(HBsAg)carriers and 424 noncarriers born before the nationwide vaccination program was initiated in *** HBV-related single nucleotide polymorphisms(SNPs)—rs477515,rs9272105,rs9276370,rs7756516,and rs9277535—were *** associated with persistent HBV infection and viral load were analyzed by a generalized estimating *** In the first-stage persistent HBV study,all SNPs except rs9272105 were associated with persistent infection.A significantly higher area under the reciprocal operating characteristic curve for nongenetic factors vs genetic factors(P<0.001)suggests that the former play a major role in persistent HBV *** the second-stage viral load study,we added 8 HBsAg carriers born after *** 309 HBsAg carriers were divided into low(n=162)and high viral load(n=147)groups with an HBV DNA cutoff of 105 cps/***,relationship to the index case,rs477515,rs9272105,and rs7756516 were associated with viral *** on the receiver operating characteristic curve analysis,genetic and nongenetic factors affected viral load equally in the HCC family cohort(P=0.3117).CONCLUSION In these east Asian adults,the mechanism of persistent HBV infection-related SNPs was a prolonged viral replication phase.

关键词： Generalized estimating equation Genetic polymorphism Genome-wide association study Hepatitis B surface antigen Hepatitis B virus Replication

Factor analysis for the statistical modeling of earthquake-induced landslides

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 123-126页

作者： Jeng-Wen LIN Meng-Hsun hsieh yu-Jen LI Department of Civil Engineering Feng Chia UniversityTaichung 40724China School of Management Fujian University of TechnologyFuzhou 350118China Ruentex Engineering&Construction Co. Ltd.Taipei 10492China

Earthquake-induced landslides are difficult to assess and predict owing to the inherent unpredictability of *** most existing studies,the landslide potential is statistically assessed by collecting and analyzing the data of historical landslide events and earthquake observation *** rainfall-induced landslides,earthquake-induced landslides cannot be predicted in advance using real-time monitoring systems,and the development of the models for these landslides should instead depend on early earthquake warnings and ***,in this study,factor analysis was performed and the frequency distribution method was employed to investigate the potential risk of the landslides caused by *** such as the slope gradient,lithology(geology),aspect,and elevation were selected and classified as influential factors to facilitate the construction of a landslide database for the area of study.

关键词： earthquake factor analysis slope landslides statistical modeling

Ordered space-time structures: Quantum carpets from Gaussian sum theory

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Science China(Physics,Mechanics & Astronomy) 2019年第7期62卷 55-62页

作者： HuiXin Xiong XueKe Song HuaiYang yuan DaPeng yu ManHong yung Department of Physics Peking University Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and Technology Department of Physics Southeast University Shenzhen Key Laboratory of Quantum Science and Engineering Southern University of Science and Technology Central Research Institute Huawei Technologies

The term "quantum carpet" can be observed in many closed quantum systems, where the evolution of a wave function exhibits a carpet-like pattern. Quantum carpet mechanisms are also akin to the classical interference patterns of light. Although the origins of quantum carpets have previously been studied by various researchers, many interesting details are still worth exploring. In this study, we present a unified framework for simultaneously analyzing three different features of quantum carpets: full revival,fractional revival, and diagonal canal. For the fractional revival feature, a complete formula is presented to explain its formation through Gaussian sum theory, in which all essential features, including phases and amplitudes, are captured analytically. We also reveal important relationships between the interference terms of diagonal canals and their geometric interpretations such that a better understanding of the development of diagonal canals can be supported.

关键词： quantum carpets fractional revival diagonal canal Gaussian sum theory

Sutured scleral fixation of existing subluxated/dislocated acrylic one-piece intraocular lenses

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 665-669页

作者： Wei-yu Huang yung-Jen Chen Department of Ophthalmology Chi Mei Medical CenterTainan City 710TaiwanChina Department of Ophthalmology Chang Gung Memorial HospitalKaohsiung City 833TaiwanChina

AIM:To evaluate the visual and refractive outcomes in cases after sutured scleral fixation of existing subluxated or dislocated acrylic one-piece intraocular lenses(IOLs).METHODS:This study retrospectively enrolled a consecutive series of patients who underwent a surgery of sutured existing subluxated or dislocated IOLs from October 2018 to June *** patients underwent comprehensive preoperative and postoperative ophthalmologic examination,and data were collected including age,sex,surgical indications,best-corrected visual acuity,refractive error,intraocular *** of intraoperative and postoperative surgical complications was ***:A total of 20 consecutive cases were enrolled for analysis with mean final follow-up period 9.8±*** acuity improved from a mean of 0.35(0.46±0.32 logMAR)preoperatively to 0.61(0.21±0.18 logMAR)at the 3-month follow-up(P=0.002).The mean amount of preoperative keratometric astigmatism and total postoperative refractive astigmatism was-1.24±0.80 diopters(D)and-1.42±0.97 D,*** was no statistically significant difference between preoperative and postoperative astigmatism(P=0.156).The mean IOL-induced astigmatism was-0.23±0.53 *** mean spherical equivalent at the 3-month follow-up was-0.1±0.94 *** major complications were noted during the follow-up ***:Surgical techniques using sutured scleral fixation of existing subluxated or dislocated acrylic one-piece IOLs result in favorable visual and refractive outcomes without major complications.

关键词： intraocular lens dislocation intraocular lens subluxation lens dislocation lens subluxation scleral fixation