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常频听阈正常接噪者非镇静听性脑干反应特征研究

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中华耳科学杂志 2024年第2期22卷 237-241页

作者：黄杭黄燕婷赵乌兰徐飞王枫浙江中医药大学医学技术与信息工程学院杭州310053

目的研究长期接噪人群非镇静听性脑干反应特征及其有效性。方法选取2023年1月—4月浙江中医药大学医学技术与信息工程学院无长期接噪史的15例青年学生为正常组,另选取杭州祖明豆腐工厂有长期接噪史(接噪时间8 h/d左右)的15例工人为接... 详细信息

目的研究长期接噪人群非镇静听性脑干反应特征及其有效性。方法选取2023年1月—4月浙江中医药大学医学技术与信息工程学院无长期接噪史的15例青年学生为正常组,另选取杭州祖明豆腐工厂有长期接噪史(接噪时间8 h/d左右)的15例工人为接噪组,两组进行非镇静听性脑干反应,比较两组Ⅰ、Ⅴ波潜伏期及Ⅴ波振幅的差异,采用双变量Pearson相关性分析,探究两组纯音与非镇静ABR的相关性。结果在80 dB nHL强度下,I波潜伏期正常组潜伏期早于接噪组,差异有统计学意义(P0.05)。两组各强度下V波振幅比较,差异均无统计学意义(P>0.05)。正常组纯音平均阈值与非镇静ABR阈值呈正相关,(r=0.540,P<0.05);接噪组纯音平均阈值与非镇静ABR阈值呈正相关(r=0.688,P<0.01)。结论在80 dB nHL刺激下Ⅰ波潜伏期延后,对噪声引起的隐性听力损失具有一定的参考价值。接噪组非镇静ABR与纯音测听的相关性高于正常组,两者交叉验证准确性更高。

关键词：接噪人群非镇静听性脑干反应隐性听力损失

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循环水保温垫和两种热空气暖风垫在犬剖腹手术中保温效果的比较

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动物医学进展 2024年第1期45卷 140-144页

作者：黄雪纯黄欣瑜王咸棋温州科技职业学院浙江温州325006 台湾中兴大学中国台湾台中86402

术中低体温会增加感染率、出血风险和死亡率,目前临床上常用外部主动加热系统提高保温效果。为了探究不同保温设备在麻醉诱导和手术过程中的保温效果,将18例进行剖腹手术的犬随机分成3组(n=6),即循环水保温垫组(W)、U形热空气暖风垫组(... 详细信息

术中低体温会增加感染率、出血风险和死亡率,目前临床上常用外部主动加热系统提高保温效果。为了探究不同保温设备在麻醉诱导和手术过程中的保温效果,将18例进行剖腹手术的犬随机分成3组(n=6),即循环水保温垫组(W)、U形热空气暖风垫组(FU)和热空气暖风垫组(FM)。结果显示,3组犬的平均食道温度在麻醉20 min后均下降,40 min后FU组食道温度上升,FM组上升缓慢。W组食道温度在40、50、60 min均显著低于FU组,与FM组无显著差异。FM组犬的食道温度相较于W和FU组缓慢上升。结果表明,全身麻醉时,可重复使用、随身体压力分散的热空气暖风垫保温效果良好,能有效降低术中低体温的发生概率。

关键词：术中低体温循环水保温垫热空气暖风垫剖腹手术全身麻醉

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Low-temperature characteristicsof rubbers and performance testsof type 120 emergencyvalve diaphragms

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Railway Sciences 2024年第1期3卷 47-58页

作者： Ming Gao Anhui Pan Yi huang Jiaqi Wang Yan Zhang Xiao Xie Huanre Han Yinghua Jia Metals and Chemistry Research Institute China Academy of Railway Sciences Corporation LimitedBeijingChina Department of Locomotive and Car China State Railway Group Company LimitedBeijingChina Quality and Technical Supervision Institute China Railway Harbin Bureau Group Company LimitedHarbinChina

Purpose–The type 120 emergency valve is an essential braking component of railway freight trains,butcorresponding diaphragms consisting of natural rubber(NR)and chloroprene rubber(CR)exhibit insufficientaging resistance and low-temperature resistance,*** order to develop type 120 emergency valverubber diaphragms with long-life and high-performance,low-temperatureresistant CR and NR were ***/methodology/approach–The physical properties of the low-temperature-resistant CR and NRwere tested by low-temperature stretching,dynamic mechanical analysis,differential scanning calorimetryand thermogravimetric ***-valve and single-vehicle tests of type 120 emergency valves werecarried out for emergency diaphragms consisting of NR and ***–The low-temperature-resistant CR and NR exhibited excellent physical *** elasticityand low-temperature resistance of NR were superior to those of CR,whereas the mechanical properties of thetwo rubbers were similar in the temperature range of 0℃–150℃.The NR and CR emergency diaphragms metthe requirements of the single-valve *** the low-temperature single-vehicle test,only the low-temperaturesensitivity test of the NR emergency diaphragm met the ***/value–The innovation of this study is that it provides valuable data and experience for futuredevelopment of type 120 valve rubber diaphragms.

关键词： Natural rubber Chloroprene rubber Low-temperature characteristic 120 emergency valve Diaphragm

Association between Low Ambient Temperature and the Severity of Acute Ischemic Stroke

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Journal of Clinical and Nursing Research 2024年第5期8卷 83-94页

作者： Xinyi huang Liming Shu Su Xiao Qiuhong Jiang Shiliang Yang Hualiang Liang Hua Hong Liang Luo Department of Critical Care Medicine The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107GuangdongChina Department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260GuangdongChina The Second Xiangya Hospital of Central South University Changsha 410011HunanChina Department of Neurology National Key Clinical Department and Key Discipline of NeurologyThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of General Practice Shenshan Central HospitalSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityShanweiChina 516600GuangdongChina School of Public Health Sun Yat-sen UniversityGuangzhou 510080GuangdongChina

Objective:To explore the relationships among ambient temperature,ischemic stroke severity,and blood ***:Meteorological data(2005–2015)were collected from the Guangzhou Meteorological Data *** stroke patients from the Department of Neurology of the First Affiliated Hospital,Sun Yat-sen University were retrospectively evaluated,each winter from 2005 to *** demographics,baseline measurements,and National Institute of Health Stroke Scale(NIHSS)score were ***:Three hundred sixty-two patients were *** median latency from symptom onset to admission was 2 d(IQR:1–3 d).During recruitment,the highest and lowest temperatures were 39℃and 1.3℃,*** was the most common comorbidity(75.1%).NIHSS scores at admission and discharge were higher in the cold-exposed group than in the controls regardless of the average temperature at *** addition,systolic and diastolic blood pressure values at admission were higher in the cold-exposed group than in the *** stratified by hypertensive status,the average and minimum temperatures at admission were negatively associated with systolic and diastolic blood pressure values in hypertensive *** in the average and minimum temperatures at symptom onset were associated with more severe ***:Ischemic stroke patients with symptom onset in winter had higher systolic blood pressure values and more serious neurologic deficits upon admission.

关键词： Low ambient temperature Stroke Blood pressure Severity

Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer

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World Journal of Clinical Oncology 2024年第7期15卷 867-894页

作者： Jing-Yu Chen Jian-Di Li Rong-Quan He Zhi-Guang huang Gang Chen Wen Zou Department of Pathology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Phosphoglycerate kinase 1(PGK1)has been identified as a possible biomarker for breast cancer(BC)and may play a role in the development and advancement of triple-negative BC(TNBC).AIM To explore the PGK1 and BC research status and PGK1 expression and mecha-nism differences among TNBC,non-TNBC,and normal breast *** PGK1 and BC related literature was downloaded from Web of Science Core Co-llection Core *** counts,key-word frequency,cooperation networks,and theme trends were *** breast,TNBC,and non-TNBC mRNA data were gathered,and differentially expressed genes *** under the summary receiver operating characteristic curves,sensitivity and specificity of PGK1 expression were *** Meier revealed PGK1’s prognostic ***1 co-expressed genes were explored,and Gene Onto-logy,Kyoto Encyclopedia of Genes and Genomes,and Disease Ontology ***-protein interaction networks were *** genes *** PGK1 and BC related publications have surged since 2020,with china leading the *** most frequent keyword was“Expression”.Collaborative networks were found among co-citations,countries,institutions,and ***1 expression and BC progression were research hotspots,and PGK1 expression and BC survival were research *** 16 TNBC vs non-cancerous breast and 15 TNBC vs non-TNBC datasets,PGK1 mRNA levels were higher in 1159 TNBC than 1205 non-cancerous breast cases[standardized mean differences(SMD):0.85,95%confidence interval(95%CI):0.54-1.16,I²=86%,P<0.001].PGK1 expression was higher in 1520 TNBC than 7072 non-TNBC cases(SMD:0.25,95%CI:0.03-0.47,I²=91%,P=0.02).Recurrence free survival was lower in PGK1-high-expression than PGK1-low-expression group(hazard ratio:1.282,P=0.023).PGK1 co-expressed genes were concentrated in ATP metabolic process,HIF-1 signaling,and glycolysis/gluconeogenesis *** PGK1 expression is a research hotspot and frontier dire

关键词： Phosphoglycerate kinase 1 Breast cancer Triple-negative breast cancer Bibliometric analysis Computational pathology

Prognostic value and predictive model of tumor markers in stageⅠtoⅢgastric cancer patients

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World Journal of Clinical Oncology 2024年第8期15卷 1033-1047页

作者： Ai-Hua Sun Xin-Yu Zhang Yang-Yang huang Lei Chen Qing Wang Xiao-Cong Jiang Department of Radiotherapy Oncology Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina Department of Hepatobiliary Surgery Fujian Provincial HospitalFuzhou 350001China Department of General Surgery Xiang'an Hospital of Xiamen UniversityXiamen 361102Fujian ProvinceChina

BACKGROUND Preoperative serum tumor markers have been widely used in the diagnosis and treatment of gastric cancer ***,few studies have evaluated the prognosis of gastric cancer patients by establishing statistical models with multiple serum tumor *** To explore the prognostic value and predictive model of tumor markers in stage I and III gastric cancer *** From October 2018 to April 2020,a total of 1236 patients with stage I to III gastric cancer after surgery were included in our *** relationship between serum tumor markers and clinical and pathological data were *** established a statistical model to predict the prognosis of gastric cancer based on the results of COX regression *** survival(OS)was also compared across different stages of gastric *** The deadline for follow-up was May 31,2023.A total of 1236 patients were included in our *** analysis found that age,clinical stage,T and N stage,tumor location,differentiation,Borrmann type,size,and four serum tumor markers were prognostic factors of OS(P<0.05).It was shown that clinical stage,tumor size,alpha foetoprotein,carcinoembryonic antigen,CA125 and CA19-9(P<0.05)were independent prognostic factors for *** to the scoring results obtained from the statistical model,we found that patients with high scores had poorer survival time(P<0.05).Furthermore,in stage I patients,the 3-year OS for scores 0-3 ranged from 96.85%,95%,85%,and 80%.In stage II patients,the 3-year OS for scores 0-4 were 88.6%,76.5%,90.5%,65.5%and 60%.For stage III patients,3-year OS for scores 0-6 were 70.9%,68.3%,64.1%,50.9%,38.4%,18.5%and 5.2%.We also analyzed the mean survival of patients with different *** stage I patients,the mean OS was 55.980 *** stage II,the mean OS was 51.550 *** mean OS for stage III was 39.422 *** Our statistical model can effectively predict the prognosis of gastric cancer patients.

关键词： Gastric cancer Tumor marker Prognosis Overall survival Model

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专著:中美社科学术体系的比较与展望

东南学术 2024年第1期 103-113,248页

作者：黄宗智赵珊美国加利福尼亚大学洛杉矶校区历史系天津商业大学法学院

改革学术评价体系,是推动学术高质量发展的重要路径之一,对此,国外先进经验有一定参考价值。在社会科学学术体系中,美国形成了以投入三四年的博士学位论文为基础、再加上六七年的后续研究的重量级专著传统。它固然存在广泛偏重主观理论... 详细信息

改革学术评价体系,是推动学术高质量发展的重要路径之一,对此,国外先进经验有一定参考价值。在社会科学学术体系中,美国形成了以投入三四年的博士学位论文为基础、再加上六七年的后续研究的重量级专著传统。它固然存在广泛偏重主观理论过于客观经验研究,偏重建构理想化的、逻辑上前后一贯的理论模式的弱点,但奠定了其在国际社科学术领域的重要地位。中国的博士学位论文制度在实际运作中则表现出深层的矛盾,没有形成较为重量级专著传统,因此使中国自身的学术水平提升受到一定限制。目前的中国社科学术体系亟须改革,需要从国家层面鼓励结合中国实际的重量级经验研究与新型社科理论的专著,来塑造具有中国主体性的专著体系。

关键词：中美专著环境美国的专著传统中国的社科学术体系新型社科理论创建

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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu Jingyi Yang Li Zhou Lin Liu Min Li Shasha Wang Mei-Qin Liu Zhixiang huang Zhen Zhang Shuning Liu Yunqi Hu Haofeng Lin Bowen Liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

In situ injectable hydrogel encapsulating Mn/NO-based immune nano-activator for prevention of postoperative tumor recurrence

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Asian Journal of Pharmaceutical Sciences 2024年第02期 104-121页

作者： Shengnan huang Chenyang Zhou Chengzhi Song Xiali Zhu Mingsan Miao Chunming Li Shaofeng Duan Yurong Hu Academy of chinese Medical Sciences Henan University of Chinese Medicine School of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Center for Quantitative Biology Peking University School of Pharmaceutical Sciences Henan University of Chinese Medicine Department of Pharmacy Chongqing University Cancer Hospital School of Pharmaceutical Sciences Henan University

Postoperative tumor recurrence remains a predominant cause of treatment failure. In this study, we developed an in situ injectable hydrogel, termed MPB-NO@DOX + ATRA gel,which was locally formed within the tumor resection cavity. The MPB-NO@DOX + ATRA gel was fabricated by mixing a thrombin solution, a fibrinogen solution containing all-trans retinoic acid（ATRA）, and a Mn/NO-based immune nano-activator termed MPB-NO@*** promoted the differentiation of cancer stem cells, inhibited cancer cell migration,and affected the polarization of tumor-associated macrophages. The outer MnO2shell disintegrated due to its reaction with glutathione and hydrogen peroxide in the cytoplasm to release Mn2+and produce O2, resulting in the release of doxorubicin（DOX）. The released DOX entered the nucleus and destroyed DNA, and the fragmented DNA cooperated with Mn2+to activate the cGAS-STING pathway and stimulate an anti-tumor immune *** addition, when MPB-NO@DOX was exposed to 808 nm laser irradiation, the Fe-NO bond was broken to release NO, which downregulated the expression of PD-L1 on the surface of tumor cells and reversed the immunosuppressive tumor *** conclusion, the MPB-NO@DOX + ATRA gel exhibited excellent anti-tumor efficacy. The results of this study demonstrated the great potential of in situ injectable hydrogels in preventing postoperative tumor recurrence.

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