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Chinese Chemical Letters 2024年第10期35卷 348-352页

作者： lin Li Bingjun Sun jin Sun lin Chen Zhonggui He Department of Pharmacy Women and Children's Hospital of Chongqing Medical University/Chongqing Health Center for Women and ChildrenChongqing 401147China Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China

Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer(TNBC)at the advanced ***,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ***,rational design of advanced drug delivery systems that can induce multiple cell death pathways is a promising strategy to combat *** is a powerful non-apoptotic cell death modality,showing potential in tumor ***,we propose a binary prodrug nanoassemblies that combines chemotherapy with ferroptosis for TNBC *** this system,paclitaxel is linked with paracetamol(ferroptosis activator)by a disulfide linkage to construct self-assembly ***,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-methyl(polyethylene glycol)-2000-tyrosine(DSPE-PEG2k-tyrosine)is applied for large neutral amino acid transporter 1(LAT1)targeting,which is highly expressed in *** prodrug nanoassemblies exhibit good stability and a glutathione(GSH)-responsive release ***,the LAT1-targeted nanoassemblies show stronger cytotoxicity,higher cellular uptake,and more obvious ferroptosis activation than non-decorated *** a TNBC mice model,the prodrug nanoassemblies demonstrate strong anti-tumor *** application of ferroptosis-assisting chemotherapy may provide a promising strategy for TNBC therapy.

关键词： Prodrug nanoassemblies Paclitaxel Ferroptosis LAT1 Triple-negative breast cancer

First-line immunotherapy for advanced non-small cell lung cancer:current progress and future prospects

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Cancer Biology & Medicine 2024年第2期21卷 117-124页

作者： Jingyi Wang lin Wu The Second Department of Thoracic Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013China Xiangya Lung Cancer Center Xiangya HospitalCentral South UniversityChangsha 410008China

Global Cancer Statistics 2022 reported the prevalence and high mortality rate of lung ***,non-small cell lung cancer(NSCLC)accounts for the majority of the histologic *** therapy for lung cancer has progressed rapidly and immune checkpoint inhibitors(ICIs)have become a leading research ***,ICI therapy has been shown to improve the prognosis of lung cancer patients.

关键词： lung cancer mortality

An improved wind quality control for the China-France Oceanography Satellite (CFOSAT) scatterometer

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Acta Oceanologica Sinica 2024年第5期43卷 100-109页

作者： Xiaoheng Mou Wenming lin School of Marine Sciences Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Space Ocean Remote Sensing and Application Ministry of Natural ResourcesBeijing 100081China

Quality control(QC)is an essential procedure in scatterometer wind retrieval,which is used to distinguish good-quality data from poor-quality wind vector cells(WVCs)for the sake of wind *** current wind processor of the China-France Oceanography Satellite(CFOSAT)scatterometer(CSCAT)adopts a maximum likelihood estimator(MLE)-based QC method to filter WVCs affected by geophysical noise,such as rainfall and wind *** the first Ku-band rotating fan-beam scatterometer,CSCAT can acquire up to 16 observations over a single WVC,giving abundant information with diverse incidence/azimuth angles,as such its MLE statistical characteristics may be different from the previous *** this study,several QC indicators,including MLE,its spatially averaged value(MLE_(m)),and the singularity exponents(SE),are analyzed using the collocated Global Precipitation Mission rainfall data as well as buoy data,to compare their sensitivity to rainfall and wind *** results show that wind error characteristics of CSCAT under different QC methods are similar to those of other Ku-band scatterometers,i.e.,SE is more suitable than other parameters for the wind QC at outer-swath and nadir regions,while MLE_(m) is the best QC indicator for the sweet region ***,SE is much more favorable than others at high wind *** combining different indicators,an improved QC method is developed for *** validation with the collocated buoy data shows that it accepts more WVCs,and in turn,improves the quality control of CSCAT wind data.

关键词： China-France Oceanography Satellite(CFOSAT) scatterometer winds quality control(QC) singularity exponent(SE)

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在γ-γ符合测量中康普顿散射所引起的符合

物理学报 1958年第2期 114-120页

作者：徐永昌郑林生中国科学院物理研究所

本文介绍一个具有0.15微秒分辨时间,测量由盖革计数管产生的脉冲的二重符合线路。并阐述在应用这符合线路观测Zn65β+射线的湮（氵威）符合时,观察到γ射线的康普顿散射所引起的符合。

关键词：康普顿散射徐永昌 Zn 康普顿效应弹性散射符合测量

Next generation desalination membrane with exceptional chlorine resistance

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Science China Chemistry 2024年第11期67卷 3500-3502页

作者： Shihong lin Xinglin Lu Department of Civil and Environmental Engineering Vanderbilt University CAS Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and Engineering National Synchrotron Radiation Laboratory University of Science and Technology of China

This highlight draws inspiration from a recent publication in Science where Zhang and co-workers [1] from Nanjing University of Science and Technology reported a novel multifunctional polyester reverse osmosis(RO) membrane and its application in seawater desalination. This research represents a notable advancement in the field, as polyester membranes may potentially compete with state-of-the-art polyamide RO membranes in the mainstream market.

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High Order IMEX Stochastic Galerkin Schemes for linear Transport Equation with Random Inputs and Diffusive Scalings

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Communications on Applied Mathematics and Computation 2024年第1期6卷 325-339页

作者： Zheng Chen lin Mu Department of Mathematics University of Massachusetts Dartmouth285 Old Westport RoadDartmouth02747MAUSA Department of Mathematics University of GeorgiaAthens30602GAUSA

In this paper,we consider the high order method for solving the linear transport equations under diffusive scaling and with random *** tackle the randomness in the problem,the stochastic Galerkin method of the generalized polynomial chaos approach has been ***,the high order implicit-explicit scheme under the micro-macro decomposition framework and the discontinuous Galerkin method have been *** provide several numerical experiments to validate the accuracy and the stochastic asymptotic-preserving property.

关键词： Stochastic Galerkin scheme linear transport equations generalized polynomial approach stochastic asymptotic-preserving property

The principle and amelioration of lithium plating in fast-charging lithium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 453-459,I0009页

作者： Yi Yang Xia-lin Zhong Lei Xu Zhuo-lin Yang Chong Yan Jia-Qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Yangtze River Delta Graduate School of Beijing Institute of Technology Jiaxing 314003ZhejiangChina

Fast charging is restricted primarily by the risk of lithium(Li)plating,a side reaction that can lead to the rapid capacity decay and dendrite-induced thermal runaway of lithium-ion batteries(LIBs).Investigation on the intrinsic mechanism and the position of Li plating is crucial to improving the fast rechargeability and safety of ***,we investigate the Li plating behavior in porous electrodes under the restricted transport of Li^(+).Based on the theoretical model,it can be concluded that the Li plating on the anodeseparator interface(ASI)is thermodynamically feasible and kinetically ***,the prior deposition of metal Li on the ASI rather than the anode-current collector interface(ACI)is verified *** order to facilitate the transfer of Li^(+)among the electrode and improve the utilization of active materials without Li plating,a bilayer asymmetric anode composed of graphite and hard carbon(GH)is *** and simulation results suggest that the GH hybrid electrode homogenizes the lithiated-rate throughout the electrode and outperforms the pure graphite electrode in terms of the rate performance and inhibition of Li *** work provides new insights into the behavior of Li plating and the rational design of electrode structure.

关键词： Graphite Hard carbon Fast charging Lithium plating Lithium-ion batteries

Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

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Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng Yun He Heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu chang-quan ling Shanghai University of Traditional Chinese Medicine Shanghai 201203China Oncology Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of Traditional Chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological Technology Co. Ltd.YantaiShandong Province 264006China. Department of Clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPCR assays and transduction assays of HEK293T cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in C57BL/6 *** The incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus Capsid engineering Transduction efficiency

Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats

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Journal of Traditional Chinese Medicine 2024年第4期44卷 670-679页

作者： LIU Tongtong ZHANG Xi YANG Hui lin Xiaoyuan LIU Jian ZHANG Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu LEI chang LONG Hongping LUO Yan XIANG Yun GE Jinwen WANG Yuhong MENG Pan Institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China the Second People's Hospital of Hunan Province Changsha 410007China The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410007China Hunan Academy of Chinese Medicine Changsha 410013China

OBJECTIVE:To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons,and to elucidate the mechanism behind the ***:The antidepressant mechanism of luteolin was studied by using CUMS rat model and primary hippocampal neurons in fetal *** vivo,novelty suppressed feeding,open-field and sucrose preference tests as well as Morris water maze were *** content of brain derived neurotrophic factor(BDNF),5-hydroxytryptamine(5-HT),norepinephrine(NE),and dopamine(DA)in serum were detected by enzyme-linked immunosorbent *** mechanisms of luteolin were explored based on neurotrophin and hippocampal neurogenesis,and *** of the septotemporal axis in hippocampus was assayed using the 5-bromo-2-deoxyuridine(BrdU),the expression of BDNF,neurotrophin-3(NT-3),and nerve growth factor(NGF)in hippocampus dentate gyrus region were measured by *** vitro,BDNF,NT-3,tropomyosin receptor kinase B(TrkB),and phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB)were detected through the high content analysis(HCA)to investigate neurotrophin and ***:Induction of CUMS in rats induced depressive symptoms,while luteolin significantly enhanced sucrose consumption,decreased feeding latency,increased locomotor activity,escape latency,distance of target quadrant and regulated the content of depressive-like *** analysis revealed that luteolin increased the abundance of new born neurons that had been labeled with BrdU,BrdU+neuronal nuclear antigen,and BrdU+doublecortin in septo-temporal axis of S2(mid-septal)and T3(mid-temporal).Moreover,expression of BDNF,NT-3,and NGF increased significantly in the septo-temporal axis of S2 and *** showed increased expression of BDNF,NT-3,TrkB and p-CREB in primary hippocampal ***:The results provided direct ev

关键词： fetal rats Survival

Efficient Spin-Flip between Charge-Transfer States for High-Performance Electroluminescence, without an Intermediate Locally Excited State

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Research 2024年第1期2023卷 339-349页

作者： Donghai Zhang Shanshan Jiang Xiaodong Tao Fulin lin lingyi Meng Xu-lin Chen Can-Zhong Lu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China FuzhouFujian 350108China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamenFujian 361021China University of Chinese Academy of Sciences Beijing 100049China

Thermally activated delayed fluorescence(TADF)materials with both high photoluminescence quantum yield(PLQY)and fast reverse intersystem crossing(RISC)are strongly desired to realize efficient and stable organic light-emitting diodes(OLEDs).Control of excited-state dynamics via molecular design plays a central role in optimizing the PLQY and RISC rate of TADF materials but remains ***,3 TADF emitters possessing similar molecular structures,similar high PLQYs(89.5%to 96.3%),and approximate energy levels of the lowest excited singlet states(S_(1)),but significantly different spin-flipping RISC rates(0.03×10^(6) s^(−1) vs.2.26×10^(6) s^(−1))and exciton lifetime(297.1 to 332.8μs vs.6.0μs)were systematically synthesized to deeply investigate the feasibility of spin-flip between charge-transfer excited states(^(3)CT–^(1)CT)transition.

关键词： transition lifetime desired