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Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine

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Stroke & Vascular Neurology 2020年第2期5卷 185-197页

作者： yunfeng chen Lining Arnold Ju Molecular Medicine Scripps Research InstituteLa JollaCaliforniaUSA School of Biomedical Engineering Heart Research Institute and Charles Perkins CentreThe University of SydneyCamperdownNew South WalesAustralia

Arterial thrombosis is in part contributed by excessive platelet aggregation,which can lead to blood clotting and subsequent heart attack and *** are sensitive to the haemodynamic *** haemodynamcis and disturbed blood flow,which occur in vessels with growing thrombi and atherosclerotic plaques or is caused by medical device implantation and intervention,promotes platelet aggregation and thrombus *** such situations,conventional antiplatelet drugs often have suboptimal efficacy and a serious side effect of excessive *** the mechanisms of platelet biomechanical activation provides insights distinct from the classic views of agonist-stimulated platelet thrombus *** this work,we review the recent discoveries underlying haemodynamic force-reinforced platelet binding and mechanosensing primarily mediated by three platelet receptors:glycoprotein Ib(GPIb),glycoprotein IIb/IIIa(GPIIb/IIIa)and glycoprotein VI(GPVI),and their implications for development of antithrombotic‘mechano-medicine’.

关键词： aggregation implantation primarily

Two-dimensional beam shaping and homogenization of high power laser diode stack with rectangular waveguide

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Frontiers of Optoelectronics 2019年第3期12卷 311-316页

作者： Yuchen SONG yunfeng chen Jianguo XIN Teng SUN School of Information and Electronics Beijing Institute of TechnologyBey ing 100081China

In this paper, the research work of twodimensional beam shaping and homogenization of high power laser diode (LD) stack by a rectangular waveguide is presented. Both the theoretical simulation and experiment results have shown that the diode stack beam can be shaped into a uniform square spot with a dimension of 10 mm×10 mm and the non-uniformity less than 5% along both directions of slow axis and fast axis, the shaped beam has a uniform pumping depth over 10 mm, which is well to be used for a rectangular laser medium end pumping.

关键词： beam shaping high power laser diode (LD) stack laser end pumping

Another strategy to assess sustainable development

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Ecological Economy 2006年第2期2卷 140-151页

作者： chen yunfeng Lu Genfa State Key Lab of Pollution Control and Resources Reuse School of Environment. Nanjing University Nanjing 210093 P.R. China

The goal of sustainoble development is to preserve sustainabitity trod simultaneously prevent catastrophe in a man-land .system. However, almost all the existing approaches to assessing sustainable development are to measure the sustainability. namely appraise from the obverse side of the sustainable development. So it seems necessary to attack the same task on the reverse, namely to measure the passibility of eatostrophe. In this paper, with a case study of Tianjin, China. we employ catastrophe theory and models to integrate Tianjin＇s sustainable development indicators, and then deduce the catastrophe risk index （ CRI） to present the level of catastrophic possibility in the city. Applying catastrophe theory, is a new strategy to assess sustainable development and shows great practical significance, especially for those developing regions or countries, who always give more priority to their economy and therefore have more obligation to make sure whether their social economic activities might bring forth any ecological environment catastrophe. Besides, being both qualitative and quantitative, the approach could be employed to explore not only static characteristics bat also dynamic mechanism of man-land system. Although our work is only a maiden attempt and still calls for further effort to improve it, the case study of Tianjin in this paper would assure as the great promising future to apply, catastrophe theory to sustoinable devetopment modeling,

关键词： Sastoinable development modeling Catastrophe theory Catastrophe sisk index (CRI) Man-land system

Co-composting of Chinese milk vetch with rice straw and using the compost as a peat substitute of seeding substrate of vegetables

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International Journal of Agricultural and Biological Engineering 2019年第1期12卷 214-220页

作者： yunfeng chen cheng Hu Donghai Liu Shuanglai Li Yan Qiao Key Laboratory of Fertilization from Agricultural Wastes Ministry of Agriculture and Rural AffairsWuhan 430064China Institute of Plant Protection and Soil Fertilizer Hubei Academy of Agricultural SciencesWuhan 430064China

Chinese milk vetch(Astragalussinicus L.)is an environment-friendly green manure used for rice with low carbon/nitrogen(C/N)ratio and high *** improve the added values of milk vetch,the feasibility of co-composting of milk vetch with rice straw was *** probability of using the milk vetch-based compost as a peat substitute in seeding substrate of vegetable was further *** changes in physicochemical properties during co-composting of milk vetch and rice straw were evaluated,depending on three treatments:(1)milk vetch alone(MV),(2)co-composting of milk vetch and rice straws with 4:1 ration(w/w)(MV+S)and(3)MV+S with the addition of 3%(w/w)microbial inoculation(MV+S+M).The entire composting durations were 15 d,24 d,and 24 d in MV,MV+S,MV+S+M *** to MV compost,both the MV+S,MV+S+M composts increased the temperature,pH,organic C,total nitrogen(N),total potassium(K)and the germination index(GI)(over 100)during the cooling/mature phase,and decreased total N loss,and generally,the improvements or reductions were greater in the MV+S+M compost than in the MV+S ***,the MV+S+M compost was added at a peat substitute rates of 0%,20%,40%,80%and 100%in a pot experiment to testify the utilization of milk vetch-based compost in *** results showed that the substrate with 40%substitute rate increased the cabbage seeding growth,and that the electrical conductivity was the limiting factor of preventing the substitute rate *** pot experiment demonstrated that the substrate with 40%peat substitute increased the cucumber growth as compared to the substrate without *** conclusion,the co-composting milk vetch with rice straw was feasible and quick,and microbial inoculation accelerated the composting process and improved the compost *** milk vetch-based composts were nutrient-rich and safe,and thus,can replace part of peat in vegetable seeding substrate.

关键词： Chinese milk vetch(Astragalussinicus L.) compost peat seeding substrate

Optimizing biochar addition for vermicomposting:a comprehensive evaluation of earthworms’activity,N_(2)O emissions and compost quality

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Biochar 2023年第1期5卷 59-70页

作者： Yupeng Wu Qinfen Li Yong Zheng Xingjun Xiong yunfeng chen Muhammad Shaaban Ronggui Hu College of Resources and Environment Huazhong Agricultural UniversityWuhan 430070China Institute of Environment and Plant Protection Chinese Academy of Tropical Agricultural SciencesHaikou 571158China Power China Kunming Engineering Corporation Limited Kunming 650051China Institute of Plant Protection and Soil Fertilizer Hubei Academy of Agricultural SciencesWuhan 430064China Department of Soil Science Bahauddin Zakariya UniversityMultan 60800Pakistan

Biochar addition has been widely used in the field to mitigate soil nitrous oxide(N_(2)O)emissions,and can be considered as a potential method to reduce N_(2)O emissions during ***,excessive biochar addition may inhibit earthworms’***,it is crucial to clarify the optimum addition volumes of biochar during *** study evaluated the impact of addition of various amounts of biochar(0,5,10,15,20 and 25%of total amount of feedstock)on earthworms’(Eisenia fetida)activity,N_(2)O emission and compost quality during *** with the treatment without biochar added,5%of biochar application significantly increased earthworm total biomass(from 177.5 to 202.2 g pot^(−1)),and cumulative burrowing activity(from 47.0%to 52.2%pixel per terrarium).The increased earthworms activity stimulated the vermicomposting process and led to the best quality of compost,which showed the highest total nutrient content(5.38%)and a significantly higher germination percentage of seeds(88%).Although N_(2)O emissions were slightly increased by 5%biochar addition,a nonsignificant difference was found between the treatment with 5%biochar and the treatment without biochar *** the contrary,20%and 25%biochar addition not only lowered N_(2)O emissions,but also significantly decreased the quality of *** results suggest that 5%biochar application is an appropriate amount to improve the quality of compost without significant N_(2)O emissions.

关键词： Earthworm Biochar addition Nitrous oxide Functional genes Burrowing activity

Academic Workshop of China Society of Desert in the Geographical Society of China successfully held in Changsha, Hunan Province

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Research in Cold and Arid Regions 2018年第6期10卷 522-524页

作者： Zhu, Qiang Tan, MingLiang chen, yunfeng Northwest Inst Ecoenvironm & Resources Gen Off Lanzhou Gansu Peoples R China

From October 26th to 27th, 2018, the Academic Workshop on Ecological Civilization and Green Development in Sandy Area, co-sponsored by China Society of Desert in the Geographical Society of China, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences (CAS), Key Laboratory of Desert and Desertification, CAS, Key Laboratory of Eco-hydrology of Inland River Basin, CAS, Shapotou Desert Research and Experiment Station,Naiman Desertification Research Station and Linze Inland River Basin Research Station, was successfully held in Changsha, Hunan Province.

关键词： Academic Workshop of China Society of Desert in the Geographical Society of China successfully held in Changsha Hunan Province

Toposelective synthesis under thermodynamic control and bioactivities of topoisomers based on diethoxycarbonyl glycoluril derivatives

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Chinese Science Bulletin 2006年第17期51卷 2164-2168页

作者： ZHOU Baohan YIN Guodong WANG Zhiguo chen yunfeng WU Anxin WAN Jian Key Laboratory of Pesticide and Chemical Biology Ministry of Education Department of Chemistry Central China Normal University Wuhan 430079 China

Six topoisomers consisting of diethoxy- carbonyl glycoluril have been successfully synthe- sized in one-pot by using a “figure-of-seven” building block through anti-connectivity and syn-connectivity reactions, respectively. The structures of all six topo- isomers were first determined by X-ray crystallogra- phy. The finding that (±) CT isomers are the dominant products under thermodynamic control can be ex- plained by the calculated relative energies of the six topoisomers. That the (±) CT isomers have the lowest energy is most likely due to the additional in- tramolecular electrostatic interactions between –NO2 and –OMe groups. The biological activities of the topoisomers were primitively investigated and the results of bioassay showed that the six topoisomers possessed obvious difference of herbicidal activity.

关键词：生物活性热力学控制生物化学 XRD

Kinetics study on the dissolution of UO_2 particles by microwave and conventional heating in 4 mol/L nitric acid

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Science China Chemistry 2008年第7期51卷 700-704页

作者： ZHAO yunfeng & chen Jing Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 102201, China Institute of Nuclear and New Energy Technology Tsinghua University Beijing China

The dissolution of UO2 particles in 4 mol·L-1 nitric acid medium at temperatures of 90-110℃ by mi- crowave heating and conventional heating has been investigated, respectively. It is found that the dissolution ratios of UO2 particles by microwave heating were 10%-40% higher than that by conven- tional heating. Kinetics research shows that the dissolution of UO2 particles in 4 mol·L-1 nitric acid is controlled by the diffusion control model for microwave heating and by the surface reaction control model for conventional heating. The diffusion control model for the dissolution of UO2 particles by mi- crowave heating could be explained by the diffuseness on the surface of UO2 particles.

关键词： uranium dioxide nitric acid dissolution microwave heating

Small extracellular vesicles secreted by urine-derived stem cells enhanced wound healing in aged mice by ameliorating cellular senescence

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Journal of Materials Science & Technology 2021年第4期63卷 216-227页

作者： Yongjin Sun Juntao Zhang Bi chen Yunlong Yang Haiyan Li Xin Niu Qing Li Weidong Wu Zongping Xie yunfeng chen Fuyue Wu Yang Wang Department of Orthopedic Surgery Institute of Microsurgery on ExtremitiesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Med-X Research Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Ruitai Biotechnology Co. LtdShanghai 201114China

Regeneration of chronic skin wounds in tissue is still a key challenge in regenerative medicine because of the accumulation of senescent cells and increasing secretion of s¨enescence-associated secretory phenotype(SASP)in the wound ***,some studies have reported that small extracellular vesicles(sEVs)derived from stem cells can alleviate cellular senescence with very low risk of tumorigenesis and immune *** our previous studies have shown that urine-derived stem cells(USCs)can be obtained easily and noninvasively and sEVs derived from USCs(USC-sEVs)have capabilities of regenerating tissue injuries,using USC-sEVs to enhance chronic skin wound healing in aged tissue might be a feasible and efficient ***,in this study,the USC-sEVs were collected and firstly loaded in a human acellular amniotic membrane(HAAM)for controlled releasing and locating the USC-sEVs in the wound site before they were implanted into a chronic skin wound in aged *** vivo results showed that the USC-sEVs in HAAM could effectively accelerate the wound healing by ameliorating cellular senescence and reducing the secretion of SASP in the aged skin *** elucidate the mechanism,USC-sEVs were used to in vitro culture human dermal fibroblasts(HDFs)and results showed that USC-sEVs could rejuvenate senescent fibroblasts by reversing the aging phenotypes of senescent HDFs and efficiently reducing the secretion of SASP after they activated the Sirt1 ***,USC-sEVs are efficient for enhancing wound healing in aged mice by ameliorating cellular senescence.

关键词： wound urine healing