Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine
作者机构：Molecular MedicineScripps Research InstituteLa JollaCaliforniaUSA School of Biomedical EngineeringHeart Research Institute and Charles Perkins CentreThe University of SydneyCamperdownNew South WalesAustralia
出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)
年 卷 期：2020年第5卷第2期
页 面：185-197页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by grants from Sydney Research Accelerator(SOAR)prize(L.A.J.) The Royal College of Pathologists of Australasia Kanematsu research award(L.A.J.) the Cardiac Society of Australia and New Zealand BAYER Young Investigator Research Grant(L.A.J.) We thank Zaverio Ruggeri,Yilong Wang,Liping Liu,Jing-fei Dong and Yi Qian for helpful discussion.Y.C.is a MERU(Medolago-Ruggeri)Foundation post-doctoral awardee.L.A.J.is an Australian Research Council DECRA fellow(DE190100609) a National Heart Foundation Future Leader fellow(102532)
主 题：aggregation implantation primarily
摘 要：Arterial thrombosis is in part contributed by excessive platelet aggregation,which can lead to blood clotting and subsequent heart attack and *** are sensitive to the haemodynamic *** haemodynamcis and disturbed blood flow,which occur in vessels with growing thrombi and atherosclerotic plaques or is caused by medical device implantation and intervention,promotes platelet aggregation and thrombus *** such situations,conventional antiplatelet drugs often have suboptimal efficacy and a serious side effect of excessive *** the mechanisms of platelet biomechanical activation provides insights distinct from the classic views of agonist-stimulated platelet thrombus *** this work,we review the recent discoveries underlying haemodynamic force-reinforced platelet binding and mechanosensing primarily mediated by three platelet receptors:glycoprotein Ib(GPIb),glycoprotein IIb/IIIa(GPIIb/IIIa)and glycoprotein VI(GPVI),and their implications for development of antithrombotic‘mechano-medicine’.
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