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Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics

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Acta Pharmaceutica Sinica B 2022年第12期12卷 4458-4471页

作者： qiang Niu Yu Liu Yujing Zheng Ziwei Tang yuna qian Ruogu Qi Jianliang Shen Ping Zhao School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityGuangzhou 510006China State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325027China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China

Pyroptosis provides a new window for relieving the tumor immunosuppressive microenvironment(TIM)and promoting systemic immune responses for tumor ***,gasdermin D(GSDMD),a key protein in the pyroptosis process mediated by caspase-1,is low expressed in the majority of tumor cells and small-molecule inhibitors of DNA methylation suffer from nonspecific or single-function *** address these issues,hexahistidine(His6)-metal assembly(HmA)was employed as the drug delivery vector to load nigericin(Nig)and decitabine(DAC)affording a dual-drug delivery system(Nig^(+)DAC)@***(Nig^(+)DAC)@HmA nanoparticles are efficiently internalized by cells through endocytosis,easily escape from the lysosome,and are highly distributed in the tumor *** up-regulates the expression of GSDMD which is then cleaved by the nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome and caspase-1 protein activated by *** cancer cell pyroptosis is thus achieved and induces a significant systemic antitumor immunity for impressive tumor suppression with negligible side effects in *** results suggest that such an easy-to-manipulate self-assembled nano-system(Nig^(+)DAC)@HmA provides a new anticancer path by enhancing pyroptosis through reinforced inflammation.

关键词： Self-assembled nanoparticle Pyroptosis NLRP3 GSDMD Inflammation IL-8 Immunotherapy responses Solid tumor

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Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

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Bioactive Materials 2021年第9期6卷 2647-2657页

作者： qiankun Zeng yuna qian Yijing Huang Feng Ding Xiaoliang Qi Jianliang Shen State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhouZhejiang325027China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325000China Department of Microbiology&Immunology School of Basic Medical SciencesWenzhou Medical UniversityWenzhouZhejiang325035China

Most commonly used wound dressings have severe problems,such as an inability to adapt to wound shape or a lack of antibacterial capacity,affecting their ability to meet the requirements of clinical ***,a nanocomposite hydrogel(XKP)is developed by introducing polydopamine nanoparticles(PDA NPs)into a food gum matrix(XK,consisting of xanthan gum and konjac glucomannan,both FDA-approved food thickening agents)for skin wound *** this system,the embedded PDA NPs not only interact with the food gum matrix to form a hydrogel with excellent mechanical strength,but also act as photothermal transduction agents to convert near-infrared laser radiation to heat,thereby triggering bacterial ***,the XKP hydrogel has high elasticity and tunable water content,enabling it to adapt to the shape of the wound and insulate it,providing a moist environment suitable for ***-vivo skin wound healing results clearly demonstrate that XKP can significantly accelerate the healing of wounds by reducing the inflammatory response and promoting vascular *** summary,this strategy provides a simple and practical method to overcome the drawbacks of traditional wound dressings,and provides further options when choosing suitable wound healing materials for clinical applications.

关键词： Wound healing Polydopamine nanoparticles Food gum hydrogel Shape adaptability Photothermal treatment

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Surface modification of electrospun fibers with mechano-growth factor for mitigating the foreign-body reaction

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Bioactive Materials 2021年第9期6卷 2983-2998页

作者： Yang Song Linhao Li Weikang Zhao yuna qian Lili Dong Yunnan Fang Li Yang Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083PR China Key Laboratory of Biorheological Science and Technology Ministry of EducationBioengineering CollegeChongqing UniversityChongqing400030PR China Department of Bioengineering University of CaliforniaLos AngelesCA90095USA Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001PR China

The implantation of synthetic polymeric scaffolds induced foreign-body reaction(FBR)seriously influence the wound healing and impair functionality recovery.A novel short peptide,mechano-growth factor(MGF),was introduced in this study to modify an electrospun polycaprolactone(PCL)fibrous scaffold to direct the macrophage phenotype transition and mitigate the *** vitro studies discovered the cell signal transduction mechanism of MGF regulates the macrophage polarization via the expression of related genes and *** found that macrophages response the MGF stimuli via endocytosis,then MGF promotes the histone acetylation and upregulates the STAT6 expression to direct an anti-inflammatory phenotype ***,an immunoregulatory electrospun PCL fibrous scaffold was modified by silk fibroin(SF)single-component layer-by-layer assembly,and the SF was decorated with MGF via click *** seeded on scaffold to identify the function of MGF modified scaffold in directing macrophage polarization in ***,rat subcutaneous implantation model and rat tendon adhesion model were performed to detect the immunomodulatory ability of the MGF-modified scaffold in *** results demonstrate that MGF-modified scaffold is beneficial to the transformation of macrophages to M2 phenotype in *** importantly,MGF-functionalized scaffold can inhibit the FBR at the subcutaneous tissue and prevent tissue adhesion.

关键词： Mechano-growth factor(MGF) Silk Macrophage polarization Foreign-body reactions(FBR) Electrospinning

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Solvent-mediated handedness inversed and amplified circularly polarized luminescence system based on camptothecin derivative

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Chinese Chemical Letters 2023年第2期34卷 188-192页

作者： Xuan Wu Ming Liu Cheng Zheng Yingying Wang Yujing Zheng yuna qian Zhiyong Liao Guoyong Fang Jianliang Shen Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China School of Ophthalmology and Optometry School of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325035China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001China College of Life and Environmental Science Wenzhou UniversityWenzhou 325000China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325000China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093China

To realize the handedness controllable circularly polarized luminescence(CPL) system remains challenging. Herein, the solvent-mediated CPL inversion and amplification systems were successfully constructed by camptothecin derivative(CPT-A). Due to the planar structure of N,N-dimethylformamide, it could coassemble with CPT-A, resulting in the alteration of g_(lum) from –0.0082 to +0.0085 by increasing water content. While in the non-planar solvent(hexafluoroisopropanol), the g_(lum) was amplified to 0.034 with the increase in water content. Moreover, the CPT-A could react with the glutathione, resulting in the anticancer drug CPT to make it more toxic to the cancer cells. Overall, the handedness controllable CPL systems were realized by tuning the supramolecular self-assembly of a prodrug.

关键词： Circularly polarized luminescence Chirality inversion and amplification Solvent-incorporated self-assembly Camptothecin derivative Stimuli-responsiveness

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Author correction to‘Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics’[Acta Pharm Sin B 12(2022)4458–4471]

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2359-2360页

The authors regret that there is an error in Fig.6 in the article due to the mistake of copying and pasting in the process of assemblingﬁgures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

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Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering

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Bioactive Materials 2021年第3期6卷 579-588页

作者： Ting Su Mengying Zhang qiankun Zeng Wenhao Pan Yijing Huang yuna qian Wei Dong Xiaoliang Qi Jianliang Shen State Key Laboratory of Ophthalmology Optometry and Vision ScienceSchool of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou325027China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou325001China School of Chemistry&Materials Engineering Fuyang Normal UniversityFuyang236037China School of Chemical Engineering Nanjing University of Science&TechnologyNanjing210094China

Polysaccharide hydrogels are widely used in tissue engineering because of their superior biocompatibility and low ***,many of these hydrogels are unrealistic for practical applications as the cost of raw materials is high,and the fabrication steps are *** study focuses on the facile fabrication and optimization of agarose-polydopamine hydrogel(APG)scaffolds for skin wound *** first study objective was to evaluate the effects of polydopamine(PDA)on the mechanical properties,water holding capacity and cell adhesiveness of *** observed that APG showed decreased rigidity and increased water content with the addition of *** importantly,decreased rigidity translated into significant increase in cell ***,the slow biodegradability and high biocompatibility of APG with the highest PDA content(APG3)was *** addition,APG3 promoted full-thickness skin defect healing by accelerating collagen deposition and promoting ***,we have developed a straightforward and efficient strategy to construct functional APG scaffold for skin tissue engineering,which has translation potentials in clinical practice.

关键词： Hydrogel Agarose Polydopamine Cell adhesion Tissue engineering

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Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics

Engineering Functional Inorganic-Organic Hybrid System Advan...

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2018年中西部地区无机化学化工学术研讨会

作者： yuna qian Zong-Wan Mao Jianliang Shen State Key Laboratory of Ophthalmology Optometry and Vision Science Wenzhou Medical University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-sen University Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Science

Cancer treatment still faces a lot of obstacles such as tumor heterogeneity, drug resistance and systemic toxicities. Beyond the traditional treatment modalities, exploitation of RNA interference（RNAi） as an emerging approach has immense potential for treatment various gene-caused diseases including cancer. The last decade has witnessed enormous research and achievements focused on RNAi biotechnology. However, delivery of small interference RNA（siRNA） remains a key challenge in the development of clinical RNAi therapeutics. Indeed, nanomaterials-formulated siRNA systems have potential applications for protection of siRNA from degradation, improving the accumulation in the target tissues, enhancing the siRNA therapy and reducing the side effects. Here, we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA therapeutics advancements. Inorganic-organic hybrid platforms as the vectors for siRNA delivery are promising to give credit to the interdisciplinary cooperation between inorganic, organic, biology and medicine.

关键词： Cancer RNA interference small interfering RNA delivery inorganic-organic hybrid nanoparticles

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Functional Inorganic-Organic Hybrid Nanomaterials for Theranostic Applications

Functional Inorganic-Organic Hybrid Nanomaterials for Theran...

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第十一届全国化学生物学学术会议

作者： yuna qian Zong-Wan Mao 沈建良 Wenzhou Institute University of Chinese Academy of Sciences MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yatsen University 中科院温州生物材料与工程研究所

Patients with cancer have limited treatment options,since some the diseases do not respond to endocrine or targeted *** 15% of breast cancers are classified as triple negative,which is a highly aggressive form of breast cancer that lacks expression of the estrogen receptor（ER）,progesterone receptor（PR）,and Her2/***,therapeutic options are limited for the TNBC patients as hormonal and targeted therapies cannot be ***,there is an urgent need to develop new therapeutic agents against ***,we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA,combination,theranostic therapeutics ***-organic hybrid platforms as the vectors for drug delivery are promising to give credit to the interdisciplinary cooperation between inorganic,organic,biology and medicine.

关键词： Cancer RNA interference Theranostic applications hybrid nanoparticles

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Functional Inorganic-Organic Hybrid Nanomaterials for Theranostic Applications

Functional Inorganic-Organic Hybrid Nanomaterials for Theran...

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中国化学会第十四届全国生物无机化学学术会议

作者： yuna qian Zong-Wan Mao 沈建良 Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Science MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-sen University State Key Laboratory of Ophthalmology Optometry and Vision Science Wenzhou Medical University

Patients with cancer have limited treatment options, since some the diseases do not respond to endocrine or targeted therapies. Approximately 15% of breast cancers are classified as triple negative, which is a highly aggressive form of breast cancer that lacks expression of the estrogen receptor（ER）, progesterone receptor（PR）, and Her2/neu. Therefore, therapeutic options are limited for the TNBC patients as hormonal and targeted therapies cannot be exploited. Accordingly, there is an urgent need to develop new therapeutic agents against TNBC. Here, we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA, combination, theranostic therapeutics advancements. Inorganic-organic hybrid platforms as the vectors for drug delivery are promising to give credit to the interdisciplinary cooperation between inorganic, organic, biology and medicine.

关键词： Cancer RNA interference Theranostic applications hybrid nanoparticles

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A theory on constructing blocked two-level designs with general minimum lower order confounding

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Frontiers of Mathematics in China 2016年第1期11卷 207-235页

作者： yuna ZHAO Shengli ZHAO Min-qian LIU LPMC and Institute of Statistics Nankai University Tianjin 300071 China School of Statistics Qufu Normal University Qufu 273165 China

Completely random allocation of the treatment combinations to the experimental units is appropriate only if the experimental units are homogeneous. Such homogeneity may not always be guaranteed when the size of the experiment is relatively large. Suitably partitioning inhomogeneous units into homogeneous groups, known as blocks, is a practical design strategy. How to partition the experimental units for a given design is an important issue. The blocked general minimum lower order confounding is a new criterion for selecting blocked designs. With the help of doubling theory and second order saturated design, we present a theory on constructing optimal blocked designs under the blocked general minimum lower order confounding criterion.

关键词： Aliased effect-number pattern general minimum lower orderconfounding second order saturated design Yates order

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