Solvent-mediated handedness inversed and amplified circularly polarized luminescence system based on camptothecin derivative

作     者：Xuan Wu Ming Liu Cheng Zheng Yingying Wang Yujing Zheng Yuna Qian Zhiyong Liao Guoyong Fang Jianliang Shen Xuan Wu;Ming Liu;Cheng Zheng;Yingying Wang;Yujing Zheng;Yuna Qian;Zhiyong Liao;Guoyong Fang;Jianliang Shen

作者机构：Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China School of Ophthalmology and OptometrySchool of Biomedical EngineeringWenzhou Medical UniversityWenzhou 325035China Oujiang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou 325001China College of Life and Environmental ScienceWenzhou UniversityWenzhou 325000China College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000China National Laboratory of Solid State MicrostructuresNanjing UniversityNanjing 210093China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第2期

页      面：188-192页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：the National Natural Science Foundation of China (No. 22101280) Wenzhou Medical University (No. KYYW201901) University of Chinese Academy of Science (Nos. WIBEZD201700103 and WIUCASQD2020005) Zhejiang Provincial Natural Science Foundation (No. LQ20B020009) for financial support 

主　　题：Circularly polarized luminescence Chirality inversion and amplification Solvent-incorporated self-assembly Camptothecin derivative Stimuli-responsiveness 

摘      要：To realize the handedness controllable circularly polarized luminescence(CPL) system remains challenging. Herein, the solvent-mediated CPL inversion and amplification systems were successfully constructed by camptothecin derivative(CPT-A). Due to the planar structure of N,N-dimethylformamide, it could coassemble with CPT-A, resulting in the alteration of g_(lum) from –0.0082 to +0.0085 by increasing water content. While in the non-planar solvent(hexafluoroisopropanol), the g_(lum) was amplified to 0.034 with the increase in water content. Moreover, the CPT-A could react with the glutathione, resulting in the anticancer drug CPT to make it more toxic to the cancer cells. Overall, the handedness controllable CPL systems were realized by tuning the supramolecular self-assembly of a prodrug.