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Inhibitory effects of prostaglandin E₁ on activation of hepatic stellate cells in rabbits with schistosomiasis

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 176-181页

作者： WeiLong Zou Zhen Yang yunjin zang DongJian Li ZhiPeng Liang ZhongYang Shen Institute of Transplantation General Hospital of the Chinese People's Armed Police Forces Beijing China. wlzouah@***

BACKGROUND: Liver fibrosis is the result of an imbalance between synthesis and degradation of extracellular matrix proteins of the liver. At the cellular and molecular levels, this progressive process is mainly characterized by activation of hepatic stellate cells (HSCs). Schistosoma japonica is one of the most prevalent causes of liver fibrosis in China. It is characterized by hepatocyte damage, inflammation, and chronic parasite egg-induced granuloma formation leading to fibrosis. This study aimed to investigate the inhibitory effects of prostaglandin E1 (PGE1) on activation of HSCs and the alteration of type Ⅰ and Ⅲ collagen in rabbits with schistosomiasis. The study may promote the clinical application of praziquantel and PGE1 as a combined therapy to reverse hepatic fibrosis caused by schistosomiasis. METHODS: Rabbits were percutaneously infected with cercaria of S. japonicum. Seven rabbits were subjected to intravenous injections of PGE1 (2.5 μg/kg daily) from days 60 to 120 after infection. The ultrastructural changes in activated HSCs were observed under transmission electron microscopy. The expression of α-smooth muscle actin (α-SMA) was detected by immunohistochemistry. Fibril-forming collagens were detected by picrosirius staining. RESULTS: Activation of HSCs was a characteristic alteration in schistosome-induced hepatic fibrosis. The expression of contraction-related α-SMA and thecontent of collagens were increased. Exogenous PGE1 markedly inhibited the activation of HSCs and reduced the expression of α-SMA around the hepatic sinusoids (P<0.01). The contents of type Ⅰ and Ⅲ collagens were significantly attenuated. The ratio of staining area to the whole field (10×3.3) under a polarized light microscope in the untreated and treated groups was 37.25±9.71 vs. 13.38±4.24 (P<0.01) and 9.66±3.52 vs. 6.23±1.81 (P<0.05), respectively. CONCLUSIONS: Activation of HSCs may play a key role in the progress of schistosome-induced hepatic fibrosis. PGE1 effect

关键词： hepatic fibrosis schistosome hepatic stellate cells prostaglandin E1 fibril-forming collagen

劈离式肝移植术后成功妊娠分娩1例并文献复习

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精准医学杂志 2024年第1期39卷 67-70页

作者：赵柳徐琳刘虹郭源李志强蔡金贞臧运金饶伟青岛大学附属医院器官移植中心肝脏病中心山东青岛266100 青岛大学移植医学研究所青岛大学附属医院产科

目的探讨劈离式肝移植(SLT)术后患者妊娠分娩的临床管理经验。方法收集1例我院器官移植中心收治的SLT术后妊娠并成功分娩患者的临床资料,并复习相关文献。结果患者因“自身免疫性肝炎后肝硬化(失代偿期)”接受同种异体原位SLT,术后出现... 详细信息

目的探讨劈离式肝移植(SLT)术后患者妊娠分娩的临床管理经验。方法收集1例我院器官移植中心收治的SLT术后妊娠并成功分娩患者的临床资料,并复习相关文献。结果患者因“自身免疫性肝炎后肝硬化(失代偿期)”接受同种异体原位SLT,术后出现轻度急性排斥反应,经调整免疫抑制药物治疗后好转。患者术后2年自然妊娠,因既往服用麦考酚钠肠溶片,选择终止妊娠并停用该药。术后3年再次妊娠并出现移植物波动,予调整抗排异药物剂量、保肝对症治疗、先兆早产保胎治疗等处理,最终在肝移植科、产科和新生儿科等相关学科共同指导下,于孕35周剖宫产诞下1名健康女婴。结论SLT受者虽然孕期可能出现移植物功能波动、早产等情况,但在多学科共同合作、科学指导用药及密切随访监测下,亦可以获得满意预后。

关键词：肝移植预后妊娠免疫抑制剂移植物排斥肝功能不全

Analysis of photocatalytic degradation of polyamide microplastics in metal salt solution by high resolution mass spectrometry

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Journal of Environmental Sciences 2024年第5期139卷 473-482页

作者： yunjin Zhong Lebing Zhuo Wangyang Lu National Engineering Lab for Textile Fiber Materials&Processing Technology(Zhejiang) School of Materials Science&EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

Microplastic pollution has become one of the most concerned focuses in the *** many treatment methods,photocatalysis is considered to be one of the most environmentally friendly *** this work,the photodegradation behavior of polyamide microplastics is studied by using polyamide 6(PA6)as model microplastics and FeCl_(3) as *** is hoped that the PA6 fiber can be effectively degraded by utilizing the strong oxidizing active species that can be produced after FeCl_(3) is irradiated in *** results shows that PA6 fiber can be almost completely degraded after 10 days of irradiation in FeCl_(3) aqueous solution,indicating that it is promising to use this new method to solve the problem of PA6type *** addition,the chain scission mechanism and degradation process of PA6 are analyzed in detail by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS),which provides a new insight for the study of polymer degradation mechanism.

关键词： FeCl_(3) Photocatalysis Polyamide 6 Chain scission

Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 172-179页

作者： Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi yunjin zang Jingyu Cao Liqun Wu Liver Disease Center Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Hepatobiliary Surgery Affiliated Hospital of Jining Medical UniversityJiningChina Department of Hepatobiliary&Pancreatic Surgery Affiliated Hospital of Qingdao UniversityQingdaoChina OrigiMed ShanghaiChina Contributions:(I)Conception and design

Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer *** many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully ***:A total of 165 HCC patients,including 146 males and 19 females,were *** median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene *** alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were *** mutational burden(TMB)was measured by an algorithm developed *** top quartile of HCC was classified as TMB ***:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC *** values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/*** most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and *** was the most common mutation type and C:G>T:A and guanine transformation were the most common *** to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TE

关键词： Hepatocellular carcinoma(HCC) gene mutation next-generation sequencing(NGS) pathological features

Granger causal representation learning for groups of time series

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Science China(Information Sciences) 2024年第5期67卷 56-68页

作者： Ruichu CAI yunjin WU Xiaokai HUANG Wei CHEN Tom Z.J.FU Zhifeng HAO School of Computer Science Guangdong University of Technology Peng Cheng Laboratory College of Science Shantou University

Discovering causality from multivariate time series is an important but challenging *** existing methods focus on estimating the Granger causal structures among multivariate time series,while ignoring the prior knowledge of these time series, e.g., the group of the time series. Focusing on discovering the Granger causal structures among groups of time series, we propose a Granger causal representation learning method to solve this problem. First, we use the multiset canonical correlation analysis method to learn the Granger causal representation of each group of time series. Then, we model the Granger causal relationships among the learned Granger causal representations using a recurrent neural network with temporal information. Finally, we formulate the above two stages into one unified optimization problem, which is efficiently solved using the augmented Lagrangian method. We conduct extensive experiments on synthetic and real-world datasets to validate the correctness and effectiveness of the proposed method.

关键词： Granger causal discovery Granger causal representation learning time series data recurrent neural network multiset canonical correlation analysis

中国肝移植术后新发消化系统恶性肿瘤文献分析报告

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器官移植 2020年第2期11卷 265-270页

作者：姜晓青张群解曼孔心涓臧运金饶伟青岛大学附属医院消化内科 266000 青岛大学附属医院器官移植中心青岛大学附属医院肝脏病中心青岛大学移植医学研究所

目的探讨我国肝移植(LT)术后新发消化系统恶性肿瘤的情况。方法检索万方数据、中国知网及维普资讯三大中文数据库中的相关文献。检索时间从各数据库建库至2019年5月9日。中文检索词为“肝移植+术后/新发+恶性肿瘤/癌”。分析我国LT术后... 详细信息

目的探讨我国肝移植(LT)术后新发消化系统恶性肿瘤的情况。方法检索万方数据、中国知网及维普资讯三大中文数据库中的相关文献。检索时间从各数据库建库至2019年5月9日。中文检索词为“肝移植+术后/新发+恶性肿瘤/癌”。分析我国LT术后新发消化系统恶性肿瘤受者的年龄分布、性别构成、新发肿瘤的诊断时间和累及器官、治疗及预后。结果经过筛选最终纳入文献16篇,LT后新发消化系统恶性肿瘤47例,男性受者居多;年龄51(23~65)岁,以中年(45~59岁)最多;术后新发消化系统恶性肿瘤的平均确诊时间为43(2~156)个月,以术后1~3年内发生的例数最多;结肠和胃是最为常见的肿瘤发生部位;治疗主要以手术联合放射治疗和化学药物治疗居多,但LT术后新发消化系统恶性肿瘤总体预后不佳,病死率高达51%。结论我国LT术后新发消化系统恶性肿瘤以结肠癌和胃癌为主,新发肿瘤的患者总体预后不佳,应重视术后的监测和预防。

关键词：肝移植新发恶性肿瘤消化系统结肠癌胃癌文献分析

ECMO联合CRRT技术在脑死亡伴心肺功能不全供者器官功能维护中的应用

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中华器官移植杂志 2019年第5期40卷 293-297页

作者：赵明坤许传屾王峰臧运金青岛大学附属医院器官移植中心 266003

目的探讨体外膜肺氧合(ECMO)联合连续性肾脏替代治疗(CRRT)技术对于捐献前出现心肺功能不全的脑死亡器官捐献者肝功能的维护作用,提高边缘性捐献者肝的利用率。方法收集并分析2015年7月至2017年5月应用ECMO联合CRRT技术进行器官功能维护... 详细信息

目的探讨体外膜肺氧合(ECMO)联合连续性肾脏替代治疗(CRRT)技术对于捐献前出现心肺功能不全的脑死亡器官捐献者肝功能的维护作用,提高边缘性捐献者肝的利用率。方法收集并分析2015年7月至2017年5月应用ECMO联合CRRT技术进行器官功能维护的5例心肺功能不全的脑死亡器官捐献者的临床资料及相应受者的临床资料。观察维护前后捐献者血压变化、血管活性药物使用剂量变化及肝、肾功能的变化以及尿量的改变情况,观察对应肝移植受者术后肝功能的恢复情况,并与18例非边缘性捐献者及接受其肝脏的受者术后肝脏功能恢复情况相比较。结果应用ECMO联合CRRT技术维护后,捐献者的血压由维护前血容量充足情况下大剂量升压药物也无法维持在高于90/60 mmHg达到100~140/60~90 mmHg,并且应用血管活性药物剂量明显减少,尿量较维护前上升。通过维护后4例捐献者肝脏可以使用,1例因总胆红素过高弃用。共获取4个肝脏,10个肾脏,对应的肝移植受者肝功能在术后与对照组受者无明显差异。结论应用ECMO联合CRRT技术可以改善伴有心肺功能不全的潜在捐献者供肝质量,提高器官捐献率和利用率。

关键词：体外膜肺氧合连续性肾脏替代治疗脑死亡器官捐献肝移植

探讨PBL和角色扮演用于传染病学临床见习教学中效果

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中国继续医学教育 2016年第21期8卷 14-15页

作者：王璐林栋栋臧运金首都医科大学附属北京佑安医院普外中心北京100069

目的探讨PBL和角色扮演用于传染病学临床见习教学中的效果。方法从首都医科大学传染病学系本科见习生中随机抽取100名作为此次研究的对象,分为研究组、常规组,每组50名见习生;研究组采取PBL联合角色扮演的教学模式,常规组实施常规临床... 详细信息

目的探讨PBL和角色扮演用于传染病学临床见习教学中的效果。方法从首都医科大学传染病学系本科见习生中随机抽取100名作为此次研究的对象,分为研究组、常规组,每组50名见习生;研究组采取PBL联合角色扮演的教学模式,常规组实施常规临床间隙教学模式,结束教学之后借助理论考试与技能操作考核两组临床见习生的专业知识,并采取不记名的方式进行问卷调查,对比两组教学效果。结果研究组学生理论及技能测试、问卷调查情况等优于常规组,两组各项满意度对比,差异具有统计学意义(P<0.05)。结论 PBL与角色扮演模式能够全面提高传染病学临床见习生学习的积极性,帮助其更好地学习传染科疾病理论知识与技能操作。

关键词： PBL教学角色扮演传染病学见习教学效果

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肝移植受者幽门螺杆菌感染诊治的临床实践

中华肝胆外科杂志 2021年第5期27卷 331-334页

作者：解曼齐兴四李晓宇郭源朱晓丹田字彬臧运金饶伟青岛大学附属医院消化内科青岛266000 青岛大学附属医院器官移植中心肝脏病中心

目的分析肝移植受者幽门螺杆菌(Hp)感染的情况,并初步探讨肝移植术后Hp根除治疗的临床实践。方法以2018年7月至2019年10月青岛大学附属医院器官移植中心规律门诊随访的130例肝移植受者为研究对象,其中男性104例,女性26例,平均年龄52.1岁... 详细信息

目的分析肝移植受者幽门螺杆菌(Hp)感染的情况,并初步探讨肝移植术后Hp根除治疗的临床实践。方法以2018年7月至2019年10月青岛大学附属医院器官移植中心规律门诊随访的130例肝移植受者为研究对象,其中男性104例,女性26例,平均年龄52.1岁,纳入移植组。按年龄和性别1∶3进行倾向性评分匹配,纳入390例健康体检者,其中男性299例,女性91例,平均年龄51.8岁,纳入对照组。所有入选者均行^(13)C尿素呼气试验,分析肝移植受者Hp感染和四联疗法根除情况。结果肝移植受者^(13)C尿素呼气试验阳性率18.5%(24/130),低于对照组36.4%(142/390),差异有统计学意义(χ^(2)=14.400,P3年的受者呼气试验阳性率分别为14.3%(6/42)、17.8%(8/45)、23.2%(10/43),呈升高趋势,但差异无统计学意义(χ^(2)=1.321,P=0.517)。共有17例(70.8%,17/24)Hp阳性肝移植受者接受根除Hp治疗,成功率为100.0%(17/17),其中10例受者完整监测治疗过程中免疫抑制剂的血药浓度,治疗过程中免疫抑制剂血药浓度是治疗前的1.7~3.6倍,免疫抑制剂减量至治疗前的1/3~1/2。7例受者出现头痛、高血压、失眠和情绪激动等药物相关不良反应。受者肝肾功能无明显波动。结论肝移植术后受者的Hp感染率为18.5%,四联疗法根除Hp治疗的效果较好,治疗过程中应注意调整免疫抑制剂剂量。

关键词：肝移植幽门螺杆菌根除治疗免疫抑制剂