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Analysis of photocatalytic degradation of polyamide microplastics in metal salt solution by high resolution mass spectrometry

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Journal of Environmental Sciences 2024年第5期139卷 473-482页

作者： yunjin Zhong Lebing Zhuo Wangyang Lu National Engineering Lab for Textile Fiber Materials&Processing Technology(Zhejiang) School of Materials Science&EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

Microplastic pollution has become one of the most concerned focuses in the *** many treatment methods,photocatalysis is considered to be one of the most environmentally friendly *** this work,the photodegradation behavior of polyamide microplastics is studied by using polyamide 6(PA6)as model microplastics and FeCl_(3) as *** is hoped that the PA6 fiber can be effectively degraded by utilizing the strong oxidizing active species that can be produced after FeCl_(3) is irradiated in *** results shows that PA6 fiber can be almost completely degraded after 10 days of irradiation in FeCl_(3) aqueous solution,indicating that it is promising to use this new method to solve the problem of PA6type *** addition,the chain scission mechanism and degradation process of PA6 are analyzed in detail by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS),which provides a new insight for the study of polymer degradation mechanism.

关键词： FeCl_(3) Photocatalysis Polyamide 6 Chain scission

Inhibitory effects of prostaglandin E₁ on activation of hepatic stellate cells in rabbits with schistosomiasis

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 176-181页

作者： WeiLong Zou Zhen Yang yunjin zang DongJian Li ZhiPeng Liang ZhongYang Shen Institute of Transplantation General Hospital of the Chinese People's Armed Police Forces Beijing China. wlzouah@***

BACKGROUND: Liver fibrosis is the result of an imbalance between synthesis and degradation of extracellular matrix proteins of the liver. At the cellular and molecular levels, this progressive process is mainly characterized by activation of hepatic stellate cells (HSCs). Schistosoma japonica is one of the most prevalent causes of liver fibrosis in China. It is characterized by hepatocyte damage, inflammation, and chronic parasite egg-induced granuloma formation leading to fibrosis. This study aimed to investigate the inhibitory effects of prostaglandin E1 (PGE1) on activation of HSCs and the alteration of type Ⅰ and Ⅲ collagen in rabbits with schistosomiasis. The study may promote the clinical application of praziquantel and PGE1 as a combined therapy to reverse hepatic fibrosis caused by schistosomiasis. METHODS: Rabbits were percutaneously infected with cercaria of S. japonicum. Seven rabbits were subjected to intravenous injections of PGE1 (2.5 μg/kg daily) from days 60 to 120 after infection. The ultrastructural changes in activated HSCs were observed under transmission electron microscopy. The expression of α-smooth muscle actin (α-SMA) was detected by immunohistochemistry. Fibril-forming collagens were detected by picrosirius staining. RESULTS: Activation of HSCs was a characteristic alteration in schistosome-induced hepatic fibrosis. The expression of contraction-related α-SMA and thecontent of collagens were increased. Exogenous PGE1 markedly inhibited the activation of HSCs and reduced the expression of α-SMA around the hepatic sinusoids (P<0.01). The contents of type Ⅰ and Ⅲ collagens were significantly attenuated. The ratio of staining area to the whole field (10×3.3) under a polarized light microscope in the untreated and treated groups was 37.25±9.71 vs. 13.38±4.24 (P<0.01) and 9.66±3.52 vs. 6.23±1.81 (P<0.05), respectively. CONCLUSIONS: Activation of HSCs may play a key role in the progress of schistosome-induced hepatic fibrosis. PGE1 effect

关键词： hepatic fibrosis schistosome hepatic stellate cells prostaglandin E1 fibril-forming collagen

Granger causal representation learning for groups of time series

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Science China(Information Sciences) 2024年第5期67卷 56-68页

作者： Ruichu CAI yunjin WU Xiaokai HUANG Wei CHEN Tom Z.J.FU Zhifeng HAO School of Computer Science Guangdong University of Technology Peng Cheng Laboratory College of Science Shantou University

Discovering causality from multivariate time series is an important but challenging *** existing methods focus on estimating the Granger causal structures among multivariate time series,while ignoring the prior knowledge of these time series, e.g., the group of the time series. Focusing on discovering the Granger causal structures among groups of time series, we propose a Granger causal representation learning method to solve this problem. First, we use the multiset canonical correlation analysis method to learn the Granger causal representation of each group of time series. Then, we model the Granger causal relationships among the learned Granger causal representations using a recurrent neural network with temporal information. Finally, we formulate the above two stages into one unified optimization problem, which is efficiently solved using the augmented Lagrangian method. We conduct extensive experiments on synthetic and real-world datasets to validate the correctness and effectiveness of the proposed method.

关键词： Granger causal discovery Granger causal representation learning time series data recurrent neural network multiset canonical correlation analysis

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劈离式肝移植术后成功妊娠分娩1例并文献复习

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精准医学杂志 2024年第1期39卷 67-70页

作者：赵柳徐琳刘虹郭源李志强蔡金贞臧运金饶伟青岛大学附属医院器官移植中心肝脏病中心山东青岛266100 青岛大学移植医学研究所青岛大学附属医院产科

目的探讨劈离式肝移植(SLT)术后患者妊娠分娩的临床管理经验。方法收集1例我院器官移植中心收治的SLT术后妊娠并成功分娩患者的临床资料,并复习相关文献。结果患者因“自身免疫性肝炎后肝硬化(失代偿期)”接受同种异体原位SLT,术后出现... 详细信息

目的探讨劈离式肝移植(SLT)术后患者妊娠分娩的临床管理经验。方法收集1例我院器官移植中心收治的SLT术后妊娠并成功分娩患者的临床资料,并复习相关文献。结果患者因“自身免疫性肝炎后肝硬化(失代偿期)”接受同种异体原位SLT,术后出现轻度急性排斥反应,经调整免疫抑制药物治疗后好转。患者术后2年自然妊娠,因既往服用麦考酚钠肠溶片,选择终止妊娠并停用该药。术后3年再次妊娠并出现移植物波动,予调整抗排异药物剂量、保肝对症治疗、先兆早产保胎治疗等处理,最终在肝移植科、产科和新生儿科等相关学科共同指导下,于孕35周剖宫产诞下1名健康女婴。结论SLT受者虽然孕期可能出现移植物功能波动、早产等情况,但在多学科共同合作、科学指导用药及密切随访监测下,亦可以获得满意预后。

关键词：肝移植预后妊娠免疫抑制剂移植物排斥肝功能不全

Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 172-179页

作者： Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi yunjin zang Jingyu Cao Liqun Wu Liver Disease Center Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Hepatobiliary Surgery Affiliated Hospital of Jining Medical UniversityJiningChina Department of Hepatobiliary&Pancreatic Surgery Affiliated Hospital of Qingdao UniversityQingdaoChina OrigiMed ShanghaiChina Contributions:(I)Conception and design

Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer *** many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully ***:A total of 165 HCC patients,including 146 males and 19 females,were *** median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene *** alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were *** mutational burden(TMB)was measured by an algorithm developed *** top quartile of HCC was classified as TMB ***:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC *** values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/*** most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and *** was the most common mutation type and C:G>T:A and guanine transformation were the most common *** to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TE

关键词： Hepatocellular carcinoma(HCC) gene mutation next-generation sequencing(NGS) pathological features

中国肝移植术后新发消化系统恶性肿瘤文献分析报告

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器官移植 2020年第2期11卷 265-270页

作者：姜晓青张群解曼孔心涓臧运金饶伟青岛大学附属医院消化内科 266000 青岛大学附属医院器官移植中心青岛大学附属医院肝脏病中心青岛大学移植医学研究所

目的探讨我国肝移植(LT)术后新发消化系统恶性肿瘤的情况。方法检索万方数据、中国知网及维普资讯三大中文数据库中的相关文献。检索时间从各数据库建库至2019年5月9日。中文检索词为“肝移植+术后/新发+恶性肿瘤/癌”。分析我国LT术后... 详细信息

目的探讨我国肝移植(LT)术后新发消化系统恶性肿瘤的情况。方法检索万方数据、中国知网及维普资讯三大中文数据库中的相关文献。检索时间从各数据库建库至2019年5月9日。中文检索词为“肝移植+术后/新发+恶性肿瘤/癌”。分析我国LT术后新发消化系统恶性肿瘤受者的年龄分布、性别构成、新发肿瘤的诊断时间和累及器官、治疗及预后。结果经过筛选最终纳入文献16篇,LT后新发消化系统恶性肿瘤47例,男性受者居多;年龄51(23~65)岁,以中年(45~59岁)最多;术后新发消化系统恶性肿瘤的平均确诊时间为43(2~156)个月,以术后1~3年内发生的例数最多;结肠和胃是最为常见的肿瘤发生部位;治疗主要以手术联合放射治疗和化学药物治疗居多,但LT术后新发消化系统恶性肿瘤总体预后不佳,病死率高达51%。结论我国LT术后新发消化系统恶性肿瘤以结肠癌和胃癌为主,新发肿瘤的患者总体预后不佳,应重视术后的监测和预防。

关键词：肝移植新发恶性肿瘤消化系统结肠癌胃癌文献分析

资本嵌入与互助共享：政策试验何以推动城市社区治理创新——基于“时间银行”的案例考察

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城市发展研究 2024年第2期31卷 98-105页

作者：邹昀瑾郭彬陈功清华大学公共管理学院北京大学人口研究所

时间银行作为一种以社会力量志愿互助服务为特征的试验改革，正成为增进公共利益和推动城市社区治理创新的重要平台。基于社会资本理论，选取上海、深圳、杭州三地的典型案例，构建“资本嵌入—互助共享”的解释性框架，论证了政策试验... 详细信息

时间银行作为一种以社会力量志愿互助服务为特征的试验改革，正成为增进公共利益和推动城市社区治理创新的重要平台。基于社会资本理论，选取上海、深圳、杭州三地的典型案例，构建“资本嵌入—互助共享”的解释性框架，论证了政策试验中的资本嵌入以及主体间的互助共享何以推进治理创新这一命题。研究发现：政府主导共享型时间银行，依托党建引领搭建共治平台，嵌入结构型社会资本促进资源流通和志愿参与；公益组织主导共享型时间银行，采用双向循环激励模式，嵌入认知型社会资本促进价值认同，提升居民归属感；社会企业主导共享型时间银行，利用数字科技为平台赋能，嵌入关系型社会资本建立系统的风险规避机制。进一步归纳提炼出三种运作逻辑：党建引领—资源流通、双向循环—晋升激励、智慧赋能—风险规避，以此阐释政策试验推动城市社区治理创新的运作逻辑。本研究为政策试验的理解注入了新的理论解读，也对时间银行的实践创新提供了有益的参考。

关键词：时间银行治理创新资本嵌入互助共享政策试验

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政策试验的合作生产与技术赋能路径

东南学术 2024年第3期 161-171页

作者：邹昀瑾郭彬陈功清华大学公共管理学院北京大学人口研究所

政策试验是推动新时代治理创新和公共政策优化的重要举措。以时间银行为代表的政策试验可以缓解基层社区治理中结构性传导阻滞和自治能力弱等问题。合作生产与技术赋能作为时间银行政策试验的过程范式,是当前建设基层治理共同体、完善... 详细信息

政策试验是推动新时代治理创新和公共政策优化的重要举措。以时间银行为代表的政策试验可以缓解基层社区治理中结构性传导阻滞和自治能力弱等问题。合作生产与技术赋能作为时间银行政策试验的过程范式,是当前建设基层治理共同体、完善网格化管理和信息化支撑的一种探索。合作生产促进了政策试验中政府与公民等多元主体的有效协作,而技术赋能为合作生产提供了创新工具,使得服务再生产过程更加高效、透明和包容。当前在政策试验中合作生产与技术赋能主要有引领型、互动型、协调型三种实践路径,在社区治理中发挥积极作用。因此,未来实践应重视技术在促进多元主体协作、提高服务效率等方面的潜力。

关键词：政策试验合作生产技术赋能时间银行治理创新

电厂汽轮机水环式真空泵真空度降低的原因及处理措施

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现代制造技术与装备 2024年第2期60卷 163-165,169页

作者：吴运金国能(泉州)热电有限公司泉州362804

电厂汽轮机的高效运行依赖于良好的真空系统,其中水环式真空泵是真空系统的核心设备之一。在实际运行过程中,真空泵往往会出现真空度降低的问题,直接影响汽轮机的运行效率和电厂的整体安全性。基于此,探讨水环式真空泵真空度降低的主要... 详细信息

电厂汽轮机的高效运行依赖于良好的真空系统,其中水环式真空泵是真空系统的核心设备之一。在实际运行过程中,真空泵往往会出现真空度降低的问题,直接影响汽轮机的运行效率和电厂的整体安全性。基于此,探讨水环式真空泵真空度降低的主要原因,并提出相应的处理措施及其效果评估方法。通过对真空度降低问题的分析,为电厂汽轮机真空系统的优化提供有价值的参考。

关键词：水环式真空泵真空度降低处理措施汽轮机