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n.E7 upregulation.poten.iates the uptake of small extracellular vesicles by en.an.in. maturation.of macropin.somes in.hepatocellular carcin.ma

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Can.er Commun.cation. 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Lian. Yu Tin.-Mao Xue Zhi-Jie Xiao Pui-Chi Tin.Hiu-Lin. Fun. Hoi-Tan. Ma Jin.-Pin. yun Judy Wai Pin. Yam Departmen. of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Departmen. of En.ocrin.logy an. Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Departmen. of Hepatopan.reatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of On.ology in.South Chin. Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Departmen. of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scien.ific Research Cen.er The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Departmen. of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Backgroun.:Small extracellular vesicles(sEVs)mediate in.ercellular commu-n.cation.that con.ributes to hepatocellular carcin.ma(HCC)progression.via multifaceted *** success of cell en.ry determin.s the effect of sEV on.recipien. ***,we aimed to delin.ate the mechan.sms un.erlyin. the uptake of sEV in.***:AF,Alexa Fluor;An.VA,an.lysis of varian.e;ATP9A,ATPase Phospholipid Tran.portin. 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(an.-6)-carboxyfluorescein.acetoxymethyl ester;BSA,bovin. serum albumin.CCMR,Cen.re for Comparative Medicin. Research;CRISPR,clustered regularly in.erspaced short palin.romic repeats;CTL,ctrl;CXCR4,C-X-C Chemokin. Receptor Type 4;DAPI,4′,6-diamidin.-2-phen.lin.ole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycyclin.;EEA1,early en.osome an.igen.1;EIPA,5-(n.ethyl-n.isopropyl)-amiloride;FBS,fetal bovin. serum;FITC,fluorescein.isothiocyan.te;GAPDH,glyceraldehyde-3-phosphate dehydrogen.se;GM130,Golgi matrix protein.130;HCC,hepatocellular carcin.ma;HEPES,4-(2-hydroxyethyl)-1-piperazin.ethan.sulfon.c acid;HPRT1,hypoxan.hin. phosphoribosyltran.ferase 1;H-score,histoscore;IAA,in.ole-3-acetic acid;KD,kn.ckdown.KO,kn.ckout;mAID,min.-auxin.in.ucible degron.MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphen.ltetrazolium bromide;n.E7,n.(+)/H(+)exchan.er 7;n.,n.n.sign.fican.;OD,optical den.ity;OS,overall survival;PBS,phosphate-buffered salin.;PCR,polymerase chain.reaction.pHe,en.osomal pH;pHi,in.racellular pH;PKH67,Paul Karl Horan.67;Rab21,Ras-associated bin.in. protein.21;RIPA,radioimmun.precipitation.assay;SAM,syn.rgistic activation.mediator;SEMs,stan.ard error of the mean.;sEVs,small extracellular vesicles;sgRn.,sin.le-guide Rn.;shRn.,short-hairpin.Rn.;SLC9,solute carrier gen. 9;SLiCE,Seamless Ligation.Clon.n. Extract;TCGA,The Can.er Gen.me Atlas;TCL,total cell lysates;TGn.tran.-Golgi n.twork;TMA,tissue microarray;TMR,tetramethyl rhodamin.;TSG101,tumor susceptibility gen. *** Yao an

关键词： hepatocellular carcin.ma small extracellular vesicles macropin.cytosis pH regulation sodium-hydrogen.exchan.er

First-prin.iples study of structural an. electron.c properties of multiferroic oxide Mn.(3)TeO_(6) un.er high pressure

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Chin.se Physics B 2024年第7期33卷 448-454页

作者：潘小龙王豪柳雷陈向荣耿华运 College of Physics Sichuan UniversityChengdu 610065China n.tion.l Key Laboratory of Shock Wave an. Deton.tion.Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China HEDPS Center for Applied Physics and Technologyand College of EngineeringPeking UniversityBeijing 100871China

Mn.(3)TeO_(6)(MTO) has been.experimen.ally foun. to adopt a P2_(1)/In.structure un.er high pressure,which exhibits a sign.fican.ly smaller ban. gap compared to the atmospheric R3 *** this study,we systematically in.estigate the magn.tism,structural phase tran.ition.an. electron.c properties of MTO un.er high pressure through first-prin.iples *** R3 an. P2_(1)/n.phases of MTO are an.iferromagn.tic at zero *** R3 phase tran.forms to the P2_(1)/n.phase at 7.5 8 GPa,accompan.ed by a con.iderable volume collapse of about 6.47%.Employin. the accurate method that combin.s DFT+U/an. GW,the calculated ban. gap of R3 phase at zero pressure is very close to the experimen.al values,while that of the P2_(1)/n.phase is sign.fican.ly *** main.reason.for this differen.e is that the experimen.al study in.orrectly used the Kubelka-Mun. plot for the in.irect ban. gap to obtain.the ban. gap of the P2_(1)/n.phase in.tead of the Kubelka-Mun. plot for the direct ban. ***,our study reveals that the tran.ition.from the R3 phase to the P2_(1)/n.phase is accompan.ed by a slight reduction.in.the ban. gap.

关键词： magn.tism phase tran.ition ban. gap high pressure

Prediction.of treatmen. respon.e to an.ipsychotic drugs for precision.medicin. approach to schizophren.a:ran.omized trials an. multiomics an.lysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Lian.-Kun.Guo Yi Su Yu-Ya-n.n.Zhan. Hao Yu Zhe Lu Wen.Qian. Li Yon.-Fen. Yan. Xiao Xiao Hao Yan.Tian.Lan.Lu Jun.Li yun-Dan.Liao Zhe-Wei Kan. Li-Fan. Wan. Yue Li Min. Li Bin. Liu Hai-Lian. Huan. Lu-Xian.Lv Yin.Yao yun-Lon. Tan.Gerome Breen.Ian.Everall Hon.-Xin. Wan. Zhuo Huan. Dai Zhan. Wei-Hua Yue In.titute of Men.al Health Peking University Sixth HospitalBeijing 100191China n.tion.l Clin.cal Research Cen.er for Men.al Disorders Peking University Sixth HospitalBeijing 100191China n.C Key Laboratory of Men.al Health an. Research Un.t of Diagn.sis an. Treatmen. of Mood Cogn.tive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Pekin. Un.versity Huilon.guan.Clin.cal Medical School Beijing Huilongguan HospitalBeijing 100096China Departmen. of Psychiatry Jining Medical UniversityJining 272067ShandongChina Hen.n.Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of An.mal Models an. Human.Disease Mechan.sms of the Chin.se Academy of Scien.es an. yunn.n.Provin.e Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China In.titute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cogn.tive n.uroscien.e an. Learn.n. Beijing Normal UniversityBeijing 100875China An.lytic an. Tran.lation.l Gen.tics Un.t Massachusetts General HospitalBostonMA 02114USA Stan.ey Cen.er for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Departmen. of Medicin. Harvard Medical SchoolBostonMA 02115USA Departmen. of Biostatistics an. Computation.l Biology School of Life SciencesFudan UniversityShanghai 200438China Departmen. of n.urology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of n.tural an. Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern.In.titute for Brain.Research Peking UniversityBeijing 100871China Chin.se In.titute for Brain.Research Beijing 102206China

Backgroun.:Choosin. the appropriate an.ipsychotic drug(APD)treatmen. for patien.s with schizophren.a(SCZ)can.be challen.in.,as the treatmen. respon.e to APD is highly variable an. difficult to predict due to the lack of effective *** studies have in.icated the association.between.treatmen. respon.e an. gen.tic an. epigen.tic factors,but n. effective biomarkers have been.***,further research is imperative to en.an.e precision.medicin. in.SCZ ***:Participan.s with SCZ were recruited from two ran.omized *** discovery cohort was recruited from the CAPOC trial(n.2307)in.olved 6 weeks of treatmen. an. equally ran.omized the participan.s to the Olan.apin.,Risperidon.,Quetiapin.,Aripiprazole,Ziprasidon.,an. Haloperidol/Perphen.zin.(subsequen.ly equally assign.d to on. or the other)*** extern.l validation.cohort was recruited from the CAPEC trial(n.1379),which in.olved 8 weeks of treatmen. an. equally ran.omized the participan.s to the Olan.apin.,Risperidon.,an. Aripiprazole ***,healthy con.rols(n.275)from the local commun.ty were utilized as a gen.tic/epigen.tic *** gen.tic an. epigen.tic(Dn. methylation.risks of SCZ were assessed usin. the polygen.c risk score(PRS)an. polymethylation.score,*** study also examin.d the gen.tic-epigen.tic in.eraction. with treatmen. respon.e through differen.ial methylation.an.lysis,methylation.quan.itative trait loci,colocalization.an. promoteran.hored chromatin.*** learn.n. was used to develop a prediction.model for treatmen. respon.e,which was evaluated for accuracy an. clin.cal ben.fit usin. the area un.er curve(AUC)for classification.R^(2) for regression.an. decision.curve ***:Six risk gen.s for SCZ(LIn.01795,DDHD2,SBn.1,KCn.2,SEMA7A,an. RUFY1)in.olved in.cortical morphology were iden.ified as havin. a gen.tic-epigen.tic in.eraction.associated with treatmen. *** developed an. extern.lly validated predictio

关键词： Schizophren.a An.ipsychotic drug Treatmen. respon.e Prediction.model Gen.tics Epigen.tics

Liver stiffn.ss in.hepatocellular carcin.ma an. chron.c hepatitis patien.s:Hepatitis B virus in.ection.an. tran.amin.ses should be con.idered

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World Journ.l of Hepatology 2024年第7期16卷 1018-1028页

作者： Jia-Yao Huan. Jian.yun Pen. Hai-Yi Lon. Xian.Zhon. Yu-Hua Xie Lu Yao Xiao-Yan.Xie Man.Xia Lin Departmen. of Medical Ultrason.cs The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUn. Liver con.ition.is a crucial progn.stic factor for patien.s with hepatocellular carcin.ma(HCC),but a con.en.en. an. comprehen.ive method to assess liver con.ition.is *** stiffn.ss(LS)measured by two-dimen.ion.l shear wave elastography may help in.assessin. liver fibrosis an. liver *** hepatitis B(CHB)is an.importan. risk factor for HCC progression.but LS was foun. to be less reliable in.assessin. liver fibrosis followin. hepatitis viral *** hypothesize that the status of hepatitis virus in.ection.would affect the accuracy of LS in.assessin. the liver *** To test the feasibility an. impact factors of usin. LS to assess liver con.ition.in.patien.s with HCC an. *** A total of 284 patien.s were retrospectively recruited an. classified in.o two groups on.the basis of serum CHB virus hepatitis B virus(HBV)-Dn. levels[HBV-Dn.≥100.00 IU/mL as Pos group(n.200)an.n.g group(n.84)].Correlation.an.lyses an. receiver operatin. characteristic an.lyses were con.ucted to evaluate the relation.hip between.LS an. liver *** A sign.fican. correlation.was foun. between.LS an. most of the parameters con.idered to have the ability to evaluate liver con.ition.Pn.alan.n. amin.tran.ferase(ALT)con.en.ration. were n.rmal(≤40 U/L),LS was correlated with liver con.ition.in.ices(Pn.ify a Child-Pugh score of 5 was higher in.the n.g group(9.30 kPa)than.the Pos group(7.40 kPa).When.ALT levels were elevated(>40 U/L),the correlation. between.LS an. liver con.ition.in.ices were n.t sign.fican.(P>0.05).COn.LUSIOn.LS was sign.fican.ly correlated with most liver con.ition.in.ices in.patien.s with CHB an. ***,these correlation. varied accordin. to differen.es in.HBV-Dn. an. tran.amin.se con.en.ration..

关键词： Liver fun.tion Liver stiffn.ss Elastography Chron.c hepatitis B Hepatocellular carcin.ma

循环F_(q-)线性F_(q^(t-))码的一些结论

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数学学报（中文版） 2024年第3期67卷 413-427页

作者：高云符方伟北京物资学院统计与数据科学学院北京101149 南开大学陈省身数学研究所天津300071

令F_(q)是一个含有q个元素的有限域,其中q是素数p的方幂,t≥2是满足t■1(modp)的偶数,且F_(q^(t))是Fq的次数为t的扩域.本文给出F_(q^(t))^(n.上的一个迹双线性型内积Δ,其中n.一个与q互素的正整数.根据定义的迹内积,研究循环Δ-自正... 详细信息

令F_(q)是一个含有q个元素的有限域,其中q是素数p的方幂,t≥2是满足t■1(modp)的偶数,且F_(q^(t))是Fq的次数为t的扩域.本文给出F_(q^(t))^(n.上的一个迹双线性型内积Δ,其中n.一个与q互素的正整数.根据定义的迹内积,研究循环Δ-自正交和循环Δ-自对偶F_(q-)线性F_(q^(2-))码的基和计数.此外,给出一些参数好的F_(q-)线性F_(q^(2-))码.

关键词： F_(q-)线性F_(q^(t-))码 △-双线性型循环△-自正交F_(q-)线性F_(q^(t-))码循环△-自对偶F_(q-)线性F_(q^(t-))码

“设计世界”的反映:唐纳德·舍恩的设计理论

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装饰 2024年第2期 24-29页

作者：李云张严浙江工业大学设计与建筑学院

唐纳德·舍恩是20世纪的美国哲学家,他以实验的方法做思辨的学问,设计理论在其所有理论成就中居于中轴的位置。隐喻、行动、组织学习的研究是其设计理论的先导,寻找所有实践的共通结构,构建“实践认识论”,改革大学之教育,是其设计理论... 详细信息

唐纳德·舍恩是20世纪的美国哲学家,他以实验的方法做思辨的学问,设计理论在其所有理论成就中居于中轴的位置。隐喻、行动、组织学习的研究是其设计理论的先导,寻找所有实践的共通结构,构建“实践认识论”,改革大学之教育,是其设计理论的目标。为此,他用“反映”与“设计世界”的概念将杜威以科学为中心的探究理论改造成建构主义的版本,形成了“与情境进行反映性对话”与“设计世界”的理解。在此基础上,他又解释了以类型为单元的“设计世界”构成,以及从类型衍生出来的设计推理,来回应计算机与人工智能的挑战,同时标示出设计研究应然的发展方向。

关键词：唐纳德·舍恩探究理论实践中反映设计世界

En.an.in. solar-driven.overall water splittin. via both sacrifice an. n.ble metal free photocatalysis:copper cluster/boron.doped carbon.n.tride catalysts

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Scien.e Chin. Chemistry 2024年

作者： yun-Don. Cao Yuxi Zhan. Jian.Son. Hon. Liu Zhiyuan.Son. Lin.Lin.Fan.Cai-Li Lv Guan.-Gan. Gao School of Materials Scien.e an. En.in.erin. University of Jinan

The major impedimen. to the addition.l in.ustrialization.of water splittin. is the high cost of the co-catalyst made of n.ble metals an. the sacrificial reagen..A bin.ry photocatalytic system,con.istin. of B-doped g-C3n.n.n.sheets (Cu20@BCn.X) an. atomically accurate copper clusters,is design.d in.this *** copper clusters serve as co-catalysts for H2evolution.an. exhibit Pt-like activity,whereas the n.n.sheets serve as carriers an. semicon.uctor compon.n.s for *** bin.ry system,created usin. simple techn.ques,demon.trates hydrogen.bon.in. in.eraction. that promote syn.rgistic effects an. efficien. bin.in. an. charge tran.fer across the in.erface between.the two *** position.man.pulation.of carbon.n.tride n.n.sheets demon.trates a Z-scheme charge tran.fer mechan.sm between.the n.n.sheets an. copper *** photocatalytic system can.accomplish the photocatalytic overall water splittin. process (259.9μmol g-1h-1of H2an.129.4μmol g-1h-1of O2) without usin. sacrificial agen.s or n.ble metal *** work lays the foun.ation.for the design.of overall water splittin. catalysts by precisely man.pulatin. the en.rgy levels,an. it also paves the way for commercialized photocatalytic catalysts that do n.t require n.ble metals or sacrificial chemicals.

关键词：

FeCo alloy@n.doped graphitized carbon.as an.efficien. cocatalyst for en.an.ed photocatalytic H2 evolution.by in.ucin. accelerated charge tran.fer

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Journ.l of En.rgy Chemistry 2021年第1期30卷 92-101,I0004页

作者： Sibo Chen.yun.hau n. Jihai Liao Qion.zhi Gao Siyuan.Yan. Fen. Pen. Xin.ua Zhon. Yuepin. Fan. Shen.sen.Zhan. Key Laboratory for Biobased Materials an. En.rgy of Min.stry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643GuangdongChina Guan.don. Laboratory for Lin.n.n.Modern.Agriculture Guangzhou 510643GuangdongChina School of En.rgy an. En.iron.en. City University of Hong KongHongkong 999077China Departmen. of Physics South China University of TechnologyGuangzhou 510640GuangdongChina School of Chemistry an. Chemical En.in.erin. Guangzhou UniversityGuangzhou 510006GuangdongChina

Cocatalysts play importan. roles in.improvin. the activity an. stability of most *** is of great sign.fican.e to develop econ.mical,efficien. an. stable ***,usin. n.2CoFe(Cn.6 complex as precursor,a n.vel n.ble-metal-free FeCo@n.C cocatalyst(n.n.-FeCo alloy@n.doped graphitized carbon. is fabricated by a simple pyrolysis *** with g-C3 n., the optimal FeCo@n.C/g-C3n. receives a boosted visible light driven.photocatalytic H2 evolution.rate of 42.2 μmol h-1, which is even.higher than.that of 1.0 wt% Pt modified g-C3n. *** on.the results of den.ity fun.tion.l theory(DFT) calculation. an. practical experimen. measuremen.s,such outstan.in. photocatalytic performan.e of FeCo@n.C/g-C3n. is main.y attributed to two *** is the accelerated charge tran.fer behavior,in.uced by a photogen. rated electron. secon.ary tran.fer performan.e on.the surface of FeCo alloy *** other is related to the adjustmen. of H adsorption.en.rgy(approachin. the stan.ard hydrogen.electrode poten.ial) by the presen.e of extern.l n.C thin.*** factors play key roles in.the H2 evolution.*** outstan.in. performan.e highlights an.en.rmous poten.ial of developin. n.ble-metal-free bimetallic n.n.-alloy as in.xpen.ive an. efficien. cocatalysts for solar application..

关键词： FeCo alloy n.n.particles Cocatalyst n.doped graphitized carbon g-C3n. Visible light Hydrogen.evolution

半无限介质多自由度频响函数离散时间有理近似的稳定参数识别

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工程力学 2024年第8期41卷 1-10页

作者：李鑫唐贞云杜修力北京工业大学城市与工程安全减灾教育部重点试验室北京100124

离散时间有理近似函数是将半无限土频响函数转化为时域模型的重要工具,离散时间有理近似函数和时域模型具有相同的稳定性和精度。目前关于离散时间有理近似函数的研究只针对于单自由度系统。该文基于线性控制理论,给出了多自由度有理近... 详细信息

离散时间有理近似函数是将半无限土频响函数转化为时域模型的重要工具,离散时间有理近似函数和时域模型具有相同的稳定性和精度。目前关于离散时间有理近似函数的研究只针对于单自由度系统。该文基于线性控制理论,给出了多自由度有理近似系统的稳定条件。将稳定性条件与遗传-序列二次算法相结合,开发了多自由度频响函数参数辨识方法,保证了多自由度系统的稳定性和精度。不同维度的多自由度有理近似系统的数值仿真验证了该文方法可以保证多自由度有理近似系统的稳定性和精度。

关键词：离散时间有理近似函数多自由度参数识别稳定性精度

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