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Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong

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Journal of Pharmaceutical Analysis 2024年第2期14卷 225-243页

作者： Bingjia Zhao Qian Zhang Yiqian He weifang Cao wei song Xiaochun Liang Department of Traditional Chinese Medicine Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China Institute of Basic Medicine Sciences Chinese Academy of Medical SciencesBeijing100005China Medical Research Center Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing100730China

Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes, for which effective therapies are currently lacking. Disturbed energy status plays a crucial role in DPN pathogenesis. However, the integrated profile of energy metabolism, especially the central carbohydrate metabolism, remains unclear in DPN. Here, we developed a metabolomics approach by targeting 56 metabolites using high-performance ion chromatography-tandem mass spectrometry (HPIC-MS/MS) to illustrate the integrative characteristics of central carbohydrate metabolism in patients with DPN and streptozotocin-induced DPN rats. Furthermore, JinMaiTong (JMT), a traditional Chinese medicine (TCM) formula, was found to be effective for DPN, improving the peripheral neurological function and alleviating the neuropathology of DPN rats even after demyelination and axonal degeneration. JMT ameliorated DPN by regulating the aberrant energy balance and mitochondrial functions, including excessive glycolysis restoration, tricarboxylic acid cycle improvement, and increased adenosine triphosphate (ATP) generation. Bioenergetic profile was aberrant in cultured rat Schwann cells under high-glucose conditions, which was remarkably corrected by JMT treatment. In-vivo and in-vitro studies revealed that these effects of JMT were mainly attributed to the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and downstream peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Our results expand the therapeutic framework for DPN and suggest the integrative modulation of energy metabolism using TCMs, such as JMT, as an effective strategy for its treatment.

关键词： Diabetic peripheral neuropathy JinMaiTong Energy metabolism Targeted metabolomics Adenosine monophosphate-activated protein kinase

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Method for detector description conversion from DD4hep to Filmbox

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Nuclear Science and Techniques 2024年第9期35卷 115-126页

作者： Zhao-Yang Yuan Tian-Zi song Yu-Jie Zeng Kai-Xuan Huang Yu-Mei Zhang Zheng-yun You School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

DD4hep serves as a generic detector description toolkit recommended for offline software development in next-generation high-energy physics(HEP)***,Filmbox(FBX)stands out as a widely used 3D modeling file format within the 3D software *** this paper,we introduce a novel method that can automatically convert complex HEP detector geometries from DD4hep description into 3D models in the FBX *** feasibility of this method was dem-onstrated by its application to the DD4hep description of the Compact Linear Collider detector and several sub-detectors of the super Tau-Charm facility and circular electron-positron collider *** automatic DD4hep–FBX detector conversion interface provides convenience for further development of applications,such as detector design,simulation,visualization,data monitoring,and outreach,in HEP experiments.

关键词： Detector description DD4hep FBX Geometry Offline software

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Optimization of the co-closing law of guide vanes and blades for bulb turbines based on CFD

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Journal of Hydrodynamics 2024年第2期36卷 363-377页

作者： Hui Liu yun-fa Lin Yong-guang Cheng song Xue Mao-jia Tang Jian Zhang Jia-yi Fan State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China Dongfang Electric Machinery Co. Ltd.Deyang618000China

The load rejection transient process of bulb turbine units is critical to safety of hydropower stations,and determining appropriate closing laws of guide vanes(GVs)and runner blades(RBs)for this process is of *** this study,we proposed a procedure to optimize the co-closing law of GVs and RBs by using computational fluid dynamics(CFD),combined with the design of experiment(DOE)method,approximation model,and genetic optimization *** sensitivity of closing law parameters on the histories of head,speed,and thrust was analyzed,and a two-stage GVs’closing law associating with a linear RBs’closing law was *** results show that GVs dominate the transient characteristics by controlling the change of *** GVs’first-stage closing speed while shortening first-stage closing time can not only significantly reduce the maximum rotational speed but also suppress the water hammer pressure;slowing GVs’second-stage closing speed is conducive to controlling the maximum reverse axial *** directly affect the runner *** RBs’closing speed can further reduce the rotational speed and the maximum reverse axial *** safety margin of each control parameter,flow patterns,and pressure pulsations of a practical hydropower station were all improved after optimization,demonstrating the effectiveness of this method.

关键词： Bulb turbine load rejection transient process double regulation closing law optimization computational fluid dynamics(CFD)

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Improving flight performance of UAVs by ice shape modulation

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Chinese Journal of Aeronautics 2024年第8期37卷 49-62页

作者： Jiajun ZHANG Xuecheng LIU Hua LIANG Like XIE Biao wei Haohua ZONG yun WU Yinghong Li National Key Lab of Aerospace Power System and Plasma Technology Air Force Engineering UniversityXi’an 710038China Institute of Aero-Engine School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

Aircraft icing poses a great threat to flight *** response to the characteristics of high-power consumption,large volume,and heavy weight of traditional anti-/de-icing technologies,the concept of ice shape modulation is proposed,which is called ice tolerant ***,the flight performance of Unmanned Aerial Vehicle(UAV)was compared in three states:no ice,full ice,and modulated ice through flight *** was found that ice shape modulation has a significant improvement effect on the aerodynamic performance of aircraft under icing *** the three modulated ice shape conditions in this experiment,the lift coefficient of the UAV under different ice shape modulation conditions increased by 18%–33%,and the stalling angle was delayed by 3°-5°.Subsequently,the pressure distribution,streamlines in the flow field,and detached vortex distribution of the UAV model in these three states were obtained through numerical simulation,to study the mechanism of ice shape modulation on the aerodynamic performance of *** simulation found that the reason for the improvement of the wings effect after ice shape modulation is that the modulated area forms a leading-edge protrusion structure similar to a vortex *** structure prolongs the mixed flow region on the wings surface and reduces the trend of flow separation,which plays a role in increasing lift and reducing drag for UAVs under icing ***,a reverse reachable set that can be used for unexpected state recovery is used as the definition of flight safety boundaries,and an aircraft dynamics model is established to obtain flight safety boundaries for different *** has found that the flight safety boundary of the UAV in a no ice state is greater than that in a modulated ice state,and the safety boundary in a modulated ice state is greater than that in a full ice *** with the full ice state,the flight safety boundary after modulation has expanded by 27.0%.The sch

关键词： Ice shape modulation Aerodynamic performance Reachable set Flight safety UAV

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Remarkably Enhanced Methane Sensing Performance at Room Temperature via Constructing a Self-Assembled Mulberry-Like ZnO/SnO_(2) Hierarchical Structure

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Energy & Environmental Materials 2024年第3期7卷 337-344页

作者： Xun Li Tian Tan wei Ji Wanling Zhou Yuwen Bao Xiaohong Xia Zhangfan Zeng yun Gao Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science&EngineeringHubei UniversityWuhan 430062China School of Artificial Intelligence Hubei UniversityWuhan 430062China

Development of metal oxide semiconductors-based methane sensors with good response and low power consumption is one of the major challenges to realize the real-time monitoring of methane *** this work,a self-assembled mulberry-like ZnO/SnO_(2)hierarchical structure is constructed by a two-step hydrothermal *** resultant sensor works at room temperature with excellent response of~56.1%to 2000 ppm CH_(4)at 55%relative *** is found that the strain induced at the ZnO/SnO_(2)interface greatly enhances the piezoelectric polarization on the ZnO surface and that the band bending results in the accumulation of chemically adsorbed O_(2)^(-)ions close to the interface,leading to significant improvement in the sensing performance of the methane gas sensor at room temperature.

关键词： heterojunction methane sensor oxygen vacancy piezoelectric polarization ZnO/SnO_(2)hierarchical structure

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Molecular-scale co-assembly membranes derived from keplerate cluster:carbonic anhydrase-mimicking nanocapsules for enhanced CO_(2)/N_(2)separation

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Science China Chemistry 2024年第10期67卷 3271-3282页

作者： Wan-Lei Zhao Hongqiang Li Ruoxuan Zheng Yixin Yang wei Chen Yu-Fei song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000China

The development of CO_(2)separation membranes with high permeability and high selectivity,as well as ultra-thin selective layers,has always been ***,a molecular-scaled co-assembly strategy is employed to fabricate the Pebax-Mo_(132)(Pebax=polyether-block-amide copolymer;Mo_(132)=(NH_(4))_(42)[Mo_(72)^(Ⅵ)Mo_(60)^(Ⅴ)O_(372)(CH_(3)COO)_(30)(H_(2)O)_(72)])*** optimal selfstanding membrane,Pebax-Mo_(132)-5%,shows a CO_(2)permeability of~384 Barrer and an ultra-high ideal CO_(2)/N_(2)selectivity of~244,outperforming most membranes reported in the *** CO_(2)permeability and ideal CO_(2)/N_(2)selectivity are increased by 70%and 367%,respectively,compared with the pristine Pebax membrane.A thin-film composite membrane prepared by spin-coating technique on a support membrane with gutter layers also exhibits a CO_(2)permeance of 838 GPU and a CO_(2)/N_(2)selectivity of *** excellent performance can be attributed to the following reasons:(1)strong hydrogen bonding interactions between{Mo_(132)}clusters and Pebax confer excellent interfacial compatibility to the mixed matrix membranes;(2)incorporation of hollow{Mo_(132)}clusters into the Pebax molecular chain decreases the crystallinity of Pebax,and thereby accelerates the chain dynamics and increases the free volume of the membrane;(3)in situ diffuse reflectance infrared Fouriertransform spectroscopy demonstrates that the{Mo_(132)}clusters can effectively catalyze the hydration reaction of CO_(2)and promote the transport of CO_(2);(4)furthermore,the 0.35 nm pores of the crown ether-type{Mo_(9)O_(9)}allow the accurate size sieving of CO_(2)(0.33 nm)and N_(2)(0.36 nm)molecules.

关键词： polyoxometalates molecular-scale assembly CO_(2)capture mixed matrix membranes

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Hypoxia-induced nuclear localization of ubiquinol-cytochrome-c reductase complex assembly factor 3(UQCC3)in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3173-3175页

作者： yun Yang Yinhao wei Yiying Sun Yong Zhou Hanshuo Yang Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041China

Dear Editor,The mitochondrion plays crucial roles in cellular energy generation and signaling *** studies have shown that nuclear-encoded mitochondrial proteins translocate into the nucleus to regulate cell function a... 详细信息

关键词： hepatocellular retrograde communicate

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Porous nanocomposites with enhanced intrinsic piezoresistive sensitivity for bioinspired multimodal tactile sensors

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Microsystems & Nanoengineering 2024年第1期10卷 243-256页

作者： Jianpeng Zhang song wei Caichao Liu Chao Shang Zhaoqiang He Yu Duan Zhengchun Peng State Key Laboratory of Radio Frequency Heterogeneous Integration(Shenzhen University) School of Physics and Optoelectronic EngineeringShenzhen University518060 ShenzhenGuangdong ProvinceP.R.China Linksense Technology Ltd. 518060 ShenzhenGuangdong ProvinceP.R.China

In this work,we propose porous fluororubber/thermoplastic urethane nanocomposites(PFTNs)and explore their intrinsic piezoresistive sensitivity to *** experiments reveal that the intrinsic sensitivity of the PFTN-based sensor to pressure up to 10 kPa increases up to 900%compared to the porous thermoplastic urethane nanocomposite(PTN)counterpart and up to 275%compared to the porous fluororubber nanocomposite(PFN)*** pressures exceeding 10 kPa,the resistance-pressure relationship of PFTN follows a logarithmic function,and the sensitivity is 221%and 125%higher than that of PTN and PFN,*** the excellent intrinsic sensitivity of the thick PFTN film,a single sensing unit with integrated electrode design can imitate human skin for touch detection,pressure perception and traction *** sensing range of our multimodal tactile sensor reaches~150 Pa,and it exhibits a linear fit over 97%for both normal pressure and shear *** also demonstrate that an electronic skin,made of an array of sensing units,is capable of accurately recognizing complex tactile interactions including pinch,spread,and tweak motions.

关键词： sensation intrinsic modal

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A Design of 2-Stage Voltage Ramp-Up SRAM Physical Unclonable Function

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Chinese Journal of Electronics 2024年第2期33卷 371-379页

作者： Minte song Nan LIU Shuaiyang ZHOU Zhengguang WANG Zhanqiang RU Peng DING wei HUANG Helun song School of Nano-Tech and Nano-Bionics University of Science and Technology of China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences

Silicon physical unclonable function（PUF） implemented by static random access memory（SRAM）exists inherent demerit of unstable cells due to noise of environment and circuits, which significantly restricts its reproducibility. In this paper, a 16T SRAM cell with reset-delay circuit and a 2-stage voltage ramp up is fabricated and reported. Compared to conventional SRAM structure, each PUF cell adds a pair of pull-up PMOS（P-channel metal oxide semiconductor） and pull-down NMOS（N-channel metal oxide semiconductor） controlled by reset and delayedreset signals respectively, resulting in two positive feedback stages with different amplification coefficients when the voltage is ramped up. PUF array consists of 4064 cells, 322 dummy cells and a group of 8 series-connected inverters with an area of 304 μm × 650 μm to match the digital post-processing module. PUF test chip was fabricated in HHGrace 110 nm platform with total area 1140 × 1140 μm2. The average HDintra（intra-chip Hamming distance, also bit error rate, BER） and HDinter（inter-chip Hamming distance） values of the 50 PUF chips in SOP16 package measured at normal point（1.5 V/25 ℃） were 1.92% and 49.85%, respectively.

关键词： Semiconductor device measurement Circuits Bit error rate Metals Aging Physical unclonable function Reproducibility of results

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Investigation of improving the thermophysical properties and corrosion resistance of RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates by component design with RE doping

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Journal of Advanced Ceramics 2024年第6期13卷 842-860页

作者： Zeyu Chen Yiling Huang Zhaoxuan Zhang wei Zheng Xuemei song Yaran Niu Yi Zeng The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

In this research,a novel method for regulating components in RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates was developed,combining the benefits of a suitable thermal expansion coefficient(CTE)and outstanding corrosion resistance against calcium–magnesium–alumino–silicate(CMAS).This approach enhanced the overall thermophysical ***,the results from the CMAS corrosion resistance test indicated that(Lu_(1/3)Yb_(1/3)Tm_(1/3))_(2)SiO_(5)/(Lu_(1/3)Yb_(1/3)Tm_(1/3))_(2)Si_(2)O_(7)and(Lu_(1/4)Yb_(1/4)Tm_(1/4)Er_(1/4))_(2)SiO_(5)/(Lu_(1/4)Yb_(1/4)Tm_(1/4)Er_(1/4))_(2)Si_(2)O_(7)exhibited exceptional resistance to CMAS penetration,even at temperatures up to 1500℃.To comprehend the corrosion mechanism of CMAS on these silicates,we introduced a reaction–diffusion model,which involved observing the changes in the interface between the corrosion product layer and the silicate *** was achieved using electron backscatter diffraction(EBSD).These findings lay a theoretical basis for selecting rare earth elements in RE_(2)SiO_(5)/RE_(2)Si_(2)O_(7)multiphase silicates based on the radii of different rare earth cations.

关键词： thermal conductivity environmental barrier coatings(EBCs) thermal expansion coefficient(CTE) multiphase silicates calcium-magnesium-alumino-silicate(CMAS)corrosion resistance reaction-diffusion

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