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Study on Effect of Anxious Emotion of the Female Who Enter IVF-ET Treatment Cycle on Treatment Outcome

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Journal of Reproduction and Contraception 2009年第4期20卷 211-216页

作者： Xiao-yu YANG yun-shan zhang Di LU Ming QIAN Nursing Department Tianjin Medical College Tianjin 300222 China Center for Reproductive Medicine Tianjin Central Hospital for Obstetrics & Gynecology Tianjin 300052 China Department of Medicial Psychology Tianjin Medical University Tianjin 300070 China

Objective To detect effect of anxious emotion of the female who enter IVF-ET treatment cycle on treatment outcome.Methods Ninety infertilio, women who joined in IVF-ET treatment were collected and they were tested with the State-Trait Anxiety Form at the day entering treatment cycle, with State Anxiety Form at 1 h before oocyte retrieval and 12 d after ET waiting for blood β-hCG result.Results The average of trait anxiety score （38.5） was used to divide patients into two groups. There were significant differences in state anxiety at the first and second test points between high score group （39.9 ± 7.8, 41.5 ± 11.2） and low score group （33.1 ±6.9, 33.7 ±8.1）, but there was no difference at the third point. At three test points, the changes of state anxiety in high-trait anxiety score group showed no difference, but in low-trait anxiety score group there was higher level at the third point than at the first point （38.4 ± 10.6 vs 32.7 ±7.4）（P〈0.05）. Compared variables of psychology, the results demonstrated that trait anxiety, score of success group （β-hCG〉 25 IU/L 12 d after IVF-ET） was higher than that of failure group （40.9 ± 9.2 vs 36.8 ± 7.6）（P〈0.05）.Conclusion Trait anxiety, may be one of mental influential factors on treatment outcome.

关键词： IVF-ET state anxiety trait anxiety treatment outcome

High-speed directly modulated distributed feedback laser based on detuned loading and photon-photon resonance effect

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Chinese Physics B 2023年第9期32卷 274-281页

作者：张云山徐逸帆郑吉林李连艳方涛陈向飞 College of Electronic and Optical Engineering&College of Flexible Electronics Nanjing University of Posts and TelecommunicationsNanjing 210023China College of Communications Engineering PLA Army Engineering UniversityNanjing 210007China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210023China

A monolithic integrated two-section distributed feedback(TS-DFB)semiconductor laser for high-speed direct modulation is proposed and analyzed *** grating structure of the TS-DFB laser is designed by the reconstructionequivalent-chirp(REC)technique,which can reduce the manufacturing cost and difficulty,and achieve high wavelength controlling *** detuned loading effect and the photon-photon resonance(PPR)effect are utilized to enhance the modulation bandwidth of the TS-DFB laser,exceeding 37 GHz,while that of the conventional one-section DFB laser is only 16 *** the bit rate of the non-return-to-zero(NRZ)signal reaches 55 Gb/s,a clear eye diagram with large opening can still be *** results show that the proposed method can enhance the modulation bandwidth of DFB laser significantly.

关键词： directly modulated laser(DML) detuned loading effect photon-photon resonance(PPR)effect reconstruction-equivalent-chirp(REC)technique

Chinese and western medicine research progress in child adenoviral pneumonia

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Journal of Hainan Medical University 2020年第22期26卷 65-70页

作者： Yue Ma shan-yun zhang Han Kong Juan-Juan Diao shandong University of Traditional Chinese Medicine Jinan 250014China Affiliated Hospital of shandong University of Traditional Chinese Medicine Jinan 250011China

Adenoviral pneumonia is one of the more serious types of community-acquired pneumonia in *** easily develops into severe pneumonia with many extrapulmonary complications and a high mortality ***,there is still no effective treatment for *** drugs are conducive to clinical *** Chinese medicine often achieves satisfactory results through staged syndrome ***,heat,sputum,stasis,and poison are considered to be the main pathological ***,phlegm,and stasis are present in its *** the progress of traditional Chinese and western medicine in children's adenoviral pneumonia,and have a clearer understanding of the law of syndrome differentiation and its prescription medication,providing ideas for clinical treatment of adenoviral pneumonia.

关键词： Adenoviral pneumonia Chinese and western medicine treatment Syndrome differentiation and treatment Research progress

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体外受精-胚胎移植中的胚胎污染与预防

生殖与避孕 2008年第1期28卷 41-45页

作者：罗海宁张云山天津市中心妇产科医院生殖医学中心天津300052

胚胎污染在体外受精-胚胎移植中发生率虽不高,但发生后常导致胚胎死亡,甚至危及整个培养体系,后果极为严重。体外受精的各个环节都有可能导致胚胎污染的发生,精液是污染的主要来源,其次为卵泡液和IVF培养体系及环境。细菌对精子的结构... 详细信息

胚胎污染在体外受精-胚胎移植中发生率虽不高,但发生后常导致胚胎死亡,甚至危及整个培养体系,后果极为严重。体外受精的各个环节都有可能导致胚胎污染的发生,精液是污染的主要来源,其次为卵泡液和IVF培养体系及环境。细菌对精子的结构和功能都会造成不同程度的影响,由细菌释放的内毒素也对配子和胚胎有着明显的毒性效应,需要引起生殖医学临床医生和实验室人员的共同重视。严格的会阴部清洗后取精、单纯的普通上游法处理精液和使用含有微量抗生素的培养液处理精子、卵子均可有效去除其中的绝大部分细菌。

关键词：体外受精胚胎移植污染

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江苏省基本药物制度实施效果评价与思考

卫生经济研究 2017年第10期34卷 45-48,48页

作者：路云张闪闪李世勇中国药科大学国际医药商学院江苏南京211198

从社会反响、可获得性、可负担性及合理用药等方面,对江苏省基本药物制度实施情况进行评价。结果显示:江苏省基本药物制度总体实施情况良好,但供应保障、补偿报销、合理用药等方面尚有完善的空间。因此,有必要立足于现实困境和"健康中国... 详细信息

从社会反响、可获得性、可负担性及合理用药等方面,对江苏省基本药物制度实施情况进行评价。结果显示:江苏省基本药物制度总体实施情况良好,但供应保障、补偿报销、合理用药等方面尚有完善的空间。因此,有必要立足于现实困境和"健康中国"的战略要求,提出完善江苏省基本药物制度的具体路径。

关键词：基本药物制度可获得性可负担性合理用药效果评价

胚胎移植前宫腔内灌注hCG在IVF-ET中的应用及hCG提高种植率和妊娠率的有关机制

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生殖与避孕 2012年第9期32卷 593-598页

作者：王会妍张帅张云山天津市中心妇产科医院生殖医学中心天津300100 天津医科大学天津300070

人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)是由胎盘合体滋养细胞合成的一种糖蛋白激素,具有维持黄体寿命、刺激雌孕激素合成、抑制植物血凝素对淋巴细胞的增殖作用等功能。最近研究表明,胚胎移植前宫腔内灌注hCG可显著提... 详细信息

人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)是由胎盘合体滋养细胞合成的一种糖蛋白激素,具有维持黄体寿命、刺激雌孕激素合成、抑制植物血凝素对淋巴细胞的增殖作用等功能。最近研究表明,胚胎移植前宫腔内灌注hCG可显著提高移植后的种植率和妊娠率,但其具体作用机制尚未完全弄清,可能与宫腔内灌注一定浓度hCG后,其能以旁分泌形式作用于子宫内膜上皮细胞和血管内皮细胞等的表面受体而发挥作用,进而促使母-胎界面血管形成、增强母-胎间的免疫耐受有关;还可能与延长子宫内膜的移植窗,使子宫内膜容受性增强有关。

关键词： hCG 种植率免疫耐受调节性T细胞(Treg)

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia zhang Jianghui shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

多重置换扩增(MDA)结合荧光PCR对植入前胚胎进行性别诊断的研究

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生殖与避孕 2011年第11期31卷 731-739页

作者：罗海宁张印峰张云山天津市中心妇产科医院天津300100

目的:建立多重置换扩增(MDA)联合荧光PCR对植入前胚胎进行性别诊断的方法,为开展性连锁遗传病的性别筛选提供实验依据。方法:在行IVF-ET助孕的患者中,选取废弃的第3日新鲜或冷冻后的2PN受精胚胎。通过显微操作活检得到单个卵裂球细胞,采... 详细信息

目的:建立多重置换扩增(MDA)联合荧光PCR对植入前胚胎进行性别诊断的方法,为开展性连锁遗传病的性别筛选提供实验依据。方法:在行IVF-ET助孕的患者中,选取废弃的第3日新鲜或冷冻后的2PN受精胚胎。通过显微操作活检得到单个卵裂球细胞,采用MDA方法对单个/2个卵裂球细胞行全基因组扩增,然后采用荧光PCR方法对AMEL、X22、SRY和XHPRT 4个性染色体相关基因或STR位点进行扩增,对其扩增产物行毛细管电泳检测,分析电泳结果确定植入前胚胎的性别。以父母的外周血单个淋巴细胞作为对照进行分析。结果:①采用蛋白酶K法(n=21)和碱法(n=17)对卵裂球细胞进行裂解行MDA,扩增成功率未见统计学差异(85.7%vs 82.4%,P>0.05);单个卵裂球组(n=15)和2个卵裂球组(n=23)MDA扩增成功率亦未见统计学差异(80.0%vs87.0%,P>0.05)。②利用MDA方法对15个胚胎的单个/2个卵裂球进行扩增,扩增成功率为86.7%(n=13)。13个胚胎中7个为男性,6个为女性,性别检测成功率100%;等位基因脱扣(alleledropout,ADO)发生率为7.7%。结论:PGD中MDA是有效且可靠的全基因组扩增方法,MDA结合荧光PCR可以用于性连锁遗传病的性别筛选、致病基因检测和对胚胎进行HLA分型。

关键词：多重置换扩增(MDA) 荧光PCR 等位基因脱扣(ADO) 植入前遗传学诊断(PGD) 全基因组扩增(WGA) X连锁遗传病

Mechanism of Xingshen Zhiyi prescription in the treatment of enuresis based on network pharmacology

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Journal of Hainan Medical University 2020年第20期26卷 38-43页

作者： Yue Ma shan-yun zhang Han Kong Dong-Dong Sun Ji-Ye Chen Yong-Jian zhang Juan-Juan Diao shandong University of Traditional Chinese Medicine Jinan 250014China Affiliated Hospital of shandong University of Traditional Chinese Medicine Jinan 250011China

Objective:To explore the mechanism of Xingshen Zhiyi Recipe(XSZYF)in the treatment of Nocturnal Enuresis(NE)based on network ***:TCMSP,DrugBank databases,PubMed and CNKI were used to obtain the active ingredients and corresponding targets of *** targets were obtained from GeneCard and OMIM *** software was used to construct a drug-disease-target network *** analysis was *** protein interaction network(PPI)was constructed using the STRING *** gene ontology functional annotation(GO)and the Tokyo Genomic Encyclopedia(KEGG)pathway enrichment analysis were performed on key targets using the DAVID online *** docking software was used for the *** of key active ingredients and key targets to verify the results of network ***:199 gene targets of XSZYF were obtained,and 2486 gene targets of *** analysis results showed that the key targets of XSZYF for treating NE include CHRM3,CHRM2,ADRB3,*** in regulating neuroactive ligand-receptor interactions,calcium signaling pathways,***:This study revealed the material basis and action mechanism of XSZYF in treating NE from the perspective of network pharmacology.

关键词： Xingshen Zhiyi Recipe Nocturnal Enuresis Network pharmacology Signal pathway