Mechanism of Xingshen Zhiyi prescription in the treatment of enuresis based on network pharmacology

作     者：Yue Ma Shan-Yun Zhang Han Kong Dong-Dong Sun Ji-Ye Chen Yong-Jian Zhang Juan-Juan Diao Yue Ma;Shan-Yun Zhang;Han Kong;Dong-Dong Sun;Ji-Ye Chen;Yong-Jian Zhang;Juan-Juan Diao

作者机构：Shandong University of Traditional Chinese MedicineJinan 250014China Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011China 

出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)

年 卷 期：2020年第26卷第20期

页      面：38-43页

学科分类：1006[医学-中西医结合] 1005[医学-中医学] 100502[医学-中医临床基础] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Shandong province development plan of TCM science and technology(No.2019-0972) 

主　　题：Xingshen Zhiyi Recipe Nocturnal Enuresis Network pharmacology Signal pathway 

摘      要：Objective:To explore the mechanism of Xingshen Zhiyi Recipe(XSZYF)in the treatment of Nocturnal Enuresis(NE)based on network ***:TCMSP,DrugBank databases,PubMed and CNKI were used to obtain the active ingredients and corresponding targets of *** targets were obtained from GeneCard and OMIM *** software was used to construct a drug-disease-target network *** analysis was *** protein interaction network(PPI)was constructed using the STRING *** gene ontology functional annotation(GO)and the Tokyo Genomic Encyclopedia(KEGG)pathway enrichment analysis were performed on key targets using the DAVID online *** docking software was used for the *** of key active ingredients and key targets to verify the results of network ***:199 gene targets of XSZYF were obtained,and 2486 gene targets of *** analysis results showed that the key targets of XSZYF for treating NE include CHRM3,CHRM2,ADRB3,*** in regulating neuroactive ligand-receptor interactions,calcium signaling pathways,***:This study revealed the material basis and action mechanism of XSZYF in treating NE from the perspective of network pharmacology.