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World Journal of Clinical Cases 2024年第6期12卷 1157-1162页

作者： Kai Yu yun-Hua Mei Department of Ultrasound Wuhan Dongxihu District People's HospitaWuhan 430400Hubei ProvinceChina Department of infectious Diseases Wuhan Dongxihu District People's HospitalWuhan 430400Hubei ProvinceChina

BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder us.ng interventional methods without undergoing thoracotomy surgery after *** case innovatively used ultrasound guidance combined with digital subtraction angiography(DsA)to completely remove the occluder,accumulating some *** sUMMARY The patient underwent left atrial appendage occlusion surgery in our hospital due to atrial *** the surgery,the occluder fell off and became free in the left ventricle,which.is very *** innovatively used ultrasound guidance,combined with DsA,and interventional surgery to successfully capture the free occluder us.ng a catcher,completely remove it,and then re implant a new left atrial appendage *** the surgery,the patient recovered very *** The size selection of the occluder is slightly conservative,and the shape of the left atrial appendage opening is irregular.

关键词： Left atrial appendage occluder Detachment Ultrasound combined with digital subtraction angiography interventional operation successfully captured Case report

Low-rank matrix recovery with total generalized variation for defending adversarial examples

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Frontiers of information Technology & Electronic Engineering 2024年第3期25卷 432-445页

作者： Wen Li Hengyou WAng Lianzhi HUO Qiang HE Linlin chEN Zhiquan HE Wing W.Y.ng school of science Beijing University of Civil Engineering and ArchitectureBeijing 100044China school of Computer science and Engineering South China University of TechnologyGuangzhou 510006China Aerospace information Research.institute Chinese Academy of SciencesBeijing 100094China Guangdong Key Laboratory of intelligent information Process.ng Shenzhen 518060China institute of Big Data Modeling and Technology Beijing University of Civil Engineering and ArchitectureBeijing 100044China

Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image *** advantage of its excellent performance in image denois.ng,we apply it to improve the robustness of deep neural ***,although TV regularization can improve the robustness of the model,it reduces the accuracy of normal samples due to its *** our work,we develop a new low-rank matrix recovery model,called LRTGV,which.incorporates total generalized variation(TGV)regularization into the reweighted low-rank matrix recovery *** the proposed model,TGV is used to better reconstruct texture information without *** reweighted nuclear norm and Li-norm can enhance the global structure ***,the proposed LRTGV can destroy the structure of adversarial noise while re-enhancing the global structure and local texture of the *** solve the challenging optimal model issue,we propose an algorithm based on the alternating direction method of *** results show that the proposed algorithm has a certain defense capability against black-box attacks,and outperforms state-of-the-art low-rank matrix recovery methods in image restoration.

关键词： Total generalized variation Low-rank matrix Alternating direction method of multipliers Adversarial example

Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis:implications for bone health

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World Journal of stem Cells 2024年第4期16卷 389-409页

作者： Ling-Ling Wang Zhan-Jin Lu shun-Kui Luo yun Li Zhe Yang Hong-yun Lu Department of Gerontology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Endocrinology and Metabolism Zhuhai People’s Hospital(Zhuhai Clinical Medical College of Jinan Universitythe First Hospital Affiliated with Medical College of Macao University of Science and Technology)Zhuhai 519000Guangdong ProvinceChina

BACKGROUND Osteoporosis(OP)has become a major public health problem *** OP treatments are based on the inhibition of bone resorption,and it is necessary to identify additional treatments aimed at enhancing *** the bone marrow(BM)niche,bone mesenchymal stem cells(BMsCs)are exposed to a hypoxic ***,a few studies have demonstrated that hypoxiainducible factor 2alpha(HiF-2α)is involved in BMsC osteogenic differentiation,but the molecular mechanism involved has not been *** To investigate the effect of HiF-2αon the osteogenic and adipogenic differentiation of BMsCs and the hematopoietic function of hematopoietic stem cells(HsCs)in the BM niche on the progression of *** Mice with BMsC-specific HiF-2αknockout(Prx1-Cre;Hif-2αfl/fl mice)were used for in vivo *** quantification was performed on mice of two genotypes with three interventions:Bilateral ovariectomy,semilethal irradiation,and dexamethasone ***,the hematopoietic function of HsCs in the BM niche was compared between the two mouse *** vitro,the HiF-2αagonist roxadustat and the HiF-2αinhibitor PT2399 were used to investigate the function of HiF-2αin BMsC osteogenic and adipogenic ***,we investigated the effect of HiF-2αon BMsCs via treatment with the mechanistic target of rapamycin(mTOR)agonist MHY1485 and the mTOR inhibitor *** The quantitative index determined by microcomputed tomography indicated that the femoral bone density of Prx1-Cre;Hif-2αfl/fl mice was lower than that of Hif-2αfl/fl mice under the three intervention *** vitro,Hif-2αfl/fl mouse BMsCs were cultured and treated with the HiF-2αagonist roxadustat,and after 7 d of BMsC adipogenic differentiation,the oil red O staining intensity and mRNA expression levels of adipogenesis-related genes in BMsCs treated with roxadustat were decreased;in addition,after 14 d of osteogenic differentiation,BMsCs treated with roxadusta

关键词： Hypoxia-inducible factor-2α Bone marrow niche Bone mesenchymal stem cells Osteoporosis Osteogenic/adipogenic differentiation Mechanistic target of rapamycin signaling pathway

Effect of Co on solidification characteristics and Microstructural Transformation of Non-equilibrium solidified Cu-Ni Alloys

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Journal of Wuhan University of Technology(Materials science) 2024年第2期39卷 444-453页

作者：安红恩 Bih-Lii chua ismail saad Willey yun Hsien Liew Materials Engineering Research Group Faculty of EngineeringUniversity Malaysia Sabah88400 Kota KinabaluSabahMalaysia College of Mechanical and Electronic Engineering Huanghe Jiaotong UniversityJiaozuo 454950China Henan Engineering Technology Research Center on intelligent Manufacturing Technology and Equipment Jiaozuo 454950China Centre of Research.in Energy and Advanced Materials Faculty of EngineeringUniversiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Nano Engineering and Materials Research group Faculty of EngineeringUniversity Malaysia Sabah88400 Kota KinabaluSabahMalaysia

Non-equilibrium solidification structures of Cu55Ni45 and Cu55Ni43Co2 alloys were prepared by the molten glass purification cycle superheating *** variation of the recalescence phenomenon with the degree of undercooling in the rapid solidification process was investigated us.ng an infrared *** addition of the Co element affected the evolution of the recalescence phenomenon in Cu-Ni *** images of the solid-liquid interface migration during the rapid solidification of supercooled melts were captured by us.ng a high-speed *** solidification rate of Cu-Ni alloys,with the addition of Co elements,was ***,the grain refinement structure with low supercooling was characterised us.ng electron backscatter diffraction(EBsD).The effect of Co on the microstructural evolution during nonequilibrium solidification of Cu-Ni alloys under conditions of small supercooling is investigated by comparing the microstructures of Cu55Ni45 and Cu55Ni43Co2 *** experimental results show that the addition of a small amount of Co weakens the recalescence behaviour of the Cu55Ni45 alloy and significantly reduces the thermal strain in the rapid solidification *** the rapid solidification phase,the thermal strain is greatly reduced,and there is a significant increase in the characteristic undercooling ***,the addition of Co and the reduction of Cu not only result in a lower solidification rate of the alloy,but also contribute to the homogenisation of the grain size.

关键词： non-equilibrium solidification recalescence effect solidification character microstructure

s.ngle-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao Li chun-Hsien chEN Kam K.H.ng Xin YUAN cho Yin YiU Human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China school of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a s.ngle pilot in commercial jets could be tech.ically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding s.ngle-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to s.ngle-Pilot Operations(sPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded us.ng a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in sPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial sPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating sPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering s.ngle pilot operations Behaviour changes Eye tracker Electroencephalogram

A review of control strategies used for morphing aircraft applications

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chinese Journal of Aeronautics 2024年第4期37卷 436-463页

作者： Muhammed s.PARANchEERiViLAKKATHiL Jafar s.PiLAKKADAN Rafic M.AJAJ Mohammadreza AMOOZGAR Davood AsADi Yahya ZWEiRi Michael i.FRisWELL Department of Aerospace Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Aerospace Engineering Advanced Research and Innovation Center(ARIC)Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Mechanical Materials&Manufacturing EngineeringUniversity of NottinghamNottingham NG72RDUK Department of Aerospace Engineering Adana Alparslan Turkes Science and Technology UniversityTurkey College of Engineering Swansea UniversitySwansea SA18ENUK

This paper reviews the various control algorithms and strategies used for fixed-wing morphing aircraft applications. it is evident from the literature that the development of control algorithms for morphing aircraft technologies focused on three main areas. The first area is related to precise control of the shape of morphing concepts for various flight conditions. The second area is mainly related to the flight dynamics, stability, and control aspects of morphing aircraft. The third area deals mainly with aeroelastic control us.ng morphing concepts either for load alleviation purposes and/or to control the instability boundaries. The design of controllers for morphing aircraft/wings is very challenging due to the large changes that can occur in the structural, aerodynamic, and inertial characteristics. in addition, the type of actuation system and actuation rate/speed can have a significant effect on the design of such controllers. The aerospace community is in strong need of such a critical review especially as morphing aircraft technologies move from fundamental research at a low Technology Readiness Level(TRL) to real-life applications. This critical review aims to identify research gaps and propose future directions. in this paper, research activities/papers are categorized according to the control strategy used. This ranges from simple Proportional integral Derivative(PiD) controllers at one end to complex robust adaptive controllers and deep learning algorithms at the other end. This includes analytical, computational, and experimental studies. in addition, the various dynamic models used and their fidelities are highlighted and discussed.

关键词： Control strategies Morphing aircraft shape morphing Flight dynamics Aeroelasticity

Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos ch.Tsirogiannis Evangelos Daskalakis Mohamed H.Hassan Abdalla M.Omar Paulo Bartolo EODH sA Research and Development DepartmentLakkoma Chalkidikis63080Greece school of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK s.ngapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + sTANAG 4569 military standard(projectile 14.5 mm × 114 mm APi B32) and especially on a design philosophy which.is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy tech.ique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-sTANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance Hybrid composites Vehicle protection

Antibacterial HA-coatings on bioresorbable Mg alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia D.V.Mashtalyar M.A.Piatkova A.i.Pleshkova i.M.imshinetskiy M.s.Gerasimenko E.A.Belov V.V.Kumeiko D.N.Kozyrev K.A.Fomenko V.V.Mostovaya B.R.Torpanov A.R.Biktimirov i.s.Osmushko s.L.sinebryukhov s.V.Gnedenkov institute of chemistry FEB RAs 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmunsky National scientific Center of Marine Biology FEB RAs 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical Dermatovenerological Dispensary 18 V St.GamarnikaVladivostok 690033Russia NMiC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

in this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic vancomycin,widely used in the treatment of infections caused by staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to sEM,EDs,XRD and XPs data,coatings had a developed morphology and contained hydroxyapatite,which.indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate PEO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility Mg alloy Plasma electrolytic oxidation Hydroxyapatite Vancomycin

NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis

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Journal of integrative Plant Biology 2024年第1期66卷 54-65页

作者： Qiao‐yun Zhu Lin‐Lin Zhang Jian‐Xiang Liu state Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China

Plants are highly susceptible to abiotic stresses,particularly heat stress during the reproductive ***,the specific molecular mechanisms underlying this sensitivity remain largely *** the current study,we demonstrate that the Nuclear Transcription Factor,X-box Binding Protein 1-Like 1(NFXL1),directly regulates the expression of DEHYDRATiON-REsPONsiVE ELEMENT-BiNDing PROTEiN 2A(DREB2A),which.is crucial for reproductive thermotolerance in ***1 is upregulated by heat stress,and its mutation leads to a reduction in silique length(seed number)under heat stress ***-seq analysis reveals that NFXL1 has a global impact on the expression of heat stress responsive genes,including DREB2A,Heat shock Factor A3(HsFA3)and Heat shock Protein 17.6(HsP17.6)in flower ***,NFXL1 is enriched in the promoter region of DREB2A,but not of either HsFA3 or *** experiments us.ng electrophoretic mobility shift assay have confirmed that NFXL1 directly binds to the DNA fragment derived from the DREB2A ***,effector-reporter assays have shown that NFXL1 activates the DREB2A *** DREB2A mutants are also heat stress sensitive at the reproductive stage,and DEREB2A is epistatic to NFXL1 in regulating thermotolerance in flower *** is known that HsFA3,a direct target of DREB2A,regulates the expression of heat shock proteins genes under heat stress ***,our findings establish NFXL1 as a critical upstream regulator of DREB2A in the transcriptional cassette responsible for heat stress responses required for reproductive thermotolerance in Arabidopsis.

关键词： Arabidopsis DREB2A heat stress NFXL1 reproductive thermotolerance

Weakly supervised Object Localization with Background suppression Eras.ng for Art Authentication and Copyright Protection

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Machine intelligence Research 2024年第1期21卷 89-103页

作者： chaojie Wu Mingyang Li Ying Gao Xinyan Xie Wing W.Y.ng Ahmad Musyafa school of Computer science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key Laboratory of Artificial intelligence in Medical image Analysis and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery and infringement is becoming increas.ngly prominent,since diverse self-media contents with all kinds of art pieces are released on the internet every *** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly supervised object localization(WsOL)with background su-perposition eras.ng(BsE),which recognizes objects with inexpensive image-level ***,integrated adversarial eras.ng(iAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region by leveraging high-level semantic ***,a background suppression module(BsM)limits the activation area of the iAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RiM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,CUB-200-2011 and iLsVRC to validate the effectiveness of our BsE.

关键词： Weakly supervised object localization eras.ng method deep learning computer vision art authentication and copyright protection