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Application and prospect of adipose stem cell transplantation in treating lymphedema

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World Journal of Stem Cells 2020年第7期12卷 676-687页

作者： zhu-Jun li Elan Yang yun-zhu li Zheng-yun liang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Lymphedema is a chronic,debilitating and incurable disease that affects 0.13%-2%of the global *** evidence indicates that adipose-derived stem cells(ADSCs)might serve as suitable seed cells for lymphatic tissue engineering and lymphedema *** To summarize applications of ADSCs for treating lymphedema in both animal studies and clinical *** A systematic search was performed on four databases-PubMed,***,the evidence-based Cochrane library,and OVID-using the following search string:(“lymphedema”or“lymphoedema”or“lymphangiogenesis”)and(“adipose-derived stem cells”or“adipose-derived stromal cells”or“adipose-derived regenerative cells”).A manual search was performed by skimming the references of relevant *** studies and clinical trials using adipose-derived cells for the treatment of any kind of lymphedema were *** A total of eight research articles published before November 2019 were included for this *** articles focused on animal studies and another three focused on clinical *** transplantation therapy was demonstrated to be effective against lymphedema in all *** animal studies found that coadministration of ADSCs and controlled-release vascular endothelial growth factor-C or platelet-rich plasma could improve the effectiveness of ADSC *** sequential clinical trials were conducted on breast cancer-related lymphedema patients,and all showed favorable *** ADSC-based therapy is a promising option for treating ***-scale,multicenter randomized controlled trials are needed to develop more effective and durable therapeutic strategies.

关键词： Lymphedema Adipose-derived stem cells Animal model Clinical trial Vascular endothelial growth factor-C Lymphangiogenesis

Application of adipose-derived stem cells in treating fibrosis

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World Journal of Stem Cells 2021年第11期13卷 1747-1761页

作者： zhu-Jun li li-Quan Wang yun-zhu li Chen-Yu Wang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Peking Union Medical College Hospital of Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China

Fibrosis is the hyperactivation of fibroblasts that results in excessive accumulation of extracellular matrix,which is involved in numerous pathological changes and ***-derived stem cells(ASCs)are promising seed cells for regenerative medicine due to their bountiful source,low immunogenicity and lack of ethical *** anti-fibrosis,immunomodulation,angiogenesis and other therapeutic effects have made them suitable for treating fibrosis-related ***,we review the literature on ASCs treating fibrosis,elaborate and discuss their mechanisms of action,changes in disease environment,ways to enhance therapeutic effects,as well as current preclinical and clinical studies,in order to provide a general picture of ASCs treating fibrotic diseases.

关键词： Adipose-derived stem cells Fibrosis Immunomodulation Modification Therapeutic effect Clinical trials

Representation learning: serial-autoencoder for personalized recommendation

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Frontiers of Computer Science 2024年第4期18卷 61-72页

作者： Yi zhu Yishuai GENG yun li Jipeng QIANG Xindong WU School of Information Engineering Yangzhou UniversityYangzhou 225127China Key Laboratory of Knowledge Engineering with Big Data(Ministry of Education of the People’s Republic of China) Hefei University of TechnologyHefei 230009China School of Computer Science and Information Engineering Hefei University of TechnologyHefei 230009China

Nowadays,the personalized recommendation has become a research hotspot for addressing information *** this,generating effective recommendations from sparse data remains a ***,auxiliary information has been widely used to address data sparsity,but most models using auxiliary information are linear and have limited *** to the advantages of feature extraction and no-label requirements,autoencoder-based methods have become quite ***,most existing autoencoder-based methods discard the reconstruction of auxiliary information,which poses huge challenges for better representation learning and model *** address these problems,we propose Serial-Autoencoder for Personalized Recommendation(SAPR),which aims to reduce the loss of critical information and enhance the learning of feature ***,we first combine the original rating matrix and item attribute features and feed them into the first autoencoder for generating a higher-level representation of the ***,we use a second autoencoder to enhance the reconstruction of the data representation of the prediciton rating *** output rating information is used for recommendation *** experiments on the MovieTweetings and MovieLens datasets have verified the effectiveness of SAPR compared to state-of-the-art models.

关键词： personalized recommendation autoencoder representation learning collaborative filtering

Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： Xin-Yu liu liang zhu Su-yun Jie Bo-Geng li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(MTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-VL).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[M]_0/[I],linear polyvalerolactones(PVLs)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experiments were carried out to prove the"living"/controllable *** the NMR experiments were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVL

A Non-Iterative Network Utilization Pricing Mechanism for P2P Energy Trading

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1301-1306页

作者： yun liu yunqiang Gao Yuanzheng li Jizhong zhu Hoay Beng Gooi School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China School of Artificial Intelligence and Automation Ministry of Education Key Laboratory of Image Processing and Intelligence ControlHuazhong University of Science and TechnologyWuhan 430074China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore IEEE

To sustain operation and maintenance of an active distribution network(ADN),a network fee should be charged by the distribution network service provider(DNSP)for facilitating the P2P energy trading *** this end,this paper models the interaction among the DNSP and multiple prosumers as a Stackelberg game,and then develops a non-iterative and decentralized transactive mechanism to simultaneously achieve optimal network utilization pricing and peer-to-peer(P2P)*** results in an ADN with four prosumers connected to a common substation bus validate the effectiveness and efficiency of the proposed scheme.

关键词： Distribution network service provider network fee non-iterative peer-to-peer trading prosumer

Few-shot incremental radar target recognition framework based on scattering-topology properties

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Chinese Journal of Aeronautics 2024年第8期37卷 246-260页

作者： Chenxuan li Weigang zhu Bakun zhu Yonggang li Graduate School Space Engineering UniversityBeijing 101400China Department of Electronic and Optical Engineering Space Engineering UniversityBeijing 101400China

The continuous emergence of new targets in open scenarios leads to a substantial decrease in the performance of Inverse Synthetic Aperture Radar(ISAR)recognition ***,data scarcity further exacerbates the challenge of identifying new classes of ISAR *** this paper,a few-shot incremental target recognition framework based on Scattering-Topology Properties(STPIL)is ***,STPIL extracts scattering-topology properties of ISAR targets as recognition ***,the pseudo-incremental training strategy effectively alleviates the algorithm’s forgetting of old knowledge,and improves compatibility with new ***,a feature embedding network,with few parameters,is designed based on the graph neural *** embedding network is highly adaptable to changes in data ***,STPIL fully considers the joint distribution and marginal distribution in scattering features,and uses the Brownian distance metric module to make the scattering-topology features more *** results on both the simulation dataset and the public measured data indicate that STPIL can effectively balance new classes with old classes,and has superior performance to other advanced methods in the incremental recognition of targets.

关键词： Brownian distance metric Graph neural networks Incremental learning Inverse Synthetic Aperture Radar(ISAR) Scattering

Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

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Nano Research 2024年第1期17卷 270-281页

作者： Zichen Ye yun li Jingchao li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao zhu Zhide Guo Xiaolan Chen State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen UniversityXiamen 361102China The High Educational Key Laboratory for Biomedical Engineering&Key Laboratory of Fire Retardant Materials of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

Lactic acid(LA)plays a major role in the occurrence,development,and spread of *** by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor *** detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic ***,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic *** importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in *** together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor ***,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward.

关键词： lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

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一种基于复合控制方式的模糊控制器实现

压电与声光 2009年第3期31卷 429-432页

作者：朱运利北京电子科技职业学院工程技术系北京100029

模糊控制技术在复杂、大滞后、难以建立精确数学模型的非线性控制过程中表现出了许多优越性能,因此,在工程控制中得到了广泛的应用。该文针对开关磁阻电机(SRM)非线性强的特点,为了保证调速系统具有较好的动、静态性能,引入复合模糊控... 详细信息

模糊控制技术在复杂、大滞后、难以建立精确数学模型的非线性控制过程中表现出了许多优越性能,因此,在工程控制中得到了广泛的应用。该文针对开关磁阻电机(SRM)非线性强的特点,为了保证调速系统具有较好的动、静态性能,引入复合模糊控制方式,采用双闭环结构设计了一种复合控制方式的模糊控制器。该控制器结构为一个双闭环结构的控制系统,采用典型的双输入、单输出复合控制的结构,即控制器分为基本的模糊控制和偏差积分控制两个部分,增加了比例积分环节,减少零点附近的摆动;内环采用一个模拟的电流控制器,外环采用一个数字控制器,应用了模糊控制的策略和算法。实际应用表明:该系统提高了控制精度,对消除扰动带来的误差和振荡,改善了系统的品质有明显的效果。

关键词：复合控制模糊控制器单片机开关磁阻电机

The role of anesthesia in peri-operative neurocognitive disorders:Molecular mechanisms and preventive strategies

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Fundamental Research 2024年第4期4卷 797-805页

作者： Ran li yun Zhang Qinxin zhu Yili Wu Weihong Song The Second Affiliated Hospital and Yuying Children's Hospital Institute of AgingKey Laboratory of Alzheimer's Disease of Zhejiang ProvinceWenzhou Medical UniversityWenzhou325035China The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 32500o0China

Peri-operative neurocognitive disorders(PNDs)include postoperative delirium(POD)and postoperative cognitive dysfunction(POCD).Children and the elderly are the two populations most vulnerable to the development of POD and POCD,which results in both high morbidity and *** are many factors,including neuroinflammation and oxidative stress,that are associated with POD and *** anesthesia is a major risk factor of ***,the molecular mechanisms of PNDs are poorly ***(DEX)is a useful sedative agent with analgesic properties,which significantly improves POCD in elderly *** this review,the current understanding of anesthesia in PNDs and the protective effects of DEX are summarized,and the underlying mechanisms are further discussed.

关键词： Peri-operative neurocognitive disorders General anesthesia Postoperative cognitive dysfunction Postoperative delirium Dexmedetomidine Alzheimer'sdisease