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Breviscapine attenuates acute pancreatitis by inhibiting expression of PKCα and NF-κB in pancreas

World Journal of Gastroenterology 2011年第14期17卷 1825-1830页

作者： Hong Zhang Cui-Zhu Cai xiao-Qin Zhang Tao Li xiao- yun jia Bao-Lan Li Liang Song xiao-Jun Ma Department of Pathophysiology Shaanxi University of Traditional Chinese Medicine Xianyang 712046 Shaanxi Province China Department of Internal Medicine Sanya Hospital of Traditional Chinese Medicine Sanya 572000 Hainan Province China

AIM:To study the effect of breviscapine (Bre) on activity of protein kinase Cα (PKCα) and nuclear factor (NF)-κB in pancreas,and the mechanism of Bre attenuating acute pancreatitis (AP). METHODS:One hundred and eight rats were randomly divided into acute necrotizing pancreatitis (ANP) group,Bre group (ANP + Bre group) and sham operation (SO) group,36 rats in each group. ANP model was induced by a retrograde injection of 4% sodium deoxycholate into the bilio-pancreatic duct. Fifteen minutes after the ANP model was induced,the rats in Bre group were intraperitoneally injected with Bre (0.4 mg/100 g body weight or 0.1 mL/100 g body weight). Survival time and mortality of rats were calculated. Serum amylase and malondialdehyde levels were measured,volume of ascites was recorded and morphology of pancreas and lung was evaluated at 1,5 and 10 h,after the ANP model was induced,respectively. Expressions of PKCα and subunit p65 of NF-κB in pancreas were detected by immunohistochemistry and Western blotting. RESULTS:The life span of rats was longer and the mortality was lower in Bre group than in ANP group 13.51 ± 5.46 vs 25.36 ± 8.11 (P < 0.05). The amylase and MDA levels as well as the volume of ascites were lower and the pathological changes in pancreas and lung were less in Bre group than ANP group (P < 0.05),indicating that the pancreatitis is less severe in Bre group than ANP group. The activation of PKCα and NF-κB p65 in pancreas was induced rapidly and reached their peak at 1 h or 5 h after ANP,but their activity in Bre group was significantly inhibited. CONCLUSION:Bre exerts its therapeutic effect on AP by inhibiting the activation of PKCα and NF-κB p65 in pancreas.

关键词： Breviscapine Acute pancreatitis Protein kinase Cα Nuclear factor-κB Rat

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Sequential loss of genetic variation in flea beetle Agasicles hygrophila （Coleoptera： Chrysomelidae） following introduction into China

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Insect Science 2013年第5期20卷 655-661页

作者： Rui-Yan Ma xiao-yun jia Wen-Zhong Liu Roger H. Laushman Long-Long Zhao Dong jia Ren Wang Department of Biosafety College of Animal Science and Technology Shanxi Agricultural University Taigu Shanxi China Department of Biology Oberlin College Oberlin Ohio USA and Chinese Academy of Agricultural Science Beijing China

The flea beetle （Agasicles hygrophila） was imported to Florida, USA and then introduced from Florida into China in 1987 as a biological control agent for the invasive plant alligator weed （Alternanthera philoxeroides）. The initial beetle population was subsequently used for sequential introductions in other areas of China, but little is known about the genetic consequences of the introductions. In this study, the genetic diversity and population structure of five beetle populations, the source Florida population, three intentionally introduced China populations and one accidentally dispersed China population, were examined using amplified fragment length polymorphisms. The results showed a clear pattern of decreasing genetic diversity with the sequential introductions. The diversity was highest in the Florida population followed by the first introduction to Chongqing and then in Kunming and Fuzhou. The lowest diversity was found in the accidentally dispersed Guangzhou population that was first recorded in 1996. Both loci parameters and Nei＇s genetic diversity showed a high variation among these populations. Genetic differentiation among populations was further verified by the GST statistic （0.136–0.432）. Beetles in Kunming had the highest gene flow with those in Guangzhou, and therefore lowest differentiation and closest genetic distance. These data show that sequential introduction influenced the genetic diversity of populations in China. Genetic diversity should be considered in planning introduction and long-term maintenance of populations.

关键词： AFLP Agasicles hygrophila biological control genetic diversity introduction

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Application of cellulase in producing reducing sugar with waste lignocellulosic

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Journal of Energy and Power Engineering 2009年第9期2卷 54-59页

作者： jiaNG xiao-yun WANG jia-de College of Biological and Environmental Engineering Zhejiang University of Technology Hangzhou 310032 China

The cellulase expands the use of waste lignocellulosic and improves the feasibility of ethanol production with waste lignocellulosic. In this paper the types, mechanisms of cellulase and its application in reducing sugar production were presented in detail. The strains that produce cellulase and methods for improving the cellulase activity in reducing sugar production with waste lignocellulosic were described.

关键词： reducing sugar cellulase waste lignocellulosic

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党的十八大以来习近平党建思想的逻辑维度与理论创新探析

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理论探讨 2017年第5期 119-125页

作者：焦晓云吴家庆湖南师范大学马克思主义学院长沙410081

习近平党建思想自成体系,其基本内容有:加强思想建设,为党员干部"补钙";加强组织建设,提高党的执政能力;加强作风建设,密切党群关系;加强制度建设,将权力放进笼子里;加强廉政建设,零容忍惩治腐败。习近平党建思想有严密的内在逻辑:以实... 详细信息

习近平党建思想自成体系,其基本内容有:加强思想建设,为党员干部"补钙";加强组织建设,提高党的执政能力;加强作风建设,密切党群关系;加强制度建设,将权力放进笼子里;加强廉政建设,零容忍惩治腐败。习近平党建思想有严密的内在逻辑:以实现中国为目标梦牵引党的建设,将全面从严治党贯穿于党建全过程,以群众路线教育实践活动作为党建的新载体。其理论创新之处在于:党的领导是中国特色社会主义最本质的特征,思想建党和制度治党同向同步发力,实现了从严治党与依法治国的有机融合,将制度建设作为反腐倡廉的治本之策。

关键词：习近平党建思想基本内容逻辑维度理论创新

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Regeneration of islet β-cells in tree shrews and rats

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Animal Models and Experimental Medicine 2018年第2期1卷 152-161页

作者： Yu-Qiong Zhao Ya-Qian Liu Ji-Fang Yuan Xin Dai Miao-Miao Niu xiao-Mei Sun De-Xuan Kuang Wen-Guang Wang Pin-Fen Tong Na Li Lei Xiang yun-xiao jia Jie-Jie Dai Hua Chen Chinese PLA General Hospital Laboratory Animal Center The Institute of Medical Biology The Chinese Academy of Medical Science and Peking Union Medical College yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases Center of Tree Shrew Germplasm Resources State Key Laboratory of Kidney Diseases Chinese PLA General Hospital

Backgroud: Current understanding of injury and regeneration of islet β-cells in diabetes is mainly based on rodent studies. The tree shrew is now generally accepted as being among the closest living relatives of primates, and has been widely used in animal experimentation. However, there are few reports on islet cell composition and regeneration of β-cells in tree ***: In this study, we examined the changes in islet cell composition and regeneration of β-cells after streptozotocin(STZ) treatment in tree shrews compared with Sprague-Dawley rats. Injury and regeneration of islet β-cells were observed using hematoxylin and eosin(HE) staining and immunohistochemical staining for insulin, glucagon, somatostatin and ***: Our data showed that in rats islet injury was most obvious on day 3 after injection, and islet morphologies were significantly restored by day 21. Regeneration of islet β-cells was very pronounced in rats, and mainly involved regeneration of centro-acinar cells and transformation of extra-islet ductal cells. In tree shrews, the regeneration of islet β-cells was not as significant. On days 3 and 7, only scattered regenerated cells were observed in the remaining islets. Further, no regeneration of centro-acinar cells was ***: The results suggest that the repair mechanism of islet β-cells in tree shrews is similar to that of humans.

关键词： β-cell rat regeneration tree shrew

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观念转型:新媒体时代的电影与电影教育

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艺术百家 2016年第5期32卷 90-93页

作者：陈晓云袁佳北京师范大学艺术与传媒学院北京100875

新媒体时代的到来,在潜移默化地改变人类生活方式、生存方式与思维方式的同时,也深刻改变了影像创作、传播与接受的方式,不仅挑战了传统影像时代的技术与知识系统,变革了影像行业/产业旧有的运作模式,而且已然开始动摇传统影像时代的理... 详细信息

新媒体时代的到来,在潜移默化地改变人类生活方式、生存方式与思维方式的同时,也深刻改变了影像创作、传播与接受的方式,不仅挑战了传统影像时代的技术与知识系统,变革了影像行业/产业旧有的运作模式,而且已然开始动摇传统影像时代的理论与美学根基。于传统影像时代蓬勃兴起的中国影视教育,如何应对新媒体时代多方面的挑战,已成为不可回避的严肃课题。文章拟从电影观念的转型出发,对影像教育的观念转型与格局转型问题进行论述。

关键词：当代中国电影艺术新媒体影像电影观念影像教育转型

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang xiao Ding Huang yunyi Yiyu Liu jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu jia Rui Mao Xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing xiao Mingming Gao Zejia He jia Zheng Hongming Bai jia-Sheng Rao Guiyun Song Wei Song xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu xiao-Li Li xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu xiao-jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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