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Prediction of chemical short-range order in high-/medium-entropy alloys

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Journal of Materials Science & Technology 2024年第2期169卷 115-123页

作者： Pei-Yu Cao Jing wang ping Jiang yun-Jiang wang Fu-ping Yuan Xiao-Lei Wu State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of ScienceBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Chemical short-range orders(CSROs),as the built-in sub-nanoscale entities in a high-/medium-entropy alloy(H/MEA),have aroused an ever-increasing *** multi-principal elements in an H/MEA to form a complex concentrated solution,a variety of sub-systems of species exist to induce the metastable ordered compounds as candidates for ultimate *** issues remain pending on the origin of CSROs as to how to judge if CSRO will form in an H/MEA and particularly,what kind of CSROs would be stably produced if there were multiple ***,the first-principles method,along with the proposed local formation energy calculation in allusion to the atomic-scale chemical heterogeneities,is used to predict the CSRO formation based on the mechanical stability,thermodynamic formation energy,and electronic *** simulations are detailed in an equiatomic ternary VCoNi MEA with three kinds of potential compounds,i.e.,L1_(1),L1_(2),and B2,in the face-centered cubic *** turns out that L1_(1)is stable but hard to grow up so as to become the final CSRO.L1_(1)is further predicted as CSROs in CrCoNi,but unable to form in FeCoNi and CrMnFeCoNi *** predictions are consistent with the experimental *** findings shed light on understanding the formation of *** method is applicable to other H/MEAs to design and tailor CSROs by tuning chemical species/contents and thermal processing for high performance.

关键词： Short-range order High-entropy alloy Microstructure First-principles calculation Gibbs free energy Local electronic density of states

The year 2020,a milestone in breaking the vicious cycle of poverty and illness in China

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Infectious Diseases of Poverty 2020年第1期9卷 1-8页

作者： yun-ping wang Xiao-Nong Zhou China National Health Development Research Centre National Health Commission of ChinaWHO Collaborating Centre for Health Systems StrengtheningBeijing 100044China National Institute of Parasitic Diseases at Chinese Center for Diseases Control and Prevention Chinese Center for Tropical Diseases ResearchShanghai 200025China WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China School of Global Health Chinese Center for Tropical Diseases ResearchJiatong University School of MedicineShanghai 200025China

Marking the end of the five-year programme initiated by the Chinese Government to lift more than 70 million people out of poverty,the year 2020 is a *** alleviation has moved strongly forward in China and the major health indicators are now better than the average of all middle-and high-income ***,the dual burden of infectious and chronic diseases remains a challenge with respect to achieving the health target in the United Nations 2030 Agenda for sustainable development goals(SDGs).In 2015,about 44%of the poor population in China were impoverished by illness but already in 2018,multi-sectoral actions delivered by the Health-related Poverty Alleviation programme had reduced the number almost by *** the past three years 15 million poor people(98%of the poor population)with infectious and chronic diseases had been treated and taken care of thanks to financial support through multiple health insurance schemes and other governmental *** article discusses the lessons learnt with regard to health-related poverty alleviation in China with special reference to those still remaining impoverished by *** of the achievements reached and provision of basic needs to those still disadvantaged and in poor health will require a major improvement of accessibility to,and affordability of,health *** next step towards enhanced productivity and better living conditions will involve upgrading of the capacity of health professionals in the poor regions,promotion of coherent efforts in health-related poverty alleviation and rural revitalization *** an additional measure,data monitoring and research on health poverty alleviation should be strengthened as they are essential to generate the evidence and knowledge needed to support the move in the direction envisioned by the SDGs,and the new Healthy China 2030 programme.

关键词： Poverty alleviation Infectious diseases Poor population Health insurance Endemic diseases China Healthy China

Holographic Polymer Nanocomposites with High Refractive Index Modulation by Doping Liquid Crystal E6M

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Chinese Journal of Polymer Science 2024年第7期42卷 926-935,I0006页

作者： Meng-yun wang Yue Zhang Dan wang Ming Yao Yi-Xuan wang Xing-ping Zhou Hai-Yan Peng Xiao-Lin Xie Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China National Anti-counterfeit Engineering Research Center Huazhong University of Science and TechnologyWuhan430074China

Holographic optical elements(HOEs)based on polymer composites have become a research hot spot in recent years for augmented reality(AR)due to the significant improvement of optical performance,dynamic range,ease of processing and high yield ***,it remains a formidable challenge to obtain a large field of view(FOV)and brightness due to the limited refractive index ***,we report an effective method to tackle the challenge by doping an epoxy liquid crystal termed E6M,which enables a large refractive index modulation of 0.050@633 nm and low haze of 5.0%at a doping concentration of 5 wt%.This achievement may be ascribed to the improved molecular ordering of liquid crystals within the holographic polymer *** high refractive index modulation can endow transmission-type holographic polymer composites with a high diffraction efficiency of 96.2%at a small thickness of 5μm,which would promise the design of thin and lightweight AR devices.

关键词： Polymer nanocomposites Holography AR/VR Refractive index modulation Liquid crystal

Exploring mechanism of hidden,steep obliquely inclined bedding landslides using a 3DEC model:A case study of the Shanyang landslide in Shaanxi Province,China

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China Geology 2024年第2期7卷 303-314,I0001-I0003页

作者： Jia-yun wang Zi-long Wu Xiao-ya Shi Long-wei Yang Rui-ping Liu Na Lu Xi’an Center of China Geological Survey/Northwest China Center for Geoscience Innovation Xi’an 710119China Xi’an University of Science and Technology Xi’an 710054China Wuhan Design&Research Institute Co. Ltd.of China Coal Technology&Engineering GroupWuhan 430064China

Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily *** phenomenon has become a focal point in landslide ***,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding *** study investigated the Shanyang landslide in Shaanxi Province,*** field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such *** findings indicate that the Shanyang landslide primarily crept along a weak interlayer under the action of *** landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip *** slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the Shanyang landslide more ***,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the *** study unveils a novel failure mode of apparent dip creep-buckling in the Shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure *** insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides.

关键词： Landslide Steep obliquely inclined bedding slope Failure mode Failure mechanism Apparent dip creep-buckling Lateral friction 3DEC model Landslide numerical model Geological hazards survey engineering

Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

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Current Medical Science 2024年第3期44卷 503-511页

作者： Jian-gang BI Qi LI Yu-sheng GUO Li-ping LIU Shi-yun BAO ping XU Department of Hepatobiliary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinology Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the role of long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the development of hepatocellular carcinoma(HCC).Methods A total of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual luciferase activity assay and RNA pull-down *** RNA expression levels of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression level of CD44 was determined by Western *** cell proliferation was detected by cell proliferation assay,and the cell invasion and migration by transwell invasion *** HCC tumor growth after PCED1B-AS1 was downregulated was determined by in vivo animal *** PCED1B-AS1 was highly expressed in HCC tissues,which was associated with poor survival of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cells,but they did not regulate the expression of each ***,PCED1B-AS1 increased the expression level of CD44,which was targeted by *** cell proliferation and invasion assay revealed that miR-34a inhibited the proliferation and invasion of HCC in vitro,while CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the role of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may play an oncogenic role by regulating the miR-34a/CD44 axis in HCC.

关键词： long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocellular carcinoma microRNA-34a(miR-34a) CD44 proliferation invasion

Normal sperm head morphometric reference values in fertile Asian males

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Asian Journal of Andrology 2024年第3期26卷 315-320页

作者： Ye-Lin Jia Ying-Bi Wu Lin Yu Yan Zheng Ting-Ting Yang Yan-yun wang Bin Zhou Lin Zhang Fu-ping Li Laboratory of Andrology West China Second University Hospital Human Sperm BankChengdu 610000China Laboratory of Molecular Translational Medicine Center for Translational MedicineChengdu 610061China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610061China NHC Key Laboratory of Chronobiology West China Second University HospitalSichuan UniversityChengdu 610000China

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive *** are available to analyze sperm head morphology,but they are limited by poor methodology comparability and *** study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads infertile Asian *** automated sperm morphology analysis system captured 23152 stained spermatozoa from confirmed *** these samples,1856 sperm head images were annotated by three experienced laboratory technicians as“normal”.Weemployed 14 novel morphometric features to describe sperm head size(head length,head width,length/width ratio,and girth),shape(ellipse intersection over union,girth intersection over union,short-axis symmetry,and long-axis symmetry),area(head,acrosome,postacrosomal areas,and acrosome area ratio),and degrees of acrosome and nuclear *** straight-forwardmethod for the morphometric analysis of sperm by accurate visual measurements is clinically *** measured parameterspresent valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian *** detailed measurement data will be valuable for interlaboratory comparisons and technician *** vitro fertilizationand andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing malefertilization potential.

关键词： fertile Asian males head morphometric reference value normal spermatozoa

Doping engineering of iron oxide nanoparticles towards high performance and biocompatible T_(1)-weighted MRI contrast agents

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Rare Metals 2024年第1期43卷 298-308页

作者： Xue Xu ping-Li Dong Yu-yun Chai Run Yang Zhen-Hui Ma Chi-Chong Lu Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Extremely small-sized iron oxide nanoparticles(IONPs) are of great interest in magnetic resonance imaging(MRI) due to their biosafety as an alternative to clinical gadolinium(Ⅲ) complexes-based contrast *** when the particle size is less than 10 nm,it has strong diffusion ability and deep penetration distance in tumor *** doping can significantly enhance the T_(1)contrast effect of nanoparticles by regulating the surface exposed ***,the nucleation and growth processes of multi-component synthesis systems are complex and difficult to be accurately controlled,leading to great challenges in the synthesis of ultra-small-sized nanoparticles with different components and ***,extremely smallsized superparamagnetic gadolinium-doped iron oxide nanoparticles(GdIONPs,Gd_(x)Fe_(3-x)O_(4) NPs) with adjustable doping amount and controllable size in the range of 3.5-7.5 nm were synthesized by thermal ***,as-synthesized GdIONPs were surface modified with a highly water-soluble and biocompatible carboxyl-polyethylene glycol-phosphoric acid ligand with high binding ***_(0.65)Fe_(2.35)O_(4) NPs exhibited very high r_(1) relaxivity of 10.6 mmol^(-1)·L·s^(-1) in terms of all metal concentrations and 49.0 mmol^(-1)·L·s^(-1) in terms of gadolinium alone,respectively,3 and 14 times higher than clinical T_(1) contrast agents(Gd-DTPA).GdIONPs can continuously obtain high resolution images of blood vessels,and can be used as an efficient and multifunctional contrast agent for MR T_(1)*** stable and efficient doping strategy provides an easy and effective method to individually optimize the magnetic properties of complex oxides and their relaxation effects for a variety of biomedical applications.

关键词： Iron oxide nanoparticles Small size Magnetic resonance imaging Substitutional doping Gd dopant

Gastric cancer incidence and mortality in Zhuanghe,China,between 2005 and 2010

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World Journal of Gastroenterology 2012年第11期18卷 1262-1269页

作者： Jing-Jing Jing Jin-Kuan Hao Li-Na wang yun-ping wang Li-Hua Sun Yuan Yuan Tumor Etiology and ScreeningDepartment of Cancer Institute and General Surgery The FirstAffiliated Hospital of China Medical University Key Labora-tory of Cancer Control in Liaoning Province Shenyang 110001Liaoning Province China yun-ping wang The Center of Disease Prevention and Control Zhuanghe116400 Liaoning Province China Office for Cancer Prevention and Control andCancer Registry of Liaoning Province Shenyang 110001 Lia-oning Province China

AIM:To investigate the incidence and mortality of gastric cancer(GC) in Zhuanghe region,northeast China and the influencing factors for their changing ***:All new cancer cases and deaths registered from 2005 to 2010 in Zhuanghe County were *** annual GC cases,constituent ratio,crude rates,age-standardized rates,their sex and age distribution and temporal trends were *** method of annual percentage change(APC) was used to estimate the trends of ***:Altogether 2634 new cases of GC and 1722 related deaths were registered,which accounted for 21.04% and 19.13% of all cancer-related incidence and deaths,*** age-standardized incidence rate steadily decreased from 57.48 in 2005 to 44.53 in 2010 per 10 5 males,and from 18.13 to 14.70 per 10 5 females,resulting in a APC of-5.81% for males and-2.89% for females over the entire *** magnitude of APC in GC mortality amounted to-11.09% and-15.23%,respectively,as the agestandardized mortality rate steadily decreased from 42.08 in 2005 to 23.71 in 2010 per 10 5 males,and from 23.86 to 10.78 per 10 5 *** had a significantly lower incidence(a male/female ratio 2.80,P < 0.001) and mortality(a male/female ratio 2.30,P < 0.001).In both genders,the peak incidence and mortality occurred in the 80-84 years age *** age-standardized mortality/incidence ratio also decreased from the peak of 0.73 in 2005 to 0.53 in 2010 for males,and from 1.32 to 0.73 for ***:Encouraging declines of incidence and mortality of GC were observed in Zhuanghe region between 2005 and 2010,possibly due to the economic development and efficient GC control strategies.

关键词：庄河地区死亡率发病率中国胃癌影响因素

A non-labeled DNA biosensor based on light addressable potentiometric sensor modified with TiO_2 thin film

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 860-866页

作者： Xiao-lin ZONG Chun-sheng WU Xiao-ling WU yun-feng LU ping wang Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China

Titanium dioxide (TiO2) thin film was deposited on the surface of the light addressable potentiometric sensor (LAPS) to modify the sensor surface for the non-labeled detection of DNA molecules. To evaluate the effect of ultraviolet (UV) treatment on the silanization level of TiO2 thin film by 3-aminopropyltriethoxysilane (APTS),fluorescein isothiocyanate (FITC) was used to label the amine group on the end of APTS immobilized onto the TiO2 thin film. We found that,with UV irradiation,the silanization level of the irradiated area of the TiO2 film was improved compared with the non-irradiated area under well-controlled conditions. This result indicates that TiO2 can act as a coating material on the biosensor surface to improve the effect and efficiency of the covalent immobilization of biomolecules on the sensor surface. The artificially synthesized probe DNA molecules were covalently linked onto the surface of TiO2 film. The hybridization of probe DNA and target DNA was monitored by the recording of I-V curves that shift along the voltage axis during the process of reaction. A significant LAPS signal can be detected at 10 μmol/L of target DNA sample.

关键词： DNA生物传感器光寻址电位传感器二氧化钛薄膜薄膜传感器标记表面涂层材料异硫氰酸荧光素紫外线照射