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Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China

Chinese Journal of Cancer 2011年第3期30卷 204-212页

作者： Hui-Min Xu Yi Liang Qiong Chen Qi-Nian Wu yun-miao guo guo-Ping Shen Ru-Hua Zhang Zhi-Wei He Yi-Xin Zeng Fang-yun Xie Tie-Bang Kang State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Pathology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China iuangdong Medical College Cancer Center Dongguan Guangdong 523808 P. R. China.

S-phase kinase-associated protein 2 (Skp2), which plays a role in cell cycle regulation, is commonly overexpressed in a variety of human cancers and associated with poor prognosis. However, its role in nasopharyngeal carcinoma (NPC) is not well understood. In this study, we examined the clinical significance of Skp2, with a particular emphasis on overall survival (OS) and disease-free survival (DFS), in NPC cases in South China, where NPC is an epidemic. Additionally, we explored the function of Skp2 in maintaining a cancer stem cell -like phenotype in NPC cell lines. Skp2 expression was assessed for 127 NPC patients using tissue microarrays and immunohistochemistry and analyzed together with clinicopathologic features, OS, and DFS. Skp2 expression was detectable, or positive, in 75.6% of patients. Although there was no correlation between Skp2 and any clinicopathologic factor, Skp2 expression significantly portended inferior OS (P = 0.013) and DFS (P = 0.012). In the multivariate model, Skp2 expression remained significantly predictive of poor OS [P = 0.009, risk ratio (RR) = 4.06] and DFS (P = 0.008, RR = 3.56), and this was also true for clinical stage (P = 0.012 and RR=3.201 for OS; P = 0.002 and RR=1.94 for DFS) and sex (P = 0.016 and RR=0.31 for OS; P = 0.006 and RR = 0.27 for DFS). After Skp2 knockdown, a colony formation assay was used to evaluate the self-renewal property of stem-like cells in the NPC cell lines CNE-1 and CNE-2. The colony formation efficiency in CNE-1 and CNE-2 cells was decreased. In Skp2-transfected CNE-1 and CNE-2 cells, side population (SP) proportion was increased as detected by flow cytometry. Skp2 is an independent prognostic marker for OS and DFS in NPC. Skp2 may play a role in maintaining the cancer stem cell-like phenotype of NPC cell lines.

关键词： Skp2 蛋白表达鼻咽癌预后患者中国全国人民代表大会细胞周期调控

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WAVES GENERATED BY A 3D MOVING BODY IN A TWO LAYER FLUID OF FINITE DEPTH

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Journal of Hydrodynamics 2005年第1期17卷 92-101页

作者： ZHUWei YOUyun-xiang miaoguo-ping ZHAOFeng ZHANGJun SchoolofNavalArchitecture OceanandCivilEngineeringShanghaiJiaotongUniversityShanghai200030China ChinaShipScientificResearchCenter Wuxi214082China

This paper is concerned with the waves generated by a 3 D body advancing beneath the free surface with constant speed in a two layer fluid of finite depth. By applying Green’s theorem, a layered integral equation system based on the Rankine source for the perturbed velocity potential generated by the moving body was derived with the potential flow theory. A four node isoparametric element method was used to treat with the solution of the layered integral equation system. The surface and interface waves generated by a moving ball were calculated numerically. The results were compared with the analytical results for a moving source with constant velocity.

关键词： internal waves two-layer fluid Rankine source wave-making wave pattern

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang guo-Cui Mao Hui-Lin Jiang Bao-Xia Dong yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma

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癌症 2015年第12期34卷 563-572页

作者： Fu-Tuo Feng Qian Cui Wen-Sheng Liu yun-miao guo Qi-Sheng Feng Li-Zhen Chen miao Xu Bing Luo Da-Jiang Li Li-Fu Hu Jaap M.Middeldorp Octavia Ramayanti Qian Tao Su-Mei Cao Wei-Hua Jia Jin-Xin Bei Yi-Xin Zeng Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Pathology VU University Medical Center Department of Medical Microbiology Qingdao University Medical College Department of Experimental Research Sun Yat-sen University Cancer Center Department of Microbiology Tumor and Cell BiologyKarolinska Institute Department of Clinical Oncology The Chinese University of Hong Kong Department of Epidemiology Cancer Prevention CenterSun Yat-sen University Cancer Center

Background:Epstein-Barr virus(EBV) commonly infects the general population and has been associated with nasopharyngeal carcinoma(NPC),which has a high incidence in certain *** study aimed to address how EBV variations contribute to the risk of ***:Using logistic regression analysis and based on the sequence variations at EBV-encoded RPMS1,a multistage association study was conducted to identify EBV variations associated with NPC risk.A protein degradation assay was performed to characterize the functional relevance of the RPMS1 ***:Based on EBV-encoded RPMS1 variations,a single nucleotide polymorphism(SNP) in the EBV genome(locus 155391:G>A,named Gl 55391 A) was associated with NPC in 157 cases and 319 healthy controls from an NPC endemic region in South China[P < 0.001,odds ratio(OR) = 4.47,95%confidence interval(CI) 2.71-7.37].The results were further validated in three independent cohorts from the NPC endemic region(P < 0.001,OR = 5.20,95%CI3.18-8.50 in 168 cases vs.241 controls,and P < 0.001,OR = 5.27,95%CI 4.06-6.85 in 726 cases vs.880 controls) and a non-endemic region(P < 0.001,OR = 7.52,95%CI 3.69-15.32 in 58 cases vs.612 controls).The combined analysis in 1109 cases and 2052 controls revealed that the SNP Gl 55391 A was strongly associated with NPC(P< 0.001,OR = 5.27,95%CI 4.31-6.44).Moreover,the frequency of the SNP Gl 55391 A was associated with NPC incidence but was not associated with the incidences of other EBV-related ***,the protein degradation assay showed that this SNP decreased the degradation of the oncogenic RPMS1 ***:Our study identified an EBV variation specifically and significantly associated with a high risk of *** findings provide insights into the pathogenesis of NPC and strategies for prevention.

关键词： Epstein-Barr virus Nasopharyngeal carcinoma RPMS1 Association

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： miao Zhou Xiongbin Luo Hang Li Shan guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

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三维有限孔径逆声散射问题的数值解

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上海交通大学学报 2001年第10期35卷 1444-1449页

作者：尤云祥缪国平刘应中上海交通大学船舶与海洋工程学院上海200030

从声散射场远场分布的信息来再现三维障碍物形状反问题的数值解 .提出了求解这类非线性且不适定反问题的一种非线性最优化方法 ,该方法的主要特点是只需声散射场的远场分布在某个有限孔径中若干个入射和观测方向上的远场信息 .数值结果... 详细信息

从声散射场远场分布的信息来再现三维障碍物形状反问题的数值解 .提出了求解这类非线性且不适定反问题的一种非线性最优化方法 ,该方法的主要特点是只需声散射场的远场分布在某个有限孔径中若干个入射和观测方向上的远场信息 .数值结果表明 ,对较小的波数 ,即使只用在较小的入射和观测范围中的远场测量信息 ,得到三维障碍物的一个合理的重构也是可能的 .

关键词：声散射远场波形反问题三维有限孔径

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点源激励波场下的逆障碍物散射问题

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上海交通大学学报 2002年第11期36卷 1703-1708页

作者：尤云祥缪国平上海交通大学船舶与海洋工程学院上海200030

研究了从点源激励散射场的近场信息来再现三维障碍物形状的反问题 ,提出了一种非线性最优化求解方法 .该算法只需求解一个不适定的线性系和一个适定的非线性最小化问题 ,而且只需要点源入射场的散射场在某个有限孔径中若干有限个入射和... 详细信息

研究了从点源激励散射场的近场信息来再现三维障碍物形状的反问题 ,提出了一种非线性最优化求解方法 .该算法只需求解一个不适定的线性系和一个适定的非线性最小化问题 ,而且只需要点源入射场的散射场在某个有限孔径中若干有限个入射和测量点上的近场测量信息 .数值结果表明 ,对较小的波数 ,即使当入射和观测孔径为 π/4立体角时。

关键词：反问题点源散射有限孔径逆声散射

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The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun yun Wen-Biao Han Yi-Yang guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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本院静脉用药集中调配中心调配危害药品对患者及医务人员的安全性研究

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中南药学 2016年第11期14卷 1276-1278页

作者：钟云浪郭苗苗阮祥梅湖北省荆门市第一人民医院药剂科湖北荆门448000 湖北省荆门市第二人民医院药剂科湖北荆门448000

目的探讨静脉用药集中调配中心(PIVAS)调配危害药品对患者及医务人员的安全性,提高患者用药安全及医务人员的职业防护。方法通过回顾性队列调查方法,采用自行设计的调查问卷,对PIVAS与普通病房2种配制环境下患者及医务人员进行调查,并... 详细信息

目的探讨静脉用药集中调配中心(PIVAS)调配危害药品对患者及医务人员的安全性,提高患者用药安全及医务人员的职业防护。方法通过回顾性队列调查方法,采用自行设计的调查问卷,对PIVAS与普通病房2种配制环境下患者及医务人员进行调查,并进行统计学分析。结果对于患者,PIVAS可提高危害药品的疗效及降低不良反应。对于医务人员,PIVAS可以在保证化疗药液质量的前提下,提高护理人员职业安全。结论 PIVAS对危害药品的合理、安全使用具有显著性优势,提高了疗效,降低毒副反应,提高患者的生活质量。

关键词：静脉用药集中调配中心危害药品安全性患者医务人员

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