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Aspirin suppresses hepatocellular carcinoma progression by inhibiting platelet activity

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2742-2756页

作者： li-Jun Zhao Zhi-Yin {2. Wei-Ting liu li-li Yu hao-Nan Qi jie Ren Chen-Guang Zhang Hematology Laboratory The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy School of Medical TechnologyXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common malignant liver disease in the ***(PLTs)are known to play a key role in the maintenance of liver homeostasis and the pathophysiological processes of a variety of liver *** is the most classic antiplatelet ***,the molecular mechanism of platelet action and whether aspirin can affect HCC progression by inhibiting platelet activity need further *** To explore the impact of the antiplatelet effect of aspirin on the development of *** Platelet-rich plasma,platelet plasma,pure platelet,and platelet lysate were prepared,and a coculture model of PLTs and HCC cells was ***-8 analysis,apoptosis analysis,Transwell analysis,and real-time polymerase chain reaction(RT-PCR)were used to analyze the effects of PLTs on the growth,metastasis,and inflammatory microenvironment of ***-PCR and Western blot were used to detect the effects of platelet activation on tumor-related signaling *** was used to block the activation and aggregation of PLTs both in vitro and in vivo,and the effect of PLTs on the progression of HCC RESULTS PLTs significantly promoted the growth,invasion,epithelial-mesenchymal transition,and formation of an inflammatory microenvironment in HCC *** PLTs promoted HCC progression by activating the mitogenactivated protein kinase/protein kinase B/signal transducer and activator of transcription three(MAPK/AKT/STAT3)signaling ***,aspirin inhibited HCC progression in vitro and in vivo by inhibiting platelet *** PLTs play an important role in the pathogenesis of HCC,and aspirin can affect HCC progression by inhibiting platelet *** results suggest that antiplatelet therapy has promising application prospects in the treatment and combined treatment of HCC.

关键词： Platelets Antiplatelet therapy Hepatocellular carcinoma Aspirin Antitumor

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Relationship of inflammatory indices with left atrial appendage thrombus or spontaneous echo contrast in patients with atrial fibrillation

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World Journal of Clinical Cases 2024年第21期12卷 4550-4557页

作者： Zhao wang Bin-hao wang Xiao-Lei Yang {4.-long Xia Sheng-Min Zhang Ying Che Department of Ultrasonography First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Arrhythmia Center First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Department of Cardiology First Affiliated Hospital of Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Ultrasonography First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Inflammatory indices derived from complete blood tests have been reported to be associated with poor outcomes in patients with atrial fibrillation(AF).The data about the relationship between inflammatory indices and left atrial appendage thrombus(LAAT)or dense spontaneous echo contrast(SEC)are *** To explore the value of inflammatory indices for predicting the presence of LAAT or dense SEC in nonvalvular AF *** A total of 4.6 patients with nonvalvular AF who underwent transesophageal echocardiography were included and divided into two groups based on the presence(study group)or absence(control group)of LAAT or dense *** indices,including the neutrophil-to-lymphocyte ratio(NLR),platelet–tolymphocyte ratio(PLR),and lymphocyte-to-monocyte ratio(LMR),were calculated from complete blood *** associations of inflammatory indices RESULTS LAAT and dense SEC were detected in 11(2.7%)and 4.(10.3%)patients,*** PLR only showed an association with LAAT/dense SEC in the univariate *** NLR(odds ratio[OR]=1.4.,95%confidence interval[CI]:1.11-1.98,P=0.007)and reduced LMR(OR=0.59,95%CI:0.4.-0.83,P=0.003)were found to be independent risk factors for the presence of LAAT/dense *** areas under the NLR and LMR curves for predicting LAAT/dense SEC were 0.73(95%CI:0.66-0.80,P3(95%CI:0.65-0.81,P2.8(sensitivity:69.8%;specificity:64.0%)and 2.4.sensitivity:71.7%;specificity:60.6%),*** Increased NLR and decreased LMR may predict LAAT/dense SEC in patients with nonvalvular AF.

关键词： Nonvalvular atrial fibrillation Left atrial appendage thrombus Spontaneous echo contrast Neutrophil–lymphocyte ratio Lymphocyte–monocyte ratio

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3M syndrome patient with a novel mutation:A case rep

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World Journal of Clinical Cases 2024年第8期12卷 1454-1460页

作者： Ming-Ran Luo Si-Ming Dai Yin li Qian wang {2. liu Peng Gao {4.a-yun liu {4.an Chen Shu-{4.e Z{2. Guo-Yong Yin Department of Orthopedics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND A rare autosomal recessive genetic disorder,3M syndrome,is characterized by severe intrauterine and postnatal growth *** with 3M syndrome typically exhibit short stature,facial deformities,long tubular bones,and high vertebral bodies but generally lack mental abnormalities or other organ *** genes associated with 3M syndrome include CUL7,OBSL1 and *** clinical and molecular characteristics of patient with 3M syn-drome are unique and serve as important diagnostic *** SUMMARY In this case,the patient displayed square shoulders,scoliosis,long slender tubular bones,and normal neurological ***,the patient did not exhibit the typical dysmorphic facial features,relative macrocephaly,or growth retardation commonly observed in individuals with 3M *** exon sequencing revealed a novel heterozygous c.56681+1G>C(Splice-3)variant and a previously reported nonsense heterozygous c.334.G>A(***1114.er)variant of ***,it is important to note that the clinical features of 3M syndrome may not always be observable,and genetic confirmation is often ***,the identification of the c.5683+1G>C variant in OBSL1 is notewor-thy because it has not been previously reported in public *** Our study identified a new variant(c.5683+1G>C)of OBSL1 that contributes to expanding the molecular profile of 3M syndrome.

关键词： 3M syndrome CUL7 OBSL1 CCDC8 Autosomal recessive Case report

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Endoscopic polidocanol foam sclerobanding for the treatment of grade Ⅱ-Ⅲ internal hemorrhoids:A prospective,multi-center,randomized study

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World Journal of Gastroenterology 2024年第38期30卷 3326-3335页

作者： Chun-Ying Qu Fei-Yu Zhang Yi Zhang Ming-Ming li Zheng-Hong li Mei-Hong {2. Lei-Ming Xu Feng Shen Wen wang Wu-lian lin Feng-Yu Gao hao Zhang Guang-Yu Chen Department of Gastroenterology&Endoscopy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina Department of Endoscopy Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014Shandong ProvinceChina Department of Endoscopy Baoshan People’s Hospital of Yunnan ProvinceBaoshan 678000Yunnan ProvinceChina Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural *** To evaluate satisfaction,{2.-term recurrence,and post-procedural pain in managing internal hemorrhoids using a combination of polidocanol foam sclerotherapy and *** This was a prospective,multicenter,randomized study.A total of 195 consecutive patients diagnosed with grade II-III internal hemorrhoids were enrolled from four tertiary {4.s and randomly divided into a cap-assisted endoscopic polidocanol foam sclerobanding(EFSB)or an ERBL *** patients were followed-up for 12.***-based severity and post-procedural pain were assessed using a hemorrhoid severity score(HSS)and a visual analog scale(VAS).Continuous variables were reported as medians and interquartile *** One hundred and ninety-five patients were enrolled,with 98 in the EFSB *** was lower in the EFSB group than in the ERBL group at 8 weeks[4.0(3.0-5.0)vs 5.0(4.0-6.0),P=0.003]and 12.month[2.0(1.0-3.0)vs 3.0(2.0-3.0),P1]of *** prolapse recurrence rate was lower in the EFSB group at 12.months(11.2.vs 2..6%,P=0.038).Multiple linear regression analysis demonstrated that EFSB treatment[B=-0.915,95%confidence interval(CI):−1.301 to−0.530,P=0.001]and rubber band number(B=0.84.,95%CI:0.595-1.092.P1)were negatively and independently associated with the VAS score 2.4}hours *** median VAS was lower in the EFSB group than in the ERBL[2.0(1.0-3.0)vs 3.0(2.0-4.0),P1].CONCLUSION Cap-assisted EFSB provided {2.-term satisfaction and effective relief from the recurrence of prolapse and pain 2.4}hours post-procedure.

关键词： Internal hemorrhoids Endoscopic therapy Polidocanol foam Sclerotherapy Rubber band ligation Sclerobanding

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Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair

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Research 2024年第1期2023卷 489-507页

作者： Xiaoping Song jifeng Zhang Si Shen Dan liu jie Zhang Wenming Yin Genlan ye Leyu {4. liu cai Honghao Hou Xiaozhong Qiu Central Laboratory The Fifth Affiliated HospitalSouthern Medical UniversityGuangzhouGuangdong 510910China Department of Anatomy Neuroscience Laboratory for Cognitive and Developmental DisordersMedical College of Jinan UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical ScienceBiomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhouGuangdong 510515China

The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(FSB),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular *** results revealed that the originally stiff,homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked MI repair performance with reduced CM apoptosis and myocardial fibrosis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical *** findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment.

关键词： bladder thereby patch

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Eco-friendly polysaccharide coatings for antifouling and dragreduction and potential application for marine devices

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Friction 2024年第4期12卷 726-744页

作者： hao YANG liguo {2. Wenhui Zhao Fagla Jules MAWIGNON Hui GUO Yongkang WU Yali ZHANG Guangneng DONG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Institute of Design Science and Basic ComponentsSchool of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Biomedical Information of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Department of Endocrinology First Affiliated Hospital of Medical CollegeXi'an Jiaotong UniversityXi’an 710061China

Traditional antifouling agents usually have a certain toxic effect on marine environments and non-target *** this study,Dictyophora indusiata polysaccharide(DIP)was applied as a natural antifouling surface modifier to prepare the surface coating for marine *** DIP coatings were prepared:*** spore polysaccharide(DISP),*** volva polysaccharide(DIVP),and *** embryonic body polysaccharide(DIEP).The antifouling,tribological,and anticorrosion behavior of the coatings were *** revealed that the three kinds of DIP coatings had excellent antifouling properties,which could effectively prevent the adhesion of Chlorella and the attachment of water-based and oily stains on the ***,the coatings showed great mechanical stability and could maintain an extremely low coefficient of friction(COF4.9 orders of magnitude higher than the control *** research showed a promising prospect of surface coating fabrication with DIP for marine devices to achieve the purpose of antifouling and drag reduction.

关键词： Dictyophora indusiata polysaccharide(DIP)coating antifouling anticorrosion lubrication and drag reduction

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Impact of frailty on outcomes of elderly patients undergoing percutaneous coronary intervention: A systematic review and metaanalysis

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World Journal of Clinical Cases 2024年第1期12卷 107-118页

作者： Shi-Shi wang wang-{2. liu Department of Emergency Medicine Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Department of Geriatrics Huzhou Third Municipal Hospitalthe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty is a common condition in elderly patients who receive percutaneous coronary intervention(PCI).However,how frailty affects clinical outcomes in this group is *** To assess the link between frailty and the outcomes,such as in-{2. complic-ations,post-procedural complications,and mortality,in elderly patients *** The PubMed/MEDliNE,EMBASE,Cochrane library,and Web of Science databases were screened for publications up to August *** primary outcomes assessed were in-{2. and all-cause mortality,major adverse cardiovascular events(MACEs),and major *** Newcastle-Ottawa Scale was used for quality *** Twenty-one studies with 739693 elderly patients undergoing PCI were *** was consistently associated with adverse *** patients had significantly higher risks of in-{2. mortality[risk ratio:3.4.,95%confidence interval(95%CI):1.90-6.2.],all-cause mortality[hazard ratio(HR):2.08,95%CI:1.78-2.4.],MACEs(HR:2.92.95%CI:1.85-4.60),and major bleeding(HR:4.60,95%CI:2.89-7.32.compared to non-frail *** Frailty is a pivotal determinant in the prediction of risk of mortality,development of MACEs,and major bleeding in elderly individuals undergoing percutaneous coronary intervention.

关键词： Frailty Elderly Percutaneous coronary intervention Systematic review Meta-analysis

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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-jie Tang Xiao-li Ma Xiang-ling He Wei-Hua pan Xiao-Hong Zhang Sha-Yi jiang Ju Gao Fu li Wei Yao Song Gu Wei-ling Zhang Qiang Zhao Shi-hao Huang Yong-Jun Fang Wei liu Hui-Zhong Niu Chun-Mei wang li-Rong Sun Hui Gao {12.-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge wang Zhong-Rong li liang-Chun Yang ye-Ming Wu Huan-Min wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2.15 to June 2.2. was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4.year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4.year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4.year 0S was 100%,97.3%,94.4.,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 2.9 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the {4. two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2.16 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the {4. two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

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Interplay between mesenchymal stem cells and macrophages:Promoting bone tissue repair

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World Journal of Stem Cells 2024年第4期16卷 375-388页

作者： Fei-Fan Zhang Yang hao Kuai-Xiang Zhang jiang-jia Yang Zhi-Qiang Zhao Hong-jian liu ji-Tian li Molecular Biology Lab Henan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital)Zhengzhou 450000Henan ProvinceChina Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Graduate School Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

The repair of bone tissue damage is a complex process that is well-orchestrated in time and space,a focus and difficulty in orthopedic *** recent years,the success of mesenchymal stem cells(MSCs)-mediated bone repair in clinical trials of large-area bone defects and bone necrosis has made it a candidate in bone tissue repair engineering and regenerative *** are closely related to *** one hand,MSCs regulate the immune regulatory function by influencing macrophages proliferation,infiltration,and phenotype polarization,while also affecting the osteoclasts differentiation of *** the other hand,macrophages activate MSCs and mediate the multilineage differentiation of MSCs by regulating the immune *** cross-talk between MSCs and macrophages plays a crucial role in regulating the immune system and in promoting tissue *** full use of the relationship between MSCs and macrophages will enhance the efficacy of MSCs therapy in bone tissue repair,and will also provide a reference for further application of MSCs in other diseases.

关键词： Bone tissue damage Inflammation Macrophages Mesenchymal stem cells Tissue regeneration

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Effect of SARS-CoV-2.infection on semen parameters in sperm bank volunteers with normal sperm concentration

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Asian Journal of Andrology 2024年第3期26卷 328-332页

作者： li wang Wen-Kai Han Xiao-Hui Song Qi-lin Zhang An-Quan Guan Yuan Gao jin-{4. Ma Center for Reproductive Medicine Shandong UniversityJinan 250001China State Key Laboratory of Reproductive Medicine and Offspring Health ShandongUniversityJinan 250001China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250001China Shandong KeyLaboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250001China Shandong Provincial Clinical Research Center for Reproductive Health Jinan 250001China Shandong Technology Innovation Center for Reproductive Health Jinan 250001China NationalResearch Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversityJinan 250001China Research Unit of Gametogenesis andHealth of ART-Offspring Chinese Academy of Medical Sciences(No.2021RU001)Jinan 250001China

In this study,we aimed to assess the effect of severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.infection on *** study comprised 110 sperm volunteers who self-reported SARS-CoV-2.infection from the Human Sperm Bank ofthe Center for Reproductive Medicine,Shandong university(jinan,{2.).The volunteers had normal sperm concentration *** volunteer provided semen samples before and after *** selected 90 days after infection as the cutoff *** parameters within 90 days after infection of 109 volunteers(group A)were compared with semen parameters before ***,semen parameters on or after 90 days after infection of 36 volunteers(group B)were compared with semen parameters ***,based on whether the volunteers had completed the three-dose SARS-CoV-2.vaccination booster,volunteersin group A and B were further divided into two subgroups *** parameters were compared before and after infection ineach *** results showed that in this cohort population,the semen quality in volunteers with normal sperm concentrationsbefore infection decreased after SARS-CoV-2.infection within 90 days,while the semen quality returned to preinfection levels after *** completion of a three-dose SARS-CoV-2.vaccination booster may exert a protective effect on semen quality after infection.

关键词： SARS-CoV-2 SARS-CoV-2.vaccination semen quality sperm donation sperm parameters

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