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Retrorectal tumors in adults:Magnetic resonance imaging findings

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World Journal of Gastroenterology 2010年第46期16卷 5822-5829页

作者： Bo-Lin Yang,yun-fei gu,Wan-Jin Shao,Hong-Jin Chen,gui-Dong Sun,Department of Coloproctology,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Hei-Ying Jin,Department of Coloproctology,The 3rd Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Xin Zhu,Department of Radiology,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Department of Radiology The Affiliated Hospital of Nanjing University of Chinese Medicine No.155 Hanzhong Road Nanjing 210029 China.

AIM:To retrospectively evaluate the magnetic resonance imaging (MRI) features of adult retrorectal tumors and compare with histopathologic ***:MRI features of 21 patients with preoperative suspicion of retrorectal tumors were analyzed based on the histopathological and clinical ***:Fourteen benign cystic lesions appeared hypointense on T1-weighted images,and hyperintense on T2-weighted images with regular peripheral *** or dermoid cysts were unilocular,and tailgut cysts were *** of intracystic intermediate signal intensity was observed in one case of tailgut cyst with a component of *** solid tumors were malignant lesions and showed heterogeneous intensity on *** adenocarcinomas showed high signal intensity on T2-weighted and mesh-like enhancing areas on fat-suppressed T2-weighted *** was a fistula between the mass and anus with an internal opening in mucinous adenocarcinomas arising from anal *** stromal tumors displayed low signal intensity on T1-weighted images,and intermediate to high signal intensity on T2-weighted *** necrosis could be seen as a high signal on T2-weighted ***:MRI is a helpful technique to define the extent of the retrorectal tumor and its relationship to the surrounding structures,and also to demonstrate possible complications so as to choose the best surgical approach.

关键词： Retrorectal tumor Presacral lesions Magnetic resonance imaging Congenital cyst Malignant tumor Diagnosis

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复杂性肛瘘手术治疗的现存问题及对策

中西医结合学报 2009年第12期7卷 1101-1103页

作者：竺平谷云飞杨柏霖南京中医药大学第一临床医学院中医外科教研室南京210000

针对目前复杂性肛瘘治疗中普遍存在的复发率高、肛门功能保护不足的现状,为解决临床医生忽视术前诊断,功能保护意识薄弱以及缺乏规范的临床诊治指南等问题,本文提出建立术前诊断"金标准"及医疗转诊机制,确立切断肛门括约肌新原则,收集... 详细信息

针对目前复杂性肛瘘治疗中普遍存在的复发率高、肛门功能保护不足的现状,为解决临床医生忽视术前诊断,功能保护意识薄弱以及缺乏规范的临床诊治指南等问题,本文提出建立术前诊断"金标准"及医疗转诊机制,确立切断肛门括约肌新原则,收集高级别循证医学证据等对策,从而制订出具有中国特色的肛瘘临床诊治指南,以期提高该病的治愈率并大幅减少术后肛门失禁。

关键词：肛瘘手术问题解决对策

黄芩苷对错配修复基因缺失LoVo细胞的抑制作用及其机制

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世界华人消化杂志 2008年第21期16卷 2376-2380页

作者：杨柏霖刘飞谷云飞金黑鹰刘秀芳南京中医药大学附属医院肛肠科江苏省南京市210029 南京中医药大学第三附属医院全国肛肠医疗中心江苏省南京市210001

目的:探讨黄芩苷诱导LoVo细胞凋亡的作用及机制.方法:将黄岑苷40mg溶于19.8mL生理盐水+100μLHCl+100μLNaOH,阿斯匹林1.8g溶于2mL乙腈+4mL NaOH+2m LHCl,分别处理LoVo细胞,1g/L乙腈溶液为对照.采用体外培养技术、TUNEL法观察细胞凋亡率... 详细信息

目的:探讨黄芩苷诱导LoVo细胞凋亡的作用及机制.方法:将黄岑苷40mg溶于19.8mL生理盐水+100μLHCl+100μLNaOH,阿斯匹林1.8g溶于2mL乙腈+4mL NaOH+2m LHCl,分别处理LoVo细胞,1g/L乙腈溶液为对照.采用体外培养技术、TUNEL法观察细胞凋亡率,变性凝胶电泳检测微卫星标志BAT-25、D2S123状况.结果:黄芩苷和阿斯匹林均能诱导LoVo细胞凋亡,在各时间点与对照组比较统计学差异有显著意义(P=0.0000);黄芩对结肠LoVo细胞的诱导凋亡作用明显强于阿司匹林,24h两者差异无统计学意义,96h和1wk两者差异统计学有显著意义(93.33%vs44.23%,63.29%vs23.20%,均P=0.0000),其作用时间在96h达到高峰,与时间不呈依赖关系.黄芩苷和阿司匹林均未影响LoVo细胞的BAT-25、D2S123微卫星状态.结论:黄芩苷具有较强诱导LoVo细胞凋亡的作用,但对LoVo细胞的BAT-25、D2S123微卫星状态无影响,其诱导LoVo细胞凋亡可能是通过其它作用途径.

关键词：黄芩苷凋亡微卫星不稳定聚合酶链反应-单链构象多态性

散发性结直肠癌微卫星不稳定性及其与临床病理生物学的关系

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世界华人消化杂志 2007年第10期15卷 1160-1164页

作者：杨柏林谷云飞赖仁胜谢玲金黑鹰南京中医药大学附属医院肛肠科江苏省南京市210029 南京中医药大学附属医院病理科江苏省南京市210029 南京中医药大学第三附属医院全国肛肠医疗中心江苏省南京市210001

目的:探讨分析中国人散发性结直肠癌微卫星不稳定的变异及其与临床病理生物学特征的关系．方法:应用荧光多重PCR方法检测105例散发性结直肠癌初诊患者微卫星状态,分析MSI结直肠癌潜在的相关临床病理生物学特征．结果:105结直肠癌中,MSI... 详细信息

目的:探讨分析中国人散发性结直肠癌微卫星不稳定的变异及其与临床病理生物学特征的关系．方法:应用荧光多重PCR方法检测105例散发性结直肠癌初诊患者微卫星状态,分析MSI结直肠癌潜在的相关临床病理生物学特征．结果:105结直肠癌中,MSI检出率24．7％,其中MSI-H 14例(13．3％),MSI-L 12例(11．4％);队列中各位点突变率分别是D5S346(5．7％), BAT26(8．6％),BAT25(10．5％),D17S250(8．6％), D2S123(10．5％);MSI结直肠癌的组织分化程度与淋巴结转移情况与MSS结直肠癌有显著的统计学差异(P=0．047,P=0．029),但在患者年龄、肿瘤位置、病理性质无显著临床意义(P>0．05)．结论:MSI结直肠癌具有低分化癌多见,淋巴结转移少等特点,淋巴结转移少可能是MSI结直肠癌具有生存优势的原因之一．

关键词：散发性结直肠癌微卫星不稳定临床病理生物学特征

“1+1+1”签约模式下社区2型糖尿病患者自我管理支持的效果研究

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上海医药 2017年第20期38卷 44-46页

作者：石云盛飞顾秋英上海市嘉定区嘉定镇街道社区卫生服务中心上海201800

目的 :研究"1+1+1"签约模式下社区2型糖尿病患者自我管理支持的效果。方法 :2016年7月抽取上海市嘉定区嘉定镇街道社区卫生服务中心社区糖尿病管理系统中122例糖尿病患者,家庭医生在自愿的基础上与患者进行"1+1+1"签约,将签约患者设为... 详细信息

目的 :研究"1+1+1"签约模式下社区2型糖尿病患者自我管理支持的效果。方法 :2016年7月抽取上海市嘉定区嘉定镇街道社区卫生服务中心社区糖尿病管理系统中122例糖尿病患者,家庭医生在自愿的基础上与患者进行"1+1+1"签约,将签约患者设为研究组(62例),未签约患者设为对照组(60例),研究组采用糖尿病自我管理支持手段管理,对照组采用常规社区综合干预手段管理。在研究开始时和6个月后分别测量两组的空腹血糖,餐后2 h血糖、糖化血红蛋白、甘油三酯、胆固醇、低密度脂蛋白胆固醇、体重指数、血压等指标。结果 :与对照组比较,研究组空腹血糖,餐后2 h血糖、糖化血红蛋白、甘油三酯、胆固醇、低密度脂蛋白胆固醇、收缩压均有明显改善,差异有统计学意义(P<0.05),患者自我管理状况均有显著改善,差异有统计学意义(P<0.05)。结论 :"1+1+1"签约模式下,糖尿病患者自我管理支持可改善糖尿病患者空腹血糖,餐后2小时血糖、糖化血红蛋白、甘油三酯、胆固醇、低密度脂蛋白胆固醇、收缩压等生化指标,提高患者自我管理能力,值得在社区推广。

关键词： 2型糖尿病 “1+1+1”签约模式自我管理支持

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基于耦合界面键合效应的石墨烯磨损研究

原子与分子物理学报 2025年第6期42卷 66-75页

作者：郑云飞卢艳武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室武汉430081 武汉科技大学精密制造研究院武汉430081

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖... 详细信息

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖端滑动过程的动态分析,揭示了考虑尖端与石墨烯之间存在界面键时石墨烯层的理化耦合作用下的磨损机理.研究结果表明:当考虑金刚石尖端与石墨烯之间化学键合时,石墨烯发生磨损破裂的临界载荷相对于不考虑界面化学键时的值减小,这是由于界面键的形成会剥离石墨烯导致石墨烯断裂所致;金属基底的粗糙度也是决定石墨烯发生磨损破裂时临界载荷的重要因素之一,当粗糙度增大,临界载荷减小,同时通过增加石墨烯层的层数(增韧)来提高石墨烯发生磨损破裂失效的临界载荷.

关键词：石墨烯层界面键分子动力学磨损破裂

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Isolation and differentiation of neural stem/progenitor cells from fetal rat dorsal root ganglia

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Science China(Life Sciences) 2010年第9期53卷 1057-1064页

作者： gu yun HU Nan LIU Jie DING fei gu XiaoSong Medical School of Soochow University Suzhou 215123China Jiangsu Key Laboratory of Neuroregeneration Nantong UniversityNantong 226001China

To find a promising alternative to neurons or schwann cells (SCs) for peripheral nerve repair applications,this study sought to isolate stem cells from fetal rat dorsal root ganglion (DRG) *** expression analysis confirmed neural stem cell characteristics of DRG-derived neurospheres in terms of expressing neural stem cell-specific genes and a set of well-defined genes related to stem cell niches and glial fate *** the influence of neurotrophic factors,bFGF and NGF,the neurospheres gave rise to neurofilament-expressing neurons and S100-expressing Schwann cell-like cells by different *** study suggests that a subpopulation of stem cells that reside in DRGs is the progenitor of neurons and glia,which could directly induce the differentiation toward neurons,or SCs.

关键词： dorsal root ganglia cell culture stem/progenitor cells immunocytochemistry induced differentiation

Early detection of noise-induced hearing loss

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World Journal of Clinical Cases 2022年第6期10卷 1815-1825页

作者： Zhao-Li Meng fei Chen fei Zhao Hai-Ling gu yun Zheng Department of Otorhinolaryngology-Head and Neck Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Cardiff School of Health Science Cardiff Metropolitan UniversityCardiff CF30UJUnited Kingdom Department of Hearing and Speech Science Xinhua CollegeSun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Hearing Speech and Language RehabilitationSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Noise-induced hearing loss(NIHL)is the second most common acquired hearing loss following *** to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in young *** is *** minor hearing pathologies before they progress to hearing problems that affect daily life is *** To compare the advantages and disadvantages of extended high frequency(EHF)and otoacoustic emission and determine an indicator of hearing pathologies at the early sub-clinical *** This cross-sectional study was implemented in West China Hospital of Sichuan University from May to September 2019.A total of 86 participants,aged 18-22 years,were recruited to establish normative thresholds for *** 159 adults,aged 18-25 years with normal hearing(0.25-8 kHz≤25 dBHL),were allocated to low noise and noise exposure *** otoacoustic emission(DPOAE),transient evoked otoacoustic emissions(TEOAE),and EHF were assessed in the two groups to determine the superior technique for detecting early-stage noise-induced *** chi-square test was used to assess the noise and low noise exposure groups with respect to extended high-frequency audiometry(EHFA),DPOAE,and TEOAE.P≤0.05 was considered statistically *** A total of 86 participants(66 females and 20 males)aged between 18 and 22(average:20.58±1.13)years were recruited to establish normative thresholds for *** normative thresholds for 9,10,11.2,12.5,14,16,18,and 20 kHz were 15,10,20,15,15,20,28,and 0 dBHL,respectively.A total of 201 participants were recruited and examined for *** them,159 adults aged between 18 and 25 years were eligible in this *** statistical difference was detected between the noise exposure and the low noise exposure groups using EHFA,DPOAE,and TEOAE(P>0.05)except in the right ear at 4 kHz using TEOAE(abnormal rate 20.4%vs 5.2%,respectively;P=0.05).CONCLUSION These results s

关键词： Early detection superiority Noise-induced hearing loss Otoacoustic emission Extended high frequency Noise Hearing loss

Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes

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Neuroscience Bulletin 2016年第4期32卷 331-340页

作者： yun-Tian Shen yun gu Wen-Feng Su Jing-fei Zhong Zi-Han Jin Xiao-Song gu Gang Chen Jiangsu Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong University Xinglin College Nantong University

Myelination by oligodendrocytes in the central nervous system requires coordinated exocytosis and endocytosis of the major myelin protein, proteolipid protein （PLP）. Here, we demonstrated that a small GTPase, Rab27b, is involved in PLP trafficking in oligodendrocytes. We showed that PLP co-localized with Rab27b in late endosomes/lysosomes in oligodendrocytes. Short hairpin- mediated knockdown of Rab27b not only reduced lysosomal exocytosis but also greatly diminished the surface expression of PLP in oligodendrocytes. In addition, knockdown of Rab27b reduced the myelin-like membranes induced by co-culture of oligodendrocytes and neurons. Our data suggest that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/ lysosomes to the cell membrane in oligodendrocytes.

关键词： Myelination Neuron-glial interaction Oligodendrocyte Lysosome Rab27b