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Glutamine and recombinant human growth hormone protect intestinal barrier function following portal hypertension surgery

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World Journal of Gastroenterology 2007年第15期13卷 2223-2228页

作者： Zhao-Feng Tang yun-biao ling Nan Lin Zheng Hao Rui-yun Xu Department of Hepatobiliary Surgery The Third Affiliated Hospital Sun Yat-sen University Guangzhou 510630 Guangdong Provice China

AIM： To evaluate the effects of combined treatment of glutamine （Gln） and recombinant human growth hormone（rhGH） on intestinal barrier function following portal hypertension surgery. METHODS： This study was designed as a prospective, randomized and controlled clinical trial. Forty two patients after portal hypertension surgery were randomly assigned into 2 groups： control group （n = 20） and supplemental group （adding Gin and rhGH, n = 22）. Every patient received isocaloric and isonitrogenous standard total parenteral nutrition （TPN） starting 3 d after surgery for 7 d. Blood samples were obtained before surgery and at the 3rd and 10th day postoperatively. Host immunity was evaluated by measuring levels of CD4, CD8, CD4/CD8, IgG, IgM and IgA, and the inflammatory responses were determined by assessing IL-2, TNF-α and C-reactive protein （CRP） levels. Intestinal permeability and integrity was evaluated by L/M test and histological examination, respectively. RESULTS： On postoperative d 10, CD4, CD4/CD8, IgG and IL-2 levels in supplemental group were significantly higher than those in control group （33.7±5.5 vs 31.0 ± 5.4, P 〈 0.05, （1.17±0.32 vs 1.05 ± 0.15, P 〈 0.05, 13.94±1.09 vs 12.33±1.33, P 〈 0.05, and 368.12 ± 59.25 vs 318.12 ± 45.65, P 〈 0.05, respectively）, whereas the increase in serum TNF-α concentration was significantly reduced （41.02 ± 27.56 vs 160.09 ± 35.17, P 〈 0.05）. The increase in L/M ratio was significantly lower in the supplemental group than in the control group （0.0166 ± 0.0017 vs 0.0339 ± 0.0028, P 〈 0.05）. Moreover, mucosal integrity in the supplemental group was better than in the control group.CONCLUSION： Postoperative administration of TPN supplemented with Gin and rhGH in patients after portal hypertension surgery improves immune function, modulates inflammatory response, prevents the intestinal mucous membrane from atrophy and preserves intestinal integrity.

关键词： Liver cirrhosis Portal hypertension Total parenteral nutrition Intestinal barrier function

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Evaluation of the effects of combined endoscopic variceal ligation and splenectomy with pericardial devascularization on esophageal varices

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World Journal of Gastroenterology 2006年第42期12卷 6889-6892页

作者： Bo Liu Mei-Hai Deng Nan Lin Wei-Dong Pan yun-biao ling Rui-yun Xu Department of Hepatobiliary Surgery Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 Guangdong Province China

AIM: To detect the hemodynamic alterations in collateral circulation before and after combined endoscopic variceal ligation (EVL) and splenectomy with pericardial devascularization by ultrasonography, and to evaluate their effect using hemodynamic parameters. METHODS: Forty-three patients with esophageal varices received combined EVL and splenectomy with pericardial devascularization for variceal eradication. The esophageal vein structures and azygos blood flow (AZBF) were detected by endoscopic ultrasonography and color Doppler ultrasound. The recurrence and rebleeding of esophageal varices were followed up. RESULTS: Patients with moderate or severe varices in the esophageal wall and those with severe peri- esophageal collateral vein varices had improvements after treatment, while the percentage of patients with severe para-esophageal collateral vein varices decreased from 54.49% to 2.33%, and the percentage of patients with detectable perforating veins decreased from 79.07% to 4.65% (P < 0.01). Color Doppler flowmetry showed a significant decrease both in AZBF (43.00%, P < 0.05) and in diameter of the azygos vein (28.85%, P < 0.05), while the blood flow rate was unchanged. The recurrence rate of esophageal varices was 2.5% (1/40, mild), while no re-bleeding cases were recorded. CONCLUSION: EVL in combination with splenectomy with pericardial devascularization can block the collateral veins both inside and outside of the esophageal wall, and is more advantagious over splenectomy in combination with pericardial devascularization or EVL in preventing recurrence and re-bleeding of varices.

关键词： Esophageal varices Endoscopic ultrasound Color Doppler ultrasonography Endoscopic variceal ligation splenectomy with pericardial devascularization

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Coordinated Control Strategy of New Energy Power Generation System with Hybrid Energy Storage Unit

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Energy Engineering 2025年第1期122卷 167-184页

作者： yun Zhang ZifenHan biao Tian Ning Chen Yi Fan School of Mechano-Electronic Engineering Xidian UniversityXi’an710071China Electric Power Control Center State Grid Gansu Electric Power CompanyLanzhou730030China Electric Power Control Center State Grid Gansu Electric Power Company Zhangye Power Supply BranchZhangye734000China

The new energy power generation is becoming increasingly important in the power *** as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power *** solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage ***,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage ***,the fuzzy control algorithm is introduced to balance the power between energy *** this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current *** is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.

关键词： Photovoltaic power suppression hybrid energy storage unit variationalmodal decomposition fuzzy control power distribution control

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The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun yun Wen-biao Han Yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

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Decreased expression of ApoF associates with poor prognosis in human hepatocellular carcinoma

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Gastroenterology Report 2019年第5期7卷 354-360,I0002页

作者： Ya-Bin Wang Bo-Xuan Zhou yun-biao ling Zhi-Yong Xiong Rui-Xi Li Yue-Si Zhong Ming-Xing Xu Yi Lu Hao Liang Gui-Hua Chen Zhi-Cheng Yao Mei-Hai Deng Department of Liver Transplantation Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery The Lingnan Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Hepatocellular carcinoma(HCC)is frequently associated withmetabolism *** evidence has demonstrated the crucial role of lipidmetabolismin HCC *** function of apolipoprotein F(ApoF),a lipid transfer inhibitor protein,in HCC is incompletely *** aimed to evaluate the functional role of ApoF in HCC in this ***:We used quantitative reverse-transcription polymerase chain reaction(qRT-PCR)to detect ApoF mRNA expression in HCC tissues and hepatoma cell lines(SMMC-7721,HepG2,and Huh7).Immunohistochemistry was performed to detect the expression of ApoF in HCC *** associations between ApoF expression and clinicopathological features as well as HCC prognosis were *** effect of ApoF on cellular proliferation and growth of SMMC-7721 and Huh7 cells was examined in vitro and in ***:ApoF expression was significantly down-regulated at both mRNA and protein levels in HCC tissues as compared with adjacent *** SMMC-7721 and Huh7 HCC cells,ApoF overexpression inhibited cell proliferation and *** a xenograft nude mouse model,ApoF overexpression effectively controlled HCC ***–Meier analysis results showed that the recurrence-free survival rate of HCC patients with low ApoF expression was significantly lower than that of other HCC *** ApoF expression was associated with several clinicopathological features such as liver cirrhosis,Barcelona Clinic Liver Cancer stage and tumor-node-metastasis ***:ApoF expression was down-regulated in HCC,which was associated with low recurrence-free survival *** may serve as a tumor suppressor in HCC and be a potential application for the treatment of this disease.

关键词： hepatocellular carcinoma biomarkers apolipoprotein F prognosis

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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利用mtDNA信息分析陶寺古牛的起源驯化

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农业生物技术学报 2025年第1期33卷 92-103页

作者：张兴杨柳侯凌云凌飞向海赵兴波华南理工大学生物科学与工程学院佛山大学动物科技学院/广东省动物分子设计与精准育种重点实验室中国农业大学动物科学技术学院/畜禽生物育种全国重点实验室

作为最重要的家畜之一，普通牛（Bos taurus）在中国的起源和传播模式受到广泛关注。本研究收集了来自黄河中游3个考古遗址的9个古代牛遗骸，提取古DNA进行PCR测序和系统发生分析，以探索中国家养牛的起源和传播。经2轮PCR实验获得4个... 详细信息

作为最重要的家畜之一，普通牛（Bos taurus）在中国的起源和传播模式受到广泛关注。本研究收集了来自黄河中游3个考古遗址的9个古代牛遗骸，提取古DNA进行PCR测序和系统发生分析，以探索中国家养牛的起源和传播。经2轮PCR实验获得4个陶寺（距今4100年前）古牛527 bp的线粒体DNA（mitochondrial DNA, mtDNA）序列。单倍型划分结果显示，陶寺古牛存在4种单倍型，都属于家养普通牛T3和T4单倍群，证实中国普通牛起源于近东地区，4 100年前就已经被华北人群利用。此外，陶寺遗址丰富的单倍型数量提示陶寺遗址古代牛群体具有较高的母系遗传多样性。群体间遗传分化指数FST（Fstatistics）分析和Median-Joining网络图表明，中国古代牛与现代东亚(FST=0.0164)及中国普通牛(FST=0.0066)均有密切的遗传关系，提示陶寺遗址古代牛群体可能是现代东亚和中国普通牛的重要母系祖先群体之一。本研究为解析我国的家牛起源和传播提供了分子遗传证据。

关键词：古代DNA 陶寺遗址普通牛起源

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Discovery of a Homolog of Siderophilin in a Plant

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Journal of Integrative Plant Biology 2005年第12期47卷 1409-1411页

作者： yun-biao FEI Peng-Xiu CAO Su-Qin GAO ling-Bo WEI Bin WANG Institute of Genetics and Developmental Biology the Chinese Academy of Sciences Beijing 100101 China

Members belonging to the siderophilin family are iron-binding and iron-transporting proteins, which includes transferrin and lactoferrin. They have only been found in animals previously. If siderophilin could be found in and isolated from a plant, its production and subsequent extensive application could be increased. The present study is the first to report the discovery of a homolog of siderophilin in a plant. In order to purify antifreeze proteins from Ammopiptanthus mongolicus （Maxim.） Cheng f., the authors processed the proteins from the leaves using techniques such as column chromatography using DEAE-Cellulose-52, gel filtration via Sephacryl S-100 HR medium, hydrophobic interaction chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Mass spectroscopy was performed on the three proteins purified and the sequence of one of the proteins （containing 32 amino acids） was found to have 97% homology with the corresponding part of one type of human lactoferrin. Moreover, one of the two peptides belongs to an iron-binding domain. So, it is possible that siderophilin also exists in plants and plays a role as an antibacterial and antifungal, among other actions.

关键词： antibacterial iron-binding domain lactoferrin siderophilin transferrin.

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Vernier effect facilitates integrated lithium niobate single-mode lasers

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Science China(Physics,Mechanics & Astronomy) 2022年第3期65卷 133-134页

作者： Xin-biao Xu Chang-ling Zou Key Laboratory of Quantum Information University of Science and Technology of ChinaChinese Academy of SciencesHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

A research group from Nankai University in China has demonstrated an integrated whispering gallery mode(WGM)microcavity laser on erbium-doped thin-film lithium niobate with a pump threshold of about 200 μW and a side-mode suppression ratio exceeding 26 d B [1]. The Vernier effect is applied to realize the single-mode lasing in a photonic molecule. The work provides a feasible scheme for on-chip single-mode laser for integrated lithium niobate on insulator(LNOI) photonic circuits, and more active devices in LNOI will be developed inspired by this work.

关键词： pump mode lithium

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Interaction of subway LIM vehicle with ballasted track in polygonal wheel wear development

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Acta Mechanica Sinica 2011年第2期27卷 297-307页

作者： ling Li Xin-biao Xiao Xue-Song Jin State Key Laboratory of Traction Power Southwest Jiaotong University 610031 Chengdu China

This paper develops a coupled dynamics model for a linear induction motor （LIM） vehicle and a subway track to investigate the influence of polygonal wheels of the vehicle on the dynamic behavior of the system. In the model, the vehicle is modeled as a multi-body system with 35 degrees of freedom. A Timoshenko beam is used to model the rails which are discretely supported by sleepers. The sleepers are modeled as rigid bodies with their vertical, lateral, and rolling motions being considered. In order to simulate the vehicle running along the track, a moving sleeper support model is introduced to simulate the excitation by the discrete sleeper supporters, in which the sleepers are assumed to move backward at a constant speed that is the same as the train speed. The Hertzian contact theory and the Shen– Hedrick–Elkins’ model are utilized to deal with the normal dynamic forces and the tangential forces between wheels and rails, respectively. In order to better characterize the linear metro system （LMS）, Euler beam theory based on modal superposition method is used to model LIM and RP. The vertical electric magnetic force and the lateral restoring force between the LIM and RP are also taken into consideration. The former has gap-varying nonlinear characteristics, whilst the latter is considered as a constant restoring force of 1 kN. The numerical analysis considers the effect of the excitation due to polygonal wheels on the dynamic behavior of the system at different wear stages, in which the used data regarding the polygonal wear on the wheel tread are directly measured at the subway site.

关键词： Linear induction motor Uneven wear Wheel out of roundness Vehicle-track coupling dynamics

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