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Esterification of acetic acid with isobutanol catalyzed by ionic liquid n-sulfopropyl-3-methylpyridinium trifluoromethanesulfonate:Experimental and kinetic study

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Chinese Journal of Chemical Engineering 2023年第11期63卷 21-30页

作者： Meng Shi Kelei Huang Ruining He Yinghua Jiang yun zou Jing Xu Zhangfa Tong Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning 530004China

As an important organic,isobutyl acetate(IbAc)has been widely used in industries because of its good biodegradability,low surface tension,and other *** industrial production of IbAc is usually catalyzed by sulfuric ***,the use of sulfuric acid has the drawbacks of causing considerable corrosion to equipment and being difficult to be *** this work,n-sulfopropyl-3-methylpyridinium trifluoromethanesulfonate([HSO_(3)-PMPY][CF_(3)SO_(3)])Bronsted acidic ionic liquid(BAIL)was used as the catalyst and the catalytic activity,solubility,and corrosiveness were evaluated for the esterification of acetic acid with *** reaction kinetics and chemical equilibrium were systemically *** to conventional acid catalysts,[HSO_(3)-PMPY][CF_(3)SO_(3)]showed higher catalytic activity,more excellent reusability,more favorable phase separation,and *** kinetic equations based on ideal homogeneous(IH),non-ideal homogeneous(NIH),and modified nonideal homogeneous(NIH-M)models were established and correlated with the experimental data to determine the parameters and *** NIH-M model exhibited the best agreement with the experimental data,owing to its prediction considering the non-ideality and the self-catalysis effect of acetic acid in this ***,the error of NIH-M model fitting was mainly caused by the difference in solubility between[HSO_(3)-PMPY][CF_(3)SO_(3)]with reactants and products in the reaction ***,the applicability of the NIH-M model was investigated by simulating the esterification of acetic acid with three short-chain alcohols(ethanol,n-butanol,and isobutanol)catalyzed by *** NIH-M model displayed an acceptable simulation for this type of acetic acid esterification reaction catalyzed by BAILs at different ranges of the BAILs concentration and *** study confirmed the industrial prospects of[HSO_(3)-PMPY][CF_(3)SO_(3)]in isobutyl acetate production and the applica

关键词： Esterification Isobutyl acetate Ionic liquid Kinetics

Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission

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World Journal of Gastroenterology 2008年第37期14卷 5674-5682页

作者： Tao Shen Xin-Min Yan yun-Lian zou Jian-Mei Gao Hong Dong The Institute of Basic Medicine of the First People'sHospital of yunnan Province Kunrning 650032YunnanProvince China

AIM: To determine whether HBV with the same characteristics causes dissimilar mutations in different hosts. METHODS: Full-length HBV genome was amplified and linked with pMD T18 vector. Positive clones were selected by double-restriction endonuclease digestion (EcoRⅠ and HindⅢ) and PCR. Twenty seven clones were randomly selected from an asymptomatic mother [at two time points: 602 (1 d) and 6022 (6 mo)] and her son [602 (S)], and the phylogenetic and mutational analysis was performed using BioEditor, Clustal X and MEGA software. Potential immune epitopes were determined by the Stabilized Matrix Method (SMM), SMM-Align Method and Emini Surface Accessibility Prediction. RESULTS: All of the 27 sequences were genotype C, the divergence between the mother and son was 0%-0.8%. Compared with another 50 complete sequences of genotype C, the mother and her son each had 13 specific nucleotides that differed from the other genotype C isolates. AA 1-11 deletion in preS1 was the dominant mutation in the mother (14/18). The 1762T/1764A double mutation existed in all clones of the mother, 3 of them were also coupled with G1896A mutation, but none were found in the son.17 bp deletion starting at nucleotide 2330 was the major mutation (5/9) in the son, which caused seven potential HLA class Ⅰ epitopes and one B cell epitope deletion, and produced a presumptive new start codon, downstream from the original one of the P gene. CONCLUSION: The HBV strain in the son came from his mother, and discrepant mutation occurred in the mother and her son during infection.

关键词： Hepatic B virus Vertical transmission Fullgenome Mutation Phylogenetic Deletion

Fruquintinib beneficial in elderly patient with neoplastic pericardial effusion from rectal cancer:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6170-6177页

作者： Ying Zhang Jia-yun zou Yan-Yan Xu Jing-Ni He Department of Clinical Oncology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Department of General Surgery Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina

BACKGROUND Neoplastic pericardial effusion(NPE)is a rare consequence of rectal cancer and carries a poor *** management has yet to be *** is an oral anti-vascular endothelial growth factor receptor tyrosine kinase inhibitor approved by the China Food and Drug Administration in September 2018 as third-line treatment of metastatic colorectal *** SUMMARY Herein,we report an elderly patient with NPE from rectal cancer who responded to the use of *** March 2015,a 65-year-old Chinese woman diagnosed with KRAS-mutated adenocarcinoma of the rectum was subjected to proctectomy,adjuvant concurrent chemoradiotherapy,and adjuvant *** October 2018,a mediastinal mass was detected via computed *** growth had invaded parietal pericardium and left hilum,displaying features of rectal adenocarcinoma in a bronchial *** and FOLFOX chemotherapeutic regimens were administered as first-and second-line *** two cycles of second-line agents,a sizeable pericardial effusion resulting in tamponade was drained by pericardial *** cytology showed cells consistent with rectal ***-agent fruquintinib was initiated on January 3,2019,as a third-line *** cycles were delivered before the NPE recurred and other lesions *** recurrence-free interval for NPE was 9.2 mo,attesting to the efficacy of ***,the patient entered a palliative care unit for best supportive *** Fruquintinib may confer good survival benefit in elderly patients with NPEs due to rectal cancer.

关键词： Neoplastic pericardial effusion Rectal cancer Fruquintinib Anti-vascular endothelial growth factor receptor tyrosine kinase inhibitor Case report

Correlation between polymorphisms in the MFN1 gene and myopia in Chinese population

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1126-1130页

作者： yun-Chun zou Jia-Hong Lei Ying Wang Shuang Xu Department of Ophthalmology and Optometry North Sichuan Medical College Department of Laboratory Medicine North Sichuan Medical College

AIM: To explore whether genetic variations in the MFN1 gene are associated with low to moderate myopia in Chinese population. METHODS: The case-control association analysis was used. The study included 100 independent myopia patients (-0.75 D <= spherical refraction <= -8.00 D) and 100 sex -matched healthy controls (with binocular spherical equivalent ranges between -0.50 D and +0.50 D). Four single nucleotide polymorphism (SNP) tags (rs3976523, rs13098637, rs6762399 and rs7618348) were selected for genotyping by direct sequencing. The frequencies of genotypes and their alleles were calculated based on the number of SNP genotypes in each sample. The Chi-square test was used to examine the difference in the frequency between the myopia cases and controls. RESULTS: Genotype distributions in the four SNPs were all in accordance with the Hardy -Weinberg equilibrium; analysis showed that rs13098637 was significantly associated with low to moderate myopia (P=0.003 and empirical P=0.010). There were no statistically significant differences observed for the genotype or allele frequencies of the other three SNPs between the myopia cases and controls in the Chinese population in this study. CONCLUSION: The current study has revealed that the C allele of rs13098637 in MFN1 had a significant association with low to moderate myopia.

关键词： myopia MFN1 gene single nucleotide polymorphism association analysis

Ductility and Ultimate Capacity of Concrete-Filled Lattice Rectangular Steel Tube Columns

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Structural Durability & Health Monitoring 2018年第2期12卷 99-110页

作者： Chengquan Wang yun zou Tianqi Li Jie Ding Xiaoping Feng Tiange Lei Jiangnan University No.1800Wuxi214000China

A kind of concrete-filled lattice rectangular steel tube(CFLRST)column was put *** numerical simulation was modeled to analyze the mechanical characteristic of CFLRST *** comparing the load-deformation curves from the test results,the rationality and reliability of the finite element model has been confirmed,moreover,the change of the section stiffness and stress in the forcing process and the ultimate bearing capacity of the column were *** on the model,the comparison of ultimate bearing capacity and ductility between CFLRST column and reinforced concrete(RC)column were also *** results of the finite element analysis show that the loading process of CFLRST column consists of elastic stage,yield stage and failure *** failure modes are mainly strength failure and failure of elastoplastic *** column has higher bearing capacities in comparison with reinforced concrete columns with the same steel *** addition,the stiffness degeneration of CFLRST column is slower than RC column and CFLRST column has good ductility.

关键词： Steel-concrete composite structure concrete-filled lattice rectangular steel tube column nonlinear finite element ultimate strength ductility

Quantificational analysis on progress of river water quality in China

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Journal of Environmental Sciences 2009年第6期21卷 770-773页

作者： yun Yi,zou Zhihong,FENG Wei,RU Mai School of Economics and Management,Beihang University,Beijing 100191,China. School of Economics and Management Beihang University Beijing 100191 China. E-mail: winniecloud81@***

In order to understand the dynamic change of water quality in a specific period of time,a type of possibility transition matrix based on the theory of Markov process was *** transition possibility with a weight to calculate the degree of absolute advancement was given based on the result of water quality *** concept of relative advancement was *** was used to evaluate the extent of water quality changed in a period of *** method was used to calculate the degrees of relative advancement for 4 rivers in China,and the results were analyzed.

关键词： water quality evaluation possibility transition matrix Markov process degree of advancement

Observer-based H_∞ Filtering of 2-D Singular System Described by Roesser Models

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自动化学报 2006年第2期32卷 213-218页

作者： XU Hui-Ling LU Jun-Wei zou yun Department of Applied Mathematics Nanjing University of Science and Technology Nanjing 210094 School of Electrical and Automation Engineering Nanjing Normal University Nanjing 210042 Department of Automation Nanjing University of Science and Technology Nanjing 210094

This paper discusses the problem of the H∞ filtering for discrete time 2-D singular Roesser models (2-D SRM). The purpose is to design an observer-based 2-D singular filter such that the error system is acceptable, jump modes free and stable, and satisfies a pre-specified H∞ performance level. By general Riccati inequality and bilinear matrix inequalities (BMI), a sufficient condition for the solvability of the observer-based H∞ filtering problem for 2-D SRM is given. A numerical example is provided to demonstrate the applicability of the proposed approach.

关键词： 2-D奇异系统跳跃模式 Riccati不等式双线性不等式

A New Exponential Stability Condition for Delayed Systems with Markovian Switching

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自动化学报 2010年第7期36卷 1025-1028页

作者： CONG Shen ZHANG Hai-Tao zou yun School of Mechanical and Electrical Engineering Heilongjiang University Harbin 150080 P.R.China Engineering Institute of Corps of Engineers PLA University of Science and Technology Nanjing 210094 P.R.China School of Automation Nanjing University of Science and Technology Nanjing 210094 P.R.China

This paper discusses the problem of exponential mean-square stability analysis for delayed systems with Markovian switching.A mode-dependent Lyapunov-Krasovskii functional taking a rather general form is used. The statistical property of Markov process is used to derive the di-erential of the functional. Considering this and applying the free-weighting matrix technique, a new stability criterion is obtained by means of linear matrix inequalities. The effectiveness of the proposed result is numerically demonstrated by examples provided finally.

关键词：时滞系统稳定性分析指数均方马尔可夫

Structurally Diverse Sesquiterpenoids from Chloranthus henryi *** and Their Anti-inflammatory Activities

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Chinese Journal of Chemistry 2023年第10期41卷 1209-1225页

作者： Dan-Yang Zhang yun-Ran Hu Hui Yang Ya-Nan Wang Shuai Liu yun-He zou Jing-Jing Zhou Peng-Yu Zhuang Xiao-Xia Wang Hang Liu School of Pharmacy North China University of Science and TechnologyTangshanHebei 063210China Department of Pharmacy Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China China Pharmaceutical University Nanjing Drum Tower Hospital NanjingJiangsu 210008China

In this study,27 new sesquiterpenoids:twenty monomers and seven dimers,with diverse structures,along with one known chlora-japonilide F(25)were isolated from the aerial parts of Chloranthus henryi ***,chlorahupetolides A(1)and B(2),two eudesmane-type merosesquiterpenoids with an undescribed C18 carbon framework,and chlorahupetene E(18)are the first example of dimers comprising two eudesmane sesquiterpenoids bridged by a four-membered ring in the *** struc-tures were characterized by nuclear magnetic resonance(NMR),electronic circular dichroism(ECD),and X-ray diffraction *** the RAW264.7 macrophages model of inflammation induced by LPS,compounds 12,18,and 25 significantly reduced NO production in a dose dependent manner and without *** mRNA expression of COX-2 was considerably inhibited by treatments with compounds 12,18,and 25.

关键词： Bioorganic chemistry Chloranthus henryi var.hupehensis Anti-inflammatory X-ray diffraction NMR spectroscopy