Structurally Diverse Sesquiterpenoids from Chloranthus henryi *** and Their Anti-inflammatory Activities
作者机构：School of PharmacyNorth China University of Science and TechnologyTangshanHebei 063210China Department of PharmacyAffiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China China Pharmaceutical University Nanjing Drum Tower HospitalNanjingJiangsu 210008China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第10期
页 面：1209-1225页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：supported by grants from the Natural Science Foundation of Hebei Province(Program No.H2022209046) Nanjing Special Fund of Traditional Chinese Medicine(Program No.ZYYB202203) the Natural Science Foundation of Hebei Province(Program No.H2022209053)
主 题：Bioorganic chemistry Chloranthus henryi var.hupehensis Anti-inflammatory X-ray diffraction NMR spectroscopy
摘 要：In this study,27 new sesquiterpenoids:twenty monomers and seven dimers,with diverse structures,along with one known chlora-japonilide F(25)were isolated from the aerial parts of Chloranthus henryi ***,chlorahupetolides A(1)and B(2),two eudesmane-type merosesquiterpenoids with an undescribed C18 carbon framework,and chlorahupetene E(18)are the first example of dimers comprising two eudesmane sesquiterpenoids bridged by a four-membered ring in the *** struc-tures were characterized by nuclear magnetic resonance(NMR),electronic circular dichroism(ECD),and X-ray diffraction *** the RAW264.7 macrophages model of inflammation induced by LPS,compounds 12,18,and 25 significantly reduced NO production in a dose dependent manner and without *** mRNA expression of COX-2 was considerably inhibited by treatments with compounds 12,18,and 25.
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