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Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong jung Doyoung jung Ah young Kim Jae Hee Seol jung Min Park Jo Won jung Jae young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

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2.47 GPa grade ultra-strong 15Co-12Ni secondary hardening steel with superior ductility and fracture toughness

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Journal of Materials Science & Technology 2021年第7期66卷 36-45页

作者： young-Kyun Kim Kyu-Sik Kim young-Beum Song jung Hyo Park Kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon22212Republic of Korea Agency for Defense Development(ADD) Yuseong-guDaegeon34186Republic of Korea

This study investigated the effect of multi-step heat treatment on the microstructure, mechanical properties and fracture behavior of thick 15 Co-12 Ni secondary hardening steel. As-quenched sample was found to have elongated prior austenite grain(PAG) and coarse lenticular martensitic structure. On the other hand, heat-treated sample was observed to have fine lenticular martensitic structure due to fine PAG size and a lot of nano-sized carbides. Also, after heat treatment, nano-scale reverted austenite film was formed at the martensite interfaces. The heat-treated sample showed 2.47 GPa superior tensile strength and superior elongation of about 12 %. The high strength was mainly due to fine block size and high number density of nano-sized carbides. The average value of plane strain fracture toughness(KIC) was 29.3 MPa m1/2, which indicated a good fracture toughness even with the high tensile strength. The tensile fracture surface was observed to have ductile fracture mode(cup-and-cone) and the formation of about ~1 μm ultra-fine dimples. In addition to this, nano-sized carbides were observed within the *** findings suggested that the nano-sized carbide had a positive effect not only on the strength but also on the ductility of the alloy. The fractured surface after toughness test, also showed ductile fracture mode with a lot of dimples. Based on the above results, correlation among microstructural evolution,deformation and fracture mechanisms along the heat-treatment was also discussed.

关键词： Ultra-high strength High Co-Ni secondary hardening steel Microstructure Tensile properties Fracture toughness Reverted austenite

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Molecular targeted therapy for hepatocellular carcinoma:Current and future

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World Journal of Gastroenterology 2013年第37期19卷 6144-6155页

作者： jung Woo Shin young-Hwa Chung Department of Internal Medicine University of Ulsan College of Medicine Ulsan University Hospital Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center

Hepatocellular carcinoma(HCC)is one of the most frequent tumors *** majority of HCC cases occur in patients with chronic liver *** regular surveillance to detect small HCC in these patients,HCC is often diagnosed at an advanced *** HCC is highly resistant to conventional systemic therapies,the prognosis for advanced HCC patients remains *** introduction of sorafenib as the standard systemic therapy has unveiled a new direction for future research regarding HCC ***,given the limited efficacy of the drug,a need exists to look beyond *** molecular targeted agents that inhibit different pathways involved in hepatocarcinogenesis are under various phases of clinical development,and novel targets are being assessed in *** review aims to summarize the efforts to target molecular components of the signaling pathways that are responsible for the development and progression of HCC and to discuss perspectives on the future direction of research.

关键词： Hepatocellular carcinoma Targeted therapy Molecular agents Sorafenib

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Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway

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World Journal of Gastroenterology 2015年第33期21卷 9749-9757页

作者： Jeong Mo Bae jung Ho Kim Ye-young Rhee Nam-yun Cho Tae-You Kim Gyeong Hoon Kang Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Internal Medicine Seoul National University College of Medicine

AIM: To validate the utility of Annexin A10 as a surrogate marker of the serrated neoplasia pathway in invasive colorectal cancers(CRCs).METHODS: A total of 1133 primary CRC patients who underwent surgical resection at Seoul National University Hospital between January 2004 and December 2007 were *** of Annexin A10 was evaluated by immunohistochemistry using tissue microarray and paired to our findings on clinicopathologic and molecular characteristics of each *** G island methylator phenotype was determined by Methy Light assay and microsatellite instability was determined by high performance liquid *** and BRAF mutation status was evaluated by direct sequencing and allele-specific *** and stage-specific survival analyses were performed to reveal the prognostic value of Annexin A10 ***: Annexin A10 expression was observed in 66(5.8%) of the 1133 *** A10 expression was more commonly found in females and was associated with proximal location,ulcerative gross type,advanced T category,N category and TNM *** with Annexin A10 expression showed an absence of luminal necrosis,luminal serration and mucin *** with Annexin A10 expression were associated with Cp G island methylator phenotype,microsatellite instability and BRAF *** survival analysis,Annexin A10 expression was associated with poor overall survival and progression-free survival,especially in stage Ⅳ ***: Annexin A10 expression is associated with poor clinical behavior and can be used a supportive surrogate marker of the serrated neoplasia pathway in invasive CRCs.

关键词： Annexin A10 Serrated neoplasia pathway CpG island

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Feasible economic strategies to improve screening compliance for colorectal cancer in Korea

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World Journal of Gastroenterology 2005年第11期11卷 1587-1593页

作者： Sang Min Park young Ho yun Soonman Kwon Department of Family Medicine Quality of Cancer Care Branch School of Public Health

ABM: While colorectal cancer (CRC) is an ideal target for population screening, physician and patient attitudes contribute to low levels of screening uptake. This study was carried out to find feasible economic strategies to improve the CRC screening compliance in Korea. METHODS: The natural history of a simulated cohort of 50-year-old Korean in the general population was modeled with CRC screening until the age of 80 years. Cases of positive results were worked up with colonoscopy. After polypectomy, colonoscopy was repeated every 3 years. Baseline screening compliance without insurance coverage by the national health insurance (NHI) was assumed to be 30%. If NHI covered the CRC screening or the reimbursement of screening to physicians increased, the compliance was assumed to increase. We evaluated 16 different CRC screening strategies based on Markov model. RESULTS: When the NHI did not cover the screening and compliance was 30%, non-dominated strategies were colonoscopy every 5 years (COL5) and colonoscopy every 3 years (COL3). In all scenarios of various compliance rates with raised coverage of the NHI and increased reimbursement of colonoscopy, COL10, COL5 and COL3 were non-dominated strategies, and COL10 had lower or minimal incremental medical cost and financial burden on the NHI than the strategy of no screening. These results were stable with sensitivity analyses. CONCLUSION: Economic strategies for promoting screening compliance can be accompanied by expanding insurance coverage by the NHI and by increasing reimbursement for CRC screening to providers. COL10 was a cost-effective and cost saving screening strategy for CRC in Korea.

关键词： Cost-effectiveness analysis Colorectal cancer Screening Compliance National health insurance Coverage Reimbursement

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Monitoring continuous k-nearest neighbor queries in the hybrid wireless network

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第3期12卷 213-220页

作者： young-Mo KWON HaRim jung Yon Dohn CHUNG Department of Computer Science and Engineering Korea UniversitySeoul 136-713Korea

In a mobile/pervasive computing environment,one of the most important goals of monitoring continuous spatial queries is to reduce communication cost for *** work uses many cellular wireless connections,which would easily become the performance bottleneck of the overall *** paper introduces a novel continuous kNN query monitoring method to reduce communication cost in the hybrid wireless network,where the moving objects in the wireless broadcasting system construct the ad-hoc *** results prove the efficiency of the proposed method,which leverages the wireless broadcasting channel as well as the WiFi link to alleviate the burden on the cellular uplink communication cost.

关键词： Continuous kNN query monitoring Ad-hoc networks Wireless broadcasting systems

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Complexity Effective Frequency and Sidelink Synchronization Algorithm for LTE Device-to-Device Communication Systems

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Computers, Materials & Continua 2020年第1期62卷 443-458页

作者： Yong-An jung Min-Goo Kang young-Hwan You Department of Computer Engineering Sejong UniversitySeoulKorea Department of IT Contents Hanshin UniversityGyeonggi-doKorea

Device-to-device(D2D)communication is considered as a major challenge in the long term evolution(LTE)network wherein devices directly communicate with each *** of the key challenges in D2D sidelink is reliable and reduced-complexity *** address this issue,a computationally efficient sequential detection scheme for integer carrier frequency offset and sidelink identity is proposed in the LTE-D2D *** perform the frequency offset detection without retrieving the sidelink identity,the conjugate relation between two primary sidelink synchronization sequences is exploited,which facilitates the detection tasks of frequency offset and sidelink identity to be *** is demonstrated from simulation results that the inherent property of the sidelink synchronization sequences is effectively used for joint detection of frequency offset and sidelink identity with significantly reduced complexity,compared to existing estimation schemes.

关键词： Long term evolution device-to-device communication carrier frequency offset sidelink identity sidelink synchronization

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Optimally arranged TiO_(2)@MoS_(2) heterostructures with effectively induced built-in electric field for high-performance lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第8期83卷 496-508,I0012页

作者： Jeongyoub Lee Changhoon Choi jung Been Park Seungho Yu Jinho Ha Hyungsoo Lee Gyumin Jang young Sun Park Juwon yun Hayoung Im Subin Moon Soobin Lee jung-Il Choi Dong-Wan Kim Jooho Moon Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Mathematics and Computing(Computational Science and Engineering) Yonsei UniversitySeoul 03722Republic of Korea

To overcome the serious technological issues affecting lithium-sulfur(Li-S) batteries,such as sluggish sulfur redox kinetics and the detrimental shuttle effect,heterostructure engineering has been investigated as a strategy to effectively capture soluble lithium polysulfide intermediates and promote their conversion reaction by integrating highly polar metal oxides with catalytically active metals ***,to fully exploit the outstanding properties of heterostructure-based composites,their detailed structure and interfacial contacts should be designed ***,optimally arranged TiO_(2)and MoS_(2)-based heterostructures(TiO_(2)@MoS_(2)) are fabricated on carbon cloth as a multifunctional interlayer to efficiently trap polysulfide intermediates and accelerate their redox *** to the synergistic effects between TiO_(2)and MoS_(2)and the uniform heterointerface distribution that induces the ideally oriented built-in electric field,Li-S batteries with TiO_(2)@MoS_(2)interlayers exhibit high rate capability(601 mA h g^(-1)at 5 C),good cycling stability(capacity-fade rate of 0.067% per cycle over 500 cycles at2 C),and satisfactory areal capacity(5.2 mA h cm^(-2)) under an increased sulfur loading of 5.2 mg cm^(-2).Moreover,by comparing with a MoS_(2)@TiO_(2)interlayer composed of reversely arranged heterostructures,the effect of the built-in electric field’s direction on the electrocatalytic reactions of polysulfide intermediates is thoroughly investigated for the first *** superior electrocatalytic activities of the rationally arranged TiO_(2)@MoS_(2)interlayer demonstrate the importance of optimizing the built-in electric field of heterostructures for producing high-performance Li-S batteries.

关键词： Lithium-sulfur batteries Shuttle effect TiO_(2)-MoS_(2)heterostructure engineering Built-in electric field Multifunctional interlayers

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Rhabdomyolysis following severe hypokalemia caused by familial hypokalemic periodic paralysis

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World Journal of Clinical Cases 2017年第2期5卷 56-60页

作者： young-Lee jung Jae-young Kang Division of Nephrology Department of Internal Medicine Sejong General Hospital

Rhabdomyolysis continues to appear with increasing frequency and represents a medical emergency requiring rapid appropriate treatment. One of the unusual causes of nontraumatic rhabdomyolysis is hypokalemic periodic paralysis without secondary causes. Primary hypokalemic periodic paralysis is a rare genetic disease characterized by episodic attacks of muscle weakness due to decreases in serum potassium. A 30-year-old woman who had 3 episodic attacks of hypokalemic periodic paralysis was admitted in emergency room with sudden onset symmetrical muscle weakness. After several hours, she started to complain myalgia and severe ache in both calves without any changes. Laboratory test showed markedly elevated creatine phosphokinase, lactic dehydrogenase levels with hypokalemia, rhabdomyolysis resulting from hypokalemia was diagnosed. Here, we report an unusual case of rhabdomyolysis caused by severe hypokalemia, which was suggested a result of familial hypokalemic periodic paralysis.

关键词： Rhabdomyolysis Hypokalemia Familial hypokalemic periodic paralysis

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Effective parameters on diameter of carbon nanotubes by plasma enhanced chemical vapor deposition

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中国有色金属学会会刊：英文版 2012年第S3期22卷 712-716页

作者： Kang young JEONG Hyun Kyung jung Hyung Woo LEE National Core Research Center for Hybrid Materials Solution Hybrid Graduate SchoolPusan National University Department of Diagnostic Radiology Inje University College of MedicineHaeundae Paik Hospital

The effective parameters on the diameter of carbon nanotubes (CNTs) by plasma enhanced chemical vapor deposition (PECVD) were *** lots of influential parameters,the effects of the catalytic film thickness and the pretreatment plasma power on the growth of CNTs were *** results show that the size of catalytic islands increases by increasing the thickness of catalytic layer,but the density of CNTs *** pretreatment duration time of 30 s is the optimal condition for growing CNTs with about 50 nm in *** increasing the pretreatment plasma power,the diameter of CNTs decreases ***,the diameter of CNTs does not change drastically from 80 to 120 *** uniformly grown CNTs with the diameter of 50 nm are obtained at the pretreatment plasma power of 100 W.

关键词： carbon nanotubes catalytic film thickness pretreatment plasma power plasma enhanced chemical vapor deposition

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