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A post-modification strategy to precisely construct dual-atom sites for oxygen reduction electrocatalysis

Journal of Energy Chemistry 2024年第3期90卷 511-517,I0012页

作者： Juan Wang Xinyan Liu Chang-Xin Zhao yun-wei Song Jia-Ning Liu Xi-Yao Li Chen-Xi Bi Xin Wan Jianglan Shui Hong-Jie Peng Bo-Quan Li Jia-qi Huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Dual-atom catalysts(DACs) afford promising potential for oxygen reduction electrocatalysis due to their high atomic efficiency and high intrinsic activity.However,precise construction of dual-atom sites remains a challenge.In this work,a post-modification strategy is proposed to precisely fabricate DACs for oxygen reduction electrocatalysis.Concretely,a secondary metal precursor is introduced to the primary single-atom sites to introduce direct metal-metal interaction,which ensures the formation of desired atom pair structure during the subsequent pyrolysis process and allows for successful construction of DACs.The as-prepared FeCo-NC DAC exhibits superior oxygen reduction electrocatalytic activity with a half-wave potential of 0,91 V vs.reversible hydrogen electrode.Zn-air batteries equipped with the FeCo-NC DAC demonstrate higher peak power density than those with the Pt/C benchmark.More importantly,this post-modification strategy is demonstrated universal to achieve a variety of dual-atom sites.This work presents an effective synthesis methodology for precise construction of catalytic materials and propels their applications in energy-related devices.

关键词： Dual-atom catalysts Electrocatalysis Oxygen reduction reaction Post-modification Zinc–air batteries

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Analysis and monitoring of drug therapy in a patient with peptic ulcer complicated by infection:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1530-1535页

作者： Yan-Ping Gou Yue Huang Li Chen wei Zheng yun-Hua Zheng The Second People’s Hospital of Meishan City&Renshou County People’s Hospital Meishan 620500Sichuan ProvinceChina Quality Evaluation and Medical Record Management The Affiliated Hospital of Southwest Jiaotong University&The Third People's Hospital of ChengduChengdu 610000Sichuan ProvinceChina Patriotic Health Campaign Qionglai City Health BureauChengdu 610000Sichuan ProvinceChina

BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.

关键词： Ampicillin-sulbactam Famotidine Lansoprazole Kangfuxin Liquid Chinese pharmacist Case report

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Investigating the reactivation of historical landslides during the 2022 Luding M_(S)6.8 earthquake

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Earthquake Science 2024年第3期37卷 200-209页

作者： Tao wei Mingyao Xia Xinxin Zhang Shaojian qi State Key Laboratory of Geohazard Prevention and Geo-environment Protection Chengdu University of TechnologyChengdu610059China

On September 5,2022,a strong earthquake with a magnitude of MS6.8 struck Luding County in Sichuan Province,China,triggering thousands of landslides along the Dadu River in the northwest-southeast(NW-SE)direction.We investigated the reactivation characteristics of historical landslides within the epicentral area of the Luding earthquake to identify the initiation mechanism of earthquake-induced landslides.Records of the two newly triggered and historical landslides were analyzed using manual and threshold methods;the spatial distribution of landslides was assessed in relation to topographical and geological factors using remote sensing images.This study sheds light on the spatial distribution patterns of landslides,especially those that occur above historical landslide areas.Our results revealed a similarity in the spatial distribution trends between historical landslides and new ones induced by earthquakes.These landslides tend to be concentrated within a range of 0.2 km from the river and 2 km from the fault.Notably,both rivers and faults predominantly influenced the reactivation of historical landslides.Remarkably,the reactivated landslides are characterized by their small to medium size and are predominantly situated in historical landslide zones.The number of reactivated landslides surpassed that of previously documented historical landslides within the study area.We provide insights into the critical factors responsible for historical landslides during the 2022 Luding earthquake,thereby enhancing our understanding of the potential implications for future co-seismic hazard assessments and mitigation strategies.

关键词： Luding earthquake co-seismic landslides historical landslides spatial distribution landslide reactivation

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Software Defect Prediction Method Based on Stable Learning

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Computers, Materials & Continua 2024年第1期78卷 65-84页

作者： Xin Fan Jingen Mao Liangjue Lian Li Yu wei Zheng yun Ge College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing210012China School of Software Nanchang Hangkong UniversityNanchang330029China Software Testing and Evaluation Center Nanchang Hangkong UniversityNanchang330029China

The purpose of software defect prediction is to identify defect-prone code modules to assist software quality assurance teams with the appropriate allocation of resources and labor.In previous software defect prediction studies,transfer learning was effective in solving the problem of inconsistent project data distribution.However,target projects often lack sufficient data,which affects the performance of the transfer learning model.In addition,the presence of uncorrelated features between projects can decrease the prediction accuracy of the transfer learning model.To address these problems,this article propose a software defect prediction method based on stable learning(SDP-SL)that combines code visualization techniques and residual networks.This method first transforms code files into code images using code visualization techniques and then constructs a defect prediction model based on these code images.During the model training process,target project data are not required as prior knowledge.Following the principles of stable learning,this paper dynamically adjusted the weights of source project samples to eliminate dependencies between features,thereby capturing the“invariance mechanism”within the data.This approach explores the genuine relationship between code defect features and labels,thereby enhancing defect prediction performance.To evaluate the performance of SDP-SL,this article conducted comparative experiments on 10 open-source projects in the PROMISE dataset.The experimental results demonstrated that in terms of the F-measure,the proposed SDP-SL method outperformed other within-project defect prediction methods by 2.11%-44.03%.In cross-project defect prediction,the SDP-SL method provided an improvement of 5.89%-25.46% in prediction performance compared to other cross-project defect prediction methods.Therefore,SDP-SL can effectively enhance within-and cross-project defect predictions.

关键词： Software defect prediction code visualization stable learning sample reweight residual network

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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-Xiu Yuan qi-Gui Cai Zhen-Yang Zhang Jian-Zhong Zhou Cai-yun Lan Jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of debate.AIM To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database Article.Studies up to December 2022 comparing nCRT and nCT in patients with EC were selected.RESULTS The analysis revealed significant differences between nCRT and nCT in terms of disease-free survival.The results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than nCRT.Moreover,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for LAEC.However,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

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Therapeutic effect of manual massage on early postpartum rectus abdominis separation and postpartum depression

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World Journal of Psychiatry 2024年第5期14卷 678-685页

作者： yun Chen Xiao-Yan Sun Cheng qian Xiao-Xing Zhang Yin-Jian Zhou Hong-yun Zhang Zhen-wei Xie Department of Gynecology Women’s Hospital School of Medicine Zhejiang UniversityHangzhou 310006Zhejiang ProvinceChina Department of Obstetrics and Gynecology Huzhou Maternity and Child Health Care HospitalHuzhou 313000Zhejiang ProvinceChina Department of Surgery Huzhou Maternity and Child Health Care HospitalHuzhou 313000Zhejiang ProvinceChina Department of Obstetrics Huzhou Maternity and Child Health Care HospitalHuzhou 313000Zhejiang ProvinceChina Department of Ultrasound Women’s Hospital School of Medicine Zhejiang UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Rectus abdominis separation(DRA)affects pelvic stability and body image.No studies have explored the effects of manual massage on early postpartum DRA and postpartum depression.AIM To analyze the curative effect of massage on early postpartum DRA and its impact on postpartum depression and thus its ability promote the overall psychosomatic rehabilitation of postpartum women.METHODS Data were retrospectively collected on 70 primiparous women with postpartum DRA who underwent rehabilitation at the Postpartum Rehabilitation Center of Huzhou Maternal and Child Health Hospital from October 2022 to September 2023.The patients were divided into the Group S(35 cases,biomimetic electrical stimulation treatment)and Group L(35 cases,biomimetic electrical stimulation combined with manual massage treatment).Baseline data,the edinburgh postpartum depression scale(EPDS)score,and the visual analog scale(VAS)scores for rectus abdominis distance,waist circumference,and lower back pain before and after treatment were compared.RESULTS No significant differences were found in the baseline data,rectus abdominis distance,waist circumference,and VAS and EPDS scores between the two groups before treatment(P>0.05).After treatment,the distance between rectus abdominis and waist circumference in Group L were significantly smaller than those in Group S(P<0.05).Furthermore,lower back pain(VAS score)and the EPDS score in Group L were significantly lower than those in Group S(P<0.05).CONCLUSION Manual massage can significantly reduce early postpartum DRA,waist circumference,and back pain and improve the patient’s mental state and postpartum depression.

关键词： Manual massage Postpartum Rectus abdominis muscle separation Postpartum depression

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The Consistency of LSE Estimators in Partial Linear Regression Models under Mixing Random Errors

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1244-1272页

作者： yun Bao YAO Yu Tan LÜ Chao LU wei WANG Xue Jun WANG School of Mathematical Sciences Anhui UniversityHefei 230601P.R.China School of Big Data and Artificial Intelligence Chizhou UniversityChizhou 247000P.R.China School of Big Data and Statistics Anhui UniversityHefei 230601P.R.China

In this paper,we consider the partial linear regression model y_(i)=x_(i)β^(*)+g(ti)+ε_(i),i=1,2,...,n,where(x_(i),ti)are known fixed design points,g(·)is an unknown function,andβ^(*)is an unknown parameter to be estimated,random errorsε_(i)are(α,β)-mix_(i)ng random variables.The p-th(p>1)mean consistency,strong consistency and complete consistency for least squares estimators ofβ^(*)and g(·)are investigated under some mild conditions.In addition,a numerical simulation is carried out to study the finite sample performance of the theoretical results.Finally,a real data analysis is provided to further verify the effect of the model.

关键词： (α,β)-mixing random variables partial linear regression model least squares estimator consistency

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Mixing states and secondary formation processes of organic nitrogen-containing single particles in Guangzhou,China

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Journal of Environmental Sciences 2024年第4期138卷 62-73页

作者： Lijun yun Chunlei Cheng Suxia Yang Zaihua Wang Mei Li qi En Zhong LiyuanMao Sulin Liu Xiaoya Cheng Duanying Chen Fan Yang Zhen Zhou Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for on-line source apportionment system of air pollutionJinan UniversityGuangzhou 510632China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou 510632China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy ScienceXi’an 710061China Institute for Environment and Climate Research Jinan UniversityGuangzhou 510632China Guangdong Academy of Sciences Institute of Resources Utilization and Rare Earth DevelopmentGuangzhou 510650China Environmental Monitoring Station of Pudong New District Shanghai 201200China

Organic nitrogen(ON)compounds play a significant role in the light absorption of brown carbon and the formation of organic aerosols,however,the mixing state,secondary formation processes,and influencing factors of ON compounds are still unclear.This paper reports on the mixing state of ON-containing particles based on measurements obtained using a highperformance single particle aerosol mass spectrometer in January 2020 in Guangzhou.The ON-containing particles accounted for 21% of the total detected single particles,and the particle count and number fraction of the ON-containing particles were two times higher at night than during the day.The prominent increase in the content of ON-containing particles with the enhancement of NO_xmainly occurred at night,and accompanied by high relative humidity and nitrate,which were associated with heterogeneous reactions between organics and gaseous NO_(x)and/or NO_(3)radical.The synchronous decreases in ON-containing particles and the mass absorption coefficient of water-soluble extracts at 365 nm in the afternoon may be associated with photo-bleaching of the ON species in the particles.In addition,the positive matrix factorization analysis found five factors dominated the formation processes of ON particles,and the nitrate factor(33%)mainly contributed to the production of ON particles at night.The results of this study provide unique insights into the mixing states and secondary formation processes of the ON-containing particles.

关键词： Organic nitrogen compounds Single particles Mixing state Secondary formation Nighttime chemistry

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In Situ Deposition of Drug and Gene Nanoparticles on a Patterned Supramolecular Hydrogel to Construct a Directionally Osteochondral Plug

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Nano-Micro Letters 2024年第1期16卷 341-359页

作者： Jiawei Kang Yaping Li Yating qin Zhongming Huang Yifan Wu Long Sun Cong Wang wei Wang Gang Feng Yiying qi Department of Orthopaedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou City 310009Zhejiang ProvincePeople’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215ZhejiangPeople’s Republic of China The Affiliated Nanhua Hospital Orthopedic Research CentreHengyang Medical SchoolUniversity of South ChinaHengyang 421001HunanPeople’s Republic of China Department of Radiology Jining No.1 People’s HospitalJining Medical UniversityJining 272000ShandongPeople’s Republic of China

The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.

关键词： Osteochondral regeneration Oriented hydrogel Kartogenin miRNA-26a

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A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect

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Chinese Journal of Polymer Science 2024年第5期42卷 559-569,I0005页

作者： Sai-Nan Liu Jia-Hui Meng Li-yun Cui Hua Chen Lin-qi Shi Ru-Jiang Ma Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer ChemistryTianjin Key Laboratory of Functional Polymer MaterialsState Key Laboratory of Medicinal Chemical BiologyFrontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin300071China Haihe Laboratory of Sustainable Chemical Transformations Tianjin300192China

Efficient intracellular delivery of protein drugs is critical for protein therapy.The combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer effect.However,co-delivery systems for efficient delivery of these two kinds of drugs are still lacking because of their different properties.Herein,we show a well-designed delivery system based on dynamic covalent bond for efficient intracellular co-delivery of ribonuclease A(RNase A)and doxorubicin(DOX).Two polymers,PEG-b-P(Asp-co-AspDA)and PAE-b-P(Asp-co-AspPBA),and two 2-acetylphenylboronic acid(2-APBA)-functionalized drugs,2-APBA-RNase A and 2-APBA-DOX,self-assemble into mixed-shell nanoparticles(RNase A/DOX@MNPs)via dynamic phenylboronic acid(PBA)-catechol bond between PBA and dopamine(DA)moieties.The PBA-catechol bond endows the nanoparticles with high stability and excellent stimulus-responsive drug release behavior.Under the slight acidic environment at tumor tissue,RNase A/DOX@MNPs are positively charged,promoting their endocytosis.Upon cellular uptake into endosome,further protonation of PAE chains leads to the rupture of endosomes because of the proton sponge effect and the cleavage of PBA-catechol bond promotes the release of two drugs.In cytoplasm,the high level of GSH removed the modification of 2-APBA on drugs.The restored RNase A and DOX show a synergistic and enhanced antic-cancer effect.This system may be a promising platform for intracellular co-delivery of protein drugs and chemotherapeutics.

关键词： Drug co-delivery Combination therapy Dynamic covalent bond

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