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Contact performance analysis of pressure controller's sealing interface in deep in-situ pressure-preserved coring system

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Petroleum Science 2022年第3期19卷 1334-1346页

作者： Jia-Nan Li Jun Wang yun-qi Hu Zhen-Xi You Meng Xu Ying-Wei Wang Zu-Jie Zou qi-Yue Kang School of Mechanical Engineering MOE Key Laboratory of Deep Underground Science and EngineeringCollege of Water Resource and HydropowerSichuan UniversityChengdu610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518061China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China State Key Laboratory of Coking Coal Exploitation and Comprehensive Utilization Pingdingshan Tianan Coal Mining Co.LTD.Pingdingshan467000China Xi'an Research Institute China Coal Technology&Engineering Group CorpXi'an710077China

The sealing performance of contact interfaces plays the most important role in the design and operation of the in-situ pressure-preserved coring *** meet the demand of ultra-high pressure-retained coring for oil and gas exploration in deep reservoirs,a quantitative analysis of the contact mechanical behavior of the pressure controller was *** on the micro-contact theory of rough surfaces,a three-dimensional numerical model of the rough contact interface between the valve cover and the valve seat was constructed,and the micro-contact behavior of the metal contact surfaces was comprehensively *** results show that the actual contact area of the valve interface increases with the increase of surface roughness before the critical contact point,but decreases after *** with the real contact model with double rough surfaces,although the simplified hard-contact model with a single rough surface can reflect the micro-contact behavior of the rough surface to a certain extent,it cannot truly reveal the microchannel morphology between the sealing interfaces under ***,the realistic double-rough-surface model should be recommended to evaluate the sealing performance of coring tools,particularly for high pressure *** material properties of valves have a significant effect on the contact characteristics of rough surfaces,which suggested that the actual contact area decreases with the increase of the elastic modulus of the contact material under the same loading *** knowledge of this work could help to enhance the seal design of pressure controllers for in-situ pressure-preserved coring.

关键词： In-situ pressure-preserved coring Metal seal Rough surface Micro contact

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Evolution of Conformation and Dynamics of Solvents in Hydration Shell along the Urea-induced Unfolding of Ubiquitin

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Chinese Journal of Polymer Science 2019年第7期37卷 708-718页

作者： Ke-Cheng Yang Feng-Chao Cui Ce Shi Wen-Duo Chen yun-qi Li Key Laboratory of Synthetic Rubber Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Smart City Research Institute Zhengzhou UniversityZhengzhou 450001China

A clear diagram for the unfolding of protein induced by denaturant is a classical but still unsolved challenge. To explore the unfolded conformations of ubiquitin under different urea concentrations, we performed hybrid Monte Carlo-molecular dynamics simulations (MC-MD) guided by small angle X-ray scattering (SAXS) structural information. Conformational ensembles sampled by the hybrid MC-MD algorithm exhibited typical 3D structures at different urea concentrations. These typical structures suggested that ubiquitin was subjected to a sequential unfolding, where the native contacts between adjacent β-sheets at first were disrupted together with the exposure of hydrophobic core, followed by the conversion of remaining β-strands and helices into random coils. Ubiquitin in 8 mol·L?1 urea is almost a random coil. With the disruption of native structure, urea molecules are enriched at protein hydrated layer to stabilize newly exposed residues. Compared with water, urea molecules prefer to form hydrogen bonds with the backbone of ubiquitin, thus occupying nodes of the hydrogen bonding network that construct the secondary structure of proteins. Meanwhile, we also found that the slow dynamics of urea molecules was almost unchanged while the dynamics of water was accelerated in the hydration shell when more residues were unfolded and exposed. The former was also responsible for the stabilization of unfolded structures.

关键词： Ubiquitin Unfolding process Hydration behavior and dynamics Water and urea

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新课标视域下客家文化融入语文教学策略探究

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嘉应学院学报 2024年第1期42卷 26-30页

作者：钟思诗汤奇云吴惠芬嘉应学院教育科学学院广东梅州514015 深圳大学广东深圳518060 梅江区风眠小学广东梅州514021

《义务教育语文课程标准(2022年版)》强调地方文化作为语文课程资源开发利用的重要性,并提出“地方文化要具有促进学生对语文知识的实践性、学习情境性以及不同课程资源有机结合凸显学习开放性”的新要求。基于此,以客家文化为例,以小... 详细信息

《义务教育语文课程标准(2022年版)》强调地方文化作为语文课程资源开发利用的重要性,并提出“地方文化要具有促进学生对语文知识的实践性、学习情境性以及不同课程资源有机结合凸显学习开放性”的新要求。基于此,以客家文化为例,以小学语文学段为实施场域,对客家文化融入语文教学应用价值、原则、现状做调研分析,对存在的“客家文化与语文教学融合不充分、客家文化融入语文教学的情境性创设不足、客家文化融入语文教学的方法单一化”的问题,提出相应的策略及课例设计,以期为丰富具有客家特色的语文教学实践理论、构建区域特色语文育人课堂做出努力。

关键词：语文课程标准语文教学客家文化

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Ihog proteins contribute to integrin-mediated focal adhesions

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Science China(Life Sciences) 2023年第2期66卷 366-375页

作者： yun qi Han Liu Kang Zhang Yihui Wu Chenghao Shen Xinhua Lin The State Key Laboratory of Genetic Engineering Institute of GeneticsSchool of Life SciencesFudan UniversityShanghai 200433China The State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100864China Current Address:Human Phenome Institute Fudan UniversityShanghai 200433China

Integrin expression forms focal adhesions, but how this process is physiologically regulated is unclear. Ihog proteins are evolutionarily conserved, playing roles in Hedgehog signaling and serving as trans-homophilic adhesion molecules to mediate cell-cell interactions. Whether these proteins are also engaged in other cell adhesion processes remains unknown. Here, we report that Drosophila Ihog proteins function in the integrin-mediated adhesions. Removal of Ihog proteins causes blister and spheroidal muscle in wings and embryos, respectively. We demonstrate that Ihog proteins interact with integrin via the extracellular portion and that their removal perturbs integrin distribution. Finally, we show that Boc, a mammalian Ihog protein,rescues the embryonic defects caused by removing its Drosophila homologs. We thus propose that Ihog proteins contribute to integrin-mediated focal adhesions.

关键词： integrin focal adhesion Ihog/Boi Drosophila

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Inferring future warming in the Arctic from the observed global warming trend and CMIP6 simulations

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Advances in Climate Change Research 2021年第4期12卷 499-507页

作者： HU Xiao-Ming MA Jie-Ru YING Jun CAI Ming KONG yun-qi School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai519082China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082China Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou730000China Department of Earth Oceanand Atmospheric ScienceFlorida State UniversityTallahassee32306USA

The emergent constraint approach is a way of using multi-model ensembles to identify the linkage between current/past climate variability and future climate changes,which has been widely used for narrowing down the uncertainty of multi-model projections of future climate *** models of the latest Coupled Model Intercomparison Project Phase 6(CMIP6)show a much stronger Arctic wanning signal but with a larger inter-model *** this study,we find that the projected Arctic warming made by multi-models in CMIP6 is positively correlated with the simulated global warming trend during the period of 1981-2011 in historical *** enables us to tighter constraints to future warming in the Arctic by using the observed global warming during the instrument *** fact that CMIP6 models tend to overestimate the trend of global mean surface temperature during 1981-2011,therefore,would imply a relative weak Arctic warming compared to the CMIP6 median warming projection.

关键词： CMIP6 Arctic warming projection Global warming Observational constraint

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Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui qiU Xiao-tang WANG Mei LI qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

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CFRP-聚合物砂浆加固震损构造柱约束砖砌体墙试验研究

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工程抗震与加固改造 2024年第1期46卷 133-141页

作者：乔崎云高晓鹏曹万林刘文超李佳峰北京工业大学北京100024 中交集团绿色建筑技术研发中心北京100011

为研究斜向碳纤维布条带或斜向聚合物砂浆条带与外覆角钢组合的加固方式对震后砌体结构的加固效果,对模拟经过地震作用的三面带构造柱约束砌体墙片进行抗震加固,并进行拟静力试验。三面砌体墙均采用角钢外覆加固,面层采用不同方式处理... 详细信息

为研究斜向碳纤维布条带或斜向聚合物砂浆条带与外覆角钢组合的加固方式对震后砌体结构的加固效果,对模拟经过地震作用的三面带构造柱约束砌体墙片进行抗震加固,并进行拟静力试验。三面砌体墙均采用角钢外覆加固,面层采用不同方式处理。研究结果表明:采用碳纤维布-聚合物砂浆条带的加固方式能很好地恢复震损墙体的承载能力和变形能力;碳纤维布条带在限制裂缝开展以及提高震损结构延性方面有一定贡献;面层采用斜向聚合物砂浆条带加固的震损墙体延性和承载力均较低。工程实际应用中,建议考虑两种材料的复合加固形式。

关键词：约束砖砌体墙震损后加固碳纤维抗震性能

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子午养心方联合艾灸治疗青中年心胆气虚型不寐临床观察

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山西中医 2024年第3期40卷 22-24页

作者：任正意齐运卫龚丹王栓伟河南省洛阳市中医院洛阳471000 河南省汝阳县中医院

目的:观察子午养心方联合艾灸治疗心胆气虚型不寐的临床疗效。方法:将青中年心胆气虚型不寐患者70例,随机分为两组。对照组34例予右佐匹克隆片口服治疗,治疗组36例予子午养心汤联合灸法(取双侧少冲穴、大敦穴、侠溪穴)治疗,10天为1个疗... 详细信息

目的:观察子午养心方联合艾灸治疗心胆气虚型不寐的临床疗效。方法:将青中年心胆气虚型不寐患者70例,随机分为两组。对照组34例予右佐匹克隆片口服治疗,治疗组36例予子午养心汤联合灸法(取双侧少冲穴、大敦穴、侠溪穴)治疗,10天为1个疗程,两组均连续治疗3个疗程。观察两组治疗前后匹斯堡失眠量表(PSqi)评分和焦虑自评量表(SAS)评分,并评价两组疗效和不良反应发生率。结果:治疗组愈显率为66.67%,对照组为38.24%,两组比较具有统计学意义(Pqi评分和SAS评分均明显降低(Pqi评分比较差异均具有统计学意义(P<0.05)。两组不良反应发生率比较,差异有统计学意义(P<0.05)。结论:子午养心方联合艾灸治疗青中年心胆气虚型不寐临床疗效肯定,可明显改善患者睡眠状态和焦虑情况,不良反应发生率较低,疗效优于单纯口服西药治疗。

关键词：不寐心胆气虚子午养心方艾灸中医药疗法

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海州露天矿内排土场边坡稳定性研究

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沈阳理工大学学报 2024年第4期43卷 92-96页

作者：董心悦祁云傅鹏彭涛薛凯隆山西大同大学煤炭工程学院山西大同037000 山西保利铁新煤业有限公司山西晋中030600 辽宁工程技术大学安全科学与工程学院辽宁阜新123000

随着露天煤矿开采规模逐渐扩大,固体废弃物堆积而成的内排土场堆高和边坡倾角逐渐变大,导致边坡失稳滑坡、崩塌等严重事故。为确保内排土场在安全稳定的前提下获得更大的排土容积,以海州露天矿南侧内排土场人工土石边坡为研究对象,基于... 详细信息

随着露天煤矿开采规模逐渐扩大,固体废弃物堆积而成的内排土场堆高和边坡倾角逐渐变大,导致边坡失稳滑坡、崩塌等严重事故。为确保内排土场在安全稳定的前提下获得更大的排土容积,以海州露天矿南侧内排土场人工土石边坡为研究对象,基于强度折减理论,采用FLAC3D数值模拟软件对内排土场人工土石边坡进行稳定性分析。结果表明:海州露天矿内排土场人工土石边坡两剖面稳定性安全系数分别为1.182和1.164,均小于安全储备系数1.3,内排土场存在边坡失稳出现滑坡的危险,需对其进行削坡处理;当削坡至35 m位置时,两剖面的稳定性系数均可达到安全储备系数。本文结果可为内排土场方案优化设计提供理论基础。

关键词：露天矿内排土场边坡稳定性安全系数

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“新冠三方”的体外抗氧化作用比较

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中国现代应用药学 2024年第7期41卷 887-894页

作者：李西蒙康媛高源刘壮壮李文静徐瑱璐张小雨蔡润兰齐云中国医学科学院北京协和医学院药用植物研究所北京100193

目的平行比较“新冠三方”(清肺排毒汤、化湿败毒方和宣肺败毒方,以下简称“三方”)的体外抗氧化作用。方法在非细胞体系中,采用FRAP法考察三方的总抗氧化能力;通过DPPH法考察三方对DPPH自由基的清除作用;采用NBT还原法考察三方对超氧... 详细信息

目的平行比较“新冠三方”(清肺排毒汤、化湿败毒方和宣肺败毒方,以下简称“三方”)的体外抗氧化作用。方法在非细胞体系中,采用FRAP法考察三方的总抗氧化能力;通过DPPH法考察三方对DPPH自由基的清除作用;采用NBT还原法考察三方对超氧阴离子的清除作用;通过基于终产物丙二醛的荧光测定法考察三方对羟自由基的清除作用;用FeSO4体外诱导大鼠肝匀浆MDA法考察三方对抗脂质过氧化的作用。依据以上5个抗氧化指标,平行比较三方提取物在非细胞体系的抗氧化能力。进一步地,在脂多糖活化的RAW264.7细胞模型上,分别使用L-012探针和MitoSOX线粒体超氧化物红色荧光探针检测胞质与线粒体活性氧(reactive oxygen species,ROS)的生成情况;通过光泽精探针检测胞质NADPH氧化酶活性,以平行比较三方提取物在细胞体系的抗氧化能力。结果在非细胞体系中,三方均能剂量依赖地清除DPPH自由基、超氧阴离子和羟自由基,并且能有效对抗脂质过氧化的发生。在等提取物浓度下,三方对DPPH自由基与超氧阴离子的清除作用相当,总抗氧化能力相当,而化湿败毒方在清除羟自由基和对抗脂质过氧化方面表现更优。在细胞体系中,三方均能通过抑制NADPH氧化酶的活性来减少脂多糖刺激RAW264.7细胞质ROS的生成;不仅如此,三方对线粒体ROS的生成也有抑制作用,其中清肺排毒汤的作用最佳。结论三方在非细胞体系和细胞体系均展现了多重体外抗氧化作用,且在不同指标上的作用强度各有优劣。考虑到抗氧化应激对COVID-19治疗的重要意义,上述结果提示三方的抗氧化能力是它们发挥治疗COVID-19作用的药效学基础之一。

关键词：清肺排毒汤化湿败毒方宣肺败毒方氧化应激新型冠状病毒感染

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