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A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets

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Virologica Sinica 2018年第2期33卷 131-141页

作者： Zhichao Xu Huiling Zhong Qingfeng Zhou yunping Du li Chen yun Zhang Chunyi xue Yongchang Cao State Key Laboratory of Biocontrol School of Life ScienceSun Yat-sen University Guangdong Wen's Group Academy Guangdong Wen's Foodstuffs Group Co. Ltd School of life Science Higher Education Mega Center Sun Yat-sen University

Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets.

关键词： Porcine deltacoronavirus (PDCoV) Genomic analysis Pathogenicity Southern China

面向DAG任务的分布式智能计算卸载和服务缓存联合优化

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 71-82页

作者：李云南子煜姚枝秀夏士超鲜永菊重庆邮电大学通信与信息工程学院重庆400065 重庆邮电大学软件工程学院重庆400065

建立了一种有向无环图(DAG,directed acyclic graph)任务卸载和资源优化问题,旨在应用最大可容忍时延等约束实现系统能耗最小化。考虑到网络中计算请求高度动态、完整的系统状态信息难以获取等因素,最后使用多智能体深度确定性策略梯度(... 详细信息

建立了一种有向无环图(DAG,directed acyclic graph)任务卸载和资源优化问题,旨在应用最大可容忍时延等约束实现系统能耗最小化。考虑到网络中计算请求高度动态、完整的系统状态信息难以获取等因素,最后使用多智能体深度确定性策略梯度(MADDPG,multi-agent deep deterministic policy gradient)算法来探寻最优的策略。相比于现有的任务卸载算法,MADDPG算法能够降低14.2%至40.8%的系统平均能耗,并且本地缓存命中率提高3.7%至4.1%。

关键词：移动边缘计算多智能体深度强化学习计算卸载资源分配服务缓存

Flutter and Thermal Buckling Properties and Active Control of Functionally Graded Piezoelectric Material Plate in Supersonic Airflow

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Acta Mechanica Solida Sinica 2020年第5期33卷 692-706页

作者： Yu xue Jinqiang li Fengming li Zhiguang Song College of Aerospace and Civil Engineering Harbin Engineering UniversityHarbin150001China

This paper is devoted to investigate the flutter and thermal buckling properties of the functionally graded piezoelectric material(FGPM)plate in supersonic airflow,and the active flutter control is carried out under different temperature *** piezoelectric material component of the FGPM plate has gradient changes along the thickness,such as piezoelectricity and dielectric *** supersonic piston theory is used to evaluate the aerodynamic *** on the first-order shear deformation theory and Hamilton’s principle with the assumed mode method,the equation of motion of the structural system is *** effect of aerodynamic pressure on the frequency and damping ratio of the FGPM plate is ***,the flutter and thermal buckling properties of the FGPM and pure metal plates are compared to show the superior aerothermoelastic properties of the FGPM *** influences of volume fraction exponent and temperature on the flutter and thermal buckling properties of the FGPM plate are also examined in *** LQR controller is adopted to achieve active flutter *** simulation results show that the present control method can largely improve dynamic stability of the FGPM plate in supersonic airflow and high-temperature environment.

关键词： Functionally graded piezoelectric material Flutter Thermal buckling Active control

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

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Frontiers of Medicine 2022年第6期16卷 896-908页

作者： Ran li Kai xue Junmin li Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Fibroblast growth factor 13(FGF13)is aberrantly expressed in multiple cancer types,suggesting its essential role in ***,we aimed to explore its definite role in the development of acute myeloid leukemia(AML)and emphasize its associations with bone marrow *** showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was related to prolonged overall survival(OS).Univariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factor.A prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-,3-,and 5-year *** mutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was related to bone marrow *** for immunity,FGF13 was remarkably associated with T cell count,immune checkpoint genes,and *** addition,FGF13 overexpression substantially inhibited the growth and significantly induced the early apoptosis of AML *** xenograft study indicated that FGF13 overexpression prolonged the survival of recipient ***,FGF13 could serve as an independent prognostic factor for AML,and it was closely related to the bone marrow microenvironment.

关键词： acute myeloid leukemia FGF13 prognosis immune-related genes bone marrow niches

Rotational effect in two-dimensional cooperative directed transport

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Frontiers of physics 2015年第1期10卷 87-94页

作者： li-Yan Qiao yun-yun li Zhi-Gang Zheng Department of Physics and the Beijing-Hong Kong-Singapore Joint Center for Nonlinear and Complex Studies Beijing Normal University Beijing 100876 China Center for Phononics and Thermal Energy Science School of Physics Science and Engineering Tongji University Shanghai 200092 China

In this review we investigate the rotation effect in the motion of coupled dimer in a two-dimensional asymmetric periodic potential. Free rotation does not generate directed transport in translational direction, while we find it plays an critical role in the motors motility when the dimer moves under the effect of asymmetry ratchet potential. In the presence of external force, we study the relation between the average current and the force numerically and theoretically. The numerical results show that only appropriate driving force could produce nonzero current and there are current transitions when the force is large enough. An analysis of stability analysis of limit cycles is applied to explain the occurrence of these transitions. Moreover, we numerically simulate the transport of this coupled dimer driven by the random fluctuations in the rotational direction. The existence of noise smooths the current transitions induced by the driving force and the resonance-like peaks which depend on the rod length emerge in small noise strength. Thanks to the noise in the rotational direction, autonomous motion emerges without the external force and large noise could make the current reversal happen. Eventually, the new mechanism to generate directed transport by the rotation is studied.

关键词： molecular motor rotational effect noise rotation-translation coupling directedtranslational motion

Multistep evolution from a metal–organic framework to ultrathin nanosheets

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Science Bulletin 2019年第14期64卷 964-967页

作者： yun li Jin Huang Zong-Wen Mo xue-Wen Zhang Xiao-Ning Cheng li Gong Dong-Dong Zhou Jie-Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Instrumental Analysis and Research Center Sun Yat-Sen University Guangzhou 510275 China

Two-dimensional (2D) materials and ultrathin nanosheets have attracted tremendous research interests [1-4]. Exfoliation of porous coordination polymers (PCPs) or metal-organic frameworks (MOFs) with 2D coordination structures is emerging as a viable strategy for preparation of new types of 2D materials [5-8]. The relatively weak bonding within and strong interactions between 2D coordination networks are the main problems for successful exfoliation [9]. Pretreatments of the layered MOFs to expand the interlayer distances can be helpful [10-12]. Capturing the exfoliation intermediates and visualizing their structures are valuable for understanding the exfoliation mechanism and confirming the structures of the final 2D materials [11,12].

关键词： Two-dimensional (2D) porous coordination polymers (PCPs) metal-organic frameworks (MOFs)

Recent Progress of Metal Organic Frameworks-Based Electrocatalysts for Hydrogen Evolution,Oxygen Evolution,and Oxygen Reduction Reaction

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Energy & Environmental Materials 2022年第4期5卷 1084-1102页

作者： Yaling Jia Ziqian xue Yinle li Guangqin li MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityGuangzhou 510275China Institute for Integrated Cell-Material Sciences(iCeMS) Kyoto UniversityKyoto 606-8501Japan

Exploring efficient and cost-saving electrocatalysts is essential to the renewable energy storage and utilization,which is still in its embryonic *** have drawn tremendous attention due to their adjustability,abundant active sites,and plentiful ***,satisfactory electrocatalytic performance has been achieved by MOFs-based electrocatalysts comparable to traditional ***-of-the-art works about the MOFs-based electrocatalysts for hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and ORR were summarized in this *** review comprises a series of modifying strategies of MOFs and their derivatives,from aspects of structure,composition,and ***,the active sites and functional mechanisms’recognition are involved in this review expecting to provide reference for rationally designing efficient *** last,the current status,challenges,and perspectives of MOFs-based electrocatalysts are also discussed.

关键词： electrocatalysts hydrogen evolution metal organic frameworks oxygen evolution oxygen reduction reaction

Potential of natural medicines for treatment of osteoporosis:a narrative review

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Journal of Traditional Chinese Medicine 2023年第1期43卷 198-204页

作者： xue Nannan JIA liyang li Qiyan yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D Dali UniversityDali 671000China Department of Stomatology the First People’s Hospital of Yunnan Province.The Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032China

OBJECTIVE:To organize the fragmented information available in the literature to describe and summarize the extracts used by natural medicines in the treatment of bone loss,and to provide evidence and support for the potential use of natural medicines in the treatment of ***:A literature survey for relevant information regarding the osteogenesis of Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,was conducted using PubM ed,ScienceDirect,MEDliNE,Springer liNK and Google Scholar electronic databases from the years ***:Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,both inhibit the activity of osteoclasts and reduce bone resorption by regulation of signaling pathways through interacting with signaling ***:In this review,the current knowledge of the novel medicines with osteogenesis properties were summarized and their potential in the treatment of bone loss were demonstrated,but the lack of research on the regulation of the signaling pathway’s mechanism of action,and the corresponding theoretical basis for the application of natural medicines in clinical osteoporosis,made it difficult to be widely applied and promoted in clinical *** experiments with some of the medicines and the mechanisms is needed to realize their potential as osteoporosis treatments.

关键词： osteoporosis natural medicines biological products molecular mechanisms of pharmacological action review

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Experimental investigation on the yield behavior of metal foam under shear-compression combined loading

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Science China(Technological Sciences) 2021年第7期64卷 1412-1422页

作者： LUO Geng xue Pu li YuLong School of Automobile Chang’an UniversityXi’an710064China School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China Joint International Research Laboratory of Impact Dynamics and its Engineering Applications Northwestern Polytechnical UniversityXi’an710072China

Metal foams are typically subjected to quasi-static or dynamic shear-compression combined loading in applications such as energy absorbers and structure protectors. The yield behavior of a metal foam under dynamic and quasi-static shear-compression combined loadings is investigated in this study. First, quasi-static and dynamic compression-shear combined tests at different loading angles are conducted using a universal testing machine and a rotatable Hopkinson bar system, respectively. Shear deformation reduces the plateau stress as the loading angle increases. Subsequently, the yield modes of the metal foam under combined loadings are investigated. Only one yield band occurs under a combined loading with large loading angles(mode I),whereas several yield bands occur under a combined loading with small loading angles(mode II). Finally, the yield surface plot of metal foam indicates significant enhancement in terms of normal stress and shear stress under dynamic loading. Quasi-static and dynamic phenomenological yield criteria for a shear-normal stress space are established to provide a brief and precise prediction of the behavior of metal foam under quasi-static and dynamic combined loadings.

关键词： metal foam yield behavior shear-compression combined loading yield mode yield criterion