Potential of natural medicines for treatment of osteoporosis:a narrative review

作     者：XUE Nannan JIA Liyang LI Qiyan XUE Nannan;JIA Liyang;LI Qiyan

作者机构：Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&DDali UniversityDali 671000China Department of Stomatologythe First People’s Hospital of Yunnan Province.The Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2023年第43卷第1期

页      面：198-204页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Supported by the National Nature Science Foundation of China(No.81660186,81160134) Yunnan Health Training Project of high level talents(No.L-2017019) the Yunnan province"Ten Thousand People Plan"Famous Medical Special Talents(YNWR-MY-2018-017) 

主　　题：osteoporosis natural medicines biological products molecular mechanisms of pharmacological action review 

摘      要：OBJECTIVE:To organize the fragmented information available in the literature to describe and summarize the extracts used by natural medicines in the treatment of bone loss,and to provide evidence and support for the potential use of natural medicines in the treatment of ***:A literature survey for relevant information regarding the osteogenesis of Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,was conducted using PubM ed,ScienceDirect,MEDLINE,Springer LINK and Google Scholar electronic databases from the years ***:Dongkuiguo(Fructus Malvae Verticillatae),Machixian(Herba Portulacae Oleraceae).etc.,both inhibit the activity of osteoclasts and reduce bone resorption by regulation of signaling pathways through interacting with signaling ***:In this review,the current knowledge of the novel medicines with osteogenesis properties were summarized and their potential in the treatment of bone loss were demonstrated,but the lack of research on the regulation of the signaling pathway’s mechanism of action,and the corresponding theoretical basis for the application of natural medicines in clinical osteoporosis,made it difficult to be widely applied and promoted in clinical *** experiments with some of the medicines and the mechanisms is needed to realize their potential as osteoporosis treatments.