检索结果-南通市图书馆

Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

引用

Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU Ying LI Ping LUAN Jianwei SheN Rui WU Yinglan XU Qiwen WANG Xinyue ZHU Yao XU Xiangru LIU Zitian JIANG yuning ZHONG Yong he yun JIANG Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China Department of health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Emergency Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting ***: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P he YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P he typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P he ratio of non-dipper hypertension in YX group was higher t

关键词： hypertension Yin deficiency syndrome random forest blood pressure rhythm blood pressure variability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Melittin analog p5RHH enhances recombinant adeno-associated virus transduction efficiency

引用

Journal of Integrative Medicine 2024年第1期22卷 72-82页

作者： Jing-shun Meng yun he heng-bin Yang Li-ping Zhou Si-yuan Wang Xi-lin Feng Omar Yahya Al-shargi Xiao-min Yu Li-qing Zhu Chang-quan Ling Shanghai University of Traditional Chinese Medicine Shanghai 201203China Oncology Department of Traditional Chinese Medicine Changhai HospitalNaval Medical UniversityShanghai 200433China Faculty of Traditional Chinese Medicine Naval Medical UniversityShanghai 200043China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology(Ministry of Education) School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200438China Yantai Fuheng Biological Technology Co. Ltd.YantaiShandong Province 264006China. Department of Clinical Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

Objective Melittin and its derivatives have been characterized to establish effective gene delivery *** capability of facilitating endosomal release enhances the nanoparticles-based gene ***,little investigation has been conducted to explore its potential application in the context of viral *** Various melittin-derived peptides were inserted into the loop VIII of the capsid proteins of recombinant adeno-associated virus *** vectors carrying either gfp or fluc genes were subjected to qPCR assays and transduction assays of heK293T cells to investigate the efficiency of vector production and gene *** addition,the ability of a specific p5RHH-rAAV vector to deliver genes was examined through in vitro transduction of different cultured cells and in vivo tail vein administration to C57BL/6 ***,the intricate details of the vector-mediated transduction mechanisms were revealed by specific pharmacological inhibitors of every stage of the rAAV2 intracellular life *** A total of 76 melittin-related peptides were compiled from existing *** them,cMA2,Melt13,p5RHH and aAR3 were found to significantly enhance the gene delivery efficiency of rAAV2 *** p5RHH-rAAV2 vectors efficiently transduced not only rAAV-potent cell lines but also cell lines previously considered resistant to ***,bafilomycin A1,a vacuolar endosome acidification inhibitor,completely inhibited the transgene expression mediated by the p5RHH-rAAV2 *** importantly,p5RHH-rAAV8 vectors also demonstrated increased hepatic transduction in vivo in C57BL/6 *** The incorporation of melittin analogues into the rAAV capsids results in a significant improvement in rAAV-mediated transgene *** further modifications remain an area of interest,our studies have substantially broadened the pharmacological prospects of melittin in the context of viral vector-mediated gene delivery.

关键词： Melittin Recombinant adeno-associated virus Capsid engineering Transduction efficiency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

从“隐喻”母题到“隐逸”主题——以《二十四史·隐逸列传》为分析路径

引用

艺术百家 2024年第2期40卷 107-114页

作者：赫云东南大学艺术学院江苏南京211189

《二十四史·隐逸列传》是分析中国传统山水画“隐逸”主题的重要文献。尽管山水画的形态、风格固然众多,但图像的母题却是解读和阐释山水画主题的重要依据。如渔父、樵夫、蓧杖人等核心母题,具有隐喻性的文化特征,指向了隐逸主题。不... 详细信息

《二十四史·隐逸列传》是分析中国传统山水画“隐逸”主题的重要文献。尽管山水画的形态、风格固然众多,但图像的母题却是解读和阐释山水画主题的重要依据。如渔父、樵夫、蓧杖人等核心母题,具有隐喻性的文化特征,指向了隐逸主题。不同的母题(母题意象)组合,可能显现不一样的隐逸主题。母题的在场以及主题的出场,在不同时空的认知场域中有不同的结构与方式。有些母题可能是原隐喻的转喻,既是隐逸叙事的主题表达的依据,也是认定隐士身份的辅助性母题,如渔船、岩穴、茅舍、枯松、童子等母题。因而,核心母题与辅助性母题的配置与逻辑结构,构成山水画的隐逸主题。

关键词：母题主题隐逸隐喻山水画

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Triceps skinfold thickness trajectories and the risk of all-cause mortality:A prospective cohort study

引用

World Journal of Clinical Cases 2024年第15期12卷 2568-2577页

作者： Na Yang Li-yun he Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND The measurement of triceps skinfold(TSF)thickness serves as a noninvasive metric for evaluating subcutaneous fat *** its clinical utility,the TSF thickness trajectories and their correlation with overall mortality have not been thoroughly *** To explore TSF thickness trajectories of Chinese adults and to examine their associations with all-cause *** This study encompassed a cohort of 14747 adults sourced from the China health and Nutrition *** class trajectory modeling was employed to identify distinct trajectories of TSF *** were classified into subgroups reflective of their respective TSF thickness *** utilized multivariate Cox regression analyses and mediation examinations to explore the link between TSF thickness trajectory and overall mortality,including contributory *** Upon adjustment for multiple confounding factors,we discerned that males in the‘Class 2:Thin-stable’and‘Class 3:Thin-moderate’TSF thickness trajectories exhibited a markedly reduced risk of mortality from all causes in comparison to the‘Class 1:Extremely thin’*** the mediation analyses,the Geriatric Nutritional Risk Index was found to be a partial intermediary in the relationship between TSF thickness trajectories and *** females,a lower TSF thickness pattern was significantly predictive of elevated all-cause mortality risk exclusively within the non-elderly *** In males and non-elderly females,lower TSF thickness trajectories are significantly predictive of heightened mortality risk,independent of single-point TSF thickness,body mass index,and waist circumference.

关键词： Triceps skinfold thickness Trajectory All-cause mortality Body mass index Geriatric Nutritional Risk Index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

民族社会工作研究的几种理论视角——基于近十年研究文献的分析

引用

贵州民族研究 2024年第2期45卷 177-182页

作者：严云鹤云南大学民族学与社会学学院云南昆明650091

民族社会工作是社会工作的组成部分,具有特定的服务对象、依从规律以及理论支撑。近十年来,相关研究文献表明,当前我国的民族社会工作理论研究还处于起步阶段,主要的运用视角涉及文化视角、发展视角、人本视角等。在立足新时代推进社会... 详细信息

民族社会工作是社会工作的组成部分,具有特定的服务对象、依从规律以及理论支撑。近十年来,相关研究文献表明,当前我国的民族社会工作理论研究还处于起步阶段,主要的运用视角涉及文化视角、发展视角、人本视角等。在立足新时代推进社会建设、社会和谐,促进各民族更加广泛、深刻地交往交流交融的背景下,加强民族社会工作理论研究有助于推动实务、实践工作的创新。

关键词：民族社会工作文化视角发展视角人本视角

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surgical treatment of liver cancer and pancreatic cancer under the China healthcare Security Diagnosis Related Groups payment system

引用

World Journal of Clinical Cases 2024年第21期12卷 4673-4679页

作者： yun-he Hu Fan Yu Yu-Zhuo Zhou Ai-Dong Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Data from the World health Organization’s International Agency for Research on Cancer reported that China had the highest prevalence of cancer and cancer deaths in *** and pancreatic cancers accounted for the highest number of new ***-world data(RWD)is now widely preferred to traditional clinical trials in various fields of medicine and healthcare,as the traditional research approach often involves highly selected populations and interventions and controls that are strictly ***,research results from the RWD match global reality better than those from traditional clinical *** To analyze the cost disparity between surgical treatments for liver and pancreatic cancer under various *** This study analyzed RWD 1137 cases within the HB1 group(patients who underwent pancreatectomy,hepatectomy,and/or shunt surgery)in *** distinguished different expenditure categories,including medical,nursing,technical,management,drug,and consumable ***,it assessed the contribution of each expenditure category to total hospital costs and performed cross-group comparisons using the non-parametric Kruskal–Wallis *** study used the Steel–Dwass test for post-hoc multiple comparisons and the Spearman correlation coefficient to examine the relationships between *** The study found that in HB11 and HB13,the total hospitalization costs were significantly higher for pancreaticoduodenectomy than for pancreatectomy and *** no significant difference was observed in the length of hospital stay between patients who underwent pancreaticoduodenectomy and pancreatectomy,both were significantly longer than those who underwent liver *** HB15,no significant difference was observed in the total cost of hospitalization between pancreaticoduodenectomy and pancreatectomy;however,both were significantly higher than those in ***,the length of hospital stay was significan

关键词： China health care security diagnosis-related groups Real-world study Liver cancer surgical treatment Pancreatic cancer surgical treatment Hospitalization costs Cost structure Average length of stay

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dipeptidyl peptidase-4 inhibitors and the risk of infection: A systematic review and meta-analysis of cardiovascular outcome trials

引用

World Journal of Diabetes 2024年第5期15卷 1011-1020页

作者： Na Yang Li-yun he Peng Liu Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling Xu Wei Li Hua-Bing Zhang Yu-Xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Endocrinology The First Affiliated Hospitaland College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina

BACKGROUND Since adverse events during treatment affect adherence and subsequent glycemic control,understanding the safety profile of oral anti-diabetic drugs is imperative for type 2 diabetes mellitus(T2DM)*** To evaluate the risk of infection in patients with T2DM treated with dipeptidyl-peptidase 4(DPP-4)*** Electronic databases were *** selection criteria included randomized controlled trials focused on cardiovascular *** these studies,the effects of DPP-4 inhibitors were directly compared to those of either other active anti-diabetic treatments or *** trials involving 53616 patients were deemed *** calculated aggregate relative risks employing both random-effects and fixed-effects approaches,contingent upon the *** The application of DPP-4 inhibitors showed no significant link to the overall infection risk[0.98(0.95,1.02)]or the risk of serious infections[0.96(0.85,1.08)],additionally,no significant associations were found with opportunistic infections[0.69(0.46,1.04)],site-specific infections[respiratory infection 0.99(0.96,1.03),urinary tract infections 1.02(0.95,1.10),abdominal and gastrointestinal infections 1.02(0.83,1.25),skin structure and soft tissue infections 0.81(0.60,1.09),bone infections 0.96(0.68,1.36),and bloodstream infections 0.97(0.80,1.18)].CONCLUSION This meta-analysis of data from cardiovascular outcome trials revealed no heightened infection risk in patients undergoing DPP-4 inhibitor therapy compared to control cohorts.

关键词： T2DM drugs treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

引用

World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： yun-Sen he Xiao-Hong Qin Min Feng Qin-Jiang Huang Meng-Jun Zhang Li-Li Guo Ming-Bin Bao Ye Tao Hong-Yuan Dai Bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Iron/B_(2)pin_(2)catalytic system enables the generation of alkyl radicals from inert alkyl C-O bonds for amine synthesis

引用

Chinese Chemical Letters 2024年第1期35卷 227-232页

作者： Yanqing Zhu Shuai Chen Zhen Zhou yun he Zhengli Liu Yang Liu Zhang Feng Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Department of Medicinal Chemistry School of PharmacyFujian Medical University(FMU)Fuzhou 350005China Affiliated Hospital of North Sichuan Medical College and Medical Imaging Key Laboratory of Sichuan Province Nanchong 637503China

A method for the generation of alkyl radicals from inert alkyl C-o bonds has been developed via an iron/borane reagent/alkoxide catalytic system,which can be employed for the synthesis of amines from nitroarenes with excellent *** reductive amination features good functional group compatibility and enables the late-stage amination of bio-relevant compounds,thus providing good opportunities for applications in medicinal *** mechanistic studies reveal that the amine synthesis may be involving a Fe/Li cation-assisted single electron transfer pathway to form alkyl radicals,and the low-valent iron speciesmaybetheactive intermediates.

关键词： C-N bond formation Reductive amination Borane reagent Iron catalysis Green chemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于多层感知机的航空发动机压气机盘应力和温度预测

引用

航空动力学报 2024年第4期39卷 205-214页

作者：王学民徐敬沛何云中国航发四川燃气涡轮研究院成都610500

将发动机可测参数作为初始特征,利用人工神经网络技术建立航空发动机压气机盘应力和温度预测的MLP(multilayer perceptron)模型,采用BP(back propagation)神经网络算法进行训练。结果表明:该方法预测结果与传统有限元计算结果吻合较好,... 详细信息

将发动机可测参数作为初始特征,利用人工神经网络技术建立航空发动机压气机盘应力和温度预测的MLP(multilayer perceptron)模型,采用BP(back propagation)神经网络算法进行训练。结果表明:该方法预测结果与传统有限元计算结果吻合较好,相对偏差均在1%以内,判定系数达到0.95以上,方均根误差均在5以内,且计算速度由小时级提升为分秒级,可为后续工程应用提供依据。

关键词：压气机轮盘神经网络多层感知机应力温度寿命管理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：