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Dietary intake and serum levels of copper and zinc and risk of hepatocellular carcinoma:A matched case-control study

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Chinese Medical Journal 2024年第5期137卷 596-603页

作者： Xiaozhan Liu Yaojun Zhang Dinuerguli Yishake Yan Luo Zhaoyan Liu yuming Chen Huilian Zhu Aiping Fang Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhouGuangdong 510080China State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China

Background:Copper and zinc are involved in the development of multiple malignancies;yet,epidemiological evidence on hepatocellular carcinoma(HCC)is *** study aimed to investigate the association between dietary intake and serum levels of copper and zinc with the risk of ***:A total of 434 case-control pairs matched for sex and age(±1 year)were included in this *** with newly diagnosed HCC were from the Guangdong Liver Cancer Cohort(GLCC)study,and healthy controls were from the Guangzhou Nutrition and health Study(GNHS).A semi-quantitative 79-item food frequency questionnaire(FFQ)was used to assess habitual dietary intakes of copper and *** levels of copper and zinc were measured by using inductively coupled plasma mass *** copper(Cu)/zinc(Zn)ratio was computed by dividing copper levels by zinc *** logistic regression models were performed to calculate the odds ratio(OR)and 95%confidence intervals(CI)for per 1 standard deviation increase(per-SD increase)in copper and zinc ***:Higher dietary intake(OR_(per-SD increase)=0.65,95%CI:0.44,0.96,P_(trend)=0.029)and serum levels of zinc(OR_(per-SD increase)=0.11,95%CI:0.04,0.30,P_(trend)he inverse association was only pronounced in men but not in women(P_(interaction)=0.041 for dietary zinc intake and 0.010 for serum zinc levels).Serum copper levels(OR_(per-SD increase)=2.05,95%CI:1.39,3.03,P_(trend)=0.020)and serum Cu/Zn ratio(OR_(per-SD increase)=6.53,95%CI:2.52,16.92,P_(trend)he effects of copper on HCC risk are not clear.

关键词： Copper Zinc hepatocellular carcinoma risk Case-control studies Dietary intake Serum

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Coupled Numerical Simulation of Electromagnetic and Flow Fields in a Magnetohydrodynamic Induction Pump

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Fluid Dynamics & Materials Processing 2024年第4期20卷 889-899页

作者： he Wang Ying he College of Transportation Ludong UniversityYantai264025China College of Intelligent Manufacturing City College of HuizhouHuizhou516025China

Magnetohydrodynamic(MHD)induction pumps are contactless pumps able to withstand harsh *** rate of fluid flow through the pump directly affects the efficiency and stability of the *** explore the influence of induction pump settings on the related delivery speed,in this study,a numerical model for coupled electromagnetic and flow field effects is introduced and used to simulate liquid metal lithium flow in the induction *** effects of current intensity,frequency,coil turns and coil winding size on the velocity of the working fluid are *** is shown that the first three parameters have a significant impact,while changes in the coil turns have a negligible *** maximum increase in working fluid velocity within the pump for the parameter combination investigated in this paper is approximately 618%.As the frequency is increased from 20 to 60 Hz,the maximum increase in the mean flow rate of the working fluid is approximately 241%.These research findings are intended to support the design and optimization of these devices.

关键词： Magnetic fluid multi-physical field coupling induction pump numerical simulation liquid metal conveying

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A 3D-printed microhemispherical shell resonator with electrostatic tuning for a Coriolis vibratory gyroscope

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Microsystems & Nanoengineering 2024年第2期10卷 25-35页

作者： Baoyin Hou Ye Zhu Chaofan he Weidong Wang Zhi Ding Wen he Yong he Lufeng Che College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou310027China Center for Microelectronics Shaoxing InstituteZhejiang UniversityShaoxing312035China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310058China School of Mechanical Engineering Zhejiang UniversityHangzhou310058China

The emergence of microhemispherical resonant gyroscopes,which integrate the advantages of exceptional stability and long lifetime with miniaturization,has afforded new possibilities for the development of whole-angle ***,existing methods used for manufacturing microhemispherical resonant gyroscopes based on MEMS technology face the primary drawback of intricate and costly ***,we report the design,fabrication,and characterization of the first 3D-printable microhemispherical shell resonator for a Coriolis vibrating *** remarkably achieve fabrication in just two steps bypassing the dozen or so steps required in traditional *** utilizing the intricate shaping capability and ultrahigh precision offered by projection microstereolithography,we fabricate 3D high-aspect-ratio resonant structures and controllable capacitive air gaps,both of which are extremely difficult to obtain via MEMS *** addition,the resonance frequency of the fabricated resonators can be tuned by electrostatic forces,and the fabricated resonators exhibit a higher quality factor in air than do typical MEMS microhemispherical *** work demonstrates the feasibility of rapidly batch-manufacturing microhemispherical shell resonators,paving the way for the development of microhemispherical resonator gyroscopes for portable inertial ***,this particular design concept could be further applied to increase uptake of resonator tools in the MEMS community.

关键词： resonator tuning electrostatic

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Feasibility and Path Analysis of Integrating Innovation and Entrepreneurship Education into“One-Stop”Student Communities

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Journal of Contemporary Educational Research 2024年第5期8卷 200-206页

作者： yuming Zhang Changshu Institute of Technology Changshu 215500Jiangsu ProvinceChina

The“one-stop”student community provides new support for innovation and entrepreneurship education in *** innovation and entrepreneurship education into the“one-stop”student community work enriches course materials,integrates teacher resources,improves students’participation in innovation and entrepreneurship,and solves problems such as low student participation,lack of course resources,insufficient teacher resources,and single evaluation methods in traditional *** various means such as exploring course resources,innovating management models,and strengthening team construction,the role of“one-stop”student communities in innovation and entrepreneurship education has been fully utilized,promoting the development of innovation and entrepreneurship education.

关键词： Innovation and entrepreneurship “One-stop”student community Feasibility Path analysis

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数字相关法在超声应力信号处理中的应用

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应用力学学报 2008年第1期25卷 158-161页

作者：胡而已何玉明陈炎明陈传尧华中科技大学武汉430074

研究了数字相关法在超声应力检测中回波时间差的自动识别计算。采用数字模拟分析,对相关运算算法的可靠性进行了验证。分析了不同采样频率和相关窗口长度对相关计算的影响,并应用插值技术提高了时间差的计算精度。该方法对实验采集的超... 详细信息

研究了数字相关法在超声应力检测中回波时间差的自动识别计算。采用数字模拟分析,对相关运算算法的可靠性进行了验证。分析了不同采样频率和相关窗口长度对相关计算的影响,并应用插值技术提高了时间差的计算精度。该方法对实验采集的超声纵波、横波及表面波的时间差分析均适用。通过对不同应力状态下采集的超声表面波信号的处理,得到了Q235钢中超声表面波传播时间差与应力的实验关系曲线,为超声应力检测奠定了基础。

关键词：相关法超声检测时间差信号识别

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Feedback processing in the primate brain and in AI systems

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Science China(Technological Sciences) 2024年第8期67卷 2297-2309页

作者： JIANG Yong he Sheng Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China University of Chinese Academy of Sciences Beijing 100049China

The primate brain and artificial intelligence(AI) can both be conceptualized as information processing systems, each with its own distinct biological and computational architectures. While there are parallels between them, their respective structural and functional connections show significant differences. In this paper, we examine the central role of feedback processing in both the primate brain and AI systems, which has been shown to be crucial in shaping neural processing. By reviewing the key features of feedback processes in the primate brain, which allows the brain to incorporate prior knowledge, contextual information, and taskdemands into early-stage processing, we highlight the divergence in goals and functions between biological and AI *** these differences is crucial for elucidating the cognitive capabilities of the primate brain and for addressing computational challenges in AI. In advocating “Cognition-Inspired-Computation”, we suggest that integrating insights from feedback processing in the primate brain into AI research will offer potentially significant improvements for the advancement of AI systems.

关键词： cognitive neuroscience artificial intelligence feedback processing attention learning

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Mode Competition of Low Voltage Backward Wave Oscillator near 500 GHz with Parallel Multi-Beam

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Chinese Journal of Electronics 2024年第2期33卷 488-495页

作者： Xiaoyan ZHAO Jincheng HU Haoran ZHANG Sidou GUO yuming FENG Lin TANG Kaichun ZHANG Diwei LIU THz Center School of Electronic Science and Engineering University of Electronic Science and Technology of China School of Computer Science Southwest Petroleum University

A backward wave oscillator with parallel multiple beams and multi-pin slow-wave structure(SWS)operating at the frequency above 500 GHz is studied. Both the cold-cavity dispersion characteristics and CST Particle Studio simulation results reveal that there are obvious mode competition problems in this kind of terahertz *** that the structure of the multi-pin SWS is similar to that of two-dimensional photonic crystals, we introduce the defects of photonic crystal with the property of filtering into the SWS to suppress high-order ***, a detailed study of the effect of suppressing higher-order modes is carried out in the process of changing location and arrangement pattern of the point defects. The stable, single-mode operation of the terahertz source is realized. The simulation results show that the ratio of the output peak power of the higher-order modes to that of the fundamental mode is less than 1.9%. Also, the source can provide the output peak power of 44.8 m W at the frequency of 502.2 GHz in the case of low beam voltage of 4.7 kV.

关键词： Low voltage Filtering Simulation Voltage Photonic crystals Machining Pins

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Yeast-Controlled Double-Shelled CacO_(3)/CaF_(2)Hollow Nanospheres with Hierarchically Porous for Sustained pH-Sensitive Drug Release

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Chinese Journal of Chemistry 2024年第15期42卷 1713-1720页

作者： Xinhe Liu Yi Chang Guanglei Ma Tingting Liu Penghui Song heng Yu Xueqing Ren yuming Guo Xiaoming Ma School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiangHenan 453007China Collaborative Innovation Center of henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistryof EducationHenan Normal UniversityXinxiangHenan 453007China

Hierarchically porous materials(HP materials)are believed one of the most hopeful matrix materials because of their distinctive multimodal pore structures and tremendous application potentials in the field of ***,green and facile synthesis of hierarchically porous nanomaterials with beneficial water dispersibility and biocompatibility is still a great ***,a novel biomimetic strategy is proposed to prepare the cell-tailored double-shelled HPCaCO_(3)/CaF_(2) hollow nanospheres under the mediation of yeast *** biomolecules derived from the secretion of yeast cells are used as conditioning and stabilizing agents to control the biosynthesis of the HPCaCO_(3)/CaF_(2) materials,which exhibit excellent water dispersibility and favorable *** double-shelled CaCO_(3)/CaF_(2) nanospheres hold hierarchically porous structure and have abundant pore channel and large specific surface area,showing high drug-loading and a prolonged drug sustainable release profile by the pore-by-pore diffusion pattern of the hierarchical ***,the HPCaCO_(3) with pH-sensitivity could controllably release drug doxorubicin hydrochloride(DOX)at the acidic tumor *** in vitro and in vivo results demonstrate that HPCaCO_(3)/CaF_(2) has the sustainable pH-sensitive drug release property,showing an enhanced therapeutic ***,this study provides a biomimetic strategy to synthesize the hierarchically porous double-shelled hollow nanomaterials for applying in sustainable drug delivery system.

关键词： Biomimetic synthesis Hierarchically porous Sustained pH-sensitive drug release Antitumor agents Drug delivery Calcium Cancer therapy/Hollow structures

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Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu

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Genes & Diseases 2024年第2期11卷 528-531页

作者： Jing he Yiran Yu Yilin he Jie he Guangyu Ji Haiquan Lu The Second Hospital and Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Department of Nursing The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250014China School of Medicine Xinjiang Medical UniversityUrumqiXinjiang 830054China School of Medicine Binzhou Medical UniversityYantaiShandong 264003China Oncology Department Jinan Zhangqiu District People's HospitalJinanShandong 250200China Key Laboratory for Experimental Teratology of the Ministry of Education Cheeloo College of MedicineShandong UniversityJinanShandong 250012China Center for Reproductive Medicine Shandong UniversityJinanShandong 250012China

Triple-negative breast cancer(TNBC)has aggressive characteristics as exemplified by the high risk of recurrence,metastasis,and patient mortality.1 Cytotoxic chemotherapy may reduce tumor burden initially,but leave behind chemo-resistant breast cancer stem cells(BCSCs)that lead to tumor recurrence and metastasis.2 Chemotherapy induces BCsC enrichment through the activation of glutathione biosynthesis pathways,which increases intracellular glutathione levels and specifies the BCSC phenotype through complicated downstream signaling pathways.3 Glutathione S-transferases(GSTs),a superfamily(which contains seven cytosolic classes:Alpha,Kappa,Mu,Omega,Pi,Theta,and Zeta,and one microsomal class MGSTs)of phase Il enzymes that catalyze the conjugation of glutathione with electrophilic compounds,play a critical role in detoxification and chemotherapy resistance of cancer ***,the role of GSTs in the regulation of BCSCs is largely elusive.

关键词： chemotherapy breast metastasis

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Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3457-3475页

作者： Manqing Tang Zhijie Zhang Ping Wang Feng Zhao Lin Miao yuming Wang Yingpeng Li Yunfei Li Zhonggao Gao College of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Tumor metastasis,the apex of cancer progression,poses a formidable challenge in therapeutic *** tumor cells(CTCs),resilient entities originating from primary tumors or their metastases,significantly contribute to this process by demonstrating remarkable *** survive shear stress,resist anoikis,evade immune surveillance,and thwart *** comprehensive review aims to elucidate the intricate landscape of CTC formation,metastatic mechanisms,and the myriad factors influencing their *** signaling pathways,such as integrin-related signaling,cellular autophagy,epithelial-mesenchymal transition,and interactions with platelets,are examined in ***,we explore the realm of precision nanomedicine design,with a specific emphasis on the anoikis‒platelet *** innovative approach strategically targets CTC survival mechanisms,offering promising avenues for combatting metastatic cancer with unprecedented precision and *** review underscores the indispensable role of the rational design of platelet-based nanomedicine in the pursuit of restraining CTC-driven metastasis.

关键词： CTCs Anoikis Platelet Cancer stem cell Metastasis Platelet‒CTC interaction Platelet targeting Nanomedicines

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