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The anthropogenic acceleration and intensification of flash drought over the southeastern coastal region of China will continue into the future

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Atmospheric and Oceanic Science Letters 2022年第5期15卷 61-67页

作者： yumiao wang Xing Yuan Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjingChina School of Hydrology and Water Resources Nanjing University of Information Science and TechnologyNanjingChina

The frequent and rapid onset of flash drought poses a serious threat to agriculture and *** human influences on flash droughts and estimating their future risks under climate change have attracted great *** on a record-breaking flash drought event in the southeastern coastal region of China in summer 2020,the authors found that the suppression of convective precipitation and high temperature caused by the persistent high geopotential height anomalies and land-atmosphere dry coupling were important reasons for the rapid onset and strong intensity of the flash *** attribution analysis with the latest CMIP6 data showed that anthropogenic climate change has not only increased the likelihood of an onset speed and intensity like those of the 2020 flash drought event,by about 93%±20%and 18%±15%,respectively,but also increased the chance of their simultaneous occurrence,by about 86%±38%,according to their joint probability *** a business-as-usual future scenario(SSP2-4.5),the likelihood of such an onset speed,intensity,and their simultaneous occurrence will further increase,by 85%±33%,49%±8%,and 81%±48%,respectively,as compared with current climate *** study highlights the importance of anthropogenic climate change for accelerating and intensifying flash drought in the southeastern coastal region of China.

关键词： Flash drought Climate change Drought onset speed Detection and attribution

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Multiscale causes of the 2022 Yangtze mega-flash drought under climate change

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Science China Earth Sciences 2024年第8期67卷 2649-2660页

作者： Xing YUAN yumiao wang Shiyu ZHOU Hua LI Chenyuan LI School of Hydrology and Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Hydrometeorological Disaster Mechanism and Warning of Ministry of Water Resources Nanjing University of Information Science and TechnologyNanjing 210044China

The 2022 Yangtze mega-flash drought is characterized by strong intensity and rapid development both in time and space,accompanied by a persistent anticyclonic circulation ***,the causes of the extreme event remain elusive given the multiscale nature of *** we presented a brief overview for the oceanic and terrestrial causes of the megaflash drought during the summer of 2022,and estimated the risk in a changing *** the soil moisture percentile as the drought index,it was found that the drought expanded to the entire Yangtze River basin within two months,with 80%of basin under severe drought conditions at the end of *** the intensity and onset speed of the 2022 mega-flash drought were ranked as the first during the past 62 years,with return periods of 86 and 259 years,*** results of composite analysis showed that the spring La Ni?a can facilitate the abrupt change from a wet/normal condition in May–June to drought in July–August over the Yangtze River basin,which was beneficial for the increase of flash drought intensity and onset speed *** analysis through the linear regression also indicated that the unprecedented intensity was associated with the negative phase of the Pacific Decadal *** by a coupling strength index for soil moisture and vapor pressure deficit,it was found that there was a strong land-atmosphere coupling over the Yangtze River basin during July–August *** attribution by using CMIP6 climate models suggested that land-atmosphere coupling increased the risks of flash drought intensity and onset speed like 2022 by 61%±6%and 64%±7%under natural climate forcings,and the synergy of coupling and anthropogenic climate change would increase the risks by 75%±22%and 85%±12%.Our findings emphasized the role of landatmosphere coupling combined with anthropogenic climate change in intensifying flash droughts.

关键词： Flash drought Yangtze River basin Land-atmosphere coupling Climate change Attribution

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Vascular Damages in Rats Immunized by α_1-Adrenoceptor Peptides

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Cellular & Molecular Immunology 2008年第5期5卷 349-356页

作者： Zihua Zhou Yuhua Liao Liudong Li Fen Wei Bin wang yumiao Wei Min wang Xiang Cheng Institute of Cardiology Union Hospital Tongji Medical College of Huazhong University of Science and Technology Wuhan 430022 China

Autoantibodies against the α1-adrenoceptor which had agonist activity as norepinephrine might play roles in the progression of hypertension, but whether the autoantibodies could induce vascular remodeling as norepinephrine is not clear. In this paper, the models with antibodies against the α1-adrenoceptor were made by immunizing Wistar rats with the synthesized the second extracellular loop of α1-adrenoceptor peptides. The homo-age male Wistar rats received BSA in the same immunizing manner and male spontaneous hypertensive rats （SHR） were used as control. All the rats were raised for one year. The blood pressure and morphological changes of arteries were measured. In the end, despite the systolic blood pressure of immunized rats had no difference with normal control, the media thickness of aortas and ratio of media to lumen in the third-order arteries of mesenteric vasculature were increased in immunized rats. The observation with electron microscope showed that the mitochondria of vascular smooth muscle cells （VSMCs） had notable hyperplasia, and the interstitial collagen fibril was increased too. The effects of purified antibodies against α1-adrenoceptor on the proliferation of cultured VSMCs, and the expressions of c-jun, c-fos and α1-adrenoceptor were detected. The results showed that the antibodies could promote the proliferation of cultured VSMCs, and enhance the expression of c-jun both in vitro and in vivo. So we concluded that antibodies against the α1-adrenoceptor could contribute to vascular damages in rats by stimulating the growth of VSMCs which might be caused by the increased c-jun expression, and might play particular roles in the pathological changes of hypertension.

关键词： α1-adrenoceptor autoantibody vascular remodeling

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Target Organ Protection from a Novel AngiotensinⅡReceptor (AT1) Vaccine ATR12181 in Spontaneously Hypertensive Rats

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Cellular & Molecular Immunology 2006年第2期3卷 107-114页

作者： Feng Zhu Yuhua Liao Liudong Li Min Cheng Fen Wei yumiao Wei Ming wang Laboratory of Cardiovascular Immunology Institute of Cardiology Union Hospital Tongji Medical College Huazhong Science ＆ Technology University Wuhan 430022 China

Hypertension produces pathophysiological changes that are often responsible for the mortality associated with the disease. It is evident that overactive renin-angiotensin systems play a central role in the development of hypertension and target organ damage associated with hypertension. We have previously found that a novel angiotensin H receptor （AT1） vaccine-ATR12181 attenuated the development of high blood pressure （BP） in spontaneously hypertensive rat （SHR） model of human essential hypertension. Our objective was to determine whether this attenuation of high BP is associated with prevention of target organ damage induced by hypertensive state. SHRs were immunized against a peptide （coded ATR12181） from the extracelluar portion of the ATIA receptor by repeated subcutaneous injections of peptide-tetanus-toxoid complex in combination with Freund＇s adjuvant. A 64 weeks long-term observation was performed. Repeated vaccinations resulted in the induction of anti-ATR12181 antibodies. At the end of observation, vaccinated SHRs manifested lower BP, decreased cardiac hypertrophy and attenuation of kidney injuries, mRNA levels of c-los and c-jun in heart and kidneys were decreased in vaccinated SHRs. Since a self antigen was used, safety of vaccine was concerned. However, the signs of autoimmune diseases were not observed in the sections of heart and kidney. These data demonstrated that repeated immunization against a domain of the extracellular portion of the AT1 receptor was able to cause a target organ protection against hypertension. Active immunization against the AT1 receptor may be considered as a promising new strategy in the treatment of hypertension.

关键词： AT1 hypertension vaccine immune system

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Glycomol: A pervasive tool for structure predication of natural saponin products basing on MS data

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Journal of Pharmaceutical Analysis 2024年第7期14卷 1095-1098页

作者： Daotong Zhao Chunguo wang Hanyun Qu Qinling Rao Bingqing Shen Yinan Jiang Jiayu Gong yumiao wang Di Geng Rui Hong Tao Lu Qing Ni Xinqi Deng Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China School of Life Sciences Beijing University of Chinese MedicineBeijing100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing100029China Beijing Research Institute of Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing100053China Xi'an Jiaotong-Liverpool University SuzhouJiangsu215123China

Due to the multitudinous structural types of glycosylated components,accurate identification of glycosylation modifications and secondary metabolite structures in herbs remains a challenge for natural drug analysis and new drug discovery[1].To solve this problem,we developed an auxiliary spectral analysis strategy based on Glyco-GNN machine learning techniques(Fig.1).It is named as“Glycomol”,an auxiliary tool for the identification of glycoside *** Glycomol,the structure of glycosylated components was analyzed in terms of parent nucleus,glycan modification sites,and glycan *** were taken as representative glycosylated components due to their high structural *** estimate the likelihood of results from this modularization strategy,first we extracted the liquid phase and mass spectrum information of 96 structure-known saponins from multi-stage mass spectrometry ***,24 standard saponins were applied for analysis and a 95.8%hit rate was achieved.

关键词： structure auxiliary saponins

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Virologica Sinica 2023年第5期38卷 813-826页

作者： Yang Li Lele Xu Dian Jiao Zifang Zheng Zhihao Chen Yang Jing Zhiwei Li Zhiqian Maa Yingtong Feng Xuyang Guo yumiao wang Yuan He Haixue Zheng Shuqi Xiao State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730046China College of Veterinary Medicine Northwest A&F UniversityYangling712100China

Porcine reproductive and respiratory syndrome(PRRS)is one of the most significant diseases affecting the pig industry *** PRRSV mutation rate is the highest among the RNA *** date,NADC30-like PRRSV and highly pathogenic PRRSV(HP-PRRSV)are the dominant epidemic strains in China;however,commercial vaccines do not always provide sufficient cross-protection,and the reasons for insufficient protection are *** study isolated a wild-type NADC30-like PRRSV,SX-YL1806,from Shaanxi *** challenge experiments in piglets showed that commercial modified live virus(MLV)vaccines provided good protection against ***,it could not provide sufficient protection against the novel strain *** explore the reasons for this phenomenon,we compared the genomic homology between the MLV strain and HP-PRRSV or NADC30-like PRRSV and found that the MLV strain had a lower genome similarity with NADC30-like *** neutralization assay showed that MLV-immune serum slightly promoted the homologous HP-PRRSV replication and significantly promoted the heterologous NADC30-like PRRSV strain replication in vitro,suggesting that antibody-dependent enhancement(ADE)might also play a role in decreasing MLV protective *** findings expand our understanding of the potential factors affecting the protective effect of PRRSV MLV vaccines against the NADC30-like strains.

关键词： NADC30-like PRRSV Modified live virus(MLV)vaccines Genomic similarity Antibody dependent enhancement(ADE) Cross protection

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Simulation of nuclear isomer production in laser-induced plasma

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Matter and Radiation at Extremes 2024年第5期9卷 1-9页

作者： Zhiguo Ma yumiao wang Yi Yang Youjing wang Kai Zhao Yixin Li Changbo Fu Wanbing He Yugang Ma Key Laboratory of Nuclear Physics and Ion-Beam Application(MoE) Institute of Modern PhysicsFudan UniversityShanghai 200433China

Nuclear isomers play essential roles in various fields,including stellar nucleosynthesis,nuclear clocks,nuclear batteries,clean nuclear energy,and-ray *** technological advances in high-intensity lasers have made it possible to excite or de-excite nuclear isomers using table-top laser *** a particle-in-cell code,we investigate the interaction of a laser with a nanowire array and calculate the production rates of the^(73m)Ge(E_(1)=13.3 keV)and^(107m)Ag(E_(1)=93.1 keV)***^(73m1)Ge,production by Coulomb excitation is found to contribute a peak efficiency of 1.0×10^(19) particles s^(−1)J^(−1),while nuclear excitation by electron capture(NEEC)contributes a peak of 1.65×10^(11)particles s^(−1)J^(−1).These results indicate a high isomeric production ratio,as well as demonstrating the potential for confirming the existence of NEEC,a long-expected but so far experimentally unobserved fundamental process.

关键词： process. isomers excitation

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英国学徒制改革之开拓者项目研究

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外国教育研究 2016年第3期43卷 16-28页

作者：王玉苗河北师范大学河北省职业技术教育研究所河北石家庄050024

学徒制的全面兴盛、《理查德学徒制评论》的发布、学徒制改革的启动是开拓者项目的背景。开拓者项目由各个开拓者团队具体实施,其核心内容是为本行业的一个或若干职业开发具有世界先进水平的学徒制标准和相应的评价方案,从而为整体学徒... 详细信息

学徒制的全面兴盛、《理查德学徒制评论》的发布、学徒制改革的启动是开拓者项目的背景。开拓者项目由各个开拓者团队具体实施,其核心内容是为本行业的一个或若干职业开发具有世界先进水平的学徒制标准和相应的评价方案,从而为整体学徒制改革提供清晰的范例。

关键词：英国学徒制开拓者项目

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达格列净致不良反应文献分析及思考

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中国全科医学 2020年第29期23卷 3649-3654,3666页

作者：王育苗赵静李玥天津市滨海新区中医医院药学科 300450

背景达格列净在国内外指南中的地位逐步提升,近年来,国外陆续出现达格列净导致患者不良反应的报道,但我国由于上市时间短,没有相应个案报道,同时缺乏大样本的临床数据证实其安全性,因此,对其不良反应的监测及分析尤为重要。目的分析达... 详细信息

背景达格列净在国内外指南中的地位逐步提升,近年来,国外陆续出现达格列净导致患者不良反应的报道,但我国由于上市时间短,没有相应个案报道,同时缺乏大样本的临床数据证实其安全性,因此,对其不良反应的监测及分析尤为重要。目的分析达格列净致不良反应的发生规律和特点,为临床合理用药提供依据。方法检索2012年11月—2020年3月中国知网(CNKI)、万方数据知识服务平台、维普网、Medline、PubMed和Springer数据库中达格列净致不良反应的个案报道,提取文献资料,包括性别、年龄、合并基础疾病、合并用药、不良反应发生时间、不良反应临床表现及累及的系统/器官、不良反应的治疗与预后、药物再暴露情况,进行统计描述和分析。结果最终纳入文献共计15篇,共15例患者应用达格列净后发生不良反应,其中男9例(60.0%)、女6例(40.0%),50岁以上发生不良反应的患者10例(66.7%),合并基础疾病11例(73.3%);服用达格列净6个月内发生不良反应患者10例(66.7%),其中糖尿病酮症酸中毒(DKA)5例(50.0%)。发生不良反应患者表现为内分泌系统相关疾病8例(53.3%),其中DKA 7例(87.5%)、高钾血症1例(12.5%);泌尿生殖系统异常4例(26.7%);肝胆、消化、运动系统损害各1例(均为6.7%)。患者经停药及抗感染、补液、手术等对症治疗处理后症状均好转或痊愈。3例(20.0%)患者继续使用达格列净,其余均未再次使用达格列净。结论达格列净所致的不良反应男性发生较多,且不良反应主要涉及内分泌系统、泌尿生殖系统,但也可能出现新的不良反应,大部分患者经停药及抗感染、补液、手术等对症治疗后症状好转或痊愈。

关键词：达格列净钠葡萄糖协同转运蛋白2 不良反应文献分析

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探索学徒制与高等职业教育相联系的美国经验与启示

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外国教育研究 2017年第4期44卷 90-102页

作者：王辉柳靖王玉苗河北师范大学河北省职业技术教育研究所河北石家庄050024

在美国,受技能危机日益严峻、大学教育的弊端屡遭诟病等因素影响,对学徒制与高等职业教育相联系的探索方兴未艾。国家层面的注册学徒制——学院合作联盟、企业开发的"升级版"学徒制项目等一系列探索活动出现。这些探索活动的成功经验包... 详细信息

在美国,受技能危机日益严峻、大学教育的弊端屡遭诟病等因素影响,对学徒制与高等职业教育相联系的探索方兴未艾。国家层面的注册学徒制——学院合作联盟、企业开发的"升级版"学徒制项目等一系列探索活动出现。这些探索活动的成功经验包括需求驱动和行业企业主导、多边合作平台发挥重要作用、区域多边协作网络成为可持续发展的有效载体等等。针对发展环境、人才培养模式、治理体系三方面,我国的现代学徒制建设可从美国经验中获取启示。

关键词：寓学于工学徒制学徒制集团社区学院

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