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Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

Open Journal of Ophthalmology 2014年第3期4卷 79-85页

作者： Yuji Kumano yumi soejima Shinichiro Numa Hiroyasu Matsui Ikuko Zushi Masahito Shigematsu Takaaki Matsui Teruo Nishida Department of Oral and Maxillofacial Surgery Saga University Saga Japan Ohshima Hospital of Ophthalmology Fukuoka Japan Zushi Eye Clinic Fukuoka Japan

Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

关键词： BSCVA LASEK Loss of Two or More Lines Preoperative Myopia Re-Evaluation

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Structural study of receptor recognition mechanism of a mouse pheromone ESPl

Structural study of receptor recognition mechanism of a mous...

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第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Makoto Hirakane Sosuke Yoshinaga Toru Sato yumi soejima Sachiko Haga Ichio Shimada Kazushige Touhara Hiroaki Terasawa Faculty of Life Sciences Kumamoto UniversityKumamotoJapan Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Graduate School of Pharmaceutical Sciences The University of TokyoTokyoJapan

Pheromones are species-specific chemical signals that regulate a wide range of social and sexual behaviours in many *** vomeronasal organ(VNO) detects the pheromonal information via vomeronasal sensory neurons(VSNs) in *** have identified a male-specific peptide ESPl(exocrine-gland-secreting peptide 1) secreted into tear fluids that stimulates female *** ESPl signal is received,the vomeronasal type 2

关键词： mouse pheromone ESP1 GPCR molecular recognition NMR

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Long-term changes in phytoplankton community,mainly cyanobacteria in Lake Kasumigaura,Japan

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Journal of Oceanology and Limnology 2024年第6期42卷 1741-1750页

作者： yumi NAGAHAMA Ibaraki Kasumigaura Environmental Science Center Tsuchiura 300-0023Japan

Lake Kasumigaura,the second largest lake in Japan,has faced water quality challenges since the 1970s owing to rapid economic growth,land use changes,and increased wastewater ***,severe cyanobacterial blooms,particularly those of Microcystis,were observed in the 1980s,emphasizing the urgent need for comprehensive ecological *** present the results of phytoplankton monitoring by the Ibaraki Kasumigaura Environmental Science Center(IKESC)since 2005 and the publication of information on cyanobacterial blooms for citizens since *** monitoring surveys identified distinct phytoplankton communities in Nishiura and Kitaura,the two main water bodies of Lake Kasumigaura,emphasizing the need for monitoring surveys at various sites in Lake *** of long-term phytoplankton data from the Lake Kasumigaura Database(National Institute of Environmental Studies,NIES)revealed that Planktothrix is the predominant cyanobacteria in Lake *** IKESC,we have responded to these potentially socially problematic phytoplankton blooms by releasing the“Bulletin of Cyanobacteria Blooms”in 2012 and the“Bulletin of Cyanobacteria Forecast”in 2020.

关键词： Microcystis Planktothrix monitoring Nishiura Kitaura bulletin for citizens

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Moral Falsity in the Eyes of the Superhuman： The Cases of Socrates and Mozi1

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Frontiers of Philosophy in China 2017年第4期12卷 515-532页

作者： yumi Suzuki Department of Philosophy The University of Hong Kong Hong Kong China

Both Socrates and Mozi are said in Plato＇s dialogues and in the Mozi respectively to have claimed that they are living a sort of life following superhuman ＂intention＂： Socrates according to the Delphic oracle, and Mozi the intention of heaven. Some modern philosophers show discomfort with their ＂superstitious＂ attitudes, taking the claims literally as a kind of groundless devotion, while others conjecture ＂sensible＂ purposes to understand the mystic elements as providing moral lessons. This paper, by responding to these modern revisions of their doctrines, aims at highlighting the necessity of their （re-）introductions of superhuman perspectives to their inquiries. Through examining the similarities in Plato＇s and Mohists＇ demonstrations, the suggestion made will be that despite countless incommensurable features, heaven＇s intention for Mohists offers a fundamental philosophical basis which enables them to develop arguments by means of sharp dichotomies, what is right or wrong, in the same way that Socrates in the Apology and in the Hippias Minor does for the development of Plato＇s constructive endeavour beyond his Socratic a/euporetic legacy. Not only are their practices dependent on the presupposition of the existence of a perspective beyond humans, but also the reality of that perspective is established though their own investigative practices.

关键词： Plato Socrates Mozi god heaven moral philosophy

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Simplification of vacuole structure during plant cell death triggered by culture filtrates of Erwinia carotovora

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Journal of Integrative Plant Biology 2015年第1期57卷 127-135页

作者： yumi Hirakawa Toshihisa Nomura Seiichiro Hasezawa Takumi Higaki Department of Integrated Biosciences Graduate School of Frontier Sciences The University of Tokyo RIKEN Center for Sustainable Resource Science

Vacuoles are suggested to play crucial roles in plant defense-related cell death. During programmed cell death, previous live cell imaging studies have observed vacuoles to become simpler in structure and have implicated this simplification as a prelude to the vacuole＇s rupture and consequent lysis of the plasma membrane. Here, we examined dynamics of the vacuole in cell cycle-synchronized tobacco BY-2 （Nicotiana tabacum L. cv. Bright Yellow 2） cells during ceil death induced by application of culture filtrates of Erwinia carotovora. The filtrate induced death in about 90% of the cells by 24 h. Prior to cell death, vacuole shape simplified and endoplasmic actin filaments disassembled; however, the vacuoles did not rupture until after plasma membrane integrity was lost. Instead of facilitating rupture, the simplification of vacuole structure might play a role in the retrieval of membrane components needed for defense-related cell death.

关键词： Actin filaments defense-related cell death Erwiniacarotovora tobacco BY-2 cells vacuoles

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Cost of treating chronic hepatitis B:Comparison of current treatment guidelines

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World Journal of Gastroenterology 2012年第42期18卷 6106-6113页

作者： Monica Robotin yumi Patton Melanie Kansil Andrew Penman Jacob George Medical and Scientific Issues Unit Cancer Council NSW153 Dowling StWooloomoolooSydney 2011Australia School of Public Health University of SydneySydney 2006Australia Cathedral Street Partners 1/96 Cathedral StWoollomoolooSydney 2011Australia Faculty of Medicine University of SydneySydney 2006Australia Storr Liver Unit Westmead Millennium Institute Westmead HospitalSydney 2145Australia

AIM:To compare program costs of chronic hepatitis B(CHB) screening and treatment using Australian and other published CHB treatment ***:Economic modeling demonstrated that in Australia a strategy of hepatocellular cancer(HCC) prevention in patients with CHB is more cost-effective than current standard care,or HCC *** upon this model,we developed the B positive program to optimize CHB management of Australians born in countries of high CHB *** estimated CHB program costs using the B positive program algorithm and compared them to estimated costs of using the CHB treatment guidelines published by the AsianPacific,American and European Associations for the Study of Liver Disease(APASL,AASLD,EASL) and those suggested by an independent United States hepatology *** used a Markov model that factored in the costs of CHB screening and treatment,individualized by viral load and alanine aminotransferase levels,and calculated the relative costs of program *** were discounted by 5% and calculated in Australian dollars(AUD).RESULTS:Using the B positive algorithm,total program costs amount to 13 979 224 AUD,or 9634 AUD per *** least costly strategy is based upon using the AASLD guidelines,which would cost 34% less than our B positive *** the EASL and the United States Expert Group guidelines would increase program costs by 46%.The largest expenditure relates to the cost of drug treatment(66.9% of total program costs).The contribution of CHB surveillance(20.2%) and HCC screening and surveillance(6.6%) is small-and together they represent only approximately a quarter of the total program ***:The significant cost variations in CHB screening and treatment using different guidelines are relevant for clinicians and policy makers involved in designing population-based disease control programs.

关键词： Chronic hepatitis B Markov model Hepatocellular cancer Treatment guidelines

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Transcatheter embolization for hemorrhage from aberrant testicular artery after partial nephrectomy:A case report

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World Journal of Clinical Cases 2023年第32期11卷 7852-7857页

作者： Juyoun Youm Min-Jeong Choi Bong Man Kim yumi Seo Department of Radiology Dankook University HospitalCheonan 31116South Korea Department of Urology Dankook University HospitalCheonan 31116South Korea

BACKGROUND Arterial bleeding typically involves the renal artery following partial nephrectomy;in this study,we present a case of bleeding originating from the testicular artery that has not been reported in previous *** SUMMARY A 52-year-old man suffered hemorrhage from a perinephric branch of the aberrant left testicular artery after an open nephron-sparing surgery for renal cell *** signs of bleeding were manifested by the patient,such as fresh blood drainage from the catheter,decreased hemoglobin levels,and significant vital sign *** computed tomography did not show evidence of active bleeding,transcatheter angiography was conducted to identify the bleeding *** spot images confirmed bleeding derived from a perinephric branch of the testicular artery originating from the segmental artery of the left renal *** n-butyl-2-cyanoacrylate,successful transcatheter arterial embolization of the affected branch was *** after the embolization procedure,the bleeding ceased,and the patient experienced complete recovery devoid of *** In patients with postoperative arterial hemorrhage after partial nephrectomy,the testicular artery can be a rare but notable source of *** bleeding site localization via angiographic evaluation,followed by transcatheter arterial embolization,can be instrumental for safe,prompt,and effective hemostasis.

关键词： Partial nephrectomy Hemorrhage Testicular artery Angiography Embolization Case report

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Novel multi-parametric diagnosis of non-alcoholic fatty liver disease using ultrasonography,body mass index,and Fib-4 index

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World Journal of Gastroenterology 2023年第23期29卷 3703-3714页

作者： Kei Funada yumi Kusano Yoshinori Gyotoku Ryosaku Shirahashi Toshikuni Suda Masaya Tamano Department of Gastroenterology Dokkyo Medical University Saitama Medical CenterKoshigaya-shi 343-8555SaitamaJapan

BACKGROUND Shear wave speed(SWS),shear wave dispersion(SWD),and attenuation imaging(ATI)are new diagnostic parameters for non-alcoholic fatty liver *** differentiate between non-alcoholic steatohepatitis(NASH)and non-alcoholic fatty liver(NAFL),we developed a clinical index we refer to as the“NASH pentagon”consisting of the 3 abovementioned parameters,body mass index(BMI),and Fib-4 *** To investigate whether the area of the NASH pentagon we propose is useful in discriminating between NASH and *** This non-invasive,prospective,observational study included patients diagnosed with fatty liver by abdominal ultrasound between September 2021 and August 2022 in whom shear wave elastography,SWD,and ATI were *** diagnosis based on liver biopsy was performed in 31 *** large pentagon group(LP group)and the small pentagon group(SP group),using an area of 100 as the cutoff,were compared;the NASH diagnosis rate was also *** patients with a histologically confirmed diagnosis,receiveroperating characteristic(ROC)curve analyses were *** One hundred-seven patients(61 men,46 women;mean age 55.1 years;mean BMI 26.8 kg/m2)were *** LP group was significantly older(mean age:60.8±15.2 years vs 46.4±13.2 years;P<0.0001).Twenty-five patients who underwent liver biopsies were diagnosed with NASH,and 6 were diagnosed with *** ROC curve analyses,the areas under the ROC curves for SWS,dispersion slope,ATI value,BMI,Fib-4 index,and the area of the NASH pentagon were 0.88000,0.82000,0.58730,0.63000,0.59333,and 0.93651,respectively;the largest was that for the area of the NASH *** The NASH pentagon area appears useful for discriminating between patients with NASH and those with NAFL.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Attenuation imaging Shear wave elastography Shear wave dispersion Diagnosis

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Desired Lifestyle of Older Adults with Dementia Living at Home from Their Perspective and That of Their Families with Support from Care Providers

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Health 2021年第12期13卷 1460-1474页

作者： yumi Okinaka Academic Field of Health Sciences Okayama University Okayama Japan

Objective: This study aimed to determine the lifestyle of older adults with dementia living at home, how their families perceive them, and how care providers support their desired lifestyle. Methods: Semi-structured interviews were conducted with 12 pairs of older adults with dementia, their families, and care providers followed by a qualitative descriptive study. Results: Older adults with dementia described their lifestyle as follows: “I continue to take pride in the way I have lived so far,” “I want to do what I can now even if I cannot do it well,” “I live peacefully with my family,” “I go out and interact with people,” and “I live this time today with care.” Families regarded the lifestyle of older adults with dementia as a desire “to continue living at home peacefully,” “to live on their own,” and that they “probably do not want anything.” Care providers’ support was based on “respect (for an older adult with dementia) as a person,” “drawing out and making use of what they can do with their current abilities through providing care,” “supporting families and confirming their sense of satisfaction with life,” and “predicting the future course and supporting decision-making.” Conclusions: To support the lifestyle of older adults with dementia, it is important to ensure that they continue to have dignity and are comfortable living with their families and in their communities without intimidation.

关键词： Older Adults with Dementia Life Aging Family Home Care

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Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy

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World Journal of Gastroenterology 2017年第4期23卷 668-675页

作者： Kouichi Sakurai Hiroko Suda yumi Ido Takayuki Takeichi Ayako Okuda Kiwamu Hasuda Masahiro Hattori Hattori Clinic Chuo-ku

AIMTo compare the effectiveness and safety of vonoprazan-based therapy with proton pump inhibitor (PPI)-based therapies to treat Helicobacter pylori (H. pylori).METHODSWe retrospectively analysed data from first-line (vonoprazan or PPI with 200 mg clarithromycin and 750 mg amoxicillin twice daily for 7 d) (n = 1353) and second-line (vonoprazan or PPI with 250 mg metronidazole and 750 mg amoxicillin twice daily for 7 d) (n = 261) eradication treatments for H. pylori -positive patients with associated gastrointestinal diseases from April 2014 to December 2015 at Hattori Clinic, Japan. The primary endpoint was the eradication rate, which was assessed with a full analysis set. The secondary endpoints were adverse events and related *** the first-line treatments, the eradication rates for vonoprazan, esomeprazol, rabeprazole, and lansoprazole were 87.9% (95%CI: 84.9%-90.5%), 71.6% (95%CI: 67.5%-75.5%), 62.9% (95%CI: 52.0%-72.9%), and 57.3% (95%CI: 50.4%-64.1%), respectively. The vonoprazan eradication rate was significantly higher than that of the PPIs (P < 0.01). Interestingly, smoking did not affect the H. pylori eradication rate in the vonoprazan group (P = 0.34), whereas it decreased the rates in the PPI groups (P = 0.013). The incidence of adverse events in the vonoprazan group was not different from the PPI group (P = 0.054), although the vonoprazan group exhibited a wider range of adverse events. Vonoprazan-based triple therapy was highly effective as a second-line treatment, with an eradication rate similar to that of PPI-based *** might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events.

关键词： Helicobacter pylori Eradication treatment Vonoprazan Proton pump inhibitors Adverse event Smoking

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