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Chinese Science Bulletin 2009年第3期54卷 369-373页

作者： YAN Dan WEI Li XIAO XiaoHe ZHOU DanLei han yumei Institute of Chinese Medicine 302 Hospital of People's Liberation Army Beijing 100039 China Chongqing Institute of Technology Chongqing 400050 China

The inhibitory effect of three berberine alkaloids (BAs) from Coptis chinensis Franch, a traditional Chinese medicinal (TCM) herb, on Bifidobacterium adolescentis growth was investigated by micro- calorimetry. The power-time curves of B. adolescentis with and without BAs were acquired, meanwhile the extent and duration of inhibitory effect on the metabolism were evaluated by the growth rate con- stant (k), half inhibitory ratio (IC50), maximum heat-output power (Pmax), peak time of maximum heat-output power (tp) and total heat production (Qt). k, Pmax and Qt decreased, and tp was prolonged with the increase of BAs concentration. The IC50 of BAs is 806 μg/mL for berberine, 341 μg/mL for cop- tisine and 236 μg/mL for palmatine. The sequence of antimicrobial activity of BAs is berberine coptisine > pal- matine. The structure-function relationship of BAs indicates that the functional group methylenedioxy or methoxyl at C2 and C3 might be the major group inducing the activities of BAs on E. coli and B. adolescentis. Meanwhile, the substituent groups at C2, C3, C9 and C10 almost have equal effect on B. shigae.

关键词：黄连素生物碱细菌大肠杆菌抑制效应

The action of medicinal animal horns on Escherichia coli growth investigated by microcalorimetry and chemometric analysis

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Chinese Science Bulletin 2010年第26期55卷 2945-2950页

作者： YAN Dan han yumei LUO JiaoYang ZhanG Ping TANG HuiYing PENG Cheng XIAO XiaoHe Institute of Chinese Medicine 302 Hospital of People's Liberation Army Beijing 100039 China Chengdu University of Traditional Chinese Medicine Chengdu 610075 China Chongqing Institute of Technology Chongqing 400050 China

The action of Cornu Cervi Pantotrichum (CCP), Cornu Cervi (CC) and Cornu Saigae Tataricae (CST) on Escherichia coli growth were investigated using microcalorimetry to find the heat change regularity of microbial growth. The similarity of thermogenic curves and thermodynamics parameters were investigated as evaluation index, such as the growth rate constant in the first expo- nential phase (k1), maximum power in the first exponential phase (P1), maximum power in the secondary exponential phase (P2), peak time in the first exponential phase (T1), peak time in the stationary phase (T2) and the total heat production in stage 1 (Q1), and the total heat production in stage 2 (Q2). Chemometric analysis was used as a reference for the bioactivity evaluation of medicinal animal horns. The results indicated that the similarity between CST and the control was smaller than that between CCP, CC and the control. Both CCP and CC could increase the heat in the microbial growth, whereas CST decreased it. The biotic thermal activity of different medicinal animal horns was objectively, qualitatively, and quantitatively evaluated by the similarity of thermogenic curves and thermodynamics parameters analysis.

关键词：生长变化规律化学计量学药用动物大肠杆菌微生物生长相似性评估热力学参数生物活性评价

Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

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Chinese Herbal Medicines 2024年第1期16卷 132-142页

作者： Weidi Zhao Cui Ji Jie Zheng Shi Zhou Junsheng Tian yumei han Xuemei Qin School of Physical Education Shanxi UniversityTaiyuan 030006China Institute of Biomedicine and Health Shanxi UniversityTaiyuan 030006China Physical Activity Sport and Exercise Research ThemeFaculty of HealthSouthern Cross UniversityLismore NSW2480Australia Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006China School of Health Yantai Nanshan UniversityYantai 265706China

Objective: This study aimed to investigate the therapeutic effects of Xiaoyao San(XYS), a herbal medicine formula, on exercise capacity and liver mitochondrial metabolomics in a rat model of depression induced by chronic unpredictable mild stress(CUMS).Methods: A total of 24 male SD rats were randomly divided into four groups: control group(C), CUMS control group(M), Venlafaxine positive treatment group(V), and XYS treatment group(X). Depressive behaviour and exercise capacity of rats were assessed by body weight, sugar-water preference test, open field test, pole test, and rotarod test. The liver mitochondria metabolomics were analyzed by using liquid chromatography-mass spectrometry(LC-MS) method. TCMSP database and Gene Cards database were used to screen XYS for potential targets for depression, and GO and KEGG enrichment analyses were ***: Compared with C group, rats in M group showed significantly lower body weight, sugar water preference rate, number of crossing and rearing in the open field test, climbing down time in the pole test,and retention time on the rotarod test(P hanged in the liver mitochondria of rats in M *** different metabolites and six metabolic pathways were regulated in the liver mitochondria of rats in X group compared with M group. The results of network pharmacology showed that 88 intersecting targets for depression and XYS were obtained, among which 15 key targets such as IL-1β, IL-6, and TNF were predicted to be the main differential targets for the treatment of depression. Additionally, a total of 1 553 GO signaling pathways and 181 KEGG signaling pathways were identified, and the main biological pathways were AGE-RAGE signaling pathway, HIF-1 signaling pathway, and calcium signaling ***

关键词： depression exercise capacity liver mitochondrial metabolomics Xiaoyao San

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丁二酸马铃薯淀粉酯的合成及性质研究

中国粮油学报 2010年第1期25卷 47-51页

作者：孙吉韩育梅内蒙古农业大学食品科学与工程学院呼和浩特010018

以马铃薯淀粉为原料,丁二酸酐为酯化剂合成低取代度酯化淀粉的最佳合成条件。试验采用湿法合成工艺,以产物取代度的高低水平为指标进行合成条件的筛选,并分析测定了产物的黏度、透明度。结果表明:合成的最佳工艺条件为反应体系pH9.0、... 详细信息

以马铃薯淀粉为原料,丁二酸酐为酯化剂合成低取代度酯化淀粉的最佳合成条件。试验采用湿法合成工艺,以产物取代度的高低水平为指标进行合成条件的筛选,并分析测定了产物的黏度、透明度。结果表明:合成的最佳工艺条件为反应体系pH9.0、丁二酸酐用量4%、反应时间60 min、反应温度30℃;随着产物取代度的增加,其黏度和透明度均有提高且呈上升趋势;酯化淀粉的黏度和透明度均高于马铃薯原淀粉及玉米酯化淀粉。

关键词：马铃薯淀粉丁二酸酐取代度黏度透明度

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发酵乳中抗性淀粉的变化及对凝胶过程的影响

中国食品学报 2020年第9期20卷 95-101页

作者：王绍帆黄欢何君韩育梅内蒙古农业大学食品科学与工程学院呼和浩特010018

研究抗性淀粉在发酵乳中的作用,选用RS2型玉米抗性淀粉(G)和微波-湿热法制备的RS3型马铃薯抗性淀粉(W),研究它们在发酵乳加工、贮藏过程中含量和形态的变化。以未添加抗性淀粉的发酵乳为对照,观察其微观结构,分析发酵乳凝胶过程的流变... 详细信息

研究抗性淀粉在发酵乳中的作用,选用RS2型玉米抗性淀粉(G)和微波-湿热法制备的RS3型马铃薯抗性淀粉(W),研究它们在发酵乳加工、贮藏过程中含量和形态的变化。以未添加抗性淀粉的发酵乳为对照,观察其微观结构,分析发酵乳凝胶过程的流变学特性与稳定性。结果表明:W相对于G残留量较高且维持在60%左右;2种抗性淀粉均保留着淀粉颗粒形态,有不同程度的损耗,主要集中在发酵后期与贮藏期;W更有利于发酵乳形成完整、均一的微观结构;含W的发酵乳微观弹性较强且有利于酪蛋白颗粒结合形成更加坚固的结构;含W发酵乳的微观稳定性优于含G的发酵乳。

关键词：抗性淀粉发酵乳微观结构凝胶过程

Response of needle dark respiration of Pinus koraiensis and Pinus sylvestriformis to elevated CO_2 concentra-tions for four growing seasons’ exposure

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Science China Earth Sciences 2007年第4期50卷 613-619页

作者： ZHOU yumei1, han ShiJie1, ZhanG HaiSen1, XIN LiHua2 & ZHENG JunQiang1 1 Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China 2 Shenyang Agricultural University, Shenyang 110161, China Institute of Applied Ecology Chinese Academy of Sciences Shenyang China Shenyang Agricultural University Shenyang China

The long-term effect of elevated CO2 concentrations on needle dark respiration of two coniferous spe- cies—Pinus koraiensis and Pinus sylvestriformis on the Changbai Mountain was investigated using open-top chambers. P. koraiensis and P. sylvestriformis were exposed to 700, 500 μmol·mol-1 CO2 and ambient CO2 (approx. 350 μmol·mol-1) for four growing seasons. Needle dark respiration was meas- ured during the second, third and fourth growing seasons’ exposure to elevated CO2. The results showed that needle dark respiration rate increased for P. koraiensis and P. sylvestriformis grown at elevated CO2 concentrations during the second growing season, could be attributed to the change of carbohydrate and/or nitrogen content of needles. Needle dark respiration of P. koraiensis was stimu- lated and that of P. sylvestriformis was inhibited by elevated CO2 concentrations during the third growing season. Different response of the two tree species to elevated CO2 mainly resulted from the difference in the growth rate. Elevated CO2 concentrations inhibited needle dark respiration of both P. koraiensis and P. sylvestriformis during the fourth growing season. There was consistent trend be- tween the short-term effect and the long-term effect of elevated CO2 on needle dark respiration in P. sylvestriformis during the third growing season by changing measurement CO2 concentrations. How- ever, the short-term effect was different from the long-term effect for P. koraiensis. Response of dark respiration of P. koraiensis and P. sylvestriformis to elevated CO2 concentrations was related to the treatment time of CO2 and the stage of growth and development of plant. The change of dark respiration for the two tree species was determined by the direct effect of CO2 and long-term acclimation. The prediction of the long-term response of needle dark respiration to elevated CO2 concentration based on the short-term response is in dispute.

关键词： elevated CO2 concentration long-term short-term dark respiration Pinus koraiensis Pinus sylvestriformis

温度对鲜切马铃薯品质影响及货架期预测模型的建立

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中国粮油学报 2022年第8期37卷 94-101页

作者：王杰索慧敏韩育梅内蒙古农业大学食品科学与工程学院呼和浩特010018

探究鲜切马铃薯在储藏流通过程中品质的变化以及预测其货架期,将经二氧化氯(chlorine dioxide,ClO_(2))、柠檬酸、D-异抗坏血酸钠、氯化钙浸泡并真空包装的鲜切马铃薯分别置于4、7、10℃条件下储存,在储藏期内对其进行感官评分,并对褐... 详细信息

探究鲜切马铃薯在储藏流通过程中品质的变化以及预测其货架期,将经二氧化氯(chlorine dioxide,ClO_(2))、柠檬酸、D-异抗坏血酸钠、氯化钙浸泡并真空包装的鲜切马铃薯分别置于4、7、10℃条件下储存,在储藏期内对其进行感官评分,并对褐变度、失重率、菌落总数、硬度进行测定,在此基础上利用Arrhenius方程建立货架期预测模型。结果表明:鲜切马铃薯在4、7、10℃下储藏,其褐变度、失重率、菌落总数、硬度指标都随储藏时间的延长而变化。其中褐变度,菌落总数以及硬度构建的货架期预测模型精确度都较高,决定系数R^(2)都在0.90以上,实测值与预测值的相对误差都低于10%,可有效预测鲜切马铃薯在4~10℃温度范围内的货架期。

关键词：鲜切马铃薯 Arrhenius方程货架期预测动力学模型

Bio-characteristic profiling related to clinic:A new technology platform for quality evaluation of Chinese materia medica

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TMR Modern Herbal Medicine 2019年第4期2卷 215-224页

作者： Li-Na Wen Ai-Ting Wang Na Guo yumei han Can Yan Dan Yan Beijing Shijitan Hospital Capital Medical University Beijing China Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing China International Cooperation & Co-construction Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing China. Experimental Research Center China Academy of Chinese Medical Sciences Beijing China. Beijing Physical Examination Center Beijing China. Guangzhou University of Chinese Medicine Guangzhou China.

Quality evaluation is a bottleneck restricting the modernization and internationalization of Chinese materia medica (CMM). Due to characteristics of multi-component, multi-efficacy, multi-target, the existing quality evaluation system still cannot fully meet quality control needs of CMM. Hence, the author put forward “Bio-characteristic profiling related to clinic, BPRC” academic concept, meanwhile, fully take the advantage of analysis method with clinical monitoring superiority or profiling characteristics, build up “BPRC” new technology platform, in order to realize “real-time, dynamic and full-range monitoring” new technologies of CMM quality evaluation system and promote the further development of CMM industry.

关键词： Bio-characteristic profiling related to clinic Correlation efficacy Quality evaluation of Chinese materia medica

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添加益生元对酸乳凝胶过程及微观结构的影响

食品科学 2019年第15期40卷 100-105页

作者：王雅楠韩育梅何君内蒙古农业大学食品科学与工程学院

为研究菊粉、低聚果糖和低聚半乳糖3种益生元对酸乳凝胶过程及微观结构的影响,以未添加益生元的酸乳为对照,利用光学微流变仪、Turbiscan稳定分析仪和扫描电子显微镜分别检测添加益生元酸乳在发酵期间及后熟贮藏期间流变学参数、稳定性... 详细信息

为研究菊粉、低聚果糖和低聚半乳糖3种益生元对酸乳凝胶过程及微观结构的影响,以未添加益生元的酸乳为对照,利用光学微流变仪、Turbiscan稳定分析仪和扫描电子显微镜分别检测添加益生元酸乳在发酵期间及后熟贮藏期间流变学参数、稳定性和微观结构,并进行对比研究。结果表明:添加菊粉更有助于酸乳形成较为均匀、疏松的微观结构;含低聚果糖的酸乳固液平衡值低于0.5,更有利于增强酸乳的固体性质;添加低聚半乳糖的酸乳微观稳定性较好。因此,3种益生元对酸乳的凝胶过程及微观结构的影响各不相同,未来还可对3种益生元进行复配处理,添加到酸乳中进一步探究对其综合品质的影响。

关键词：酸乳益生元凝胶过程微观结构

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大孔吸附树脂纯化断血流总皂苷工艺研究

中药材 2005年第10期28卷 83-86页

作者：张毅鄢丹韩玉梅重庆市药品检验所重庆400015 成都中医药大学成都611730

目的:研究大孔吸附树脂纯化断血流总皂苷的工艺条件及参数。方法:以洗脱率、精制度等为指标,考察大孔吸附树脂对断血流总皂苷的吸附性能和洗脱参数。结果:11.4m l断血流总皂苷样品液(生药0.2g/m l)上大孔吸附树脂(Φ15mm×H90mm,干重2.5... 详细信息

目的:研究大孔吸附树脂纯化断血流总皂苷的工艺条件及参数。方法:以洗脱率、精制度等为指标,考察大孔吸附树脂对断血流总皂苷的吸附性能和洗脱参数。结果:11.4m l断血流总皂苷样品液(生药0.2g/m l)上大孔吸附树脂(Φ15mm×H90mm,干重2.5g),用蒸馏水,30%、70%乙醇各3BV依次洗脱,断血流总皂苷富集于70%乙醇洗脱液部位。结论:采用大孔吸附树脂技术富集、纯化断血流总皂苷,其洗脱率为86.8%,精制度为153.2%,该法可较好地纯化断血流总皂苷。

关键词：大孔吸树脂纯化断血流总皂苷