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Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation

Science China(Life Sciences) 2021年第7期64卷 1097-1115页

作者： Yun Zhang Yanfang Yang Jun Ye Yue Gao Hengfeng Liao Junzhuo Zhou Yu Feng Dongdong liu Yingying Meng Xiaoguang Chen Lili Gao yuling liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

As a potential cancer immunotherapeutic agent,chlorogenic acid(CHA)has entered phase II clinical trials in China as a lyophilized powder formulation for treating ***,the in vivo instability of CHA necessitates daily intramuscular injections,resulting in patient *** this study,CHA-phospholipid complex(PC)-containing PEGylated liposomes(CHA-PC PEG-Lipo,named as CPPL),with CHA-PC as the drug intermediate,were prepared to lower the administration *** demonstrated excellent physicochemical properties,enhanced tumor accumulation,and inhibited tumor growth even when the administration interval was prolonged to 4 days when compared to a CHA solution and CHA-PC loaded liposomes(CHA-PC Lipo,labeled as CPL),both of which only demonstrated antitumor efficacy with once-daily *** evaluation of the in vivo antitumor immune mechanism suggested that the extended antitumor immune efficacy of CPPL could be attributed to its distinct immune-stimulating mechanism when compared with CHA solution and CPL,such as stimulating both CD4+and CD8+T cell infiltration,inhibiting myeloid-derived suppressor cell expression,reducing the expression of Th2 related factors,and notably,increasing the memory T cells in tumor *** CHA-containing formulation could reduce the frequency of in vivo CHA administration during cancer treatment via T cells,especially memory T cell regulation.

关键词： chlorogenic acid PEGylated liposomes T cell regulation immunotherapy

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How to turn the ＂learning＂ in the flipped classroom

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International Journal of Technology Management 2017年第6期 7-9页

作者： yuling liu Department of Media Arts Chongqing College Of Electronic Engineering Chongqing 401331 China

Today is the era of information technology, information technology has already penetrated into people＇ s life, not only that, nowin the education teaching is a common phenomenon, of course, in Chinese has been more than ten years of new curriculum reform, but due tovarious reasons, the performance of the new curriculum is not ideal, in the western teaching. We learn from the experience, the implementationof the flip classroom change. This change is Chinese education has progress In this paper, how to realize the ＂flipped classroom learning＂ flipelaborated what is flipped classroom, flip the classroom principle, implementation status, significance and effect of the implementation of Chinaflipping the classroom and flipping the classroom according to the status of recommendations.

关键词： flipped classroom connotation principle significance present situation suggestion

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The stability of a novel weakly alkaline slurry of copper interconnection CMP for GLSI

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Journal of Semiconductors 2018年第2期39卷 78-85页

作者： Caihong Yao Chenwei Wang Xinhuan Niu Yan Wang Shengjun Tian Zichao Jiang yuling liu School of Electronics and Information Engineering Hebei University of Technology Tianjin 300130 China Tianjin Key Laboratory of Electronic Materials and Devices Tianjin 300130 China

Chemical mechanical polishing（CMP） is one of the important machining procedures of multilayered copper interconnection for GLSI, meanwhile polishing slurry is a critical factor for realizing the high polishing performance such as high planarization efficiency, low surface roughness. The effect of slurry components such as abrasive（colloidal silica）, complexing agent（glycine）, inhibitor（BTA） and oxidizing agent（H_2O_2） on the stability of the novel weakly alkaline slurry of copper interconnection CMP for GLSI was investigated in this paper. First, the synergistic and competitive relationship of them in a peroxide-based weakly alkaline slurry during the copper CMP process was studied and the stability mechanism was put forward. Then 1 wt% colloidal silica, 2.5 wt% glycine,200 ppm BTA, 20 m L/L H_2O_2 had been selected as the appropriate concentration to prepare copper slurry, and using such slurry the copper blanket wafer was polished. From the variations of copper removal rate, root-mean square roughness（Sq） value with the setting time, it indicates that the working-life of the novel weakly alkaline slurry can reach more than 7 days, which satisfies the requirement of microelectronics further development.

关键词： stability weakly alkaline slurry CMP copper interconnection

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Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma

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Bioactive Materials 2020年第3期5卷 694-708页

作者： Jun Ye Yanfang Yang Jing Jin Ming Ji Yue Gao Yu Feng Hongliang Wang Xiaoguang Chen yuling liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050PR China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050PR China

Tumor-associated macrophages(TAMs)generally display an immunosuppressive M2 phenotype and promote tumor progression and metastasis,suggesting their potential value as a target in cancer *** acid(CHA)has been identified as a potent immunomodulator that promotes the polarization of TAMs from an M2 to an M1 ***,rapid clearance in vivo and low tumor accumulation have compromised the immunotherapeutic efficacy of CHA in clinical *** this study,mannosylated liposomes are developed for targeted delivery of CHA to *** immunoregulatory effects of CHA,along with the overall antitumor efficacy of CHA-encapsulated mannosylated liposomes,are investigated through in vitro and in vivo *** prepared CHA-encapsulated mannosylated liposomes exhibit an ideal particle size,favorable stability,and preferential accumulation in tumors via the mannose receptor-mediated TAMs-targeting ***,CHA-encapsulated mannosylated liposomes inhibit G422 glioma tumor growth by efficiently promoting the polarization of the pro-tumorigenic M2 phenotype to the anti-tumorigenic M1 ***,these findings indicate that CHA-encapsulated mannosylated liposomes have great potential to enhance the immunotherapeutic efficacy of CHA by inducing a shift from the M2 to the M1 phenotype.

关键词： Chlorogenic acid Mannosylated liposome Tumor-associated macrophage Cancer immunotherapy Drug delivery

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A green cross-linking method for the preparation of renewable threedimensional graphene sponges for efficient adsorption of Congo red dye

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Chinese Journal of Chemical Engineering 2024年第2期66卷 84-93页

作者： Zhuang liu Bo Gao Haoyuan Han yuling Li Haiyang Fu Donghui Wei Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China

Graphene-based materials possess significant potential for the treatment of dye wastewater due to their exceptional adsorption properties toward stubborn ***,their utilization is hindered by high preparation costs,low yields,environmental pollution during synthesis,and challenges in regenerating the *** study proposes a novel approach to address these limitations by developing nitrogen-doped three-dimensional(3D)polyvinyl alcohol(PVA)crosslinked graphene sponges(N-PGA)using a cross-linking method with ammonium *** method offers a relatively mild,environmentally friendly *** carbonate serves as both a reducing and modifying agent,facilitating the formation of the intrinsic structure of N-PGA and acting as a nitrogen ***,PVA is utilized as the cross-linking *** results demonstrate that N-PGA exhibits a favorable internal 3D hierarchical porous structure and possesses robust mechanical *** measured specific surface area(BET)of N-PGA was as high as406.538 m^(2)·g^(-1),which was favorable for its efficient adsorption of Congo red(CR)dye *** an initial concentration of 50 mg·L^(-1),N-PGA achieved an impressive removal rate of 89.6%and an adsorption capacity of 112 mg·g^(-1)for CR ***,it retained 79%of its initial adsorption capacity after 10 cycles,demonstrating excellent regeneration *** summary,the synthesized N-PGA displays remarkable efficacy in the adsorption of CR dye in wastewater,opening up new possibilities for utilizing 3D porous graphene nanomaterials as efficient adsorbents in wastewater treatment.

关键词： Green chemistry Graphene sponge Adsorbents Adsorption Congo red Regeneration

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棕榈粕发酵原料对肉牛生长性能、表观消化率及经济效益的影响

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饲料工业 2024年第16期45卷 66-70页

作者：聂立秀王魏苹王萌田茂金刘桂芹金亚倩刘玉玲翟桂玉宋世龙朱相宝安桂芹姜鹏禹城市畜牧业发展中心山东德州251200 山东旭昶生物科技有限公司山东德州251200 聊城大学农学与农业工程学院山东聊城252000 山东省畜牧总站山东济南250000 哈尔滨工业大学黑龙江哈尔滨150001

试验旨在研究以棕榈粕为主要原料,以酿酒酵母菌和消化酶为发酵剂的发酵原料对肉牛生长性能、表观消化率及经济效益的影响。试验选用条件相近的育肥牛18头,随机等分成2组,对照组饲喂基础饲粮,试验组用棕榈粕发酵原料替代50%基础精料补充... 详细信息

试验旨在研究以棕榈粕为主要原料,以酿酒酵母菌和消化酶为发酵剂的发酵原料对肉牛生长性能、表观消化率及经济效益的影响。试验选用条件相近的育肥牛18头,随机等分成2组,对照组饲喂基础饲粮,试验组用棕榈粕发酵原料替代50%基础精料补充料,试验期共95 d。结果显示:①与对照组相比,试验组平均日增重(ADG)提高11.51%(P<0.01),平均料重比(F/G)降低9.48%(P<0.01);②试验组酸性洗涤纤维(ADF)、淀粉的表观消化率显著高于对照组(P<0.05);中性洗涤纤维(NDF)的表观消化率极显著高于对照组(P<0.01);粪便分析筛测试结果表明,试验组筛上层残留物质比例极显著低于对照组(P<0.01),下层残留物质比例显著低于对照组(P<0.05),中间层残留物质比例极显著高于对照组(P<0.01);③试验组与对照组相比,每千克增重的饲料成本降低13.66%(15.74元/kg vs 13.59元/kg),毛利润提高29.44%。研究结果表明,棕榈粕发酵原料对肉牛生长性能、消化代谢、经济效益等方面有较好的改善和提升作用。

关键词：棕榈粕发酵原料酿酒酵母菌肉牛生长性能消化吸收经济效益

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Nitric oxide removal from flue gas coupled with the Fe^(Ⅱ)EDTA regeneration by ultraviolet irradiation

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Chinese Journal of Chemical Engineering 2024年第4期68卷 133-143页

作者： Yuan Xu Ziwei liu Ying Dai Jinbo Ouyang Zhuyao Li yuling Zhu Jianhua Ding Feiqiang He School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China

During wet complexation denitrification of flue gas,Fe^(Ⅱ)EDTA regeneration,also known as reducing Fe^(Ⅱ)EDTA and Fe^(Ⅱ)EDTA-nitric oxide(NO)to Fe^(Ⅱ)EDTA,is *** this paper,ultraviolet(UV)light was used for the first time to reduce Fe^(Ⅱ)*** experimental result demonstrated that Fe^(Ⅱ)EDTA-NO reduction rate increased with UV power increasing,elevated temperature,and initial Fe^(Ⅱ)EDTA-NO concentration ***^(Ⅱ)EDTA-NO reduction rate increased first and then decreased as pH value increased(2.0-10.0).Fe^(Ⅱ)EDTA-NO reduction with UV irradiation presented a first order reaction with respect to Fe^(Ⅱ)*** with other Fe^(Ⅱ)EDTA regeneration methods,Fe^(Ⅱ)EDTA regeneration with UV show more superiority through comprehensive consideration of regeneration rate and ***,NO absorption experiment by Fe^(Ⅱ)EDTA solution with UV irradiation confirmed that UV can significantly promote the NO removal performance of Fe^(Ⅱ)*** oxygen concentration(3%(vol))and acidic environment(pH=4)was favorable for NO *** UV power increasing as well as temperature decreasing,NO removal efficiency *** addition,the mechanism research indicates that NO from flue gas is mostly converted to NO_(2)-,NO_(3)-,NH_(4)^(+),N_(2),and N_(2)O with Fe^(Ⅱ)EDTA absorption liquid with UV *** strengthens NO removal in Fe^(Ⅱ)EDTA absorption liquid by forming a synergistic effect of ***,compared with NO removal methods with Fe^(Ⅱ)EDTA,Fe^(Ⅱ)EDTA combined UV system shows prominent technology advantage in terms of economy and secondary pollution.

关键词： Fe^(II)EDTA Ultraviolet Flue gas Nitric oxide Regeneration Absorption

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直接控制网格节点分布的曲线网格生成技术研究

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应用力学学报 2007年第4期24卷 637-640页

作者：刘玉玲西安理工大学西安710048

指出了Thompson与Thomas曲线网格生成方法中控制网格分布的调节函数的问题所在,克服了Thomas曲线网格生成法中边界处局部线性化近似假定的缺陷,经过严格推导得出一组新的调节函数P、Q的表达式,并给出了曲线网格生成实例。实例检验表明,... 详细信息

指出了Thompson与Thomas曲线网格生成方法中控制网格分布的调节函数的问题所在,克服了Thomas曲线网格生成法中边界处局部线性化近似假定的缺陷,经过严格推导得出一组新的调节函数P、Q的表达式,并给出了曲线网格生成实例。实例检验表明,该调节函数能够对复杂边界的单连通域或多连通域生成理想的曲线网格,即边界处网格正交,内部网格分布能够适应物理量场变化的情形。在实际水利工程流场数值模拟中,该方法能够准确地使用边界条件,提高求解的精确度。

关键词： Poisson方程边界正交曲线网格调节函数

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弯道水流数值模拟研究

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应用力学学报 2007年第2期24卷 310-312页

作者：刘玉玲刘哲西安理工大学西安710048

采用边界拟合坐标技术,生成边界处正交的曲线网格,在曲线坐标系中进行弯道水流数值计算。借鉴现有关于弯道水流流速分布的研究成果,对曲线坐标系平面二维浅水方程作了修正,修正后的方程组能够计入弯道环流引起的横向的动量交换,即考虑... 详细信息

采用边界拟合坐标技术,生成边界处正交的曲线网格,在曲线坐标系中进行弯道水流数值计算。借鉴现有关于弯道水流流速分布的研究成果,对曲线坐标系平面二维浅水方程作了修正,修正后的方程组能够计入弯道环流引起的横向的动量交换,即考虑了二次流对流线弯曲的复杂水力特性的影响。通过连续弯道实例计算,验证了该模型的可靠性和实用性。

关键词：边界拟合坐标技术曲线网格横向动量交换二次流

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Self-microemulsion drug delivery system for improving the bioavailability of baicalein

Self-microemulsion drug delivery system for improving the bi...

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2018年第十二届中国药物制剂大会

作者：廖恒锋 yuling liu Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing Key Laboratory of Drug Delivery Technology and Novel Formulations

Baicalein, a flavonoid present in the root of Scutellaria baicalensis, has been reported to have multiple pharmacological activities including anti-inflammatory activity, anticancer, anti-viral effect and anti-allergic activity. And it’s also an effective treatment for respiratory virus infection in children. Its poor water solubility leads to its low oral bioavailability. And only a few formulation approaches have been performed to improve its oral absorption through the technique of HP-beta-CD inclusion, solid dispersion or nanocrystal. But these formulations can not meet the need of medication compliance for children. At the same time, with the discovery of more and more water-insoluble drugs including baicalein,selfmicroemulsion drug delivery system（SMEDDS） has been more often used to enhance the dissolution and absorption of them by researchers. And it’s easy to adjust dosage and meet the compliance of pediatric medications, for SMEDDS is a kind of liquid preparation. It has been demonstrated that many factors can affect the emulsifying efficiency of SMEDDS and the absorption of loaded drug, such as the ratio of oil, surfactant and co-surfactant, the size of oil droplets, zeta potential and so on. This study aims to prepare baicalein self-microemulsion（BA-SMEDDS） and explore the performance of it in vitro and vivo. The BA-SMEDDS used ethyl oleate, tween-80 and transcutol HP as oil, surfactant and co-surfactant. Meanwhile, the characteristics of the BA-SMEDDS were investigated, such as emulsifying efficiency, oil droplets size, zeta potential, viscosity, cloud point, morphology observation, release in vitro, cellular uptake and bioavailability. The results showed that BA-SMEDDS could rapidly form clear microemulsion within one minute, when it was diluted with distilled water and gently stirred to mix thoroughly. And the oil droplets size and zeta potential of BA-SMEDDS were（11.6±0.3）nm and（-16.71±0.34）mv, respectively. Moreover, release in vitro of BA-SMEDDS and

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