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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3124-3138页

作者： Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong jin Lan Xiao Leilei Bao Can Xu yulin Li Ying Lu Jie Gao Department of Pharmacy Naval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China Centre for Biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage Cancer therapy

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The haplotype-resolved T2T genome of teinturier cultivar Yan73 reveals the genetic basis of anthocyanin biosynthesis in grapes

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Horticulture Research 2023年第11期10卷 180-192页

作者： Kekun Zhang Mengrui Du Hongyan Zhang Xiaoqian Zhang Shuo Cao Xu Wang Wenrui Wang Xueqiang Guan Penghui Zhou jin Li Wenguang Jiang Meiling Tang Qiuling Zheng Muming Cao Yongfeng Zhou Keqin Chen Zhongjie Liu yulin Fang College of Enology Heyang Viti-Viniculture StationNingxia Helan Mountain’s East Foothill Wine Experiment and Demonstration StationNorthwest A&F UniversityYangling 712100China National Key Laboratory of Tropical Crop Breeding Shenzhen BranchGuangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen518120China College of Agriculture Shanxi Agricultural UniversityTaigu 030801China Shandong Grape Research Institute Shanda South RoadJinan 250199China Shandong Technology Innovation Center of Wine Grape and Wine COFCO Great Wall Wine(Penglai)Co.Ltd.Yantai 265600China Yantai Changyu Group Co. Ltd.Yantai 264001China Yantai Academy of Agricultural Sciences Gangcheng West StreetYantai 264000China Viticulture and Wine Research Institute Guangxi Academy of Agricultural SciencesNanning 530007China National Key Laboratory of Tropical Crop Breeding Tropical Crops Genetic Resources InstituteChinese Academy of Tropical Agricultural SciencesHaikou 570100China

Teinturier grapes are characterized by the typical accumulation of anthocyanins in grape skin,flesh,and vegetative tissues,endowing them with high utility value in red wine blending and nutrient-enriched foods ***,due to the lack of genome information,the mechanism involved in regulating teinturier grape coloring has not yet been elucidated and their genetic utilization research is still ***,the cultivar‘Yan73’was used for assembling the telomere-to-telomere(T2T)genome of teinturier grapes by combining the High Fidelity(HiFi),Hi-C and ultralong Oxford Nanopore Technologies(ONT)*** haplotype genomes were assembled,at the sizes of 501.68 Mb and 493.38 Mb,*** the haplotype 1 genome,the transposable elements(TEs)contained 32.77%of long terminal repeats(LTRs),while in the haplotype 2 genome,31.53%of LTRs were detected in ***,obvious inversions were identified in chromosome 18 between the two *** profiling suggested that the gene expression patterns in‘Cabernet Sauvignon’and‘Yan73’were diverse depending on tissues,developmental stages,and *** transcription program of genes in the anthocyanins biosynthesis pathway between the two cultivars exhibited high similarity in different tissues and developmental stages,whereas the expression levels of numerous genes showed significant *** with other genes,the expression levels of VvMYBA1 and VvUFGT4 in all samples,VvCHS2 except in young shoots and VvPAL9 except in the E-L23 stage of‘Yan73’were higher than those of‘Cabernet Sauvignon’.Further sequence alignments revealed potential variant gene loci and structure variations of anthocyanins biosynthesis related genes and a 816 bp sequence insertion was found in the promoter of VvMYBA1 of‘Yan73’haplotype 2 ***‘Yan73’T2T genome assembly and comparative analysis provided valuable foundations for further revealing the coloring mechanism of teinturier grapes and the genetic imp

关键词： coloring resolved similarity

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CNN based Relocalization Method for Indoor Moving Robot with Planar State Constraint

CNN based Relocalization Method for Indoor Moving Robot with...

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第40届中国控制会议

作者： Aolei Yang Yanling Chen Hongzhou jin Ling Chen Renjun Chen yulin Xu School of Mechatronic Engineering and Automation Shanghai University College of Engineering and Design Hunan Normal University

Mobile robots are prone to be kidnapped when they perform autonomous navigation *** this paper,we propose an image based relocalization method for indoor mobile robot after being *** can be globally relocalized in endto-end manner by using a single RGB ***,a deep convolutional regression neural network model of encoder-decoder shape was *** encoder part of the model consists of some pre-trained lightweight residual blocks with less ***,the decoder part consists of some up-convolutional layers introduced to preserve partial detailed information of the input ***,in order to reduce the model complexity of the regression system and with the fact that a planar moving robot is not a full-degree of-freedom system,we propose a novel state parameterization method based on planar motion of indoor mobile ***,experimental results on public dataset show that the proposed image based relocalization method improves the accuracy of robot pose prediction to some extent.

关键词： mobile robot relocalization planar state constraint pose regression

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Based on network pharmacology to explore the mechanism of nephrotoxicity of Xanthii Fructus

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Asian Toxicology Research 2022年第1期4卷 24-31页

作者： Tao Chen Tengda Li Wenna Zhang yulin Song Yuman Tang Rui Gong Hua jin Nankai University Hospital Tianjin300071China Tianjin University of Traditional Chinese Medicine Tianjin301617China Chinese Medicine College Tianjin University of Traditional Chinese MedicineTianjin301617China

Objective:To explore the potential mechanism of nephrotoxicity induced by Xanthii Fructus(XF)through network ***:The active ingredients and targets of XF were screened through Traditional Chinese Medicine Systems Pharmacology Database,PubChem Database and Swiss Target Prediction Database,and the related pathogenic genes of nephrotoxicity were downloaded from Genecards,pharmGKB and OMIM *** potential target is the intersection of XF and the pathogenic gene of *** software was used to construct a network of“XF-Potential active ingredient-Target-Nephrotoxicity network”.Protein protein interaction(PPI)network was constructed by String database,and the data was analyzed and sorted out to obtain the key active components and core target proteins of *** functional enrichment analysis and KEGG pathway enrichment analysis of key target proteins were performed by R ***:11 active components,167 targets,6839 nephrotoxicity related pathogenic genes and 139 intersection target genes were screened from *** constructing the network of“XF-Potential active ingredient-target-nephrotoxicity network”and PPI network,the key active ingredients of XF were identified as Moupinamide,Beta-sitosterol and Stigmasterol,and the core target proteins were CASP3,HSP90AA1 and *** were 2072 GO entries(P<0.05),including 1876 Biological Process(BP),64 Cellular Component(CC)and 132 Molecular Function(MF).KEGG enrichment analysis revealed 138 pathways(P<0.05),mainly involving p53 signaling pathway,IL-17 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the nephrotoxicity of ***:The core target protein of XF HSP90AA1,CASP3 and TP53 participate in p53 signaling Pathway,PI3K-Akt signaling Pathway,IL-17 signaling Pathway and other pathways to regulate apoptosis and induce inflammatory responses,resulting in kidney damage.

关键词： Network pharmacology Nephrotoxicity Inflammatory responses Apoptosis

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地震作用下的风电机组振动仿真分析

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太阳能学报 2012年第2期33卷 179-184页

作者：何玉林王磊杜静金鑫重庆大学机械学院重庆400044 电子科技大学能源学院成都611731

应用基于多柔体动力学的联合仿真技术对地震作用下的风力发电机振动响应进行了研究。首先采用GDW理论进行风力机气动载荷计算分析,在Fortran下建立风力发电"叶轮—机舱—塔架"整机的多柔体系统动力学模型,将该系统模型转化为ADAMS分析... 详细信息

应用基于多柔体动力学的联合仿真技术对地震作用下的风力发电机振动响应进行了研究。首先采用GDW理论进行风力机气动载荷计算分析,在Fortran下建立风力发电"叶轮—机舱—塔架"整机的多柔体系统动力学模型,将该系统模型转化为ADAMS分析模型。然后通过动态链接文件和根据Eurocode8编写的地震载荷谱,在ADAMS中进行地震作用下的风力机系统联合仿真。仿真数据同Bladed软件结果比较表明,该联合仿真方法可较好的模拟风力机在地震作用下的振动响应。该文为研究地震对风力发电机的影响进行了一次有益的探索。

关键词：多柔体系统动力学 GDW理论地震载荷风力发电机联合仿真振动

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超边际分析框架下“双循环”新发展格局的策略选择——基于中美贸易摩擦的分析

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中国管理科学 2024年第6期32卷 196-206页

作者：刘渝琳谢缙重庆大学公共管理学院重庆400044

针对新冠疫情背景下保护主义、内顾倾向抬头的问题,利用超边际分析方法构建了一个同时存在国内市场和国际市场的两国贸易模型。根据关税、交易效率、生产技术等参数变化前后中美两国产业结构、生产—消费者效用的比较,揭示美国对中国单... 详细信息

针对新冠疫情背景下保护主义、内顾倾向抬头的问题,利用超边际分析方法构建了一个同时存在国内市场和国际市场的两国贸易模型。根据关税、交易效率、生产技术等参数变化前后中美两国产业结构、生产—消费者效用的比较,揭示美国对中国单方面加征关税的影响以及中国“双循环”新发展格局策略的应对选择。理论与数值模拟结果表明:(1)美国长期的单方面加征关税会损害两国的利益,加大了贸易条件的扭曲程度;(2)改善贸易条件、提升进出口商品的生产技术将有利于构建“双循环”新发展格局,中国可由此激发国内市场活力,获得新的经济增长源。

关键词： “双循环”新发展格局贸易条件技术壁垒超边际分析

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风力机结构耦合振动分析

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中国机械工程 2008年第1期19卷 9-13页

作者：金鑫何玉林杜静刘桦重庆大学重庆400044

采用通用动态尾流理论进行风力机气动力学的计算分析,并用MATLAB/Simulink进行编程,建立了风力机传动链的数学模型。在MATLAB/Simulink中进行传动链系统的编程运算,建立了风力机ADAMS柔性多体结构动力学仿真模型,并利用MATLAB/Simulink... 详细信息

采用通用动态尾流理论进行风力机气动力学的计算分析,并用MATLAB/Simulink进行编程,建立了风力机传动链的数学模型。在MATLAB/Simulink中进行传动链系统的编程运算,建立了风力机ADAMS柔性多体结构动力学仿真模型,并利用MATLAB/Simulink和ADAMS进行风力机振动性能的联合仿真。仿真时将气动载荷加载到风力机叶片结构上,将传动系统模型的反扭矩加到AD-AMS风轮模型上,同时考虑风力机的结构变形对气动性能、传动性能产生的影响。仿真最终实现了风力机系统振动性能耦合分析,其数据同实验测试数据比较表明,该联合仿真方法可以较好地模拟风力机的振动特性。

关键词：通用动态尾流理论联合仿真风力发电机振动

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风力发电机耦合振动分析

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振动与冲击 2007年第8期26卷 144-147,153页

作者：金鑫何玉林刘桦何婧重庆大学机械学院重庆400044

采用叶素动量理论进行风力机气动力学的计算分析,并用MATLAB/simulink进行编程,建立风力机传动链的数学模型并在MATLAB/simulink中进行传动链系统的编程运算,建立风力机ADAMS柔性多体结构动力学仿真模型,将MATLAB/simulink和ADAMS进行... 详细信息

采用叶素动量理论进行风力机气动力学的计算分析,并用MATLAB/simulink进行编程,建立风力机传动链的数学模型并在MATLAB/simulink中进行传动链系统的编程运算,建立风力机ADAMS柔性多体结构动力学仿真模型,将MATLAB/simulink和ADAMS进行风力机振动性能的联合仿真;将计算的气动载荷加载到风力机叶片结构上,将传动系统模型的反扭矩加到ADAMS风轮模型上,同时风力机的结构变形也对气动性能、传动性能产生耦合影响,仿真最终实现风力机系统振动性能耦合分析。仿真数据同实验测试数据比较表明,该联合仿真方法可以较好的模拟风力机的振动特性。研究为风力机振动特性分析进行了一次有益的探索。

关键词：叶素动量理论联合仿真风力发电机振动

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